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1. 发明申请

WO1989011874A1 MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：磁共振成像
公开(公告)号：WO1989011874A1
公开(公告)日：1989-12-14
申请号：PCT/GB1989000617
申请日：1989-06-02
申请人： HALL, Laurence, David , BRAYBROOK, Julian, Hugh
IPC分类号： A61K49/00
CPC分类号： A61K49/1893 , A61K49/06 , A61K49/1878
摘要： A preparation suitable for clinical administration for use as a contrast agent in magnetic resonance imaging comprises a porous particulate substance with paramagnetic material bound with respect to the surface thereof, the preparation being such that no significant release of the paramagnetic material occurs in undesired locations in clinical use. Such materials can be safely used for clinical diagnostic purposes with humans and animals.
摘要翻译：在磁共振成像中适用于临床给药用作造影剂的制剂包括具有顺磁材料的多孔颗粒物质，其相对于其表面结合，所述制剂使得在临床上不期望的位置不发生顺磁材料的显着释放使用。这些材料可以安全地用于人和动物的临床诊断目的。

2. 发明申请

WO2012030134A3 IRON OXIDE NANOCAPSULES, METHOD OF MANUFACTURING THE SAME, AND MRI CONTRAST AGENT USING THE SAME 审中-公开
标题翻译：氧化铁纳米粒子，其制造方法和使用其的MRI对比剂
公开(公告)号：WO2012030134A3
公开(公告)日：2012-06-28
申请号：PCT/KR2011006396
申请日：2011-08-30
申请人： HANWHA CHEMICAL CORP , JEON BONG-SIK , KIM EUNG GYU , KWON EUN BYUL , PARK JU YOUNG , MYEONG WAN JAE
发明人： JEON BONG-SIK , KIM EUNG GYU , KWON EUN BYUL , PARK JU YOUNG , MYEONG WAN JAE
IPC分类号： B82B3/00 , A61K49/06
CPC分类号： A61K49/1893 , A61K49/1824 , A61K49/1827 , A61K49/1839 , A61K49/1857 , A61K49/1887
摘要： Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanopart icles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. [Relation 1] 5 = 100* Dm(I0)/ Cv(I0) [Relation 2] 2.5 = 100* Dm(Cap)/ Cv(Cap) [Relation 3] 0.5 wt% m(I0) m(Cap) = 200 nm.
摘要翻译：本发明提供了一种具有高对比度的MRI造影剂的氧化铁纳米胶囊，其中具有附着于其上的疏水配体的多个氧化铁纳米颗粒被包封在包括可生物降解的聚合物和表面活性剂的包封材料中，并且满足关系1,2 ，3，4和5。还提供了一种制造氧化铁纳米胶囊的方法。 [关系1] 5 = 100 * Dm（I0）/ Cv（I0）[关系2] 2.5 = 100 * Dm（Cap）/ Cv（Cap）[关系3] 0.5wt％m（I0）m（Cap）= 200nm。

3. 发明申请

WO1992010213A1 MOLECULAR SIEVE-ENCLOSED PARAMAGNETIC ION FOR DIAGNOSIS 审中-公开
标题翻译：用于诊断的分子筛附加的参照物
公开(公告)号：WO1992010213A1
公开(公告)日：1992-06-25
申请号：PCT/US1991009222
申请日：1991-12-06
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , YOUNG, Stuart, W. , BALKUS, Kenneth, J., Jr. , SHERRY, A., Dean
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： A61K49/00
CPC分类号： A61K49/1893 , Y10S514/836 , Y10S514/974 , Y10T436/24
摘要： The invention relates to a method of using molecular sieve-enclosed paramagnetic ions as image brightening or image contrast agents. In particular, zeolite enclosed trivalent gadolinium is useful in MRI studies of the entire gastrointestinal tract, providing excellent images. Zeolite-enclosed gadolinium complexes may be conveniently administered in oral preparations without side effects of diarrhea. Other transition metal ions, including divalent manganese may be enclosed in any suitable molecular sieve which has ion exchange properties sufficient to exchange the selected metal. The exchanged paramagnetic metal ion may be a free ion within the zeolite framework or ligated with a chelator. Alternatively, a paramagnetic metal ion may be included as part of the molecular sieve framework.

4. 发明申请

WO2012030134A2 IRON OXIDE NANOCAPSULES, METHOD OF MANUFACTURING THE SAME, AND MRI CONTRAST AGENT USING THE SAME 审中-公开
标题翻译：氧化铁纳米胶囊，其制造方法以及使用该方法的MRI造影剂
公开(公告)号：WO2012030134A2
公开(公告)日：2012-03-08
申请号：PCT/KR2011/006396
申请日：2011-08-30
申请人： HANWHA CHEMICAL CORPORATION , JEON, Bong-Sik , KIM, Eung Gyu , KWON, Eun Byul , PARK, Ju Young , MYEONG, Wan Jae
发明人： JEON, Bong-Sik , KIM, Eung Gyu , KWON, Eun Byul , PARK, Ju Young , MYEONG, Wan Jae
IPC分类号： B82B3/00 , A61K49/06
CPC分类号： A61K49/1893 , A61K49/1824 , A61K49/1827 , A61K49/1839 , A61K49/1857 , A61K49/1887
摘要： Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanopart icles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. [Relation 1] 5 ≤ 100* D m (I0)/ Cv(I0) [Relation 2] 2.5 ≤ 100* D m (Cap)/ C v (Cap) [Relation 3] 0.5 wt% m (I0) m (Cap) ≤ 200 nm.
摘要翻译：提供了用于具有高对比度的MRI造影剂的氧化铁纳米胶囊，其中连接有疏水性配体的多个氧化铁纳米颗粒被包封在包含生物可降解聚合物和表面活性剂的包封材料中，并且满足下面的关系1,2,3,4和5。还提供了制造氧化铁纳米胶囊的方法。（I 0）/ C v（I 0）2.5≤100* D m（Cap）/ C n（1）其中，（Cap）[关系3] 0.5重量％ F（I 0）＆lt; 50重量％[关系4] 1nm < D（m）（I 0）＆lt; 25nm [关系5] 50nm < D _{m（cap）≤200 nm。}

5. 发明申请

WO02037088A1 MATERIAL WHICH IS PROVIDED WITH AN NMR CONTRAST AGENT AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译： WITH A核磁共振造影剂提供的材料及其制备方法
公开(公告)号：WO02037088A1
公开(公告)日：2002-05-10
申请号：PCT/DE2001/004000
申请日：2001-10-19
IPC分类号： A61K49/12 , G01N24/08 , A61K9/70 , A61L33/00 , G01R33/28
CPC分类号： A61K49/1893 , A61K49/105 , A61K49/12
摘要： The invention relates to a material comprising at least the following: a matrix (2), especially with a polymer base; a support which is worked into said matrix. The material data can be detected by means of an NMR device (5). The inventive material is characterized in that the support is loaded with at least one active agent (Z) and with a contrast agent (X), these forming a support/active agent/contrast agent adduct (3); and in that the distribution of the adduct (3) and therefor, the active agent (Z) in the matrix (2), can be measured using the NMR device (5). The support is preferably a molecular sieve. The invention also relates to an advantageous method for producing the inventive material.
摘要翻译：本发明涉及包含一种材料，至少包括：一个矩阵（2），特别是基于聚合物; 并且其被并入基质载体; 其中，所述素材数据可以由NMR装置来检测（5）。本发明的材料现在的特征在于，所述的载体与至少一种活性物质（Z），并且还包括将造影剂（X）被加载，即，以形成载体/活性物质/造影剂加合物（3）; 由NMR装置（5）加合物的分布的装置被测量（3），因此在基体中的活性物质（Z）（2）。载体优选是分子筛。此外，提出了一种用于生产本发明材料的有利方法。

6. 发明申请

WO1993008846A1 CONTRAST MEDIA 审中-公开
标题翻译：对比媒体
公开(公告)号：WO1993008846A1
公开(公告)日：1993-05-13
申请号：PCT/EP1992002550
申请日：1992-10-29
申请人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED SALUTAR, INC. , FELLMANN, Jere, Douglas
发明人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED SALUTAR, INC.
IPC分类号： A61K49/00
CPC分类号： A61K49/1893 , A61K51/1258 , A61K2123/00
摘要： There are provided improved diagnostic metal containing molecular sieves for use as contrast agents in diagnostic imaging techniques such as X-ray, scintigraphy and, especially, MRI. For MRI the diagnostic metals are paramagnetic metal ions. Reduced risk of toxic metal release in vivo, especially into the GI tract, is achieved by surface modification of the molecular sieve.
摘要翻译：提供了改进的含有分子筛的诊断金属，用作诊断成像技术如X射线，闪烁照相术，特别是MRI中的造影剂。对于MRI，诊断金属是顺磁金属离子。通过分子筛的表面改性，降低体内有毒金属释放特别是胃肠道的风险。

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