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1. 发明申请

WO2010018477A2 MODEL ENHANCED IMAGING 审中-公开
标题翻译：模型增强成像
公开(公告)号：WO2010018477A2
公开(公告)日：2010-02-18
申请号：PCT/IB2009/053192
申请日：2009-07-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , SABCZYNSKI, Joerg , RENISCH, Steffen , CARLSEN, Ingwer-Curt , KABUS, Sven , OPFER, Roland , KAUS, Michael , BZDUSEK, Karl, Antonin , WEESE, Juergen , PEKAR, Vladimir
发明人： SABCZYNSKI, Joerg , RENISCH, Steffen , CARLSEN, Ingwer-Curt , KABUS, Sven , OPFER, Roland , KAUS, Michael , BZDUSEK, Karl, Antonin , WEESE, Juergen , PEKAR, Vladimir
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , A61B2034/105 , A61B2090/374 , A61B2090/3762 , A61N5/103 , A61N7/02 , A61N2005/1041 , G06F19/00 , G06F19/321 , G06F19/324 , G16H10/60 , G16H50/20 , G16H50/50
摘要： A therapy treatment response simulator includes a modeler (202) that generates a model of a structure of an object or subject based on information about the object or subject and a predictor (204) that generates a prediction indicative of how the structure is likely to respond to treatment based on the model and a therapy treatment plan. In another aspect, a system includes performing a patient state determining in silico simulation for a patient using a candidate set of parameters corresponding to another patient and producing a first signal indicative of a predicted state of the patient, and generating a second signal indicative of whether the candidate set of parameters are suitable for the patient based on a known state of the patient.
摘要翻译：治疗治疗反应模拟器包括基于关于对象或对象的信息生成对象或对象的结构的模型的建模器（202），以及生成表示结构如何响应的预测的预测器（204）基于模型治疗和治疗方案。在另一方面，一种系统包括使用与另一患者相对应的参数的候选组来执行患者状态的计算机模拟，并产生指示患者的预测状态的第一信号，以及产生指示是否基于患者的已知状态，候选参数组适合于患者。

2. 发明申请

WO2012123894A1 STUDYING DOSIMETRIC IMPACT OF MOTION TO GENERATE ADAPTIVE PATIENT-SPECIFIC MARGINS IN EBRT PLANNING 审中-公开
标题翻译：研究运动的量化影响在EBRT规划中产生适应症患者特异性标记
公开(公告)号：WO2012123894A1
公开(公告)日：2012-09-20
申请号：PCT/IB2012/051178
申请日：2012-03-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BHARAT, Shyam , BZDUSEK, Karl, Antonin , PARIKH, Parag, Jitendra , NOEL, Camille, Elizabeth
发明人： BHARAT, Shyam , BZDUSEK, Karl, Antonin , PARIKH, Parag, Jitendra , NOEL, Camille, Elizabeth
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1031 , A61N2005/1072
摘要： A treatment planning system (106) for generating patient-specific treatment margins. The system (106) includes one or more processors (142). The processors (142) are programmed to receive a radiation treatment plan (RTP) for irradiating a target (122) over the course of one or more treatment fractions. The RTP including one or more treatment margins around the target (122) and a planned dose distribution for the target (122). The processors (142) are further programmed to receive motion data for at least one of the treatment fractions of the RTP from one or more target surrogates (124), calculate a motion-compensated dose distribution for the target (122) using the motion data and the planned dose distribution, compare the motion-compensated dose distribution to the planned dose distribution, and adjust the treatment margins based on dosimetric differences between the motion-compensated dose distribution and the planned dose distribution.
摘要翻译：一种用于产生患者特异性治疗边缘的治疗计划系统（106）。系统（106）包括一个或多个处理器（142）。处理器（142）被编程为接收用于在一个或多个处理部分的过程中照射目标（122）的放射线治疗计划（RTP）。 RTP包括目标周围的一个或多个治疗边缘（122）和目标（122）的计划剂量分布。处理器（142）还被编程为从一个或多个目标代理（124）接收RTP的处理分数中的至少一个的运动数据，使用运动数据计算目标（122）的运动补偿剂量分布和计划剂量分布，将运动补偿剂量分布与计划剂量分布进行比较，并根据运动补偿剂量分布与计划剂量分布之间的剂量差异来调整治疗余量。

