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1. 发明申请

WO2015088427A1 PISTON AND PROCESS COLUMN 审中-公开
标题翻译：活塞和加工柱
公开(公告)号：WO2015088427A1
公开(公告)日：2015-06-18
申请号：PCT/SE2014/051463
申请日：2014-12-08
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： BERGSTROM, Andreas , ERIKSSON, Stefan, Kjell
IPC分类号： G01N30/60 , B01D15/10
CPC分类号： G01N30/606 , B01D15/18 , B01D15/206 , B01D15/22 , B23P6/02 , G01N30/6021
摘要： The invention discloses a piston (4;24;54) for a process column, said piston comprising a top side (5;25;55) and a bed contact side (6;26;56), wherein said top side comprises a drainage trench (8;28;58).
摘要翻译：本发明公开了一种用于处理塔的活塞（4; 24; 54），所述活塞包括顶侧（5; 25; 55）和床接触侧（6; 26; 56），其中所述顶侧包括排水沟槽（8; 28; 58）。

2. 发明申请

WO02055538A2 CONTINUOUS SEPARATION METHOD 审中-公开
标题翻译：连续分离方法
公开(公告)号：WO02055538A2
公开(公告)日：2002-07-18
申请号：PCT/EP2002/000175
申请日：2002-01-10
IPC分类号： B01D15/18 , B01D15/20 , C07K1/22 , B01D15/08
CPC分类号： B01J20/285 , B01D15/18 , B01D15/1864 , B01D15/203 , B01J20/28004 , C07K1/22
摘要： The present invention relates to a method of separating a tagged protein product from a raw cell culture comprising the steps of providing a chromatography column com-prising an adsorption resin and a sample of cell culture, passing said sample over said column to capture tagged protein product to the resin, optionally washing the resin by passing a suitable liquid over the column, and eluting the protein product from the col-umn. During the whole processing, the sample, washing liquid and eluent are added at flow rates that maintain an essentially continuous flow throughout the column, and at least two samples are processed in parallel. The invention also relates to an apparatus especially suitable for performing a method of separating a tagged protein product from a raw cell culture.
摘要翻译：本发明涉及一种从原始细胞培养物中分离标记的蛋白质产物的方法，包括以下步骤：提供一种色谱柱，该色谱柱与吸附树脂和细胞培养物样品相接触，将所述样品通过所述柱以捕获标记的蛋白质产物任选地通过使合适的液体通过柱子洗涤树脂，并从柱洗脱蛋白质产物。在整个处理过程中，样品，洗涤液和洗脱液以保持基本上连续的整个柱的流速加入，并且至少两个样品被并行处理。本发明还涉及一种特别适于执行从原始细胞培养物中分离标记的蛋白质产物的方法的装置。

3. 发明申请

WO99058217A1 A NEW CHROMATOGRAPHIC METHOD AND CHROMATOGRAPHIC COLUMNS THEREFOR 审中-公开
标题翻译：一种新的色谱方法及其色谱柱
公开(公告)号：WO99058217A1
公开(公告)日：1999-11-18
申请号：PCT/SE1999/000812
申请日：1999-05-12
IPC分类号： B01J20/283 , B01D15/08 , B01J20/281 , C40B60/00 , G01N30/02 , G01N30/16 , G01N30/52 , G01N30/56 , G01N30/60 , G01N30/62 , G01N30/88 , G01N30/95
CPC分类号： B01D15/18 , B01D15/24 , B01J20/281 , B01J2219/00274 , B01J2220/54 , G01N30/02 , G01N30/48 , G01N30/6017 , G01N30/6082 , G01N2030/165 , G01N2030/524 , G01N2030/562 , B01D15/26 , G01N30/62 , G01N30/95 , G01N21/64
摘要： A chromatographic column for simultaneous purification of several compounds in a sample by dry column chromatography comprised by a plastic tube and containing a sorbent is described, wherein there is an empty volume on top of the sorbent large enough to hold the amount of developing solvent needed to develop the column, wherein the plastic material is transparent or semitransparent to UV and visible light and can be cut with a sharp object, and wherein the sorbent particle size is
摘要翻译：描述了用于通过由塑料管和含有吸附剂组成的干柱色谱同时纯化样品中几种化合物的色谱柱，其中在吸附剂顶部存在足够大的空容积以保持所需的显影溶剂量开发色谱柱，其中塑料材料对UV和可见光是透明的或半透明的，并且可以用锋利的物体切割，并且其中吸附剂粒度<40μm并含有荧光材料。

