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1. 发明申请

WO2012129488A3 GENE SIGNATURES ASSOCIATED WITH REJECTION OR RECURRENCE OF CANCER 审中-公开
标题翻译：与癌症排斥或复发相关的基因标记
公开(公告)号：WO2012129488A3
公开(公告)日：2012-12-27
申请号：PCT/US2012030312
申请日：2012-03-23
申请人： UNIV VIRGINIA COMMONWEALTH , MANJILI MASOUD H , KMIECIAK MACIEJ , TOOR AMIR A , IDOWU MICHAEL O , BEAR HARRY D , PAYNE KYLE K , MARINCOLA FRANCESCO M , WANG ENA
发明人： MANJILI MASOUD H , KMIECIAK MACIEJ , TOOR AMIR A , IDOWU MICHAEL O , BEAR HARRY D , PAYNE KYLE K , MARINCOLA FRANCESCO M , WANG ENA
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57415 , G01N2800/54
摘要： Methods and tools for assessing the prognosis for patients following treatment of primary tumors are provided. The methods involve identifying immune- or cancer-related genetic markers whose differential expression patterns at tumor lesions are indicative of either tumor recurrence or recurrence-free survival. The methods and tools of the invention assist physicians by providing objective decision-making tools for planning patient treatment protocols.
摘要翻译：提供了评估原发肿瘤治疗后患者预后的方法和工具。该方法涉及鉴定免疫或癌症相关的遗传标记，其在肿瘤损伤处的差异表达模式指示肿瘤复发或无复发存活。本发明的方法和工具通过提供用于规划患者治疗方案的客观决策工具来帮助医师。

2. 发明申请

WO2012103424A9 DIAGNOSTIC AND PROGNOSTIC MARKERS FOR METASTASIS 审中-公开
标题翻译：用于METASTASIS的诊断和预防标记
公开(公告)号：WO2012103424A9
公开(公告)日：2012-10-18
申请号：PCT/US2012022876
申请日：2012-01-27
申请人： UNIV VIRGINIA COMMONWEALTH , FISHER PAUL B , DAS SWADESH
发明人： FISHER PAUL B , DAS SWADESH
IPC分类号： G01N33/68 , G01N33/574
CPC分类号： G01N33/6893 , G01N33/57407 , G01N2333/4745 , G01N2800/56
摘要： Methods for monitoring cancer metastasis and/or monitoring the response of a patient to cancer therapy directed against metastatic cancer are provided. The methods involve measuring Insulin Growth Factor Binding Protein-2 (IGFBP-2) and/or other biomarkers in biological (e.g., blood, plasma, serum) samples from the patient.

3. 发明申请

WO2012048204A3 PRODRUGS UTILIZING A TRANSPORTER DIRECTED UPTAKE MECHANISM 审中-公开
标题翻译：利用转运蛋白直接吸收机制的产品
公开(公告)号：WO2012048204A3
公开(公告)日：2012-07-12
申请号：PCT/US2011055231
申请日：2011-10-07
申请人： UNIV VIRGINIA COMMONWEALTH , WALSH SCOTT W , GERK PHILLIP M , WANG MENG , LANDSBERG ANDREW K
发明人： WALSH SCOTT W , GERK PHILLIP M , WANG MENG , LANDSBERG ANDREW K
IPC分类号： A61K47/48 , A61K9/127 , A61K31/426 , A61K31/505 , A61K31/573 , A61K47/30
CPC分类号： A61K47/48061 , A61K31/426 , A61K31/505 , A61K31/573 , A61K47/542
摘要： Prodrugs comprising a lipophilic drug linked to a transport moiety that can be taken up by a fatty acid transporter are provided. The transport moiety comprises a lipid chain connected to a hydrophilic group (e.g. a carboxylic acid, a phosphate, or a sphingosine-like moiety). Due to the presence of the transport moiety, the prodrugs are substrates for endogenous fatty acid transporter systems. The transport moiety thus serves as a carrier or targeting moiety to facilitate uptake of the entire prodrug complex by endogenous fatty acid transporter systems, thereby moving the prodrug into cells and tissues where drug distribution and effects are desired. Hydrolysis of the chemical linkage between the lipid-like moiety and the lipophilic drug releases the drug in an active form within the cells or tissues.
摘要翻译：提供了包含连接到可被脂肪酸转运蛋白摄取的转运部分的亲脂性药物的前药。转运部分包含连接至亲水基团（例如羧酸，磷酸盐或鞘氨醇样部分）的脂质链。由于转运部分的存在，前药是内源性脂肪酸转运蛋白系统的底物。因此转运部分充当载体或靶向部分以促进内源性脂肪酸转运体系统摄取整个前体药物复合物，由此将前体药物移动到需要药物分布和作用的细胞和组织中。脂质样部分和亲脂性药物之间的化学连接的水解释放细胞或组织内活性形式的药物。

