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    • 1. 发明申请
    • EPIDITHIODIKETOPIPERAZINE COMPOUNDS, COMPOSITIONS, AND METHODS
    • 吡虫啉酮化合物,组合物和方法
    • WO2015095821A1
    • 2015-06-25
    • PCT/US2014/071719
    • 2014-12-19
    • GLOBAVIR BIOSCIENCES, INC.
    • BALAN, CheneraMAHAJAN, SumitNAGAVARAPU, UshaGUPTA, Shalabh
    • A61K31/4995
    • C07D285/15A61K31/548A61K45/06C07D513/08C07D519/00
    • Epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of their synthesis, as part of treating, inhibiting and reducing transcription and translation of hypoxia inducible genes are described. In another aspect, the present disclosure describes a method for interfering with hypoxia-induced transcriptional pathway in a cell comprising: contacting the cell with at least one compound disclosed herein. In another aspect, the present disclosure describes a method for treating breast cancer, a solid cancer, a blood cancer, a subject suffering from carcinoma in need of said treatment, and renal cell carcinoma (RCC), comprising: administering to the subject an effective amount of at least one compound disclosed herein. In some embodiments of the methods described herein, the method further comprises administering an additional anti-cancer and/or cytotoxic agent.
    • 描述了基于其的药物组合物及其合成方法,作为治疗,抑制和减少缺氧诱导型基因的转录和翻译的一部分。 在另一方面,本公开描述了干扰细胞中缺氧诱导的转录途径的方法,包括:使细胞与本文公开的至少一种化合物接触。 另一方面,本公开内容描述了一种治疗乳腺癌,实体癌症,血液癌症,患有需要治疗的癌症的受试者和肾细胞癌(RCC)的方法,其包括:对受试者施用有效的 本文公开的至少一种化合物的量。 在本文所述方法的一些实施方案中,所述方法还包括施用另外的抗癌和/或细胞毒性剂。