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1. 发明申请

WO2016141320A3 NON-NEUROINVASIVE VIRUSES AND USES THEREOF 审中-公开
标题翻译：非神经病毒病毒及其用途
公开(公告)号：WO2016141320A3
公开(公告)日：2016-10-27
申请号：PCT/US2016020960
申请日：2016-03-04
申请人： UNIV NORTHWESTERN , UNIV NEBRASKA , TRUSTEES OF TUFTS COLLEGE (AKA TUFTS UNIVERSITY)
发明人： SMITH GREGORY A , SOLLARS PATRICIA JANE , PICKARD GARY EDWARD , HELDWEIN EKATERINA E
IPC分类号： A61K39/12 , A61K39/245 , A61K39/25 , C12N15/01 , G01N33/68
CPC分类号： A61K39/12 , A61K2039/5254 , C07K14/005 , C07K2299/00 , C12N2710/16034 , C12N2710/16622 , C12N2710/16632 , C12N2710/16634 , C12N2710/16643 , C12N2710/16722 , C12N2710/16732 , C12N2710/16734 , C12N2710/16743
摘要： Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
摘要翻译：本文提供了疫苗接种和研究应用的组合物和方法。特别地，本文提供的是非神经侵袭性疱疹病毒和α疱疹病毒及其用途。

2. 发明申请

WO2015134368A2 RECOMBINANT HERPES SIMPLEX VIRUS 2 (HSV-2) VACCINE VECTORS 审中-公开
标题翻译：重组疱疹单纯疱疹病毒2（HSV-2）疫苗载体
公开(公告)号：WO2015134368A2
公开(公告)日：2015-09-11
申请号：PCT/US2015/018272
申请日：2015-03-02
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人： JACOBS, William , GONZALEZ MUNOZ, Pablo, A. , HEROLD, Betsy
IPC分类号： H02P9/02
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/572 , C07K14/005 , C12N7/00 , C12N2710/16621 , C12N2710/16622 , C12N2710/16634 , C12N2710/16643 , C12N2710/16662 , C12N2710/16671
摘要： Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each provided.
摘要翻译：重组单纯疱疹病毒2（HSV-2）疫苗载体，其病毒体，包含其的组合物和疫苗及其使用方法各自提供。

3. 发明申请

WO2014047350A1 ONCOLYTIC VIRUS ENCODING PD-1 BINDING AGENTS AND USES OF THE SAME 审中-公开
标题翻译： ONCOLYTIC VIRUS编码PD-1结合剂及其用途
公开(公告)号：WO2014047350A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060716
申请日：2013-09-19
申请人： MORNINGSIDE TECHNOLOGY VENTURES LTD. , NOLIN, Westley B.
发明人： NOLIN, Westley B. , NG, Shi Chung , DINGES, Jason R. , CHAN, Gerald L.
IPC分类号： C12N15/00 , A01N63/00 , A01N65/00 , A61K39/395
CPC分类号： A61K35/768 , A61K35/761 , A61K35/763 , A61K2039/505 , C07K16/2803 , C07K16/2818 , C07K2317/76 , C12N7/00 , C12N2710/10032 , C12N2710/10043 , C12N2710/10071 , C12N2710/16632 , C12N2710/16643 , C12N2710/16671 , C12N2710/24132 , C12N2710/24143 , C12N2710/24171 , C12N2810/859
摘要： The present disclosure concerns the use of oncolytic viruses for the treatment of cancer. In particular, the use of a herpes simplex virus, a vaccinia virus, or an adenovirus containing a gene encoding a PD-1 binding agent, such as a scFv polypeptide, to achieve a particular degree of oncolysis is described. In some embodiments, the oncolytic virus expressing the PD-1 binding agent is effective at inducing immune responses that kill cancer cells at distant sites from the primary tumor. An oncolytic virus can also be engineered to be less toxic or damaging to non-cancer cells by mutation or modification of gene products such that the alterations render the viruses better able to infect the host, less toxic, and/or better able to selectively infect cancer cells.
摘要翻译：本公开涉及使用溶瘤病毒治疗癌症。特别地，描述了使用单纯疱疹病毒，牛痘病毒或含有编码PD-1结合剂（例如scFv多肽）的基因的腺病毒以达到特定程度的溶解。在一些实施方案中，表达PD-1结合剂的溶瘤病毒在诱导免疫应答方面是有效的，所述免疫应答杀死远处与原发肿瘤的癌细胞。溶瘤病毒也可以被设计为通过基因产物的突变或修饰来对非癌细胞毒性较小或有害，使得改变使病毒更好地感染宿主，较少毒性和/或更好地选择性感染癌细胞。

