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1. 发明申请

WO2006135702A2 METHODS OF USING REDOX-ACTIVE SURFACTANTS TO CONTROL POLYMER INTERACTIONS 审中-公开
标题翻译：使用红外活性表面活性剂控制聚合物相互作用的方法
公开(公告)号：WO2006135702A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022350
申请日：2006-06-09
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , ABBOTT, Nicholas, L. , LYNN, David, M. , KONDO, Yukishige , JEWELL, Christopher, M. , HAYS, Melissa
发明人： ABBOTT, Nicholas, L. , LYNN, David, M. , KONDO, Yukishige , JEWELL, Christopher, M. , HAYS, Melissa
IPC分类号： C12N15/88
CPC分类号： A61K47/4803 , A61K31/295 , A61K31/555 , A61K47/541 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/88
摘要： The present invention provides methods utilizing redox-active surfactants to provide electrochemical control over polymer interactions. In one embodiment, the invention is directed to a transfection method using a redox-active transfection agent that preferentially promotes transfection dependent on the oxidation state of the transfection agent. Accordingly, certain methods according to the invention provide spatial and/or temporal control of cell transfection.
摘要翻译：本发明提供利用氧化还原活性表面活性剂提供聚合物相互作用的电化学控制的方法。在一个实施方案中，本发明涉及使用依赖于转染剂的氧化态优先促进转染的氧化还原活性转染试剂的转染方法。因此，根据本发明的某些方法提供细胞转染的空间和/或时间控制。

2. 发明申请

WO2005023931A1 BIOCIDAL POLYMERS 审中-公开
标题翻译：生物聚合物
公开(公告)号：WO2005023931A1
公开(公告)日：2005-03-17
申请号：PCT/US2004/028748
申请日：2004-09-03
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , GELLMAN, Samuel, H. , GELMAN, Michael, A. , WEISBLUM, Bernard , LYNN, David, M.
发明人： GELLMAN, Samuel, H. , GELMAN, Michael, A. , WEISBLUM, Bernard , LYNN, David, M.
IPC分类号： C08L25/04
CPC分类号： A61K31/785 , A61K31/74 , C08F257/02 , C08F265/04 , C08F265/10 , C08F283/06 , C08G65/04 , C08G65/329 , C08L25/04 , C08L33/08 , C08L33/26 , C08L35/06 , C08L51/003 , C08L55/00 , C08L59/04 , C08L2666/04 , C08L2666/02
摘要： Pharmaceutical compositions containing biocidal co-polymers of poly(styrenes), poly(acrylates), poly(acrylamides), and poly(C 1 -C 6 )alkylene glycols are disclosed, along with methods of using the compositions to treat microbial infections in mammals.
摘要翻译：公开了含有聚（苯乙烯），聚（丙烯酸酯），聚（丙烯酰胺）和聚（C 1 -C 6）亚烷基二醇的杀生物共聚物的药物组合物，以及使用该组合物治疗哺乳动物微生物感染的方法。

3. 发明申请

WO2009049092A1 COVALENT ASSEMBLY OF ULTRATHIN POLYMERIC FILMS 审中-公开
标题翻译：超高分子聚合物薄膜的组合
公开(公告)号：WO2009049092A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079417
申请日：2008-10-09
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , LYNN, David, M. , BUCK, Maren, E. , ZHANG, Jingtao
发明人： LYNN, David, M. , BUCK, Maren, E. , ZHANG, Jingtao
IPC分类号： C08F26/06 , C08F126/06
CPC分类号： C08F26/06 , C08F126/06 , C08F220/04 , C08F222/10 , C08F226/06 , Y10T156/11 , Y10T428/265 , Y10T428/31649 , Y10T428/31667 , Y10T428/31699 , Y10T428/31909 , Y10T428/31928 , Y10T428/31935
摘要： In one aspect, described herein are ultrathin films comprising an azlactone functionalized polymer and a primary amine functionalized polymer. Also described herein are ultrathin films including reactive, nonreactive, partially reactive/nonreactive, hydrophobic, hydrophilic, and mixed hydrophobic/hydrophilic ultrathin films. In another aspect, described herein are methods for making surface attached and freestanding ultrathin films.
摘要翻译：在一个方面，本文描述的是包含吖内酯官能化聚合物和伯胺官能化聚合物的超薄膜。本文还描述了超薄膜，其包括反应性，非反应性，部分反应性/非反应性，疏水性，亲水性和混合的疏水/亲水性超薄膜。在另一方面，本文描述了制备表面附着和独立超薄膜的方法。

