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1. 发明申请

WO2016157142A1 COMPOSITION FOR USE IN TREATING CELIAC DISEASE 审中-公开
标题翻译：用于治疗CELIAC疾病的组合物
公开(公告)号：WO2016157142A1
公开(公告)日：2016-10-06
申请号：PCT/IB2016/051872
申请日：2016-04-01
申请人： STEGI-RA TRUST , CICCOCIOPPO, Rachele
发明人： CICCOCIOPPO, Rachele
IPC分类号： A61K35/28 , G01N33/50
CPC分类号： A61K9/127 , A61K35/50 , A61P1/00 , A61P37/00 , C12N2500/00 , C12N2501/998 , G01N33/505
摘要： Method of preparation of a composition comprising extracellular vesicles(10) derived from stem cells mesenchymal isolated from chorion of human placenta, said method being characterized in that it comprises: - a step of extraction of extracellular vesicles(10) da stem cells mesenchymal (5), said cells (5) being derived from chorion (C) in advance separated from the placenta (200) in a step of separation chorion-placenta (93), and - a step (251, 252, 253) of sterilization and elimination of contaminating proteins from a semi- finished fluid containing said extracellular vesicles(10), wherein said step (251, 252, 253) of sterilization and elimination of contaminating proteins comprises a first step of ultracentrifugation (252, 253) of the said semi-finished fluid, and wherein - said first step of ultracentrifugation (252) is performed following of a phase of filtration (251 ) of the said semi-finished fluid.
摘要翻译：制备包含衍生自人胎盘绒毛膜分离的干细胞间充质的细胞外小泡（10）的组合物的方法，所述方法的特征在于其包括： - 提取细胞外囊泡（10）的步骤，干细胞间充质干细胞），所述细胞（5）在分离绒毛膜胎盘（93）的步骤中预先从胎盘（200）分离而衍生自绒毛膜（C），和 - 灭菌和消除的步骤（251,252,253）从包含所述细胞外囊泡（10）的半成品流体中污染蛋白质，其中灭菌和消除污染蛋白质的所述步骤（251,252,253）包括所述半定量的超离心（252,253）的第一步骤，成品流体，并且其中 - 在所述半成品流体的过滤阶段（251）之后执行所述超离心的第一步骤（252）。

2. 发明申请

WO2012054811A1 CULTURED PANCREAS ISLETS 审中-公开
标题翻译：培养的胰蛋白酶
公开(公告)号：WO2012054811A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/057234
申请日：2011-10-21
申请人： CELL & TISSUE SYSTEMS, INC. , TAYLOR, Michael J. , BAICU, Simona C.
发明人： TAYLOR, Michael J. , BAICU, Simona C.
IPC分类号： C12N5/071
CPC分类号： C12N5/0677 , C12N2500/00
摘要： Methods of preparing pancreatic islets that may comprise pancreatites are provided. The methods may involve subjecting a pancreas and/or pieces thereof to disruption, such as, for example, an enzyme digest, and seeding the recovered cellular product comprising islets in a culture medium comprising at least a detectable amount of endocrine tissue and/or exocrine tissue.
摘要翻译：提供了可能包含胰腺的胰岛的制备方法。所述方法可以包括使胰腺和/或其碎片受到破坏，例如酶消化，并将包含胰岛的回收的细胞产物接种在包含至少可检测量的内分泌组织和/或外分泌的培养基中组织。

3. 发明申请

WO2017010950A1 MODULATION OF HEPATITIS B VIRUS REPLICATION 审中-公开
标题翻译：乙型肝炎病毒复制的调节
公开(公告)号：WO2017010950A1
公开(公告)日：2017-01-19
申请号：PCT/SG2016/050338
申请日：2016-07-15
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： REN, Ee Chee , KO, Hui Ling
IPC分类号： A61K38/00 , A61K38/04 , A61P31/20
CPC分类号： A61K38/17 , A61K31/713 , C07K14/00 , C07K14/02 , C12N2500/00 , G01N33/5008
摘要： Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication, by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting of SNAI2, SOX7 and other factors, the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment, the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention, a method of identifying at least one factor that modulates replication of a virus is also disclosed.
摘要翻译：目前公开的是通过将细胞与至少一种调节至少一个因子组成的试剂接触，所述试剂从由SNAI2，SOX7和其他因素组成的特定组中进行调节，筛选所述试剂和使用其用于治疗患者的HBV感染或与HBV感染相关的疾病或病症的药物中。在一个优选的实施方案中，所述试剂是衍生自SOX7或SNAI2的一种肽或其装订肽。作为单独的发明，还公开了鉴定至少一种调节病毒复制因子的方法。

