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    • 3. 发明申请
    • MULTIFUNCTIAL MULTIREACTOR CHEMICAL SYNTHESIS INSTRUMENT
    • 多功能多功能化学合成仪器
    • WO2005105296A3
    • 2007-01-04
    • PCT/US2005008879
    • 2005-03-16
    • AKRIBIO CORPYOUNG LI
    • YOUNG LI
    • B01J19/00B01L3/00B32B5/02F28F13/00
    • B01J19/0046B01J2219/00283B01J2219/00308B01J2219/00344B01J2219/00353B01J2219/00389B01J2219/00416B01J2219/00481B01J2219/00493B01J2219/00495B01J2219/00585B01J2219/00599B01J2219/00689B01J2219/00695B01J2219/00698B01J2219/0072
    • A stand alone instrument for enhancing chemical and physical reactions on the "bench" level by providing a single instrument capability of performing a variety of functions on a plurality of reaction vessels at the same time (in parallel), includes heating, cooling and five other functional capabilities, and more particularly to such instruments that provide the matrix of plural functions and plural reaction vessels, with the further ability of providing real time energy balance data on each reactor. Thus, the instruments provide for any or all of heating, cooling, reflux, inert gas blanketing, vacuuming, stirring and evaporation at each reactor. (The words "reactor", "microreactor", "reaction vessel" and "vessel" are used interchangeably herein, and generally refer to bench scale flasks, beakers and other reactors used by bench chemists, biochemists, physicists, biologists, research doctors, and the like.) In some embodiments, the instruments include cooling units which uniquely rely upon phase change coolant injections. In other embodiments, the instruments include cofinger stoppers, described below. The instruments may include both the phase change coolant systems and the cofinger stopper arrangements.
    • 通过提供在多个反应容器上同时(并联)地执行各种功能的单一仪器能力,在“台”级上增强化学和物理反应的独立仪器包括加热,冷却和其他五个 更具体地涉及提供多个功能矩阵和多个反应容器的这种仪器,具有在每个反应器上提供实时能量平衡数据的进一步能力。 因此,这些仪器提供在每个反应器中的加热,冷却,回流,惰性气体覆盖,抽真空,搅拌和蒸发中的任何一种或全部。 (“反应器”,“微反应器”,“反应容器”和“容器”一词在本文中可以互换使用,通常是指台式化学家,生物化学家,物理学家,生物学家,研究医师使用的台式烧瓶,烧杯和其他反应器, 在一些实施例中,仪器包括唯一依赖于相变冷却剂注入的冷却单元。 在其他实施例中,仪器包括如下所述的cofinger塞子。 这些仪器可以包括相变冷却剂系统和共转手止动器装置。
    • 4. 发明申请
    • MULTIFUNCTIAL MULTIREACTOR CHEMICAL SYNTHESIS INSTRUMENT
    • 多功能多功能化学合成仪器
    • WO2005105296A2
    • 2005-11-10
    • PCT/US2005/008879
    • 2005-03-16
    • AKRIBIO CORP.YOUNG, Li
    • YOUNG, Li
    • B01J19/00
    • B01J19/0046B01J2219/00283B01J2219/00308B01J2219/00344B01J2219/00353B01J2219/00389B01J2219/00416B01J2219/00481B01J2219/00493B01J2219/00495B01J2219/00585B01J2219/00599B01J2219/00689B01J2219/00695B01J2219/00698B01J2219/0072
    • A stand alone instrument for enhancing chemical and physical reactions on the "bench" level by providing a single instrument capability of performing a variety of functions on a plurality of reaction vessels at the same time (in parallel), includes heating, cooling and five other functional capabilities, and more particularly to such instruments that provide the matrix of plural functions and plural reaction vessels, with the further ability of providing real time energy balance data on each reactor. Thus, the instruments provide for any or all of heating, cooling, reflux, inert gas blanketing, vacuuming, stirring and evaporation at each reactor. (The words "reactor", "microreactor", "reaction vessel" and "vessel" are used interchangeably herein, and generally refer to bench scale flasks, beakers and other reactors used by bench chemists, biochemists, physicists, biologists, research doctors, and the like.) In some embodiments, the instruments include cooling units which uniquely rely upon phase change coolant injections. In other embodiments, the instruments include cofinger stoppers, described below. The instruments may include both the phase change coolant systems and the cofinger stopper arrangements.
    • 通过提供在多个反应容器上同时(并联)地执行各种功能的单一仪器能力,在“台”级上增强化学和物理反应的独立仪器包括加热,冷却和其他五个 更具体地涉及提供多个功能矩阵和多个反应容器的这种仪器,具有在每个反应器上提供实时能量平衡数据的进一步能力。 因此,这些仪器提供在每个反应器中的加热,冷却,回流,惰性气体覆盖,抽真空,搅拌和蒸发中的任何一种或全部。 (“反应器”,“微反应器”,“反应容器”和“容器”一词在本文中可以互换使用,通常是指台式化学家,生物化学家,物理学家,生物学家,研究医师使用的台式烧瓶,烧杯和其他反应器, 在一些实施例中,仪器包括唯一依赖于相变冷却剂注入的冷却单元。 在其他实施例中,仪器包括如下所述的cofinger塞子。 这些仪器可以包括相变冷却剂系统和共转手止动器装置。
    • 6. 发明申请
    • MULTIPORT COFINGER MICROREACTOR STOPPER AND DEVICE
    • 多功能COFINGER MICROREACTOR STOPPER AND DEVICE
    • WO2005105295A2
    • 2005-11-10
    • PCT/US2005007898
    • 2005-03-09
    • AKRIBIO CORPYOUNG LI
    • YOUNG LI
    • B01J19/00B01L3/00
    • B01J19/0093B01J19/0013B01J19/0053B01J19/0073B01J2219/00078B01J2219/00788B01J2219/00804B01J2219/0081B01J2219/00822B01J2219/00831B01J2219/00833B01J2219/00873B01J2219/00891B01L3/569B01L2200/026B01L2300/042B01L2300/047
    • The present invention is a multiport cofinger as well as a device that includes a multiport cofinger stopper and a microreactor. The stopper includes a main housing with a central orifice and a plurality of outer orifices located about the central orifice, and a sealing mechanism on the sidewall of the main housing. The cofinger is a concentric set of two tubes, but not necessarily symmetrically concentric. The cofinger has at least one inside tube and an outside tube, and each of the tubes has an upper end and a lower end, the lower end of which may be closed or open. The sealing mechanism may be a tapering of the sidewall of the main housing to permit force fitting thereof into an opening of the microreactor or it may be designed for external stopper connection. Alternatively, it is at least one O-ring located about said sidewall of said main housing. In some embodiments, the main housing has an upper section and a lower section, with the lower section of smaller diameter than the upper section.
    • 本发明是一种多端口合成器以及包括多端口共转移器塞子和微反应器的装置。 止动器包括具有中心孔的主壳体和围绕中心孔定位的多个外孔,以及在主壳体的侧壁上的密封机构。 cofinger是一组同心的两根管,但不一定对称地同心。 共同型手指具有至少一个内管和外管,并且每个管具有上端和下端,其下端可以是封闭的或敞开的。 密封机构可以是主壳体的侧壁的锥形,以允许将其压配合到微反应器的开口中,或者可以设计用于外部止动器连接。 或者,它是位于所述主壳体的所述侧壁周围的至少一个O形环。 在一些实施例中,主壳体具有上部和下部,下部的直径小于上部。