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1. 发明申请

WO2017136376A1 POLYELECTROLYTE COMPLEXES FOR DELIVERY OF AGENTS TO THE CNS 审中-公开
标题翻译：用于向CNS递送药剂的聚电解质络合物
公开(公告)号：WO2017136376A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/015930
申请日：2017-02-01
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： KABANOV, Alexander V. , JIANG, Yuhang , YI, Xing
IPC分类号： A61K38/00 , A61K38/02 , A61K47/30 , A61K47/50 , A61P25/00
CPC分类号： A61K38/185 , A61K9/0043 , A61K9/0085 , A61K9/146 , A61K47/30 , A61K47/34 , A61K47/541 , A61K47/60 , A61K47/645
摘要： The present invention relates to compositions and methods for the delivery of agents to a subject, particularly to the central nervous system (CNS).
摘要翻译：本发明涉及用于将药剂递送给受试者，尤其是中枢神经系统（CNS）的组合物和方法。

2. 发明申请

WO2017034991A1 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：包含治疗药物的治疗性纳米颗粒及其制备方法和使用方法
公开(公告)号：WO2017034991A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/047799
申请日：2016-08-19
申请人： PFIZER INC.
发明人： HORHOTA, Allen , SONG, Young-ho , JOSHI, Ujjwal , SIMMONS, Matthew , BOYLAN, Nicholas
IPC分类号： A61K47/48 , A61K49/08 , A61K31/4188
CPC分类号： A61K9/5153 , A61K31/713 , A61K47/541
摘要： The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include methods of making and using such nanoparticles.
摘要翻译：本公开内容通常涉及包含内溶酶体逃逸剂，核酸和聚合物的纳米颗粒。其它方面包括制备和使用这些纳米颗粒的方法。

3. 发明申请

WO2015199309A1 양이온성 분자 수송체 및 음이온성 생리활성 물질을 포함하는 피부 투과용 조성물 审中-公开
标题翻译：用于皮肤渗透的组合物，含有阳离子分子转运体和阴离子活性材料
公开(公告)号：WO2015199309A1
公开(公告)日：2015-12-30
申请号：PCT/KR2015/001574
申请日：2015-02-16
申请人： 포항공과대학교 산학협력단
发明人： 정성기 , 이우설
IPC分类号： A61K31/375 , A61K31/6615 , A61K47/22
CPC分类号： A61K31/685 , A61K9/0014 , A61K31/196 , A61K31/616 , A61K31/661 , A61K31/6615 , A61K31/665 , A61K31/7008 , A61K31/7072 , A61K31/721 , A61K31/728 , A61K47/18 , A61K47/183 , A61K47/541 , A61K47/645 , A61K49/0021 , A61K49/0041 , A61K49/0043 , A61K49/0056 , A61K49/0071
摘要： 본 발명은 양이온성 화합물; 및 음이온성 생리활성물질이 이온 결합된 이온 결합체를 포함하며, 피부 내로 상기 생리활성물질을 전달하기 위한, 피부 투과용 조성물에 관한 것으로, 본 발명에 따르면 진단시약, 의약품, 형광물질 등과 같은 다양한 종류의 음이온성 생리활성물질을 세포막 및 피부막을 용이하게 통과시켜 피부의 표피층 내지 진피층으로 전달할 수 있다.
摘要翻译：本发明涉及一种用于皮肤渗透的组合物，其中所述组合物含有阳离子化合物与阴离子生物活性物质离子组合的离子缀合物，并将生物活性物质输送到皮肤中。根据本发明，允许诸如诊断试剂，药物和荧光材料的各种阴离子生物活性物质容易地通过细胞膜和皮肤层，因此可以被递送到表皮层和真皮层皮肤。

