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1. 发明申请

WO2016116868A1 VOLUMETRIC MODULATED ARC THERAPY (VMAT) WITH NON-COPLANAR TRAJECTORIES 审中-公开
标题翻译：非共振TRAJECTORIES的体积调制电弧疗法（VMAT）
公开(公告)号：WO2016116868A1
公开(公告)日：2016-07-28
申请号：PCT/IB2016/050265
申请日：2016-01-20
申请人： KONINKLIJKE PHILIPS N.V. , MASSACHUSETTS GENERAL HOSPITAL
发明人： PAPP, David , UNKELBACH, Jan , BORTFELD, Thomas , BAL, Matthieu Frederic
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1047 , A61N5/1081 , A61N2005/1041
摘要： A method includes determining a set of candidate beam directions. The radiation therapy method further includes selecting a sub-set of non-coplanar beam directions of interest from the set of candidate beam directions based on a fluence optimization using a beam angle selection algorithm. The radiation therapy method further includes determining a set of delivery options based on a beam trajectory algorithm, wherein the delivery options at least include a non-coplanar trajectory during radiation treatment delivery. The radiation therapy method further includes optimizing the delivery options to generate a VMAT radiation plan with non-coplanar beam trajectories. The optimizing of the delivery options includes optimizing at least one machine parameter.
摘要翻译：一种方法包括确定一组候选波束方向。辐射治疗方法还包括基于使用波束角选择算法的注量优化，从所述候选波束方向组中选择非共面波束方向子集。放射治疗方法还包括基于束轨迹算法确定一组递送选项，其中递送选项至少包括放射治疗递送期间的非共面轨迹。辐射治疗方法还包括优化递送选项以产生具有非共面波束轨迹的VMAT辐射计划。交付选项的优化包括优化至少一个机器参数。

2. 发明申请

WO2016070190A1 PHYSICIAN DIRECTED RADIATION TREATMENT PLANNING 审中-公开
标题翻译：医疗指导性辐射治疗计划
公开(公告)号：WO2016070190A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/058658
申请日：2015-11-02
申请人： SIRIS MEDICAL, INC.
发明人： CARPENTER, Colin Morehouse , DAVIDI, Ran , PATTISON, Adam J.
IPC分类号： A61N5/10 , G06Q50/22
CPC分类号： A61N5/103 , A61N2005/1041 , A61N2005/1074
摘要： The treatment planning engine empowers radiation treatment decision makers, such as a physician, to efficiently identify effective radiation treatment outcomes for a given patient during the contouring stage. Specifically, using the treatment planning engine, the physician may iteratively and in real-time evaluate different treatment outcomes for a patient before selecting an optimal outcome that will guide the delivery of radiation treatment to the patient. By providing real-time information as to potential toxicity and treatment efficacy during the contouring stage, the physician is empowered to make informed decisions at the preliminary contouring stage.
摘要翻译：治疗计划引擎使辐射治疗决策者（如医师）能够在轮廓加工阶段有效地识别给定患者的有效辐射治疗结果。具体来说，使用治疗计划引擎，医生可以迭代地并且实时评估患者的不同治疗结果，然后选择将指导辐射治疗给患者的最佳结果。通过在轮廓加工阶段提供关于潜在毒性和治疗功效的实时信息，医生有权在初步轮廓阶段做出明智的决定。

3. 发明申请

WO2013082192A1 METHODS FOR DETECTION AND CHARACTERIZATION OF IONIZING RADIATION EXPOSURE IN TISSUE 审中-公开
标题翻译：检测和表征组织中放射性辐射暴露的方法
公开(公告)号：WO2013082192A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/066901
申请日：2012-11-28
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL , CHIN, Michael, S.
发明人： CHIN, Michael, S.
IPC分类号： A61B5/145 , G03B15/14 , G01T1/08
CPC分类号： G06T7/0012 , A61B5/0075 , A61B5/0077 , A61B5/14551 , A61B5/443 , A61B2505/01 , A61N5/1071 , A61N2005/1041 , A61N2005/1059 , G01T7/00 , G03B15/14
摘要： The invention is based on the discovery of hyperspectral imaging-based methods that enable effective, efficient and non-invasive detection and characterization of ionizing radiation exposure in tissue. Methods of the invention allow for complete visualization and quantification of oxygenation and perfusion changes in irradiated skin. The invention enables rapid identification of individuals exposed to ionizing radiation after a radiological attack or accident. Methods of the invention can offer quantitative metrics to identify people exposed to higher doses of ionizing radiation well before the appearance of any dermal injury and permit appropriate triage to healthcare facilities.
摘要翻译：本发明基于发现基于高光谱成像的方法，其能够有效，有效和非侵入性地检测和表征组织中的电离辐射暴露。本发明的方法允许完全可视化和定量照射的皮肤中的氧合和灌注变化。本发明能够在放射性攻击或事故发生之后快速识别暴露于电离辐射的个体。本发明的方法可以提供定量度量，以便在出现任何真皮损伤之前，识别暴露于较高剂量的电离辐射的人员，并允许对医疗机构进行适当的分诊。