4. 发明申请

WO2011119925A3 SYNTHETIC HERPES SIMPLEX VIRUSES FOR TREATMENT OF CANCERS 审中-公开
标题翻译：合成用于治疗癌症的简单病毒
公开(公告)号：WO2011119925A3
公开(公告)日：2012-06-21
申请号：PCT/US2011029939
申请日：2011-03-25
申请人： UNIV LOUISIANA STATE , KOUSOULAS KONSTANTIN G , WALKER JASON
发明人： KOUSOULAS KONSTANTIN G , WALKER JASON
IPC分类号： C12N15/869 , A61P35/00 , C12N7/01 , C12N15/38 , C12N15/53
CPC分类号： C12N7/00 , A61K35/763 , A61K45/06 , C12N2710/16632 , C12N2710/16643 , C12N2710/16662 , A61K2300/00
摘要： New recombinant oncolytic viral vectors have been constructed based on a known herpes simplex virus-1 with a single 34.5 gene and a synctial mutation (called OncSyn (OS) virus), which was designed to be more immunogenic than the parental OS virus largely due to deletion of the viral gene viral host shutoff (vhs) gene (the "OSV" virus). In another embodiment, the OSV virus was constructed to constitutively express 15-PGDH (the "OSVP" virus), the principal enzyme responsible for degradation of PGE2. OSVP was shown to decrease both breast tumors and prostate cancer tumors in mice models. In addition, OSVP was shown to trigger substantial inflammatory cytokine production and promote anti-tumor immune responsiveness. These altered viruses, OSV and OSVP, can be used to treat various cancers including breast, prostate, liver, colon, and other tissues. Other exogenous genes can be added to either OSV or OSVP to improve the therapeutic response.
摘要翻译：已经基于已知的具有单个34.5基因和合成突变（称为OncSyn（OS）病毒）的单纯疱疹病毒-1构建了新的重组溶瘤病毒载体，其被设计为比亲本OS病毒更具免疫原性，主要是由于病毒基因病毒宿主关闭（vhs）基因（“OSV”病毒）的缺失。在另一个实施方案中，构建OSV病毒以组成型表达导致PGE2降解的主要酶的15-PGDH（“OSVP”病毒）。 OSVP显示在小鼠模型中减少乳腺肿瘤和前列腺癌肿瘤。此外，OSVP被证明可以引发大量的炎性细胞因子产生并促进抗肿瘤免疫反应。这些改变的病毒，OSV和OSVP可用于治疗各种癌症，包括乳腺癌，前列腺癌，肝癌，结肠癌和其他组织。可以将其他外源基因加入到OSV或OSVP中以改善治疗反应。

5. 发明申请

WO2009097129A1 RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION 审中-公开
标题翻译：使用哺乳动物细胞的重组病毒生产
公开(公告)号：WO2009097129A1
公开(公告)日：2009-08-06
申请号：PCT/US2009/000577
申请日：2009-01-29
申请人： APPLIED GENETIC TECHNOLOGIES CORPORATION , KNOP, Dave , THOMAS, Darby , VERES, Gabor
发明人： KNOP, Dave , THOMAS, Darby , VERES, Gabor
IPC分类号： C12N7/00 , C12N7/02 , C12N15/86
CPC分类号： C12N15/8645 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/16643 , C12N2710/16662 , C12N2750/14122 , C12N2750/14143 , C12N2800/50
摘要： The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy.
摘要翻译：本发明通常提供使用悬浮液中生长的细胞来生产重组AAV病毒颗粒的方法。本发明提供用于递送编码治疗性蛋白质的基因的方法中使用的重组AAV颗粒，以及在基因治疗中使用重组AAV颗粒的方法。

