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1. 发明申请

WO2015066611A2 MICRORNA PROFILES IN HEART FAILURE: METHODS AND SYSTEMS FOR DETECTION AND USE 审中-公开
标题翻译： MICRORNA在心力衰竭中的特征：用于检测和使用的方法和系统
公开(公告)号：WO2015066611A2
公开(公告)日：2015-05-07
申请号：PCT/US2014063690
申请日：2014-11-03
申请人： UNIV COLUMBIA , UNIV ROCKEFELLER
发明人： SCHULZE PAUL CHRISTIAN , TUSCHL THOMAS , AKAT KEMAL
IPC分类号： C12Q1/68 , A61K48/00
CPC分类号： C12Q1/6883 , A61M1/1001 , A61M1/101 , A61M1/122 , C12N15/113 , C12N2310/11 , C12N2320/31 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The level of miRNAs in a sample from a patient is assayed and used as an indicator of the efficacy of a therapeutic intervention for a cardiovascular disease, such as heart failure. The levels of a plurality of miRNAs, such as myomirs, may be measured. Based on the measured level of the miRNAs, the therapeutic intervention may be modified, adjusted, continued or discontinued. The miRNA level may also be used to assess the severity or disease progression of a cardiovascular disease.
摘要翻译：测定来自患者的样品中的miRNA的水平并将其用作心血管疾病（例如心力衰竭）的治疗干预的功效的指标。可以测量多种miRNA如myomir的水平。基于测量的miRNA水平，治疗干预可以被修改，调整，继续或停止。 miRNA水平也可用于评估心血管疾病的严重程度或疾病进展。

2. 发明申请

WO2014127258A3 METHODS TO PROTECT AGAINST AND TREAT MULTIPLE SCLEROSIS 审中-公开
标题翻译：防止和治疗多发性硬化症的方法
公开(公告)号：WO2014127258A3
公开(公告)日：2014-10-23
申请号：PCT/US2014016522
申请日：2014-02-14
申请人： UNIV CORNELL , UNIV ROCKEFELLER
发明人： VARTANIAN TIMOTHY , RUMAH KAREEM RASHID , FISCHETTI VINCENT A
IPC分类号： A61K39/395 , A61P25/00 , A61P25/28
CPC分类号： C07K16/1282 , A61K31/7048 , A61K35/741 , A61K35/742 , A61K38/47 , A61K39/00 , A61K2039/505 , C07K2317/76 , C12Q1/689 , C12Q2600/118 , C12Q2600/142 , C12Y302/01017 , G01N33/56911 , G01N2333/33 , G01N2469/20 , G01N2500/04 , G01N2500/10 , G01N2800/285
摘要： The invention provides epsilon toxin (ETX) produced by Clostridium perfringens type B or type D as a causative toxin for human multiple sclerosis (MS). The invention further identifies ETX binding receptor MAL for ETX mediated cell death and other toxin- logical activities in MS. Methods and compositions to prevent humans from multiple sclerosis (MS) and/or treating MS by directly or indirectly interfering with epsilon toxin (ETX), its binding receptor (e.g., MAL), or ETX-receptor interactions so as to inhibit or suppress downstream ETX mediated receptor signaling activities are provided. Also provided are various methods to detect, diagnose, monitor, assess multiple sclerosis (MS) by determining an expression level of ETX gene or its encoding protein in human patient suspected for and/or at risk for multiple sclerosis (MS).
摘要翻译：本发明提供由产气荚膜梭状芽孢杆菌B型或D型作为人多发性硬化症（MS）致病毒素产生的ε毒素（ETX）。本发明进一步鉴定ETX结合受体MAL用于ETX介导的细胞死亡和MS中的其他毒素活性。通过直接或间接干扰ε-毒素（ETX），其结合受体（例如MAL）或ETX-受体相互作用来抑制或抑制多发性硬化（MS）和/或治疗MS以抑制或抑制下游的方法和组合物提供了ETX介导的受体信号传导活性。还提供了通过确定怀疑为和/或具有多发性硬化（MS）风险的人类患者中ETX基因或其编码蛋白的表达水平来检测，诊断，监测，评估多发性硬化（MS）的各种方法。