4. 发明申请

WO2012058522A3 CANCER IMAGING WITH THERAPY: THERANOSTICS 审中-公开
标题翻译：癌症成像与治疗：THERANOSTICS
公开(公告)号：WO2012058522A3
公开(公告)日：2012-06-28
申请号：PCT/US2011058249
申请日：2011-10-28
申请人： UNIV VIRGINIA COMMONWEALTH , UNIV JOHNS HOPKINS , POMPER MARTIN GILBERT , BHANG HYO-EUN , FISHER PAUL
发明人： POMPER MARTIN GILBERT , BHANG HYO-EUN , FISHER PAUL
IPC分类号： C12Q1/04 , A01K67/027 , C12N5/09 , C12N5/10 , C12N15/86 , G01N33/52
CPC分类号： A61K49/0002 , A61K38/20 , A61K49/0013 , A61K49/0045 , A61K49/04 , A61K51/0491 , A61K51/0495 , C12N15/85 , C12N2710/10043 , C12Q1/6886 , C12Q1/6897 , G01N33/574
摘要： Genetic constructs comprising reporter genes operably linked to cancer specific or cancer selective promoters (such as the progression elevated gene-3 (PEG-3) promoter) are provided, as are methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. Transgenic animals in which a reporter gene is linked to a cancer specific or cancer selective promoter, and which may be further genetically engineered, bred or selected to have a predisposition to develop cancer, are also provided.
摘要翻译：提供了包含与癌症特异性或癌症选择性启动子可操作地连接的报道基因（例如升高基因-3（PEG-3）启动子）的遗传构建体，以及它们用于癌症成像，癌症治疗和组合成像和治疗方案。还提供了转基因动物，其中报道基因与癌症特异性或癌症选择性启动子连接，并且可以进一步基因工程改造，繁殖或选择以具有发展癌症的倾向。

5. 发明申请

WO2012012257A3 BIVALENT MULTIFUNCTIONAL LIGANDS TARGETING Aß OLIGOMERS AS TREATMENT FOR ALZHEIMER'S DISEASE 审中-公开
标题翻译：以阿司匹林治疗阿尔茨海默病为目标的双重多功能配体
公开(公告)号：WO2012012257A3
公开(公告)日：2012-05-31
申请号：PCT/US2011043980
申请日：2011-07-14
申请人： UNIV VIRGINIA COMMONWEALTH , ZHANG SHIJUN , GUO TAI LIANG
发明人： ZHANG SHIJUN , GUO TAI LIANG
IPC分类号： A61K31/56 , A61K31/4192 , A61K31/575 , A61P25/00 , A61P25/28
CPC分类号： C07J43/003 , A61K31/4192 , A61K31/56 , A61K31/575 , A61K49/0052 , G01N33/6896 , A61K2300/00
摘要： Bivalent multifunctional ?ß oligomerization inhibitors (BMAOIs) that target multiple risk factors involved in Alzheimer's disease are provided. The BMAOIs are useful for the treatment and/or prevention of Alzheimer's disease, as well as for diagnostic imaging of ?ß plaques in brain tissue. The BMAOIs comprise i) an ?ß oligomer (ApO)-inhibitor moiety which may have antioxidant activity (e.g. curcumin, curcumin derivatives, curcumin hybrids, resveratrol, etc.); ii) a cell membrane/lipid raft (CM/LR) anchoring moiety (e.g. cholesterol, cholesterylamine, a steroid, etc.); and iii) a spacer or linker moiety that stably links i) and ii) together.
摘要翻译：提供了针对涉及阿尔茨海默病的多种危险因素的二价多功能βß寡聚化抑制剂（BMAOI）。 BMAOI可用于治疗和/或预防阿尔茨海默氏病，以及脑组织中斑块的诊断成像。 BMAOI包含i）可具有抗氧化活性的αβ低聚物（ApO） - 抑制剂部分（例如姜黄素，姜黄素衍生物，姜黄素杂合体，白藜芦醇等）; ii）细胞膜/脂质筏（CM / LR）锚定部分（例如胆固醇，胆固醇胺，类固醇等）; 和iii）将i）和ii）稳定连接在一起的间隔物或接头部分。

