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1. 发明申请

WO2016154034A1 APTAMER-BASED SENSORS, IMPLANTABLE DEVICES AND DETECTION SYSTEM 审中-公开
标题翻译：基于APTAMER的传感器，可植入设备和检测系统
公开(公告)号：WO2016154034A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023219
申请日：2016-03-18
申请人： VERILY LIFE SCIENCES LLC
发明人： SCHWARTZ, Jerrod, Joseph , THOMPSON, Jason, Donald , BAJAJ, Vikram, Singh
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1473
CPC分类号： A61B5/002 , A61B5/0031 , A61B5/07 , A61B5/14503 , A61B5/14546 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/14735
摘要： A system for measuring and/or monitoring an analyte present in interstitial fluid in skin is provided. The system includes a substrate that may be implanted into the skin and a reader device. The substrate includes a sensor comprising aptamer conjugates and is configured to obtain one or more measurements related to at least one analyte in interstitial fluid. The reader device is configured to detect the analyte in interstitial fluid via interaction with the substrate.
摘要翻译：提供了用于测量和/或监测存在于皮肤间隙液中的分析物的系统。该系统包括可以植入皮肤的基底和读取器装置。衬底包括包含适体缀合物的传感器，并且被配置为获得与间质液中的至少一种分析物相关的一个或多个测量。读取器装置被配置为通过与基底的相互作用来检测间质液中的分析物。

2. 发明申请

WO2015123461A1 REFLOWED GOLD NANOSTRUCTURES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY 审中-公开
标题翻译：用于表面增强拉曼光谱的反射金纳米结构
公开(公告)号：WO2015123461A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/015698
申请日：2015-02-12
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： WALAVALKAR, Sameer , CHANG, Chieh-feng , SCHERER, Axel , MARIN, Brandon , FRASER, Scott E.
IPC分类号： G01N21/65 , G01N21/55 , B82B1/00 , B82B3/00
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/076 , A61B5/14735 , A61B5/6848 , A61B5/686 , A61B2562/0233 , A61B2562/0285 , A61B2562/12 , B82Y30/00 , B82Y40/00 , G01N21/658 , H01L27/14698
摘要： Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.
摘要翻译：描述了纳米柱传感器的方法和系统。纳米玻璃可以在基底上定义，金属沉积在纳米柱上。热处理可以回流纳米柱上的金属，在纳米柱的顶端形成金属灯泡。这些结构可以在用生物制剂进行功能化时具有增强的光学检测，或者可以通过与纳米柱上的金属层相互作用来检测气体，颗粒和液体。

3. 发明申请

WO2011056274A1 IMPROVED OPTICAL SENSOR CONFIGURATION FOR RATIOMETRIC CORRECTION OF BLOOD GLUCOSE MEASUREMENT 审中-公开
标题翻译：改进的光学传感器配置用于血糖测量的比例校正
公开(公告)号：WO2011056274A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/044761
申请日：2010-08-06
申请人： GLUMETRICS, INC. , MARKLE, David, R. , GAMSEY, Soya , PEYSER, Thomas, A.
发明人： MARKLE, David, R. , GAMSEY, Soya , PEYSER, Thomas, A.
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/1459 , A61B5/14735 , A61B2562/0238 , A61B2562/043 , G01N21/7703 , G01N2021/7786
摘要： Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.
摘要翻译：本发明的实施例涉及一种用于检测血糖的光学传感器。该传感器包括一个化学指示器系统，该化学指示器系统设置在光纤的远端与无创伤的尖端部分之间的间隙内，其中光纤和无创伤的尖端部分通过耦合部件耦合，诸如穿过的杆或海波管或笼差距。传感器还包括用于产生和检测与血糖无关的光学参考信号的装置，使得能够对光学系统中的伪影进行血糖测量的比例校正。

