基本信息:
- 专利标题： MEDICAL DEVICES, COMPOSITIONS AND METHODS FOR TREATING VULNERABLE PLAQUE
- 专利标题（中）：医疗器械，组合物和治疗易损液体的方法
- 申请号：PCT/US2002/007244 申请日：2002-03-08
- 公开(公告)号：WO2002072014A2 公开(公告)日：2002-09-19
- 发明人： BROWN, David, L.
- 申请人： VOLCANO THERAPEUTICS, INC. , BROWN, David, L.
- 申请人地址： Suite 200, 28202 Cabot Road, Laguna Niguel, CA 92677 US
- 专利权人： VOLCANO THERAPEUTICS, INC.,BROWN, David, L.
- 当前专利权人： VOLCANO THERAPEUTICS, INC.,BROWN, David, L.
- 当前专利权人地址： Suite 200, 28202 Cabot Road, Laguna Niguel, CA 92677 US
- 代理机构： CULLMAN, Louis, C.
- 优先权： US60/274,331 20010308
- 主分类号： A61K
- IPC分类号： A61K
摘要：
Medical devices, compositions and methods for treating or preventing atherosclerotic plaque rupture are disclosed. Specifically, medical devices that deliver to a treatment site metalloproteinase inhibitors (MMPI) are disclosed. The medical devices include catheters, guide wires, vascular stents, micro-particles, electronic leads, probes, sensors, drug depots, transdermal patches, and vascular patches. Representative MMPIs included zinc chelators, urea derivatives, caprolactone-based inhibitors, phoshoinamides, piperazines, sulfonamides, tertiary amines, carbamate derivatives, mercaptoalcohols, mecaptoketones, antimicrobial tertracyclines, non-antimicrobial tetracyclines, and derivatives and combinations thereof. In one embodiment a self-expanding vascular stent is coated with at least one MMPI and deployed at a site within an artery where vulnerable plaque has been identified.
摘要（中）：
公开了用于治疗或预防动脉粥样硬化斑块破裂的医疗装置，组合物和方法。 具体地，公开了递送到治疗部位金属蛋白酶抑制剂（MMPI）的医疗装置。 医疗装置包括导管，引导线，血管支架，微粒子，电子引线，探针，传感器，药物库，透皮贴片和血管贴片。 代表性的MMPI包括锌螯合剂，脲衍生物，基于己内酯的抑制剂，磷酰胺，哌嗪，磺酰胺，叔胺，氨基甲酸酯衍生物，巯基醇，麦芽糖酮，抗微生物四环素，非抗微生物四环素及其衍生物和组合。 在一个实施方案中，自扩张血管支架涂覆有至少一种MMPI并且部署在已经鉴定易感斑块的动脉内的部位。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |