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    • 8. 发明申请
    • NANOPARTICLES WITH INORGANIC CORE AND METHODS OF USING THEM
    • 无机碳纳米管及其使用方法
    • WO2006068653A3
    • 2007-03-08
    • PCT/US2005011110
    • 2005-04-01
    • GEN ELECTRICMALENFANT PATRICKACAR HAVVABONITATEBUS JR PETERDIXON WILLIAMKULKARNI AMIT
    • MALENFANT PATRICKACAR HAVVABONITATEBUS JR PETERDIXON WILLIAMKULKARNI AMIT
    • A61K49/18
    • A61K49/1848A61K49/186B82Y5/00
    • An aspect of the invention includes a nanoparticle including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating includes of at least coating structure I, II, or III wherein the nanoparticle is substantially non-agglomerated and has diameter in a range from about 1nm to about 100 nm. An aspect of the invention also encompasses a method of making a substantially non-agglomerated nanoparticle having a diameter in a range from about 1nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III. An aspect of the invention also encompasses various methods of using the substantially non-agglomerated nanoparticle having a diameter in a range from about 1nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III.
    • 本发明的一个方面包括纳米颗粒,其包括具有表面的基本上单分散的无机核,涂层基本覆盖基本上单分散的无机核的表面,其中该涂层至少包括涂层结构I,II或III,其中纳米颗粒是 基本上非团聚并且具有在约1nm至约100nm范围内的直径。 本发明的一个方面还包括制备直径在约1nm至约100nm范围内的基本上非团聚的纳米颗粒的方法,包括基本上单分散的无机芯,其表面和涂层基本上覆盖基本上单分散的表面 无机芯,其中涂层包括涂层结构I,II或III。 本发明的一个方面还包括使用直径在约1nm至约100nm范围内的基本上未附聚的纳米颗粒的各种方法,包括基本上单分散的无机芯,其表面和涂层基本上覆盖基本上单分散的表面 无机芯,其中涂层包括涂层结构I,II或III。
    • 9. 发明申请
    • CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING
    • 磁共振成像对比剂
    • WO2005112758A1
    • 2005-12-01
    • PCT/US2005/017341
    • 2005-05-18
    • GENERAL ELECTRIC COMPANYACAR, Havva, Y.SYUD, FaisalGARAAS, RachelBONITATEBUS, JR., PeterKULKARNI, Amit
    • ACAR, Havva, Y.SYUD, FaisalGARAAS, RachelBONITATEBUS, JR., PeterKULKARNI, Amit
    • A61B5/055
    • A61K49/186B82Y5/00
    • A contrast agent for magnetic resonance imaging having a plurality of nanoparticles (100, 200). Each of the nanoparticles (100, 200) has: a signal generating core (110, 210) having a diameter of up to 10 nm; at least one organic layer (120, 230) of at least one of a polymer, a monomer (122), and a surfactant; and a water soluble outer shell of at least one of a polymer, a monomer (122), and a ligand. The organic layer (120, 230) is adsorbed upon and substantially surrounds and stabilizes the signal generating core. The water soluble outer shell solubilizes and provides biocompatibility for each of the nanoparticles (100, 200). The contrast agents provide enhanced relaxivity, high signal-to-noise ratios, and targeting abilities. In addition, the contrast agents possess resistance to agglomeration, controlled particle size, blood clearance rate, and biodistribution. Methods of making such contrast agents and nanoparticles (100, 200) are also disclosed.
    • 一种用于具有多个纳米颗粒(100,200)的磁共振成像的造影剂。 每个纳米颗粒(100,200)具有:具有高达10nm的直径的信号产生芯(110,210); 至少一种聚合物,单体(122)和表面活性剂中的至少一种的有机层(120,230); 和聚合物,单体(122)和配体中的至少一种的水溶性外壳。 有机层(120,230)被吸附在基本上并且基本上包围和稳定信号产生芯。 水溶性外壳增溶并为每种纳米颗粒(100,200)提供生物相容性。 造影剂提供增强的松弛度,高信噪比和靶向能力。 此外,造影剂具有抗凝集,受控粒度,血清清除率和生物分布。 还公开了制备这种造影剂和纳米颗粒(100,200)的方法。
    • 10. 发明申请
    • CONTROLLABLE COMFORT SHELL FOR VEHICLE SEAT
    • 用于车辆座椅的可控舒适外壳
    • WO2013040085A2
    • 2013-03-21
    • PCT/US2012/054933
    • 2012-09-12
    • FAURECIA AUTOMOTIVE SEATING, INC.KULKARNI, AmitGOLIGORSKY, DavidPROULX, Timothy, R.
    • KULKARNI, AmitGOLIGORSKY, DavidPROULX, Timothy, R.
    • B60N2/68A47C7/40
    • B60N2/667B60N2/028B60N2/66B60N2/68Y10T29/49826
    • A vehicle seat includes a seat back having a support frame coupled to a seat foundation. The seat back also further includes a deformable seat shell adapted to assume various shapes between initial position and final positions in response to variable rearward loads applied by a seated passenger. The seat shell is coupled to the support frame by a compliant shell-motion controller via upper and lower motion-control links. The motion-control links allow pivotal motion, and at least one of the links includes a spheroidal joint. A link foundation extends between and interconnects the upper and lower motion-control links and is coupled to the support frame so that the link foundation does not move during seat shell deformation. The shell-motion controller may be pre-assembled as part of a backrest or the motion-control links may be formed after the link foundation is attached to the support frame.
    • 车辆座椅包括具有联接到座椅基座的支撑框架的座椅靠背。 座椅靠背还进一步包括可变形的座椅外壳,其适于在初始位置和最终位置之间呈现各种形状,以响应由乘坐者施加的可变向后负载。 座椅外壳通过上部和下部运动控制连杆通过顺应式外壳运动控制器连接到支撑框架。 运动控制连杆允许枢转运动,并且至少一个连杆包括球体关节。 连杆基座在上部和下部运动控制连杆之间延伸并互连,并且连接到支撑框架,使得连杆基座在座椅壳体变形期间不移动。 壳运动控制器可以预先组装成靠背的一部分,或者可以在链接基座附接到支撑框架之后形成运动控制链接。