6. 发明申请

WO2008106694A2 SYSTEMS, METHODS AND COMPOSITIONS FOR OPTICAL STIMULATION OF TARGET CELLS 审中-公开
标题翻译：用于目标细胞光刺激的系统，方法和组合物
公开(公告)号：WO2008106694A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/055727
申请日：2008-03-03
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： ZHANG, Feng , DEISSEROTH, Karl , GRADINARU, Viviana
IPC分类号： A61K38/17
CPC分类号： A61N5/062 , A01K67/0333 , A01K2217/052 , A01K2227/703 , A01K2267/0356 , A61K38/00 , A61K48/005 , A61K48/0058 , A61K48/0083 , A61N5/0613 , A61N5/0622 , C07K14/00 , C07K14/195 , C07K14/215 , C12N13/00 , C12N15/86 , C12N2710/10343 , C12N2710/16643 , C12N2740/16043 , C12N2740/16071 , C12N2750/14143 , C12N2830/002
摘要： Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments/
摘要翻译：使用光，例如体内或体外，使用各种方法和装置来实施靶细胞的刺激。一个实例涉及用于递送光激活的基于NpHR的分子的载体，其包含编码基于光激活的基于NpHR的分子和启动子的核酸序列。分子的高表达表现出小于约75％的毒性水平，或者使用至少两种基于NpHR的分子变体表达光激活的NpHR基蛋白。每个变体的特征在于可用于表达基于光激活的基于NpHR的分子，其通过产生抑制电流来抑制神经元的去极化来响应光。其他方面和实施方案涉及用于离子泵的物质和分子的组合物，用于控制细胞中的抑制性电流的系统，方法，试剂盒，组合物（例如，在体内和体外环境/

7. 发明申请

WO2006135602A3 HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS 审中-公开
标题翻译：基于病毒的基于组合物的组合物及其在临床和周期中的使用方法
公开(公告)号：WO2006135602A3
公开(公告)日：2007-06-07
申请号：PCT/US2006021806
申请日：2006-06-05
申请人： UNIV ROCHESTER , FEDEROFF HOWARD J , BOWERS WILLIAM J
发明人： FEDEROFF HOWARD J , BOWERS WILLIAM J
IPC分类号： A01N63/00
CPC分类号： C12N15/86 , A61K48/00 , C12N7/00 , C12N15/90 , C12N2710/16643 , C12N2800/40 , C12N2800/90
摘要： Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.
摘要翻译：公开了通过将哺乳动物（例如，在子宫内）暴露于包含顺式元件侧翼的转基因和编码转座酶的序列的疱疹病毒扩增子颗粒来降低哺乳动物的出生缺陷的严重性的组合物和方法。表达后，转座酶将转基因插入到哺乳动物内的细胞（例如神经元）的基因组中，转基因表达补偿与出生缺陷有因果关系的蛋白质或基因缺陷的多肽或RNA。