4. 发明申请

WO2010107243A2 굽힘 거동을 나타내는 전기감응성 고분자층이 부착된 바이오센서 审中-公开
标题翻译：电感聚合物层的生物传感器涂层弯曲行为
公开(公告)号：WO2010107243A2
公开(公告)日：2010-09-23
申请号：PCT/KR2010/001645
申请日：2010-03-17
申请人： 한양대학교 산학협력단 , 윤장현 , 김선일 , 김선정
发明人： 윤장현 , 김선일 , 김선정
IPC分类号： G01N33/48 , G01N27/26 , G01N33/50
CPC分类号： G01N33/5438 , A61B5/14532 , A61B5/14546 , A61B5/14735 , G01N33/54393
摘要： 본 발명은 굽힘 거동을 나타내는 전기감응성 고분자층이 부착된 바이오센서에 관한 것으로서, 보다 구체적으로는 바이오리셉터의 표면에 부착된 전기감응성 고분자층 및 상기 전기감응성 고분자층에 연결된 전극을 포함하는 바이오센서로서, 상기 전극에 전기자극을 제공하면 전기감응성 고분자층이 굽힘 거동을 보이고, 이에 의해 바이오리셉터의 표면이 애널라이트에 노출될 수 있어 애널라이트의 농도 분석이 이루어지는 바이오센서에 관한 것이다. 본 발명에 따른 바이오센서는 이식형 바이오센서로서 이용되었을 때 선택적으로 바이오리셉터가 애널라이트에 노출될 수 있어 바이오센서의 수명이 탁월하게 연장될 수 있는 장점이 있다.
摘要翻译：本发明涉及涂覆有表现出弯曲行为的电活性聚合物层的生物传感器，更具体地涉及一种生物传感器，其包括涂覆在生物受体的表面上的电活性聚合物层和连接到电活性聚合物层的电极。因此，当电脉冲被馈送到电极时，电活性聚合物层显示弯曲行为，因此生物受体的表面可以暴露于分析物以使分析物的浓度分析。当用作可植入生物传感器时，通过将生物受体选择性地暴露于分析物，本发明的生物传感器有利地具有显着增加的寿命。

5. 发明申请

WO2008143651A3 A SYSTEM FOR IN VIVO BIOSENSING BASED ON THE OPTICAL RESPONSE OF ELECTRONIC POLYMERS 审中-公开
标题翻译：基于电子聚合物光学响应的生物体感染系统
公开(公告)号：WO2008143651A3
公开(公告)日：2009-01-15
申请号：PCT/US2007025044
申请日：2007-12-05
申请人： UNIV OHIO STATE RES FOUND , EPSTEIN ARTHUR J , NEMZER LOUIS R
发明人： EPSTEIN ARTHUR J , NEMZER LOUIS R
IPC分类号： A61B5/00 , G01N21/77
CPC分类号： A61B5/14735 , A61B5/14532 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/681
摘要： A system for continuous in vivo biosensing of specific analyte molecule concentrations based on the dynamic optical properties of electronic polymers is disclosed. The biosensor system includes at least one implant member subcutaneously exposed to the interstitial fluid of the subject, and a reader member at least temporarily positioned over the implant member to probe it with light of specific wavelengths through the skin. The system has many potential applications, including the real-time monitoring of blood glucose levels in diabetics as a method to supplement or replace conventional capillary blood testing.
摘要翻译：公开了一种基于电子聚合物的动态光学性质的特定分析物分子浓度的连续体内生物传感的系统。生物传感器系统包括皮下暴露于受试者的间质液体的至少一个植入物构件，以及读取器构件，其至少临时定位在植入物构件上方，以通过皮肤的特定波长的光探测它。该系统具有许多潜在应用，包括实时监测糖尿病患者的血糖水平，作为补充或替代常规毛细血管血液检测的方法。