4. 发明申请

WO2010148275A2 BIOREACTOR SYSTEM 审中-公开
标题翻译：生物系统
公开(公告)号：WO2010148275A2
公开(公告)日：2010-12-23
申请号：PCT/US2010039119
申请日：2010-06-18
申请人： KIYATEC LLC , GEVAERT MATTHEW R , ORR DAVID E
发明人： GEVAERT MATTHEW R , ORR DAVID E
IPC分类号： C12M3/00 , C12N5/07 , G01N33/15 , G01N33/50
CPC分类号： G01N33/5029 , C12M23/34 , C12M23/44 , C12M29/04 , C12M35/08 , C12N5/0693 , C12N2500/00 , C12N2502/00 , C12N2503/00 , C12N2503/02 , G01N33/5011 , G01N33/5091
摘要： Disclosed herein are bioreactor systems and methods of utilizing said systems.
摘要翻译：本文公开了生物反应器系统和利用所述系统的方法。

5. 发明申请

WO2004031343A2 HUMAN FORESKIN CELLS SUITABLE FOR CULTURING STEM CELLS 审中-公开
标题翻译：人类骨骼细胞适用于培养干细胞
公开(公告)号：WO2004031343A2
公开(公告)日：2004-04-15
申请号：PCT/IL2003/000804
申请日：2003-10-07
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. , AMIT, Michal , ITSKOVITZ-ELDOR, Joseph
发明人： AMIT, Michal , ITSKOVITZ-ELDOR, Joseph
IPC分类号： C12N
CPC分类号： C12N5/0606 , C12N5/0031 , C12N5/0043 , C12N5/0056 , C12N5/0603 , C12N5/0611 , C12N5/0665 , C12N5/0695 , C12N5/0696 , C12N2500/00 , C12N2500/99 , C12N2502/13 , C12N2502/1323 , C12N2506/02 , C12N2533/50 , C12N2533/90
摘要： A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.
摘要翻译：包含人包皮细胞的细胞培养物，当与其共同培养时，人包皮细胞能够将干细胞保持在未分化状态。

6. 发明申请

WO2017049228A1 MODIFIED NATURAL KILLER CELLS HAVING ANTI-FUGETACTIC PROPERTIES AND USES THEREOF 审中-公开
标题翻译：具有抗氧化性质的改性天然杀伤细胞及其用途
公开(公告)号：WO2017049228A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/052333
申请日：2016-09-16
申请人： THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL
发明人： POZNANSKY, Mark C. , VIANELLO, Fabrizio
IPC分类号： C12N5/0783
CPC分类号： A61K35/17 , A61K31/395 , A61K39/3955 , A61K2039/505 , C12N5/0646 , C12N2500/00 , C12N2510/00
摘要： This invention provides ex vivo methods for making modified natural killer cell compositions having overall anti-fugetactic properties for the effective and efficient treatment of tumors or cancers in a patient, and compositions and use thereof.
摘要翻译：本发明提供了用于制备具有整体抗融合性质的改良天然杀伤细胞组合物用于有效和有效地治疗患者肿瘤或癌症的离体方法及其组合物和用途。

7. 发明申请

WO2016042572A1 A METHOD OF INDUCING BONE FORMATION BY EX-VIVO OSTEOBLAST CULTURING FOR IMPLANTATION 审中-公开
标题翻译：诱导骨形成的方法用于植入植物体外培养
公开(公告)号：WO2016042572A1
公开(公告)日：2016-03-24
申请号：PCT/IN2015/000277
申请日：2015-07-08
申请人： JASWANTRAI DOSHI, Vishal
发明人： JASWANTRAI DOSHI, Vishal
IPC分类号： C12N5/077 , A61K35/32
CPC分类号： C12N5/0654 , A61K35/32 , A61L27/02 , A61L27/3821 , A61L27/3847 , A61L27/54 , A61L2430/02 , C12N2500/00 , C12N2500/02 , C12N2506/1353
摘要： An ex-vivo culturing method of osteoblasts for implantation, comprising a culturing of adult live osteoblasts as an ex-vivo procedure. The ex-vivo culture, which leads to the formation of the active substance, further comprises the steps of isolation of osteo-progenitor cells, differentiation of osteo-progenitor cells in to osteoblasts, expansion culture, cell culture harvest and wash followed by filling and packaging. This method is instrumental in accelerating the process of bone formation.
摘要翻译：用于植入的成骨细胞的离体培养方法，包括作为离体程序培养成年活的成骨细胞。导致活性物质形成的离体培养物还包括分离骨祖细胞，将骨祖细胞分化成成骨细胞，扩增培养，细胞培养收获和洗涤，随后填充和打包。这种方法有助于加速骨形成过程。