3. 发明申请

WO2010018477A3 MODEL ENHANCED IMAGING 审中-公开
标题翻译：模型增强成像
公开(公告)号：WO2010018477A3
公开(公告)日：2011-04-07
申请号：PCT/IB2009053192
申请日：2009-07-22
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , SABCZYNSKI JOERG , RENISCH STEFFEN , CARLSEN INGWER-CURT , KABUS SVEN , OPFER ROLAND , KAUS MICHAEL , BZDUSEK KARL ANTONIN , WEESE JUERGEN , PEKAR VLADIMIR
发明人： SABCZYNSKI JOERG , RENISCH STEFFEN , CARLSEN INGWER-CURT , KABUS SVEN , OPFER ROLAND , KAUS MICHAEL , BZDUSEK KARL ANTONIN , WEESE JUERGEN , PEKAR VLADIMIR
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , A61B2034/105 , A61B2090/374 , A61B2090/3762 , A61N5/103 , A61N7/02 , A61N2005/1041 , G06F19/321 , G06F19/324 , G16H10/60 , G16H50/20 , G16H50/50
摘要： A therapy treatment response simulator includes a modeler (202) that generates a model of a structure of an object or subject based on information about the object or subject and a predictor (204) that generates a prediction indicative of how the structure is likely to respond to treatment based on the model and a therapy treatment plan. In another aspect, a system includes performing a patient state determining in silico simulation for a patient using a candidate set of parameters corresponding to another patient and producing a first signal indicative of a predicted state of the patient, and generating a second signal indicative of whether the candidate set of parameters are suitable for the patient based on a known state of the patient.
摘要翻译：治疗治疗反应模拟器包括基于关于对象或对象的信息生成对象或对象的结构的模型的建模器（202），以及生成表示结构如何响应的预测的预测器（204）基于模型治疗和治疗方案。在另一方面，一种系统包括使用与另一患者相对应的参数的候选组来执行患者状态的计算机模拟，并产生指示患者的预测状态的第一信号，以及产生指示是否基于患者的已知状态，候选参数组适合于患者。

4. 发明申请

WO2009050615A1 METHOD AND APPARATUS FOR INTENSITY MODULATED ARC THERAPY SEQUENCING AND OPTIMIZATION 审中-公开
标题翻译：强度调制弧疗法测序和优化的方法和装置
公开(公告)号：WO2009050615A1
公开(公告)日：2009-04-23
申请号：PCT/IB2008/054022
申请日：2008-10-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , BZDUSEK, Karl, Antonin
发明人： BZDUSEK, Karl, Antonin
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/103 , A61N5/1047
摘要： A treatment planner (102) generates fluence maps (140) indicative of a desired fluence distribution at various locations (304, 312) along a treatment arc (302). A converter (142) converts the fluence distributions (140) to treatment device settings (144). The settings (144) may include multiple segments. A segment distributor (146) distributes the settings to locations in the vicinity of their original positions.
摘要翻译：治疗计划器（102）沿着治疗弧（302）产生指示在各个位置（304,312）期望的注量分布的注量度图（140）。 A转换器（142）将注量分布（140）转换成治疗装置设置（144）。设置（144）可以包括多个段。分段分配器（146）将设置分配到其原始位置附近的位置。