4. 发明申请

WO2010018477A3 MODEL ENHANCED IMAGING 审中-公开
标题翻译：模型增强成像
公开(公告)号：WO2010018477A3
公开(公告)日：2011-04-07
申请号：PCT/IB2009053192
申请日：2009-07-22
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , SABCZYNSKI JOERG , RENISCH STEFFEN , CARLSEN INGWER-CURT , KABUS SVEN , OPFER ROLAND , KAUS MICHAEL , BZDUSEK KARL ANTONIN , WEESE JUERGEN , PEKAR VLADIMIR
发明人： SABCZYNSKI JOERG , RENISCH STEFFEN , CARLSEN INGWER-CURT , KABUS SVEN , OPFER ROLAND , KAUS MICHAEL , BZDUSEK KARL ANTONIN , WEESE JUERGEN , PEKAR VLADIMIR
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , A61B2034/105 , A61B2090/374 , A61B2090/3762 , A61N5/103 , A61N7/02 , A61N2005/1041 , G06F19/321 , G06F19/324 , G16H10/60 , G16H50/20 , G16H50/50
摘要： A therapy treatment response simulator includes a modeler (202) that generates a model of a structure of an object or subject based on information about the object or subject and a predictor (204) that generates a prediction indicative of how the structure is likely to respond to treatment based on the model and a therapy treatment plan. In another aspect, a system includes performing a patient state determining in silico simulation for a patient using a candidate set of parameters corresponding to another patient and producing a first signal indicative of a predicted state of the patient, and generating a second signal indicative of whether the candidate set of parameters are suitable for the patient based on a known state of the patient.
摘要翻译：治疗治疗反应模拟器包括基于关于对象或对象的信息生成对象或对象的结构的模型的建模器（202），以及生成表示结构如何响应的预测的预测器（204）基于模型治疗和治疗方案。在另一方面，一种系统包括使用与另一患者相对应的参数的候选组来执行患者状态的计算机模拟，并产生指示患者的预测状态的第一信号，以及产生指示是否基于患者的已知状态，候选参数组适合于患者。

5. 发明申请

WO2008106522A2 SYSTEM AND METHOD FOR OPTIMIZATION OF A RADIATION THERAPY PLAN IN THE PRESENCE OF MOTION 审中-公开
标题翻译：辐射治疗方案优选运动方法的系统与方法
公开(公告)号：WO2008106522A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/055147
申请日：2008-02-27
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , FLYNN, Ryan, Thomas , MACKIE, Thomas, R.
发明人： FLYNN, Ryan, Thomas , MACKIE, Thomas, R.
IPC分类号： G21K1/00
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1042 , A61N2005/1041 , G21K1/046
摘要： A computer-implemented method for optimizing a radiation treatment plan for a radiotherapy machine providing independently controlled radiation along a plurality of rays y directed toward a patient and configured to account for the effects of patient motion. The method includes generating a probability distribution function quantitatively expressing patient motion, identifying a prescribed total dose D p i at the voxels i in a treatment area, assigning a fluence value W j for each ray j based on an iterative function, calculating an actual total dose D d i produced each voxel i within the assigned fluence values and calculating an expectation value of the dose per energy fluence, [d ÿ ] based on the actual total dose D d i and the probability distribution function.
摘要翻译：一种用于优化放射治疗机的辐射治疗计划的计算机实现的方法，所述放射治疗机器沿着朝向患者的多条射线y提供独立控制的辐射，并且被配置为考虑患者运动的影响。该方法包括产生定量表达患者运动的概率分布函数，识别规定的总剂量D <