4. 发明申请

WO2015061321A1 HYPOXIA-TARGETED DELIVERY SYSTEM FOR PHARMACEUTICAL AGENTS 审中-公开
标题翻译：用于药物代理的HYPOXIA定向递送系统
公开(公告)号：WO2015061321A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/061582
申请日：2014-10-21
申请人： NORTHEASTERN UNIVERSITY
发明人： TORCHILIN, Vladimir , BISWAS, Swati , PERCHE, Federico
IPC分类号： C07H21/02 , A61K31/7105 , A61P35/00
CPC分类号： A61K47/48215 , A61K9/10 , A61K9/14 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K45/06 , A61K47/48023 , A61K47/4803 , A61K47/48053 , A61K47/48192 , A61K47/48807 , A61K47/54 , A61K47/541 , A61K47/544 , A61K47/59 , A61K47/60 , A61K47/6909 , A61K49/0041 , A61K49/0054 , C07H21/00 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2320/31 , C12N2320/32
摘要： Molecular compositions, nanoparticle compositions, and pharmaceutical compositions of the invention provide for the delivery of a polynucleotide to a hypoxic cell or tissue. The compositions can also be used for the delivery a hydrophobic pharmaceutical agent, either alone or in combination with a polynucleotide, to a hypoxic cell or tissue. Methods of making such compositions and methods of using such composition to treat a condition associated with a hypoxic cell or tissue are provided as well. Also provideded are kits for use in treating a condition associated with a hypoxic cell or tissue.
摘要翻译：本发明的分子组合物，纳米颗粒组合物和药物组合物提供将多核苷酸递送至缺氧细胞或组织。组合物还可用于将疏水性药剂单独或与多核苷酸组合递送至缺氧细胞或组织。还提供了制备这种组合物的方法和使用这种组合物来治疗与缺氧细胞或组织相关的病症的方法。还提供了用于治疗与缺氧细胞或组织相关的病症的试剂盒。

5. 发明申请

WO2014144842A3 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2014144842A3
公开(公告)日：2015-04-09
申请号：PCT/US2014029421
申请日：2014-03-14
申请人： RHYTHM METABOLIC INC
发明人： SHARMA SHUBH , VAN DER PLOEG LEONARDUS H T , HENDERSON BART
IPC分类号： C07K7/54 , A61K38/12
CPC分类号： A61K38/12 , A61K9/08 , A61K9/10 , A61K9/146 , A61K38/08 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/38 , A61K47/541 , A61K47/542 , A61K47/544
摘要： The present invention relates to an ionic complex comprising a cationic polypeptide and an anionic excipient selected from: a PEG-carboxylic acid; a fatty acid having 10 or more carbon atoms; an anionic phospholipid; and a combination thereof. The invention also relates to a pharmaceutical composition comprising the ionic complex of the invention and a pharmaceutically acceptable carrier. The cationic polypeptide of the ionic complex has pharmacological activity and the complex can provide a more desirable pharmacokinetic profile for the cationic polypeptide of the complex as compared to the cationic polypeptide alone following administration. As such, the invention also relates to the use of the the ionic complex and pharmaceuctical composition comprising same to treat a subject suffering from a disease or disorder that is responsive to the cationic polypeptide of the ionic complex.
摘要翻译：本发明涉及包含阳离子多肽和阴离子赋形剂的离子络合物，其选自：PEG-羧酸; 具有10个或更多个碳原子的脂肪酸; 阴离子磷脂; 及其组合。本发明还涉及包含本发明的离子络合物和药学上可接受的载体的药物组合物。离子络合物的阳离子多肽具有药理活性，并且与施用后单独的阳离子多肽相比，复合物可以为复合物的阳离子多肽提供更理想的药代动力学特征。因此，本发明还涉及包含其的离子络合物和药物组合物用于治疗患有对离子复合物的阳离子多肽有响应的疾病或病症的受试者的用途。