3. 发明申请

WO2014134043A2 MULTI-POLE ION TRAP FOR MASS SPECTROMETRY 审中-公开
标题翻译：用于大量光谱的多点离子阱
公开(公告)号：WO2014134043A2
公开(公告)日：2014-09-04
申请号：PCT/US2014018330
申请日：2014-02-25
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , SHERMAN VADIM , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： H01J49/42
CPC分类号： H01J49/06 , H01J49/02 , H01J49/36 , H01J49/4225 , H01J49/424
摘要： An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis.
摘要翻译：离子阱包括用于容纳离子的容纳区域和位于包围容纳区域的规则多面体结构上的多个电极。电极位于包围结构的每个顶点上，并且多边形表面中的至少一个包括配置成在表面上形成多个四极的附加电极。交替的RF电压被施加到多个电极，使得直接相邻的电极在任何时间点具有相等的幅度和相反的极性。在多面体结构上的这种构造形成了用于排斥来自每个正多边形表面的离子并将其包含在陷阱中的势垒。质量选择过滤器可以从四极杆形成，用于在不同的m / z窗口中进行并行质量分析。将小直流电势施加到四极体之外的平板电极优先消耗单电荷离子以增强信噪比分析。

4. 发明申请

WO2014071067A3 TREATMENT AND DIAGNOSIS OF COLON CANCER 审中-公开
标题翻译：结肠癌的治疗和诊断
公开(公告)号：WO2014071067A3
公开(公告)日：2014-07-03
申请号：PCT/US2013067860
申请日：2013-10-31
申请人： UNIV ROCKEFELLER
发明人： TAVAZOIE SOHAIL , LOO JIA MIN
IPC分类号： A61P35/04 , A61P35/00 , C12Q1/68 , G01N33/53
CPC分类号： A61K31/197 , A61K9/0019 , A61K31/337 , A61K31/4168 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/7068 , A61K31/7072 , A61K31/7088 , A61K45/06
摘要： The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
摘要翻译：本发明公开了诊断和治疗结肠癌的新药和方法。还公开了相关的阵列，试剂盒和筛选方法。

5. 发明申请

WO2013016468A3 COMPOSITIONS AND METHODS FOR IMPROVING POTENCY AND BREADTH OR HIV ANTIBODIES 审中-公开
标题翻译：提高潜能和传播能力的组合物和方法或HIV抗体
公开(公告)号：WO2013016468A3
公开(公告)日：2013-05-02
申请号：PCT/US2012048209
申请日：2012-07-25
申请人： CALIFORNIA INST OF TECHN , UNIV ROCKEFELLER , DISKIN RON , BJORKMAN PAMELA J , NUSSENZWEIG MICHEL , SCHEID JOHANNES
发明人： DISKIN RON , BJORKMAN PAMELA J , NUSSENZWEIG MICHEL , SCHEID JOHANNES
IPC分类号： A61K39/42 , A61P31/18 , C07K16/10 , C12N15/13 , C12N15/49
CPC分类号： C07K16/1063 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) antibodies having improved potency and breadth.
摘要翻译：本发明的实施方案涉及用于具有改善的效力和广度的抗HIV（抗-CD4结合位点）抗体的组合物和方法。

