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1. 发明申请

WO2014197598A3 TRIPARTITE CANCER THERANOSTIC NUCLEIC ACID CONSTRUCTS 审中-公开
标题翻译：三磷酸核苷酸核酸结构
公开(公告)号：WO2014197598A3
公开(公告)日：2015-06-04
申请号：PCT/US2014040912
申请日：2014-06-04
申请人： UNIV JOHNS HOPKINS , UNIV VIRGINIA COMMONWEALTH
发明人： FISHER PAUL B , DAS SWADESH K , MENEZES MITCHELL E , SARKAR DEVANAND , POMPER MARTIN G
IPC分类号： A61K48/00
CPC分类号： A61K48/0058 , A61K9/0019 , A61K38/20 , A61K41/0028 , A61K41/0033 , A61K49/0013 , A61K49/0045 , A61K49/0054 , A61K51/00 , A61K51/0491 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/10043 , C12N2710/10343 , C12N2710/16143 , C12N2710/16171 , C12N2830/008 , C12Q1/6897
摘要： The presently disclosed subject matter generally relates to genetic constructs and methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. In particular, the presently disclosed subject matter relates to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.
摘要翻译：目前公开的主题通常涉及其用于癌症成像，癌症治疗和组合成像和治疗方案中的遗传构建体和方法。特别地，目前公开的主题涉及允许同时进行癌症特异性病毒复制，诊断基因产物的表达和治疗基因表达的三方式癌症核糖核酸构建体。

2. 发明申请

WO2014036807A1 重组单纯疱疹病毒、其制备方法及应用审中-公开
公开(公告)号：WO2014036807A1
公开(公告)日：2014-03-13
申请号：PCT/CN2013/001040
申请日：2013-09-05
申请人：刘滨磊
发明人：刘滨磊 , 葛科立 , 张叔人 , 张文 , 李洁 , 张郁 , 董英
IPC分类号： C12N7/01 , C12Q1/70 , C12Q1/02 , G01N21/64 , A61P35/00 , A61K39/245 , C12N15/63 , C12R1/93
CPC分类号： A61K39/245 , A61K35/763 , A61K39/12 , A61K49/0045 , A61K49/0097 , C12N2710/16621 , C12N2710/16632 , C12N2710/16643 , C12N2830/008 , C12N2830/85 , G01N33/574 , G01N2333/03
摘要：本发明提供了一种重组单纯疱疹病毒及其制备方法，其是将含有ICP4基因的单纯疱疹病毒基因组中的ICP4基因启动子替换为人端粒酶逆转录酶启动子hTERTp或其他肿瘤特异性启动子，从而更有选择性地在人肿瘤细胞内生长繁殖，有效杀伤癌细胞。本发明还提供了该重组单纯疱疹病毒在制备治疗肿瘤药物中的应用。本发明还提供了另一种重组单纯疱疹病毒，其是在前述重组单纯疱疹病毒基因组中插入荧光蛋白表达盒，使其能在肿瘤细胞内发光，可实现肿瘤的早期诊断及肿瘤转移的诊断。

3. 发明申请

WO2013177255A3 CHIMERIC LUCIFERASES 审中-公开
公开(公告)号：WO2013177255A3
公开(公告)日：2014-03-13
申请号：PCT/US2013042178
申请日：2013-05-22
申请人： CONNECTICUT COLLEGE
发明人： BRANCHINI BRUCE
IPC分类号： C12N9/02 , C12N15/06
CPC分类号： C12N9/0069 , A61K49/0045 , A61K49/0097 , C07K2319/00 , C07K2319/61 , C12Q1/66 , C12Y113/12007
摘要： Described herein are novel chimeric luciferase molecules with enhanced properties, and methods of using these chimeric luciferase molecules.
摘要翻译：本文描述了具有增强性质的新型嵌合荧光素酶分子以及使用这些嵌合荧光素酶分子的方法。