6. 发明申请

WO2014091436A1 NANOPARTICLES BASED ON A GAG AND A SQUALENE 审中-公开
标题翻译：基于GAG和SQUALENE的纳米颗粒
公开(公告)号：WO2014091436A1
公开(公告)日：2014-06-19
申请号：PCT/IB2013/060842
申请日：2013-12-12
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PARIS-SUD 11
发明人： RALAY-RANAIVO, Bettina , COUVREUR, Patrick , DESMAELE, Didier , BIANCHINI, Elsa , BORGEL, Delphine , GREF, Ruxandra
IPC分类号： A61K47/48 , A61K31/727 , A61P7/02
CPC分类号： A61K9/19 , A61K9/4891 , A61K9/5123 , A61K31/727 , A61K45/06 , A61K47/541 , A61K47/6907
摘要： The present invention relates to nanoparticles comprising at least one negatively charged glycosaminoglycan-type macromolecule or a derivative thereof, non-covalently coupled to at least one molecule of a cationic hydrocarbon-based radical of squalene nature represented by the formula (I) which follows: (I) wherein: A, B, C, D, E and F are a hydrogen atom or a methyl group; Z and Y represent a radical (formula (II)), an ethyltrialkylammonium radical, an ethylguanidium radical or a 1-[ethylideneamino]guanidinium radical with the proviso that at least one of Z and Y is different from (formula (II)), the symbol * showing the position of the attachment of the radical to the structure; and n is equal to 1 or 2. The present invention also relates to a method for preparing said nanoparticles, and to a lyophilisate, a solid dosage form and pharmaceutical or dermatological compositions comprising said nanoparticles. Said nanoparticles are useful as medicines and more particularly as anticoagulant agents.
摘要翻译：本发明涉及包含至少一种带负电荷的糖胺聚糖型大分子或其衍生物的纳米颗粒，所述至少一种带负电荷的糖胺聚糖型大分子或其衍生物与由下式（I）表示的角鲨烯性质的基于阳离子烃的基团的至少一个分子非共价偶联：（I）其中：A，B，C，D，E和F是氢原子或甲基; Z和Y代表一个基团（式（II）），乙基三烷基铵基，乙基胍基或1- [亚乙基氨基]胍基，条件是Z和Y中的至少一个不同于（式（II）），符号*表示激进组织对结构的附着位置; 并且n等于1或2.本发明还涉及制备所述纳米颗粒的方法，还涉及冻干物，固体剂型和包含所述纳米颗粒的药物或皮肤病学组合物。所述纳米颗粒可用作药物，更特别地可用作抗凝血剂。

7. 发明申请

WO2010078300A1 DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF 审中-公开
标题翻译：双功能离子液体及其盐
公开(公告)号：WO2010078300A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069652
申请日：2009-12-29
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA , MONASH UNIVERSITY , ROGERS, Robin, D. , DALY, Daniel, T. , GURAU, Gabriela , MACFARLANE, Douglas , TURANJANIN, Jelena , DEAN, Pamela, M. , QUEEN'S UNIVERSITY BELFAST , SCOTT, Janet, L. , BICA, Katharina , SEDDON, Kenneth, R.
发明人： ROGERS, Robin, D. , DALY, Daniel, T. , GURAU, Gabriela , MACFARLANE, Douglas , TURANJANIN, Jelena , DEAN, Pamela, M. , SCOTT, Janet, L. , BICA, Katharina , SEDDON, Kenneth, R.
IPC分类号： A01N55/02 , A61K31/555
CPC分类号： A61K47/4803 , A61K47/541
摘要： Disclosed herein are ionic liquid compositions comprising active pharmaceutical, biological, and nutritional compounds, and methods of use. Further disclosed are compositions of matter including liquid ion pairs alone or in solution and their use; compositions of ionic liquids that are 'solvated,' for example, 'hydrated' and their uses.
摘要翻译：本文公开了包含活性药物，生物和营养化合物的离子液体组合物和使用方法。进一步公开的是包括单独或溶液中的液体离子对的物质组成及其用途; “溶剂化”的离子液体的组成，例如“水合”及其用途。