6. 发明申请

WO2012145209A3 ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：抗炎药物
公开(公告)号：WO2012145209A3
公开(公告)日：2013-01-17
申请号：PCT/US2012033095
申请日：2012-04-11
申请人： UNIV ROCKEFELLER , RAVETCH JEFFREY V , ANTHONY ROBERT , KOBAYASHI TOSHIHIKO , WERMELING FREDRIK
发明人： RAVETCH JEFFREY V , ANTHONY ROBERT , KOBAYASHI TOSHIHIKO , WERMELING FREDRIK
IPC分类号： C12N5/078 , A01N63/00
CPC分类号： A61K35/15 , A61K35/28 , A61K38/20 , A61K47/68 , C07K16/00 , C07K16/244 , C07K2317/41 , C07K2317/52 , C12N5/064 , C12N5/0645 , C12N2501/2333 , C12N2501/998 , C12N2506/11 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/6869 , G01N2333/545 , G01N2500/04 , G01N2500/10
摘要： This invention concerns anti-inflammatory agents and methods for treating inflammatory disorders. Also disclosed are methods for identifying or evaluating anti-inflammatory agents or compositions.
摘要翻译：本发明涉及抗炎剂和治疗炎症性疾病的方法。还公开了鉴定或评估抗炎剂或组合物的方法。

7. 发明申请

WO2012145630A2 STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIA 审中-公开
标题翻译： STRATTOCOCCUS BACTERIOPHAGE LYSINS用于检测和治疗GRAM阳性细菌
公开(公告)号：WO2012145630A2
公开(公告)日：2012-10-26
申请号：PCT/US2012034456
申请日：2012-04-20
申请人： UNIV ROCKEFELLER , FISCHETTI VINCENT A , SCHMITZ JONATHAN , GILMER DANIEL , EULER CHAD
发明人： FISCHETTI VINCENT A , SCHMITZ JONATHAN , GILMER DANIEL , EULER CHAD
IPC分类号： A61K38/46
CPC分类号： C12N9/2462 , A61K38/162 , A61K38/47 , A61K38/50 , A61K45/06 , C12Y302/01017
摘要： The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.
摘要翻译：本发明提供了可用于预防和治疗改善和治疗包括链球菌和葡萄球菌在内的革兰氏阳性菌及其相关条件的方法，组合物和制品。本发明提供了组合物和方法，该组合物和方法并入并利用来自猪链球菌的噬菌体溶素，特别是PlySs2和/或PlySs1裂解酶及其变体，包括其截短。提供了治疗人的方法。

8. 发明申请

WO2012065055A2 FUSION PROTEINS FOR HIV THERAPY 审中-公开
标题翻译：用于HIV治疗的融合蛋白
公开(公告)号：WO2012065055A2
公开(公告)日：2012-05-18
申请号：PCT/US2011060357
申请日：2011-11-11
申请人： UNIV ROCKEFELLER , HO DAVID , HUANG YAOXING , PACE CRAIG , SONG RUIJIANG , FANG QING
发明人： HO DAVID , HUANG YAOXING , PACE CRAIG , SONG RUIJIANG , FANG QING
IPC分类号： C07K16/46 , A61K39/42 , A61P31/18
CPC分类号： C07K16/2812 , C07K16/1063 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Disclosed herein are fusion antibodies created to provide both an antigen-binding site that targets the CD4 receptor and an antigen-binding site that targets the HIV envelope. The fusion antibodies disclosed herein provide improved potency and breadth against HIV as compared to monospecific antibodies, and additionally provide high barrier against viral resistance. Also disclosed are pharmaceutical formulations and therapeutic methods utilizing such fusion proteins.
摘要翻译：本文公开了产生融合抗体以提供靶向CD4受体的抗原结合位点和靶向HIV包膜的抗原结合位点。与单特异性抗体相比，本文公开的融合抗体提供改善的针对HIV的效力和广度，并且另外提供抗病毒抗性的高度屏障。还公开了利用这种融合蛋白的药物制剂和治疗方法。