6. 发明申请

WO2017136937A1 KNOWLEDGE-BASED BRACHYTHERAPY PLANNING BASED ON PRIMITIVE FEATURES COMPUTED FROM ANATOMICAL CONTOUR DATA 审中-公开
标题翻译：基于解剖轮廓数据计算的基于知识的BRACHYTHERAPY规划
公开(公告)号：WO2017136937A1
公开(公告)日：2017-08-17
申请号：PCT/CA2017/050150
申请日：2017-02-09
申请人： SUNNYBROOK RESEARCH INSTITUTE
发明人： RAVI, Ananth , NICOLAE, Alexandru
IPC分类号： A61B34/10 , A61N5/00 , G06F19/00
CPC分类号： A61B34/10 , A61N5/1027 , A61N5/103 , A61N2005/1041 , G06F19/00 , G06F19/325 , G06F19/3481
摘要： Described here are systems and methods for knowledge-based brachytherapy planning. These systems and methods are capable of automatically generating treatment plans for prostate brachytherapy in clinically relevant times. Primitive features computed from anatomical contours of the target organ are used to retrieve a template plan from a database. The template plan is then adjusted in a stochastic search algorithm.
摘要翻译：这里描述的是用于基于知识的近距离治疗计划的系统和方法。这些系统和方法能够在临床相关时间自动生成前列腺近距离放射治疗计划。从目标器官的解剖轮廓计算出的原始特征用于从数据库检索模板计划。然后使用随机搜索算法调整模板计划。

7. 发明申请

WO2016144914A1 SYSTEMS AND METHODS FOR AUTOMATED RADIATION TREATMENT PLANNING WITH DECISION SUPPORT 审中-公开
标题翻译：自动辐射治疗计划与决策支持系统与方法
公开(公告)号：WO2016144914A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/021271
申请日：2016-03-07
申请人： DUKE UNIVERSITY , WU, Qingrong Jackie , GE, Yaorong , YIN, Fangfang , YUAN, Lulin , SHENG, Yang , LI, Taoran , LIU, Jianfei
发明人： WU, Qingrong Jackie , GE, Yaorong , YIN, Fangfang , YUAN, Lulin , SHENG, Yang , LI, Taoran , LIU, Jianfei
IPC分类号： G06Q50/00
CPC分类号： A61N5/103 , A61N5/1031 , A61N5/1039 , A61N2005/1041 , A61N2005/1074 , G06F19/00 , G06F19/325 , G06Q50/24 , G16H40/63 , G16H50/20 , G16H50/30 , G16H50/50
摘要： Systems and methods for automated radiation treatment planning with decision support are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk and a cancer target of a patient. The method also includes determining the appropriate models and model settings for the given patient case. Further, the method includes generating automatically one or more radiation treatment plans using the proper models learned from a plurality of radiation treatment plans of prior patient cases based on certain relationships, including one of a match or similarity, between the patient information and geometric characterization of the patient and the other patients. The method also includes presenting the determined one or more radiation treatment plans via a user interface.
摘要翻译：披露了具有决策支持的自动辐射治疗计划的系统和方法。根据一个方面，一种方法包括基于患者信息和几何特征来接收一个或多个处于危险中的器官和患者的癌症靶标的数据。该方法还包括确定给定患者病例的适当模型和模型设置。此外，该方法包括使用从先前患者病例的多个放射治疗计划中获知的适当模型自动生成一个或多个放射治疗计划，所述适当模型基于某些关系，包括患者信息和几何特征之间的匹配或相似性之一患者和其他患者。该方法还包括经由用户界面呈现确定的一个或多个辐射治疗计划。