4. 发明申请

WO2005007819A2 CHARGE-DYNAMIC POLYMERS AND DELIVERY OF ANIONIC COMPOUNDS 审中-公开
标题翻译：充电动态聚合物和交联化合物
公开(公告)号：WO2005007819A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/021787
申请日：2004-07-07
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , LYNN, David, M. , MILLER, Adam, D.
发明人： LYNN, David, M. , MILLER, Adam, D.
IPC分类号： C12N
CPC分类号： A61K9/5138 , A61K9/5146 , C08L79/02 , Y10T428/265 , Y10T428/31504 , Y10T428/31551 , Y10T428/31909 , Y10T428/31928
摘要： The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.
摘要翻译：本发明提供了可用于递送阴离子分子的动态电荷态阳离子聚合物。动态电荷态阳离子聚合物被设计成具有通过从聚合物中去除可除去的官能团而减少的阳离子电荷密度。本发明还提供了包含与聚阴离子络合的聚合物的聚电解质复合物。还提供了使用聚电解质配合物递送阴离子化合物的方法。本发明提供了可用于递送阴离子分子的动态电荷状态阳离子聚合物。动态电荷态阳离子聚合物被设计成具有通过从聚合物中去除可除去的官能团而减少的阳离子电荷密度。本发明还提供了包含与聚阴离子络合的聚合物的聚电解质复合物。还提供了使用聚电解质络合物递送阴离子化合物的方法。

5. 发明申请

WO2009049100A3 ULTRATHIN MULTILAYERED FILMS FOR CONTROLLED RELEASE OF ANIONIC REAGENTS 审中-公开
公开(公告)号：WO2009049100A3
公开(公告)日：2009-04-16
申请号：PCT/US2008/079428
申请日：2008-10-09
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , LYNN, David, M. , ZHANG, Jingtao , LIU, Xianghui
发明人： LYNN, David, M. , ZHANG, Jingtao , LIU, Xianghui
IPC分类号： A61K9/52
摘要： Multilayered films, particularly ultrathin multilayered films comprising cationic polymers which are useful for controlled release of anionic species, particularly for controlled release of nucleic acids. The multilayer films herein are useful for temporal controlled released of anionic species, particularly one or more anionic peptides, proteins, nucleic acids or other anionic biological agents. In one aspect, the invention relates to multilayer films which release anionic species (anions) with separate and/or distinct release profiles, particularly wherein the anions are one or more anionic peptides, proteins or nucleic acids or other anionic biological agents.

6. 发明申请

WO2011153337A2 SOLAR ENERGY COLLECTION, STORAGE AND DISTRIBUTION SYSTEM AND METHOD 审中-公开
标题翻译：太阳能收集，储存和分配系统及方法
公开(公告)号：WO2011153337A2
公开(公告)日：2011-12-08
申请号：PCT/US2011/038910
申请日：2011-06-02
申请人： LYNN, David, M.
发明人： LYNN, David, M.
IPC分类号： F24S23/30 , F24S23/70
CPC分类号： F24S10/70 , F24S20/20 , F24S23/31 , F24S23/79 , F24S25/10 , F24S50/20 , F24S60/00 , F24S80/65 , Y02E10/41 , Y02E10/43 , Y02E10/44 , Y02E10/47
摘要： A system for collecting, storing and distributing solar energy includes a primary solar energy reflector, a secondary solar energy reflector, a solar energy storage and distribution device and a conveying system that transports heat energy between the storage device and a heat-dependent use application. Also disclosed are methods for collecting, storing and distributing solar energy.
摘要翻译：用于收集，存储和分配太阳能的系统包括初级太阳能反射器，次级太阳能反射器，太阳能储存和分配装置以及在存储装置和热依赖使用应用之间传送热能的输送系统。还公开了用于收集，存储和分配太阳能的方法。

7. 发明申请

WO2007140402A1 METHODS OF MAKING DECOMPOSABLE THIN FILMS OF POLYELECTROLYTES AND USES THEREOF 审中-公开
标题翻译：制备聚电解质薄膜的方法及其用途
公开(公告)号：WO2007140402A1
公开(公告)日：2007-12-06
申请号：PCT/US2007/069964
申请日：2007-05-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WOOD, Kris, C. , CHUANG, Helen, F. , BATTEN, Robert, D. , LYNN, David, M. , CUNNINGHAM, Paula, T. Hammond
发明人： WOOD, Kris, C. , CHUANG, Helen, F. , BATTEN, Robert, D. , LYNN, David, M. , CUNNINGHAM, Paula, T. Hammond
IPC分类号： B32B27/18
CPC分类号： C08G63/6854
摘要： A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.
摘要翻译：一种可分解的薄膜，包括多个交替电荷的聚电解质层，其中薄膜的分解的特征在于至少部分聚电解质层的降解。