8. 发明申请

WO2007140243A2 HEPATIC STELLATE CELL PRECURSORS AND METHODS OF ISOLATING SAME 审中-公开
标题翻译： HEPATIC STELLATE CELL PRECURSORS和隔离方法
公开(公告)号：WO2007140243A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069645
申请日：2007-05-24
申请人： UNIV NORTH CAROLINA , KUBOTA HIROSHI , REID LOLA M
发明人： KUBOTA HIROSHI , REID LOLA M
IPC分类号： C12N5/00 , C12N5/071 , C12N5/074
CPC分类号： C12N5/0018 , C12N5/067 , C12N5/0672 , C12N2500/00 , C12N2500/05 , C12N2500/20 , C12N2500/25 , C12N2500/32 , C12N2500/36 , C12N2500/38 , C12N2500/90 , C12N2501/00 , C12N2501/11 , C12N2501/235 , C12N2501/33 , G01N33/56966
摘要： The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-I+, VCAM-I+, ß3-integrin+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle a-actin, nestin, hepatocyte growth factor, stromal derived factor- la and Hlx homeobox transcriptional factor.
摘要翻译：本发明涉及肝星状细胞的前体细胞，包含其的组合物及其分离方法。前体的表面抗原谱是MHC Ia类阴性，ICAM-1 +，VCAM-1 +，β3-整联蛋白+。除了这些表面标志物的表达外，细胞还表达细胞内标志物结蛋白，波形蛋白，平滑肌α-肌动蛋白，巢蛋白，肝细胞生长因子，基质衍生因子-1a和Hlx同源异体转录因子。

9. 发明申请

WO2005065242A2 METHOD OF TREATING CANCER USING PLATELET RELEASATE 审中-公开
标题翻译：使用放射治疗癌症的方法
公开(公告)号：WO2005065242A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043088
申请日：2004-12-23
申请人： AM BIOSOLUTIONS , MISHRA, Allan
发明人： MISHRA, Allan
IPC分类号： A61K35/12 , A61K35/14 , A61K35/15 , A61K35/16 , A61K35/19 , A61K35/28 , C12N5/00 , C12N5/078
CPC分类号： C12N5/0644 , A61K35/15 , A61K35/16 , A61K35/19 , A61K35/28 , A61K41/0014 , C12N5/0018 , C12N2500/00 , C12N2500/60 , C12N2500/84 , C12N2501/305 , C12N2502/11
摘要： Platelets are concentrated from the blood of a patient. The platelets are treated by a method such as ultrasound or agitation to obtain platelet releasate. The releasate as a whole or a component thereof is formulated into an injectable formulation which is administered to the same patient the platelets were extracted from in order to treat the patient's cancer.
摘要翻译：血小板从患者的血液中浓缩。通过诸如超声或搅动的方法治疗血小板以获得血小板释放。作为整体或其组分的释放物被配制成可注射制剂，其向相同的患者施用血小板以从患者的癌症中提取。

10. 发明申请

WO2016196774A1 METHODS AND DEVICES FOR THE PRODUCTION AND DELIVERY OF BENEFICIAL FACTORS FROM STEM CELLS 审中-公开
标题翻译：用于从干细胞生产和递送受益因子的方法和装置
公开(公告)号：WO2016196774A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035487
申请日：2016-06-02
申请人： AELAN CELL TECHNOLOGIES, INC.
发明人： LUNYAK, Victoria , GAUR, Meenakshi
IPC分类号： A61K39/00 , A61K38/43
CPC分类号： A61K35/28 , A61K38/2013 , A61K38/43 , A61P35/00 , C07K16/246 , C12N5/00 , C12N5/0018 , C12N5/0663 , C12N2500/00 , C12Q1/6886 , C12Q2600/158 , G01N33/574 , G01N2333/4703 , G01N2333/475 , G01N2333/495 , G01N2333/55 , G01N2333/705 , G01N2333/91205 , G01N2333/96466 , G01N2333/96486 , A61K2300/00
摘要： Provided herein are methods and devices related to inducing a population of self-renewing or senescent stem cells, to produce one or more beneficial factors for the treatment of a disease or disorder in an individual. Also provided are compositions and methods for inducing senescence, useful for inducing senescence in a population of stem cells, in order to produce one or more beneficial factors for the treatment of a disease or disorder in an individual. Methods and devices to control and customize the production of the beneficial factors for the requirements of a disease or disorder being treated are described. Also provided are factor production units for the production of the beneficial factors, and devices for the delivery of the beneficial factors to an individual in need.
摘要翻译：本文提供了与诱导自我更新或衰老干细胞群体相关的方法和装置，以产生用于治疗个体疾病或病症的一种或多种有益因子。还提供了用于诱导衰老的组合物和方法，其可用于在干细胞群体中诱导衰老，以产生用于治疗个体疾病或病症的一种或多种有益因子。描述了用于控制和定制所治疗的疾病或病症需求的有益因子的生产的方法和装置。还提供了用于生产有益因子的要素生产单元，以及将有益因素交付给有需要的个体的装置。

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