5. 发明申请

WO2013030707A1 INTEGRATION OF USER INPUTS AND CORRECTION OF DEFORMATION VECTOR FIELD IN DEFORMABLE IMAGE REGISTRATION WORKFLOW 审中-公开
标题翻译：用户输入的整合和变形矢量校正在可变图像注册工作流中的变化
公开(公告)号：WO2013030707A1
公开(公告)日：2013-03-07
申请号：PCT/IB2012/054169
申请日：2012-08-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MALLYA, Yogisha , BZDUSEK, Karl Antonin
发明人： MALLYA, Yogisha , BZDUSEK, Karl Antonin
IPC分类号： G06T7/00 , A61N5/10
CPC分类号： G06T7/0012 , A61N5/103 , G06F3/0481 , G06F3/04845 , G06T7/30 , G06T2200/24 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20012 , G06T2207/20104 , G06T2207/30096
摘要： Adeformation vector field (DVF) (22)is computed that relatively spatially registers a first image (16)and a second image (14). A contour (26)delineating a structure in the first image is adapted using the DVF to generate an initial contour (52)for the structure in the second image. A final contour (56)is received for the structure in the second image. The DVF is corrected based on the initial and final contours for the structure in the second image to generate a corrected DVF (32).The correction may comprise computing an adjustment DVF (62)relating the initial and final contoursand combining the DVF and the adjustment DVF to generate the corrected DVF.The final contour may be received by displaying the second image overlaid with the initial contour, and receiving user adjustments of the overlaid contour withthe overlaid contour updated for each received user adjustment.
摘要翻译：计算相对空间地登记第一图像（16）和第二图像（14）的信息矢量场（DVF）（22）。使用DVF来适应描绘第一图像中的结构的轮廓（26），以生成第二图像中的结构的初始轮廓（52）。接收第二图像中的结构的最终轮廓（56）。基于第二图像中的结构的初始和最终轮廓来校正DVF以产生校正的DVF（32）。校正可以包括计算与初始和最终轮廓相关联的调整DVF（62），并将DVF和调整 DVF以产生校正的DVF。可以通过显示覆盖有初始轮廓的第二图像来接收最终轮廓，并且接收用于对每个接收的用户调整更新的重叠轮廓的用户调整。

6. 发明申请

WO2012172454A1 HYBRID POINT-BASED REGISTRATION 审中-公开
标题翻译：基于混合点的注册
公开(公告)号：WO2012172454A1
公开(公告)日：2012-12-20
申请号：PCT/IB2012/052802
申请日：2012-06-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BZDUSEK, Karl Antonin , ALLAIRE, Stephane
发明人： BZDUSEK, Karl Antonin , ALLAIRE, Stephane
IPC分类号： G06T7/00
CPC分类号： G06T3/0068 , A61N5/1038 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T7/30 , G06T7/33 , G06T7/344 , G06T7/38 , G06T2207/10072 , G06T2207/20221
摘要： A system (28, 32) generates an image registration map. The system (28, 32) includes one or more processors (32) which receive a first image and a second image. Corresponding interest points in the first image and the second image are identified. Corresponding structures in the first and second images are identified and corresponding boundary points are identified on their boundaries. A registration map is generated from pairs of the corresponding interest points and a subset of pairs of the corresponding boundary points. The registration map is applied to one of the first and second images to register the one image to the other and propagate objects of interest over.
摘要翻译：系统（28,32）生成图像配准图。系统（28,32）包括接收第一图像和第二图像的一个或多个处理器（32）。识别第一图像和第二图像中的对应兴趣点。识别第一和第二图像中的相应结构，并在其边界上识别对应的边界点。从对应的兴趣点的对和对应的边界对的子集生成登记图。将注册图应用于第一和第二图像之一，以将一个图像注册到另一个图像并传播感兴趣的对象。