8. 发明申请

WO2006135702A2 METHODS OF USING REDOX-ACTIVE SURFACTANTS TO CONTROL POLYMER INTERACTIONS 审中-公开
标题翻译：使用红外活性表面活性剂控制聚合物相互作用的方法
公开(公告)号：WO2006135702A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022350
申请日：2006-06-09
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , ABBOTT, Nicholas, L. , LYNN, David, M. , KONDO, Yukishige , JEWELL, Christopher, M. , HAYS, Melissa
发明人： ABBOTT, Nicholas, L. , LYNN, David, M. , KONDO, Yukishige , JEWELL, Christopher, M. , HAYS, Melissa
IPC分类号： C12N15/88
CPC分类号： A61K47/4803 , A61K31/295 , A61K31/555 , A61K47/541 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/88
摘要： The present invention provides methods utilizing redox-active surfactants to provide electrochemical control over polymer interactions. In one embodiment, the invention is directed to a transfection method using a redox-active transfection agent that preferentially promotes transfection dependent on the oxidation state of the transfection agent. Accordingly, certain methods according to the invention provide spatial and/or temporal control of cell transfection.
摘要翻译：本发明提供利用氧化还原活性表面活性剂提供聚合物相互作用的电化学控制的方法。在一个实施方案中，本发明涉及使用依赖于转染剂的氧化态优先促进转染的氧化还原活性转染试剂的转染方法。因此，根据本发明的某些方法提供细胞转染的空间和/或时间控制。

9. 发明申请

WO2006010939A1 COMPOSITION FOR DELIVERY OF AN ACTIVE AGENT 审中-公开
标题翻译：用于递送活性剂的组合物
公开(公告)号：WO2006010939A1
公开(公告)日：2006-02-02
申请号：PCT/GB2005/002977
申请日：2005-07-29
申请人： QUADRANT DRUG DELIVERY LIMITED , MARTYN, Glen, Patrick , COGHLAN, David, John, St.
发明人： MARTYN, Glen, Patrick , COGHLAN, David, John, St.
IPC分类号： A61K9/00
CPC分类号： A61K38/28 , A61K9/006 , A61K47/541
摘要： A composition for oromucosal delivery of a biologically active agent, which composition releases the active agent within 5 minutes when applied to an oramucosal surface in use, comprises a biologically active agent and a matrix-former. The biologically active agent may be present as an ion pair complex.
摘要翻译：用于生物活性剂的粘膜递送的组合物包含生物活性剂和基质成型剂，所述组合物在施用于使用中的粘膜表面时在5分钟内释放活性剂。生物活性剂可以作为离子对复合物存在。

10. 发明申请

WO2005041924A3 ADMINISTRATION OF LEVODOPA AND CARBIDOPA 审中-公开
标题翻译：莱维多和卡比洛的管理
公开(公告)号：WO2005041924A3
公开(公告)日：2005-11-10
申请号：PCT/US2004036039
申请日：2004-10-29
申请人： ALZA CORP , WONG PATRICK S L , YAN DONG , HWANG STEPHEN , GUITTARD GEORGE V
发明人： WONG PATRICK S L , YAN DONG , HWANG STEPHEN , GUITTARD GEORGE V
IPC分类号： A61K9/00 , A61K9/127 , A61K9/20 , A61K9/22 , A61K9/24 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/205 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/48 , B65D88/76 , C07C53/126 , C07C229/08 , C07C229/28 , C07C229/34 , C07C279/00 , A61P3/10
CPC分类号： A61K31/662 , A61K9/0004 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/541 , A61K47/585 , A61K2300/00
摘要： Disclosed are substances, compositions, dosage forms and methods that comprise levodopa and/or carbidopa.
摘要翻译：公开了包含左旋多巴和/或卡比多巴的物质，组合物，剂型和方法。

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