9. 发明申请

WO2010033667A3 WSTF REGULATES THE DNA DAMAGE RESPONSE OF H2A.X VIA NOVEL TYROSINE KINASE ACTIVITY 审中-公开
标题翻译： WSTF通过新的酪氨酸激酶活性调节H2A.X的DNA损伤反应
公开(公告)号：WO2010033667A3
公开(公告)日：2010-06-03
申请号：PCT/US2009057263
申请日：2009-09-17
申请人： UNIV ROCKEFELLER , ALLIS C DAVID , XIAO ANDREW
发明人： ALLIS C DAVID , XIAO ANDREW
IPC分类号： G01N33/53
CPC分类号： C12N9/12 , C12Q1/485 , G01N33/6842 , G01N2500/02
摘要： The present invention relates to methods of detecting and regulating cellular DNA damage as well as methods of screening compounds suitable for modulating cellular DNA damage. The methods of the present invention utilize antibodies that selectively bind to a phosphorylated tyrosine residue in a SQEY tyrosine phosphorylation motif sequence or a phosphorylated serine residue in a KENSSQ phosphorylation motif sequence, where the phosphorylated serine residue is closest to the glutamine residue. Also encompassed by the present invention are methods of treating a subject having cancer. These methods involve the administration of an agent that modulates the phosphorylation of the tyrosine residue in a SQEY motif. Suitable agents for modulating the phosphorylation of the tyrosine residue of the SQEY motif are also disclosed.
摘要翻译：本发明涉及检测和调节细胞DNA损伤的方法以及筛选适于调节细胞DNA损伤的化合物的方法。本发明的方法利用选择性结合SQEY酪氨酸磷酸化基序序列中的磷酸化酪氨酸残基或KENSSQ磷酸化基序序列中的磷酸化丝氨酸残基的抗体，其中磷酸化丝氨酸残基最接近谷氨酰胺残基。本发明还包括治疗患有癌症的受试者的方法。这些方法涉及施用调节SQEY基序中酪氨酸残基的磷酸化的试剂。还公开了用于调节SQEY基元的酪氨酸残基磷酸化的合适试剂。

10. 发明申请

WO2010030936A3 NOVEL AUTOPHAGY REGULATORS ATG14L AND RUBICON 审中-公开
标题翻译：新型自动调节器ATG14L和RUBICON
公开(公告)号：WO2010030936A3
公开(公告)日：2010-05-27
申请号：PCT/US2009056728
申请日：2009-09-11
申请人： SINAI SCHOOL MEDICINE , UNIV ROCKEFELLER , YUE ZHENYU , ZHONG YUN
发明人： YUE ZHENYU , ZHONG YUN
IPC分类号： A01N37/18 , A61K38/00
CPC分类号： C07K14/4702 , C07K14/4747
摘要： The present invention provides for up- and down- regulation of cellular autophagy, e.g., for treating cancer or neurological disease. The invention results, in part, from discovery of two novel proteins, ATGl 4L (previously called "BISC") and Rubicon (previously called "BIRC"), which bind to a Class III phophatidylinositol 3'- kinase (PI3K)/Vps34-Beclin 1 autophagic complex. ATG 14L and Rubicon each regulate autophagic activity in an opposing manner. ATG 14L and Rubicon can be used, for example, to increase/decrease autophagic activity, to increase/decrease PI3K7Vps34 kinase activity, and in so doing, treat diseases and disorders, such as cancer, neurodegenerative disease, stroke, metabolic disease, and age-related disease. ATG14L can increase autophagic activity and PI3K/Vps34 kinase activity; and Rubicon can decrease autophagic activity and PI3K/Vps34 kinase activity.
摘要翻译：本发明提供细胞自噬的上调和下调，例如用于治疗癌症或神经疾病。本发明部分地由两种新型蛋白质ATG14L（以前称为“BISC”）和Rubicon（以前称为“BIRC”）的发现结合，其结合于III类磷酸肌醇3'-激酶（PI3K）/ Vps34- Beclin 1自噬复合体。 ATG 14L和Rubicon各自以相反的方式调节自噬活性。 ATG 14L和Rubicon可以用于例如增加/减少自噬活性，增加/减少PI3K7Vps34激酶活性，并且这样做可以治疗诸如癌症，神经变性疾病，中风，代谢疾病和年龄的疾病和病症相关疾病 ATG14L可增加自噬活性和PI3K / Vps34激酶活性; Rubicon可降低自噬活性和PI3K / Vps34激酶活性。

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