4. 发明申请

WO1985004594A1 METHOD AND UNIT FOR SEQUENTIAL CENTRIFUGAL STRATIFICATION CHROMATOGRAPHY 审中-公开
标题翻译：用于顺序离心分离色谱的方法和单元
公开(公告)号：WO1985004594A1
公开(公告)日：1985-10-24
申请号：PCT/CH1985000054
申请日：1985-04-03
申请人： NYIREDY, Szabolcs , ERDELMEIER, Clemens , STICHER, Otto
IPC分类号： B01D15/08
CPC分类号： G01N30/90 , B01D15/18 , G01N30/94 , G01N2030/381
摘要： The method and plant disclosed combine the advantages of the preparatory centrifugal stratification chromatography, of the analytical horizontal, anticircular and sequential thin layer chromatography. In this new on-line preparatory method the addition of solvent may be varied in parallel, locally and temporally. It is thus possible to improve sections of the integral chromatogram in their separation by selecting for these partial problems the optimum composition of the solvent. The separations are basically obtained in two different ways: 1. The circular separations are effected by means of the centrifugal force by using a sequential solvent supply (20), the separation taking place from the inside to the outside. The separated substances may be brought back to the inner part of the layer by recycling. 2. The anticircular separations are performed by means of the capillary force by using an annular-shaped solvent supply (19), the substance zones being concentrated and/or developed from the outside to the inside. The possibilities of circular and anticircular applications may be combined as desired so that the separation path may be prolonged practically in an illimited manner and thus the capacity and separation power may be considerably increased.
摘要翻译：所公开的方法和工艺结合了准备离心分层色谱，分析水平，反循环和顺序薄层色谱的优点。在这种新的在线准备方法中，溶剂的添加可以在本地和时间上并行地变化。因此，通过选择溶剂的最佳组成，可以对其分离中的积分色谱图进行改进。分离基本上以两种不同的方式获得：1.通过使用顺序溶剂供应（20）通过离心力实现圆形分离，分离从内部到外部进行。分离的物质可以通过再循环回到层的内部。通过使用环形溶剂供应（19）通过毛细管力进行反圆分离，物质区域从外部到内部集中和/或显影。可以根据需要组合圆形和反圆形应用的可能性，使得实际上可以以不必要的方式延长分离路径，从而可以显着增加容量和分离功率。

5. 发明申请

WO2018203231A1 LAMINAR FLOW IN CARBON DIOXIDE BASED CHROMATOGRAPHY 审中-公开
公开(公告)号：WO2018203231A1
公开(公告)日：2018-11-08
申请号：PCT/IB2018/053009
申请日：2018-05-01
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： TARAFDER, Abhijit , HILL, Jason F.
IPC分类号： G01N30/32 , G01N30/28 , B01D15/40
CPC分类号： B01D15/18 , B01D15/16 , B01D15/161 , B01D15/163 , B01D15/40 , G01N30/28 , G01N30/32 , G01N30/38 , G01N30/54 , G01N2030/027
摘要： The present disclosure relates generally to a system of method development in a highly-compressible fluid based chromatography system. In particular, the disclosure relates to method development in a carbon dioxide based chromatography system which can avoid non-laminar flow conditions. The system can include characterization of the chromatographic system in the form of one or more charts that can be used during method development to select chromatographic separation conditions that avoid non-laminar flow. For example, the onset of non-laminar conditions can be plotted as a function of volumetric flow rate and the mobile phase composition, e.g., carbon dioxide: methanol (v/v %).

6. 发明申请

WO2016205867A1 MULTI-STAGE SEPARATION DEVICE FOR USE WITH FLOWABLE SYSTEM OF SUBSTANCES 审中-公开
标题翻译：具有可流动系统物质的多级分离装置
公开(公告)号：WO2016205867A1
公开(公告)日：2016-12-29
申请号：PCT/AU2016/000227
申请日：2016-06-23
申请人： TOMLE STRATEGIES PTY LTD
发明人： CRASTI, Leo , TOMLINSON, David, John
IPC分类号： B01D21/26 , C02F1/38 , B04C5/081
CPC分类号： B01D21/26 , B01D15/18 , B01D17/0217 , B01D21/24 , B04C1/00 , B04C7/00 , B04C9/00 , B04C2009/004 , C02F1/38
摘要： A multi-stage separation device for separating a first fluid from at least one other second substance, the first fluid and second substance forming a flowable system of substances. The device comprising a housing having a substantially cylindrical form about a central axis with a wall disposed between a first end and second end, and an inlet disposed near said first end of the housing and an outlet in the second end. The wall when viewed in cross section perpendicular to the central axis has an ever decreasing radius spiralling between at least a first edge of said wall and a second edge of the wall. The first edge and second edge form part of the periphery of an inlet in the housing. At least one permeable cylindrical separation module is disposed within the housing.
摘要翻译：一种用于将第一流体与至少一种其它第二物质分离的多级分离装置，所述第一流体和第二物质形成物质的可流动系统。该装置包括具有围绕中心轴线的基本圆柱形的壳体，壁设置在第一端和第二端之间，以及设置在壳体的第一端附近的入口和在第二端的出口。当在垂直于中心轴线的横截面中观察时，所述壁在所述壁的至少第一边缘和所述壁的第二边缘之间具有不断缩小的半径。第一边缘和第二边缘形成壳体中入口周边的一部分。至少一个可渗透的圆柱形分离模块设置在壳体内。