4. 发明申请

WO2008144052A2 BIOLUMINESCENT IMAGING OF STEM CELLS 审中-公开
标题翻译：干细胞的成像成像
公开(公告)号：WO2008144052A2
公开(公告)日：2008-11-27
申请号：PCT/US2008006429
申请日：2008-05-19
申请人： WALIA RAMPYARI
发明人： WALIA RAMPYARI
IPC分类号： A61K49/00
CPC分类号： A61K49/0047 , A61K49/0045 , A61K49/0097
摘要： Methods and compositions for detecting and localizing light originating from cultured stem cells or stem cells injected into tissue or an animal, especially a mammal, are described. Also disclosed are methods for localization of stem cells in selected regions, as well as for tracking stem cells within the mammal, and for causing stem cell differentiation.
摘要翻译：描述了用于检测和定位源自培养的干细胞或注射到组织或动物，特别是哺乳动物的干细胞中的光的方法和组合物。还公开了用于在选定区域中定位干细胞的方法，以及用于跟踪哺乳动物内的干细胞和用于引起干细胞分化的方法。

5. 发明申请

WO2006121631A2 REAL TIME IMAGING DURING SOLID ORGAN TRANSPLANT 审中-公开
标题翻译：实体运输期间的实时成像
公开(公告)号：WO2006121631A2
公开(公告)日：2006-11-16
申请号：PCT/US2006016089
申请日：2006-04-26
申请人： NOVADAQ TECHNOLOGIES INC , CROFT RICHARD L , MANGAT GURPREET , BRZOZOWSKI LUKASZ
发明人： CROFT RICHARD L , MANGAT GURPREET , BRZOZOWSKI LUKASZ
IPC分类号： A61K49/00
CPC分类号： A61K49/0045 , A61K49/0019 , A61K49/0032 , A61K49/0034 , A61K49/0041 , A61K49/0043
摘要： The invention provides methods and systems for imaging vessels in a subject. In certain embodiments the vessels may be associated with a solid organ transplant.
摘要翻译：本发明提供了用于在受试者中成像血管的方法和系统。在某些实施方案中，血管可以与实体器官移植物结合。

6. 发明申请

WO2005120546A2 COMPOSITIONS AND METHODS FOR TOPICAL DIAGNOSTIC AND THERAPEUTIC TRANSPORT 审中-公开
标题翻译：用于局部诊断和治疗运输的组合物和方法
公开(公告)号：WO2005120546A2
公开(公告)日：2005-12-22
申请号：PCT/US2005006931
申请日：2005-03-03
申请人： ESSENTIA BIOSYSTEMS INC , DAKE MICHAEL D , WAUGH JACOB M
发明人： DAKE MICHAEL D , WAUGH JACOB M
IPC分类号： A61K38/17 , A61K47/48
CPC分类号： A61K31/7048 , A61K9/0014 , A61K31/343 , A61K31/4164 , A61K31/4196 , A61K31/4418 , A61K31/496 , A61K31/513 , A61K31/7076 , A61K38/1767 , A61K38/4893 , A61K47/59 , A61K47/6455 , A61K49/0041 , A61K49/0043 , A61K49/0045 , A61K49/0054 , A61K49/0063 , C07K16/32 , C12Y304/24069
摘要： Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGF. The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternately, the compositions can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.
摘要翻译：提供了可用于递送（包括透皮递送）生物活性剂，例如非蛋白质非核苷酸治疗剂和基于蛋白质的治疗剂（不包括胰岛素，肉毒杆菌毒素，抗体片段和VEGF）的组合物和方法。组合物和方法特别适用于局部递送抗真菌剂和适合免疫的抗原剂。或者，组合物可以用可用于靶向组合物递送以及成像组分的组分制备。