7. 发明申请

WO2012123861A1 CORRELATED IMAGE MAPPING POINTER 审中-公开
标题翻译：相关图像映射点
公开(公告)号：WO2012123861A1
公开(公告)日：2012-09-20
申请号：PCT/IB2012/051084
申请日：2012-03-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BZDUSEK, Karl Antonin , ROWBOTTOM, Carl Graham , HARDCASTLE, Nicholas Gordon Lance , SIEBERS, Jeffrey Vincent
发明人： BZDUSEK, Karl Antonin , ROWBOTTOM, Carl Graham , HARDCASTLE, Nicholas Gordon Lance , SIEBERS, Jeffrey Vincent
IPC分类号： G06T7/00
CPC分类号： G06T7/0014 , G06T7/12 , G06T7/30 , G06T2200/24 , G06T2207/20212
摘要： A system (106) visualizing an image registration mapping in an intuitive interactive manner. The system (106) includes a display (110) and one or more processors (116). The processors (116) are programmed to receive a first image and a second image and obtain an image registration mapping from the first image to the second image. Even more, the processors (116) are programmed to display the first image adjacent to the second image on the display (110) and obtain one or more reference image locations. Each of the reference image locations is defined in the coordinate frame of one of the first image and the second image. Moreover, the processors (116) are programmed to highlight each of the reference image locations on the one of the first image and the second image and highlight a correlated image location for each of the reference image locations in the other one of the first image and the second image. The correlated image locations are determined using the image registration mapping.
摘要翻译：系统（106）以直观的交互方式可视化图像配准映射。系统（106）包括显示器（110）和一个或多个处理器（116）。处理器（116）被编程为接收第一图像和第二图像，并获得从第一图像到第二图像的图像配准映射。更重要的是，处理器（116）被编程为在显示器（110）上显示与第二图像相邻的第一图像，并获得一个或多个参考图像位置。每个参考图像位置被定义在第一图像和第二图像之一的坐标系中。此外，处理器（116）被编程为突出第一图像和第二图像之一上的每个参考图像位置，并突出显示第一图像和第二图像中的另一个中的每个参考图像位置的相关图像位置，以及第二个图像。使用图像配准映射来确定相关图像位置。

8. 发明申请

WO2012069965A1 INTERACTIVE DEFORMATION MAP CORRECTIONS 审中-公开
标题翻译：互动变形地图校正
公开(公告)号：WO2012069965A1
公开(公告)日：2012-05-31
申请号：PCT/IB2011/055145
申请日：2011-11-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BZDUSEK, Karl Antonin , ALLAIRE, Stephane , HARDCASTLE, Nicholas Gordon Lance , UNIVERSITY OF WISCONSIN , TOME, Wolfgang Axel , UNIVERSITY HEALTH NETWORK
发明人： BZDUSEK, Karl Antonin , ALLAIRE, Stephane , HARDCASTLE, Nicholas Gordon Lance , TOME, Wolfgang Axel
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1038
摘要： A radiation therapy planning system includes a planning module (20) which receives a first planning image set from a diagnostic imaging apparatus (10) and uses automatic segmentation tools (22) or manual segmentation tools (24) and a radiation therapy planning system (32) to generate a first radiation therapy plan. After the first radiation therapy plan has been applied for one or more therapy sessions, a second planning image set is generated. The planning module (20) uses a deformable image registration algorithm (30) to register the planning image set sand generate a corresponding deformation map which is applied to segmented objects of interest (OOIs) of the segmented first planning image set to propagate the objects of interest onto the second planning image set. The deformation map is corrected in accordance with deviations between the propagated and actual OOI locations in two steps: 1) manual and/or automated corrections of the propagated OOIs are performed, such as region of interest contour corrections and/or landmark point of interest positions; 2) a corrected global deformation map is generated from these local OOI corrections. The corrected deformation map is applied to the first radiation therapy plan and an accumulated radiation map depicting the radiation accumulated in each OOI during the therapy session(s) implemented with the first radiation therapy plan.
摘要翻译：辐射治疗计划系统包括规划模块（20），其从诊断成像设备（10）接收第一规划图像集并且使用自动分割工具（22）或手动分割工具（24）和放射治疗计划系统（32））产生第一次放射治疗计划。在第一次辐射治疗计划已经应用于一个或多个治疗会话之后，产生第二规划图像集。规划模块（20）使用可变形图像配准算法（30）来注册规划图像集合砂，生成适用于分段的第一规划图像集合的分割对象（OOI）的相应变形图，以传播分割的第一规划图像集合的对象感兴趣的第二个规划图像集。变形图根据传播的和实际的OOI位置之间的偏差在两个步骤中被校正：1）执行传播的OOI的手动和/或自动校正，例如感兴趣的区域轮廓校正和/或地标点的兴趣位置 ; 2）从这些局部OOI校正产生校正的全局变形图。校正的变形图应用于第一放射治疗计划和描绘在用第一放射治疗计划实施的治疗会话期间累积在每个OOI中的辐射的累积辐射图。

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