8. 发明申请

WO2014135974A8 SYSTEMS AND METHODS FOR DEVELOPING AND MANAGING ONCOLOGY TREATMENT PLANS 审中-公开
标题翻译：用于开发和管理肿瘤治疗计划的系统和方法
公开(公告)号：WO2014135974A8
公开(公告)日：2015-08-20
申请号：PCT/IB2014000726
申请日：2014-02-12
申请人： ELEKTA AB
发明人： CHRISTODOULEAS JOHN , HUBBELL ROBERT , VAN DER PAS MARJORIE , MACDONALD FAYE A , GOLDWEIN JOEL , NORTON RANDY
IPC分类号： G06F19/00
CPC分类号： G06F19/325 , A61N2005/1041
摘要： Embodiments of the invention provide systems and methods for managing oncology care plans. The systems and methods involve or include: retrieving a standard care plan from an electronically stored library of oncology care plans provided by one or more clinical content providers; receiving, from a user, a modification to the standard care plan; generating a local care plan that includes the standard care plan and the modification to the standard care plan; retrieving, from the electronically stored library of oncology care plans, an updated standard care plan that includes one or more updates to the standard care plan provided by the one or more clinical content providers; and automatically generating an updated local care plan that includes the updated standard care plan and the modification to the standard care plan.
摘要翻译：本发明的实施例提供用于管理肿瘤学护理计划的系统和方法。该系统和方法涉及或包括：从一个或多个临床内容提供者提供的电子存储的肿瘤学护理计划库中检索标准护理计划; 从用户接收对标准护理计划的修改; 生成包括标准护理计划和对标准护理计划的修改的当地护理计划; 从电子存储的肿瘤学护理计划库中检索更新的标准护理计划，该更新的标准护理计划包括由一个或多个临床内容提供者提供的标准护理计划的一个或多个更新; 并自动生成包括更新的标准护理计划和对标准护理计划的修改的更新的本地护理计划。

9. 发明申请

WO2015028641A1 A SYSTEM AND METHOD FOR VISUALIZING INFORMATION IN A PROCEDURE OF PLACING SOURCES 审中-公开
标题翻译：一种用于在信息来源中可视化信息的系统和方法
公开(公告)号：WO2015028641A1
公开(公告)日：2015-03-05
申请号：PCT/EP2014/068440
申请日：2014-08-29
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BROSENS-KESSELS, Angelique Carin Johanna Maria , BINNEKAMP, Dirk
IPC分类号： A61N5/10 , A61B18/24
CPC分类号： A61N5/1071 , A61B18/24 , A61B34/20 , A61N5/1001 , A61N5/1007 , A61N5/1027 , A61N5/103 , A61N2005/1041 , A61N2005/1074
摘要： A system (100) for and a method of visualizing quality information to a person performing a procedure of temporarily or permanently placing energy provision sources in a part of a body of a living being are provided. The body comprises a volume of interest. The system (100) comprising an input (104) for receiving a treatment plan (102), a data storage (108) for storing positions (P1, P2) of previously placed energy provision sources, a sub-system (106) for determining a shape and a position of the volume of interest, a tracking system (107) for obtaining tracking information relating to a placement tool for guiding a to-be-placed energy provision source towards a specific position, a processing device (110) configured for calculating a dose-volume histogram (114) for the volume of interest, and a display device (112) for presenting the dose-volume histogram (114) to the person.
摘要翻译：提供了一种用于将质量信息可视化的系统（100）以及对执行临时或永久性地将能量提供源放置在生命体的一部分中的程序的人进行可视化的方法。身体包含感兴趣的体积。所述系统（100）包括用于接收治疗计划（102）的输入（104），用于存储先前放置的能量提供源的位置（P1，P2）的数据存储（108），用于确定感兴趣体积的形状和位置，用于获取与用于将待放置的能量供应源朝向特定位置引导的放置工具相关的跟踪信息的跟踪系统（107），配置用于计算感兴趣体积的剂量 - 体积直方图（114），以及用于向人呈现剂量 - 体积直方图（114）的显示装置（112）。

10. 发明申请

WO2014197994A1 METHOD AND SYSTEM FOR AUTOMATED QUALITY ASSURANCE AND AUTOMATED TREATMENT PLANNING IN RADIATION THERAPY 审中-公开
标题翻译：辐射治疗自动质量保证和自动治疗规划方法与系统
公开(公告)号：WO2014197994A1
公开(公告)日：2014-12-18
申请号：PCT/CA2014/050551
申请日：2014-06-12
申请人： UNIVERSITY HEALTH NETWORK
发明人： PURDIE, Thomas G. , MCINTOSH, Christopher , SVISTOUN, Igor
IPC分类号： A61N5/10 , A61N5/00 , G06F19/00
CPC分类号： G06F19/327 , A61N5/103 , A61N5/1038 , A61N5/1048 , A61N2005/1041 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H40/20
摘要： Methods and systems for evaluating a proposed treatment plan for radiation therapy, for evaluating one or more delineated regions of interest for radiation therapy, and/or for generating a proposed treatment plan for radiation therapy. Machine learning based on historical data may be used.
摘要翻译：用于评估放射治疗计划的治疗计划的方法和系统，用于评估放射治疗的一个或多个所划定的感兴趣区域和/或用于产生用于放射治疗的拟议治疗计划。可以使用基于历史数据的机器学习。

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