6. 发明申请

WO2012033893A2 HYPERHALOGENS AND HIGHLY ELECTRONEGATIVE COMPOSITIONS 审中-公开
标题翻译： HYPERHALOGENS和高电子组成
公开(公告)号：WO2012033893A2
公开(公告)日：2012-03-15
申请号：PCT/US2011050788
申请日：2011-09-08
申请人： UNIV VIRGINIA COMMONWEALTH , JENA PURU
发明人： JENA PURU
IPC分类号： C01G7/00 , C01B35/12 , C01G3/00
CPC分类号： C01B35/1027 , A01N59/16 , A01N59/20 , A61K33/24 , A61K33/34 , C01B35/127 , C09K3/00
摘要： Hyperhalogens, a new class of highly electronegative species, are now invented. A hyperhalogen is a superhalogen-containing composition in which the electron affinity (EA) of the hyperhalogen is even larger than that of the superhalogens they are composed of. Novel production methods are provided in which highly electronegative species are produced by surrounding a central metal atom by superhalogen moieties.
摘要翻译：现在发明了一种新的高负电性物种 - 高卤素。高卤素是含有超卤素的组合物，其中高卤素的电子亲和力（EA）甚至大于它们组成的超级卤素的电子亲和力（EA）。提供了新的生产方法，其中通过超级卤素部分围绕中心金属原子生产高负电性物种。

7. 发明申请

WO2012006072A2 AIR IMPEDANCE ELECTROSPINNING FOR CONTROLLED POROSITY 审中-公开
标题翻译：用于控制孔隙的空气阻抗电气控制
公开(公告)号：WO2012006072A2
公开(公告)日：2012-01-12
申请号：PCT/US2011042144
申请日：2011-06-28
申请人： UNIV VIRGINIA COMMONWEALTH , BOWLIN GARY L , MCCLURE MICHAEL J , SIMPSON DAVID G , YANG HU
发明人： BOWLIN GARY L , MCCLURE MICHAEL J , SIMPSON DAVID G , YANG HU
IPC分类号： D04H3/16 , A61F2/02 , A61L27/38 , A61L27/56 , D01D5/00
CPC分类号： A61F2/02 , D01D5/0061 , D01D5/0076 , D01F6/62 , D01F6/625 , D04H1/728
摘要： Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering.
摘要翻译：电纺材料使用气流阻抗技术制造，这导致生产支架，其中一些区域是致密的，具有低孔隙率，而另一些区域则不那么致密并且更多孔。致密区域为支架提供结构支撑，而多孔区域允许细胞和其他材料进入支架，当用于组织工程。

8. 发明申请

WO2011123427A9 TREATMENT OF CANCER BY INHIBITING ACTIVITY OR EXPRESSION OF LATE SV-40 FACTOR 审中-公开
标题翻译：通过抑制活性或表达最初的SV-40因子来治疗癌症
公开(公告)号：WO2011123427A9
公开(公告)日：2011-12-15
申请号：PCT/US2011030293
申请日：2011-03-29
申请人： UNIV VIRGINIA COMMONWEALTH , SARKAR DEVANAND , FISHER PAUL B
发明人： SARKAR DEVANAND , FISHER PAUL B
IPC分类号： A61K48/00 , A61K31/7105 , A61K39/395 , A61P35/00 , C12Q1/68
CPC分类号： A61K31/7105 , A61K2039/505 , C07K16/18 , C07K16/303 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57438