7. 发明申请

WO2004042361A3 TRANSGENIC ANIMALS EXPRESSING LIGHT-EMITTING FUSION PROTEINS AND DIAGNOSTIC AND THERAPEUTIC METHODS THEREFOR 审中-公开
标题翻译：表达发光融合蛋白的转基因动物及其诊断和治疗方法
公开(公告)号：WO2004042361A3
公开(公告)日：2004-07-08
申请号：PCT/US0335154
申请日：2003-11-03
申请人： DANA FARBER CANCER INST INC , KAELIN WILLIAM G JR , LIVINGSTON DAVID M , KIM TAE-YOU
发明人： KAELIN WILLIAM G JR , LIVINGSTON DAVID M , KIM TAE-YOU
IPC分类号： A01K67/027 , A01K67/033 , A61K38/02 , A61K38/44 , A61K49/00 , A61P11/00 , C07K14/47 , C12N9/00 , C12Q1/26 , G01N20060101 , G01N33/50 , G01N33/542 , G01N33/573
CPC分类号： A61K49/0045 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K49/0047 , C07K14/4702 , C07K2319/60 , C12N9/93 , C12Q1/26 , G01N33/573 , G01N2333/90245 , G01N2500/02
摘要： Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the lightgenerating fusion protein is "turned on" only under such conditions
摘要翻译：公开了具有配体结合位点和产光多肽部分的产光融合蛋白以及它们在药物筛选和发现中作为诊断剂以及作为治疗剂的用途。产光融合蛋白具有这样的特征，其中多肽部分的生物发光随着配体在配体结合位点处的结合而改变。配体可以是例如仅在某些条件下存在于环境中的酶，例如处于低氧状态的泛素连接酶，使得仅在这样的条件下“开启”光生融合蛋白

8. 发明申请

WO2003057007A2 SYSTEM FOR MONITORING BACTERIAL TUMOR TREATMENT 审中-公开
标题翻译：监测细菌性肿瘤治疗的系统
公开(公告)号：WO2003057007A2
公开(公告)日：2003-07-17
申请号：PCT/US2002/041822
申请日：2002-12-31
申请人： ANTICANCER, INC.
发明人： ZHAO, Ming, M.D., Ph.D. , LI, Xiao-Ming, M.D., Ph.D. , YANG, Meng, M.D., Ph.D. , XU, Mingxu, M.D. , JIANG, Ping, M.D. , LI, Linga, M.D.
IPC分类号： A61B
CPC分类号： A61K49/0045 , A61K49/0008 , A61K49/0047 , A61K49/0097
摘要： A method to follow the progress of tumor treatment in subjects utilizes bacteria that have been modified to express a fluorescent protein. The method can also monitor expression of genes associated with the bacteria that produce therapeutic agents during the course of treatment, optionally against a background of fluorescence generated by the tumor itself. The method permits visualization of the progress of treatment in live subjects so that treatments can be modified according to their efficacy.
摘要翻译：在受试者中遵循肿瘤治疗进展的方法利用已被修饰以表达荧光蛋白的细菌。该方法还可以监测在治疗过程中产生治疗剂的细菌相关基因的表达，任选地针对肿瘤本身产生的荧光背景。该方法允许可视化活体受试者的治疗进展，从而可以根据疗效对治疗进行修改。

9. 发明申请

WO2002080756A2 IMAGING SYSTEMS FOR IN VIVO PROTOCOLS 审中-公开
标题翻译：用于体检方案的成像系统
公开(公告)号：WO2002080756A2
公开(公告)日：2002-10-17
申请号：PCT/US2002/010829
申请日：2002-04-05
申请人： JOHNS HOPKINS UNIVERSITY
发明人： YANG, Xiaoming , KUMAR, Ananda , CHEN, Hunter, H.
IPC分类号： A61B
CPC分类号： A61K49/0045 , A61B1/042 , A61B1/043 , A61B1/12 , A61B1/3137 , A61B5/0071 , A61B5/0084 , A61B5/02007 , A61B2560/0233 , A61K49/0047 , G01N21/6447
摘要： New digital optical imaging techniques are provided which can enable intravascular, external, or minimally-invasive transpercutaneous tracking of vascular gene expression and diagnosis of a variety of disorders and diseases including atherosclerosis. Preferred optical imaging systems for use in the invention can detect extrinsic/intrinsic fluorescent/luminous signals emitted from deep-seated vessels.
摘要翻译：提供了新的数字光学成像技术，其可以使血管内，外部或微创的经皮跟踪血管基因表达和诊断各种疾病和疾病，包括动脉粥样硬化。用于本发明的优选光学成像系统可以检测从深层血管发射的外在/本征荧光/发光信号。