7. 发明申请

WO2015183290A1 APPARATUS AND METHOD FOR INTRODUCING A SAMPLE INTO A SEPARATION UNIT OF A CHROMATOGRAPHY SYSTEM 审中-公开
标题翻译：将样品引入色谱系统的分离单元的装置和方法
公开(公告)号：WO2015183290A1
公开(公告)日：2015-12-03
申请号：PCT/US2014/040073
申请日：2014-05-29
申请人： AGILENT TECHNOLOGIES, INC.
发明人： WIKFORS, Edwin, E.
IPC分类号： B01D15/40 , B01D15/14 , B01D15/30 , G01N30/02 , G01N30/16
CPC分类号： B01D15/14 , B01D15/18 , B01D15/1878 , B01D15/325 , B01D15/40 , G01N30/16 , G01N30/20 , G01N30/32 , G01N30/34 , G01N30/38 , G01N30/463 , G01N30/465 , G01N2030/324 , G01N2030/342
摘要： An apparatus introduces a sample into a separation unit of a chromatography system with a mobile phase, including first and second mobile phase components. The apparatus includes first and second pump systems, and an injection unit. The first pump system provides the first mobile phase component, first and second portions of the first mobile phase component flowing through first and second branches, respectively. The second pump system provides the second mobile phase component, first and second portions of the second mobile phase component flowing through third and fourth branches, respectively. The injection unit receives a combined stream of the first portions of the first and second mobile phase components provided via the first and third branches, respectively, and to injects the sample into the combined stream to form a sample-containing stream. The sample-containing stream is subsequently combined with the second portions of the first and second mobile phase components provided via the second and fourth branches, respectively, to form a diluted sample-containing stream, which flows to the separation unit for separating sample constituents.
摘要翻译：装置将样品引入具有流动相的色谱系统的分离单元，其包括第一和第二流动相组分。该装置包括第一和第二泵系统和注射单元。第一泵系统提供第一流动相分量，第一流动相分量的第一和第二部分分别流经第一和第二分支。第二泵系统提供第二流动相分量，第二流动相组分的第一和第二部分分别流经第三和第四分支。注射单元接收经由第一和第三分支提供的第一和第二流动相组分的第一部分的组合流，并将样品注入组合流中以形成含样品的流。随后将含样品流与经由第二和第四分支提供的第一和第二流动相组分的第二部分组合以形成稀释的含样品流，其流到分离单元以分离样品组分。

8. 发明申请

WO2015060764A1 A REACTOR FOR BIOLOGICAL OR CHEMICAL TRANSFORMATION 审中-公开
标题翻译：生物或化学转化反应物
公开(公告)号：WO2015060764A1
公开(公告)日：2015-04-30
申请号：PCT/SE2014/051118
申请日：2014-09-26
申请人： NORDIC CHEMQUEST AB
发明人： BYSTRÖM, Emil , SCHERMAN, Henrik , IRGUM, Knut
IPC分类号： B01J19/18 , B01F7/00 , B01F11/00 , B01J8/10 , C12N11/00
CPC分类号： B01D15/18 , B01F7/163 , B01F7/1645 , B01F15/00896 , B01F2215/0427 , B01F2215/0431 , B01J8/10 , B01J19/006 , B01J19/0066 , B01J19/18 , B01J20/20 , B01J2208/028
摘要： The present invention relates to a new reactor for performing, by means of at least one solid reaction member, biological or chemical transformation, or physical or chemical trapping from, or release of agents to, a fluidic medium, which reactor is comprised of a reactor vessel comprising means for enhancing fluidic shear stress, and a transformation device operatively mounted in said reactor vessel. The invention also provides a kit of parts comprising a reactor vessel comprising means for enhancing fluidic shear stress and a transformation device. Finally, the invention provides a method of using said reactor and/or said kit of parts for biological or chemical transformation or physical or chemical trapping from, or release of agents to, a fluidic medium, by means of at least one solid reaction member.
摘要翻译：本发明涉及一种用于通过至少一个固体反应构件进行生物或化学转化，或物理或化学捕获或者将试剂释放到流体介质的新反应器，所述反应器由反应器容器包括用于增强流体剪切应力的装置，以及可操作地安装在所述反应器容器中的转化装置。本发明还提供了一种包括反应器容器的试剂盒，其包括用于增强流体剪切应力的装置和转化装置。最后，本发明提供了一种使用所述反应器和/或所述试剂盒用于通过至少一种固体反应构件进行生物或化学转化或物理或化学捕获或将试剂释放到流体介质中的方法。