9. 发明申请

WO2010117575A3 ACCURATE PELVIC FRACTURE DETECTION FOR X-RAY AND CT IMAGES 审中-公开
标题翻译： X射线和CT图像的精确检测
公开(公告)号：WO2010117575A3
公开(公告)日：2011-01-13
申请号：PCT/US2010027601
申请日：2010-03-17
申请人： UNIV VIRGINIA COMMONWEALTH , NAJARIAN KAYVAN , VASILACHE SIMINA , SMITH REBECCA , WARD KEVIN R
发明人： NAJARIAN KAYVAN , VASILACHE SIMINA , SMITH REBECCA , WARD KEVIN R
IPC分类号： A61B6/00
CPC分类号： G06T7/0012 , A61B6/032 , A61B6/505 , A61B6/5217 , A61B6/5235 , G06T7/11 , G06T2207/10081 , G06T2207/10116 , G06T2207/20212 , G06T2207/30008
摘要： Accurate pelvic fracture detection is accomplished with automated X-ray and Computed Tomography (CT) Images for diagnosis and recommended therapy. The system combines computational methods to process images from two different modalities, using Active Shape Model (ASM), spline interpolation, active contours, and wavelet transform. By processing both X-ray and CT Images, features which may be visible under one modality and not under the other are extracted and validates and confirms in format ion visible in both. The X-ray component uses hierarchical approach based on directed Hough Transform to detect pelvic structures, removing the need for manual initialization. The X-ray component uses cubic spline interpolation to regulate ASM deformation during X-ray image segmentation. Key regions of the pelvis are first segmented and identified, allowing detection methods to be specialized to each structure using anatomical knowledge. The CT processing component is able to distinguish bone from other non-bone objects with similar visual characteristics, such a blood and contrast fluid, permitting detection and quantification of soft tissue hemorrhage. The CT processing component draws attention to slices where irregularities are detected, reducing the time to fully examine a pelvic CT scan. The quantitative measurement of bone displacement and hemorrhage area are used as input for a trauma decision-support system, along with physiological signals, injury details and demographic information.
摘要翻译：使用自动化X射线和计算机断层扫描（CT）图像进行准确的骨盆骨折检测，用于诊断和推荐治疗。该系统结合计算方法来处理来自两种不同模态的图像，使用主动形状模型（ASM），样条插值，主动轮廓和小波变换。通过处理X射线和CT图像，可以在一种模式下而不是在另一种模式下可见的特征被提取并且以两种格式离子可见的方式进行验证和确认。 X射线组件使用基于定向霍夫变换的分层方法来检测骨盆结构，消除手动初始化的需要。 X射线成分使用三次样条插值来调节X射线图像分割过程中的ASM变形。骨盆的关键区域首先被分割和识别，从而允许使用解剖学知识来检测各种结构的检测方法。 CT处理组件能够将具有类似视觉特征的骨骼与其他具有类似视觉特征的非骨骼物体（如血液和造影剂）区分开，从而允许检测和定量软组织出血。 CT处理组件提请注意检测不规则的切片，减少完全检查盆腔CT扫描的时间。骨移位和出血面积的定量测量用作创伤决策支持系统的输入，以及生理信号，损伤细节和人口统计信息。

10. 发明申请

WO2010083384A3 NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS 审中-公开
标题翻译：非肽类，强效和选择性阿片类受体拮抗剂
公开(公告)号：WO2010083384A3
公开(公告)日：2010-12-02
申请号：PCT/US2010021157
申请日：2010-01-15
申请人： UNIV VIRGINIA COMMONWEALTH , ZHANG YAN , SELLEY DANA E , DEWEY WILLIAM
发明人： ZHANG YAN , SELLEY DANA E , DEWEY WILLIAM
IPC分类号： C07D491/10 , A61K31/4355 , A61P25/32 , C07D403/12 , C07D405/12
CPC分类号： C07D405/12 , C07D403/12 , C07D491/10
摘要： Selective, non-peptide antagonists of the ma opioid receptor { MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction.
摘要翻译：提供了阿片受体（MOR）的选择性非肽拮抗剂及其使用方法。拮抗剂可以用于例如在竞争性结合测定中鉴定MOR激动剂，并且用于治疗与涉及MOR的成瘾相关的病症，例如，海洛因，处方药和酒瘾。

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