8. 发明申请

WO2005110438A2 METHODS AND PRODUCTS RELATED TO THE INTRACELLULAR DELIVERY OF POLYSACCHARIDES 审中-公开
标题翻译：与多糖的细胞内递送相关的方法和产品
公开(公告)号：WO2005110438A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/013110
申请日：2005-04-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BERRY, David, A. , ANDERSON, Daniel, G. , LYNN, David, M. , SASISEKHARAN, Ram , LANGER, Robert, S.
发明人： BERRY, David, A. , ANDERSON, Daniel, G. , LYNN, David, M. , SASISEKHARAN, Ram , LANGER, Robert, S.
IPC分类号： A61K31/726
CPC分类号： A61K45/06 , A61K31/726 , A61K31/727 , A61K31/737 , A61K31/785 , A61K47/593 , A61K2300/00
摘要： The invention relates, in part, to methods and compositions for the intracellular delivery of polysaccharides. In particular, the methods and compositions relate to the intracellular delivery of glycosaminoglycans, such as heparin. The invention in other aspects relates to the use of glycosaminoglycans for the treatment of proliferative disorders, such as cancer. The invention is still other aspects relates to improving cell viability. The invention also relates to the delivery of polysaccharides while avoiding unwanted effects of the polysaccharides. For example, heparin can be delivered while avoiding its anticoagulant effects.
摘要翻译：本发明部分地涉及多糖的细胞内递送的方法和组合物。特别地，所述方法和组合物涉及糖胺聚糖如肝素的细胞内递送。本发明在其它方面涉及糖胺聚糖用于治疗增殖性疾病如癌症的用途。本发明还涉及提高细胞活力的其它方面。本发明还涉及多糖的递送，同时避免多糖的不期望的影响。例如，可以输送肝素同时避免其抗凝血作用。

9. 发明申请

WO2003035716A1 METHODS OF MAKING DECOMPOSABLE THIN FILMS OF POLYELECTROLYTES AND USES THEREOF 审中-公开
标题翻译：制备聚电解质薄膜的方法及其用途
公开(公告)号：WO2003035716A1
公开(公告)日：2003-05-01
申请号：PCT/US2002/034191
申请日：2002-10-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LYNN, David, M. , VAZQUEZ, Eduardo , LANGER, Robert, S. , HAMMOND, Paula
发明人： LYNN, David, M. , VAZQUEZ, Eduardo , LANGER, Robert, S. , HAMMOND, Paula
IPC分类号： C08G63/685
CPC分类号： C09D151/08 , A61K9/5026 , A61K9/5073 , A61K9/5089 , B01J13/02 , B01J13/22 , B82Y30/00 , C08F283/00 , C08F283/01 , C08F283/02 , C08F287/00 , C08F291/00 , C08J5/20 , C08L51/006 , C08L51/08 , C08L53/00 , C08L73/02 , C08L85/02 , C09D151/006 , C09D153/00 , Y10T428/24942 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987 , Y10T428/2989 , Y10T428/2991 , Y10T428/31678 , Y10T428/31786 , Y10T428/31797 , C08L2666/02
摘要： A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.
摘要翻译：一种可分解的薄膜，包括多个交替电荷的聚电解质层，其中薄膜的分解的特征在于至少部分聚电解质层的降解。

10. 发明申请

WO2005055979A3 PH TRIGGERABLE POLYMERIC PARTICLES OR FILMS CONTAINING A POLY (BETA-AMINO ESTER) 审中-公开
公开(公告)号：WO2005055979A3
公开(公告)日：2005-06-23
申请号：PCT/US2004/040135
申请日：2004-12-02
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LITTLE, Steven, R. , ANDERSON, Daniel, G. , LYNN, David, M. , LANGER, Robert, S.
发明人： LITTLE, Steven, R. , ANDERSON, Daniel, G. , LYNN, David, M. , LANGER, Robert, S.
IPC分类号： A61K9/00
摘要： A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent (s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent such as a poly (beta-amino ester) and a polymer. Agents including nucleic acids may be delivered intracellularly using the inventive pH triggerable particles. Upon exposure to an acidic environment such as the endosome or phagosome of a cell, the particles dissolve or disrupt due to protonation or an increase in solubility of the pH triggering agent. Pharmaceutical compositions and methods of preparing and administering these particles are also described. These particles may be particularly useful in genetic vaccination.

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