9. 发明申请

WO02055538A3 CONTINUOUS SEPARATION METHOD 审中-公开
标题翻译：连续分离方法
公开(公告)号：WO02055538A3
公开(公告)日：2003-01-30
申请号：PCT/EP0200175
申请日：2002-01-10
申请人： AMERSHAM BIOSCIENCES AB , PLESS THOMAS
发明人： PLESS THOMAS
IPC分类号： B01D15/18 , B01D15/20 , C07K1/22 , B01D15/08
CPC分类号： B01J20/285 , B01D15/18 , B01D15/1864 , B01D15/203 , B01J20/28004 , C07K1/22
摘要： The present invention relates to a method of separating a tagged protein product from a raw cell culture comprising the steps of providing a chromatography column com-prising an adsorption resin and a sample of cell culture, passing said sample over said column to capture tagged protein product to the resin, optionally washing the resin by passing a suitable liquid over the column, and eluting the protein product from the col-umn. During the whole processing, the sample, washing liquid and eluent are added at flow rates that maintain an essentially continuous flow throughout the column, and at least two samples are processed in parallel. The invention also relates to an apparatus especially suitable for performing a method of separating a tagged protein product from a raw cell culture.
摘要翻译：本发明涉及一种从原始细胞培养物中分离标记的蛋白质产物的方法，包括以下步骤：提供一种色谱柱，该色谱柱与吸附树脂和细胞培养物样品相接触，将所述样品通过所述柱以捕获标记的蛋白质产物任选地通过使合适的液体通过柱子洗涤树脂，并从柱洗脱蛋白质产物。在整个处理过程中，样品，洗涤液和洗脱液以保持基本上连续的整个柱的流速加入，并且至少两个样品被并行处理。本发明还涉及一种特别适于执行从原始细胞培养物中分离标记的蛋白质产物的方法的装置。

10. 发明申请

WO2012081983A1 DISPOSABLE HORIZONTAL OR RADIAL FLOW TYPE CHROMATOGRAPHIC COLUMN 审中-公开
标题翻译：可排放的水平或径向流式色谱柱
公开(公告)号：WO2012081983A1
公开(公告)日：2012-06-21
申请号：PCT/NL2011/050858
申请日：2011-12-16
申请人： RAEDTS, Marcellus Johannes Hubertus
发明人： RAEDTS, Marcellus Johannes Hubertus
IPC分类号： G01N30/38 , G01N30/50 , G01N30/60 , B01D15/22
CPC分类号： B01D15/18 , B01D15/22 , G01N30/38 , G01N30/50 , G01N30/60 , G01N30/6017 , G01N30/603 , G01N30/6091 , G01N2030/386
摘要： A liquid chromatography column, utilizing horizontal or radial flow of sample material passing there through, preferably in inward direction, comprising: a housing defining a chamber therein and including at least one removable end section, e.g. screw lid; a first and second longitudinally extending porous frits positioned within said chamber of said housing; a bed or packing of, preferably particulate, chromatographic separation material positioned within said chamber of said housing and intermediate said porous frits, the first of said porous frits being adjacent said housing and an inlet channel, the second of said porous frits being positioned adjacent a core member and an outlet channel; distribution means operatively connected to said inlet channel; collector means operatively connected to said outlet channel, said distribution means and said inlet channel being constructed to direct associated material to be separated in said bed evenly across a longitudinal length of said bed in a substantially horizontal direction.
摘要翻译：液相色谱柱，利用样品材料的水平或径向流动优选地在内部通过，包括：壳体，其中限定室，并且包括至少一个可移除端部，例如，螺丝盖; 位于所述壳体的所述室内的第一和第二纵向延伸的多孔玻璃料; 位于所述壳体的所述室内且位于所述多孔玻璃料之间的床或填充物，优选颗粒状的色谱分离材料，所述多孔玻璃料中的第一个邻近所述壳体和入口通道，所述多孔玻璃料中的第二个位于邻近核心成员和出口渠道; 分配装置可操作地连接到所述入口通道; 收集器装置可操作地连接到所述出口通道，所述分配装置和所述入口通道被构造成在基本上水平的方向上将所述床中的待分离的相关材料均匀地引导到所述床的纵向长度上。

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