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    • 3. 发明申请
    • ION EXCHANGER, PRODUCTION THEREOF, AND PROCESS FOR SEPARATING BIOPOLYMER BY USING SAME
    • 离子交换器,其生产方法和使用相同方法分离生物聚合物的方法
    • WO1993003841A1
    • 1993-03-04
    • PCT/JP1992001061
    • 1992-08-24
    • MITSUBISHI KASEI CORPORATIONKUDO, KeikoKINIWA, Hideaki
    • MITSUBISHI KASEI CORPORATION
    • B01J39/16
    • B01J39/26B01J39/16B01J47/014
    • An ion exchanger comprising a composite having a degree of swelling in water of 2 to 7 ml/g of resin, said composite being prepared by holding a cross-linked gel, which comprises a hydrophilic natural macromolecule having a three-dimensional cross-linked network structure and has ion-exchange groups, in the pores of a porous particle of a hydrophilic cross-linked copolymer having pores with a diameter of 0.01 to less than 1 mu m, a pore volume of 30 to 70 % of the resin volume and preferably a particle diameter of 5 to 500 mu m; a process for the production thereof; and a process for separating biopolymers such as proteins by using the ion exchanger. This exchanger undergoes little volume change, serves to remedy the shortcomings of conventional cross-linked gels in passing various liquids, and has merits of being free from nonspecific adsorption and having high adsoprtion and desorption rates in the separation of biopolymers such as proteins.
    • 一种离子交换剂,其包含在水中具有2至7ml / g树脂的溶胀度的复合物,所述复合物通过保持交联凝胶制备,所述交联凝胶包含具有三维交联网络的亲水天然大分子 结构,并具有离子交换基团,在具有直径为0.01至小于1μm的孔的亲水性交联共聚物的多孔颗粒的孔中,孔体积为树脂体积的30至70%,优选为 粒径5〜500μm; 一种生产过程; 以及通过使用离子交换剂分离生物聚合物如蛋白质的方法。 该交换器经历很小的体积变化,用于弥补常规交联凝胶在通过各种液体时的缺点,并且具有不具有非特异性吸附的优点,并且在分离生物聚合物如蛋白质中具有高的吸附和解吸速率。