8. 发明申请

WO2007024668A2 TARGETING OF HERPES SIMPLEX VIRUS TO SPECIFIC RECEPTORS 审中-公开
标题翻译：将单纯疱疹病毒靶向特异性受体
公开(公告)号：WO2007024668A2
公开(公告)日：2007-03-01
申请号：PCT/US2006032291
申请日：2006-08-18
申请人： UNIV CHICAGO , KAMIYAMA HIRONAGA , ZHOU GUOYING , ROIZMAN BERNARD
发明人： KAMIYAMA HIRONAGA , ZHOU GUOYING , ROIZMAN BERNARD
IPC分类号： C07K14/035 , C12N15/869
CPC分类号： C12N15/86 , A61K35/763 , C12N2710/16632 , C12N2710/16643 , C12N2810/80 , C12N2810/855 , C12N2810/859
摘要： The invention relates to engineered Herpes simplex virus (HSV) particles exhibiting a binding pair member that specifically binds to, or targets, one or more specific binding partners, such as receptors, including binding partners lacking at least one of a cytoplasmic domain or a transmembrane domain. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected, receptor, which itself may be a product of genetic engineering. The ability to selectively target cells renders the HSV particles particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.
摘要翻译：本发明涉及工程化的单纯疱疹病毒（HSV）颗粒，其显示结合对成员，其特异性结合或靶向一种或多种特异性结合配偶体，如受体，包括缺乏胞质结构域或跨膜结构中的至少一种的结合配偶体域。而且，提供了用于生产这种HSV颗粒的重组载体。通过降低HSV对其天然受体的亲和力并增加对所选受体的亲和力，本发明的HSV颗粒可用于靶向表达选择的受体的细胞，所述受体本身可以是基因工程的产物。选择性靶向细胞的能力使得HSV颗粒特别适用于选择性诊断，治疗和成像携带选择的结合对成员的细胞，例如受体。本发明还提供了对携带选择的结合对成员如受体的细胞进行基于多核苷酸的疗法。

9. 发明申请

WO2005049846A9 MUTANT HERPES SIMPLEX VIRUS AND USE THEREOF IN THE TREATMENT OF SQUAMOUS CELL CANCER 审中-公开
标题翻译：突变体可以使用简单的病毒及其在治疗鳞状细胞癌中的应用
公开(公告)号：WO2005049846A9
公开(公告)日：2006-10-19
申请号：PCT/GB2004004908
申请日：2004-11-17
申请人： CRUSADE LAB LTD , SLOAN KETTERING INST CANCER , BROWN SUSANNE MOIRA , DUNN PAUL , SINGH BHUVANESH , GANLY IAN
发明人： BROWN SUSANNE MOIRA , DUNN PAUL , SINGH BHUVANESH , GANLY IAN
IPC分类号： C12N15/113 , C12N15/869
CPC分类号： A61K38/00 , C12N15/1135 , C12N15/86 , C12N2710/16643 , C12N2840/203
摘要： An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.
摘要翻译：单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码与鳞状细胞癌相关致癌基因（asSCCRO）反义的核酸; 和单纯疱疹病毒，其中所述单纯疱疹病毒基因组包含编码能够抑制或沉默鳞状细胞癌相关致癌基因（SCCRO）核酸或多肽的表达的短干扰核糖核酸（siRNA）分子的核酸以及方法用于生成和应用此类病毒。

10. 发明申请

WO2005097981A3 NOVEL HERPES SIMPLEX VIRUSES 审中-公开
标题翻译：新颖的草原简单的病毒
公开(公告)号：WO2005097981A3
公开(公告)日：2006-03-23
申请号：PCT/GB2005001313
申请日：2005-04-05
申请人： CRUSADE LAB LTD , BROWN SUSANNE MOIRA , CONNER JOE
发明人： BROWN SUSANNE MOIRA , CONNER JOE
IPC分类号： A61K48/00 , C07K14/62 , C12N7/00 , C12N15/869 , C07K14/60
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0066 , A61K2039/5256 , C07K14/62 , C12N2710/16643 , C12N2830/00 , C12N2830/002 , C12N2830/85 , C12N2840/203
摘要： An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding insulin is disclosed. Viruses disclosed are capable of expressing insulin. They may lack neurovirulence and may find use in the treatment of diseases involving abnormal insulin expression or function, such as diabetes.
摘要翻译：公开了一种单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码胰岛素的核酸。所公开的病毒能够表达胰岛素。它们可能缺乏神经毒力，可用于治疗涉及胰岛素异常或功能异常的疾病，如糖尿病。

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