10. 发明申请

WO0125399A2 NON-INVASIVE TUMOR IMAGING BY TUMOR-TARGETED BACTERIA 审中-公开
标题翻译：通过肿瘤标记的细菌进行非侵入性肿瘤成像
公开(公告)号：WO0125399A2
公开(公告)日：2001-04-12
申请号：PCT/US0027397
申请日：2000-10-04
申请人： VION PHARMACEUTICALS INC , SLOAN KETTERING INST CANCER
发明人： BERMUDES DAVID G , KING IVAN CHEUNG-LAM , BLASBERG RONALD G , TJUVAJEV JURI G
IPC分类号： A61K49/00 , A61P35/00 , C12N
CPC分类号： A61K49/0045 , A61K49/0047 , A61K49/0097
摘要： The present invention provides non-invasive compositions and methods to detect solid tumors using tumor-targeted bacteria. specifically, the present invention provides compositions and methods for detecting solid tumors in vivo by delivery of a marker gene to a solid tumor via a population of tumor-targeted bacteria, methods for detecting solid tumors by detecting a compound incorporated into the bacteria, methods for detecting solid tumors by detecting an infection caused by the bacteria at the tumor site(s), methods for detecting solid tumors by detecting an antigen present on the surface of the bacterial vectors. When detecting a tumor entails detecting a marker gene product expressed by the tumor-targeted bacteria, the marker gene product can be detected directly in the tumor, by the use of a labeled moiety that interacts with the marker gene product, or by the use of the labeled marker substrate. Thus, if a marker gene product is directly detectable, it can be detected directly. When a marker gene product is not directly detectable, a labeled moiety that interacts with the marker gene product is detected, or a labeled marker substrate is used and a labeled marker metabolite is detected. A tumor can thus be localized or detected by scanning a subject to detect the marker gene product, a labeled complex comprising the marker gene product and its interacting moiety, or a labeled marker metabolite, respectively, thereby imaging the tumor. Specifically, the attenuated tumor-targeted bacteria of the invention are facultative aerobes or facultative anaerobes which are modified to encode the marker gene. Still further, this invention provides compositions and methods of simultaneously imaging and treating a tumor in a subject using one or a plurality of populations tumor-targeted organisms. The invention provides non-invasive, clinically applicable methods for imaging tumors which can be implemented using existing imaging techniques to monitor and evaluate in vivo cancer treatments in human subjects. Kits are also provided.
摘要翻译：本发明提供使用肿瘤靶向细菌检测实体瘤的非侵入性组合物和方法。具体地，本发明提供通过肿瘤靶向细菌群体将标记基因递送至实体瘤的体内检测实体瘤的组合物和方法，通过检测化合物检测实体瘤的方法通过检测由肿瘤部位的细菌引起的感染来检测实体瘤的方法，通过检测存在于细菌载体表面上的抗原来检测实体瘤的方法。当检测肿瘤需要检测由肿瘤靶向细菌表达的标志物基因产物时，可以通过使用与标记基因产物相互作用的标记部分直接在肿瘤中检测标记基因产物，或通过使用标记标记底物。因此，如果标记基因产物是直接可检测的，则可以直接检测。当标记基因产物不能直接检测时，检测到与标记基因产物相互作用的标记部分，或使用标记的标记底物并检测标记的标记物代谢物。因此，可以通过扫描受试者来分析肿瘤，以分别检测标记基因产物，包含标记基因产物及其相互作用部分的标记复合物或标记的标记物代谢物，从而对肿瘤进行成像。具体地，本发明的减毒肿瘤靶向细菌是修饰以编码标记基因的兼性有氧运动或兼性厌氧菌。此外，本发明提供了使用一个或多个群体肿瘤靶向生物体同时成像和治疗受试者肿瘤的组合物和方法。本发明提供用于成像肿瘤的非侵入性临床适用方法，其可以使用现有成像技术来实施以监测和评价人类受试者的体内癌症治疗。还提供套件。

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