6. 发明申请

WO03011354A3 MEMBRANE FOR USE WITH IMPLANTABLE DEVICES 审中-公开
标题翻译：膜与可植入器件的使用
公开(公告)号：WO03011354A3
公开(公告)日：2003-08-14
申请号：PCT/US0223902
申请日：2002-07-26
申请人： DEXCOM INC , BRAUKER JAMES H , SHULTS MARK C , TAPSAK MARK A
发明人： BRAUKER JAMES H , SHULTS MARK C , TAPSAK MARK A
IPC分类号： G01N27/327 , A61B5/145 , A61B5/1473 , A61L31/10 , A61L31/14 , C12M1/34 , C12M1/40 , C12Q1/26 , C12Q1/54 , G01N27/416 , A61L27/44
CPC分类号： A61B5/14735 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2562/02 , A61L31/10 , A61L31/14 , Y10T428/249921
摘要： The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer and instead forms a foreign body response (FBR) layer including: an innermost FBR layer (40) composed generally of macrophages and foreign body giant cells (41) that forms over the entire surface (48a) of the membrane (48); an intermediate FBR layer (42) composed primarily of fibroblasts (43) and fibrous matrix (44); and an outermost FBR layer (46) is loose connective granular tissue containing new blood vessels (45); wherein the innermost layer (40) is resistant to cellular attachment and is impermeable to cells and wherein the outermost layer (46) supports tissue attachment and interferes with barrier cell layer formation. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
摘要翻译：本发明提供了一种用于与可植入装置一起使用的生物界面膜，该生物界面膜干扰阻挡细胞层的形成，并形成异物反应（FBR）层，其包括：最内层的FBR层（40），其通常由巨噬细胞和异物在膜（48）的整个表面（48a）上形成的巨细胞（41）; 主要由成纤维细胞（43）和纤维基质（44）组成的中间FBR层（42）; 最外面的FBR层（46）是含有新血管的松散结缔组织颗粒组织（45）; 其中最内层（40）抵抗细胞附着并且对细胞是不可渗透的，并且其中最外层（46）支持组织附着并干扰阻挡细胞层形成。此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传递或测量装置。

7. 发明申请

WO2003006992A1 OPTICAL SENSOR CONTAINING PARTICLES FOR IN SITU MEASUREMENT OF ANALYTES 审中-公开
标题翻译：用于测量分析仪的含有传感器的光学传感器
公开(公告)号：WO2003006992A1
公开(公告)日：2003-01-23
申请号：PCT/EP2002/007108
申请日：2002-06-27
申请人： TORSANA DIABETES DIAGNOSTICS A/S , PETERSSON, Bo , KRISTENSEN, Jesper
发明人： PETERSSON, Bo , KRISTENSEN, Jesper
IPC分类号： G01N33/543
CPC分类号： A61B5/14532 , A61B5/14735 , A61B5/415 , A61B5/417 , A61B5/418 , G01N33/54373
摘要： The invention relates to a sensor for the in vivo measurement of an analyte, comprising a plurality of particles of suitable size such that when implanted in the body of a mammal the particles can be ingested by macrophages and transported away from the site of implantation, each particle containing the components of an assay having a readout which is an optical signal detectable transdermally by external optical means, and either each particles being contained within a biodegradable material preventing ingestion by the macrophages, or each particle being non-biodegradable. The invention relates to a process for the detection of an analyte using such a sensor, comprising implantation of the sensor into the skin of a mammal, transdermal detection of analyte using external optical means, degradation of the biodegradable material, ingestion of the particles by macrophages, and removal of the particles from the site of implantation by macrophages.
摘要翻译：本发明涉及一种用于体内测量分析物的传感器，其包括多个适当大小的颗粒，使得当植入哺乳动物的体内时，颗粒可被巨噬细胞摄取并从植入部位移出，每个含有具有通过外部光学装置透皮检测的光学信号的读数的测定组分的颗粒，以及每种颗粒都包含在可生物降解的材料内，防止巨噬细胞摄取，或每个颗粒不可生物降解。本发明涉及一种使用这种传感器检测分析物的方法，包括将传感器植入哺乳动物的皮肤，使用外部光学手段对分析物进行透皮检测，降解生物可降解材料，通过巨噬细胞摄入颗粒，并从巨噬细胞植入部位去除颗粒。

8. 发明申请

WO2015138688A1 WEARABLE ELECTROCHEMICAL SENSOR AND METHOD 审中-公开
标题翻译：耐磨电化学传感器及方法
公开(公告)号：WO2015138688A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020112
申请日：2015-03-12
申请人： GLUCOVATION, INC.
发明人： SURI, Jeff T. , BOOCK, Robert , SAN VICENTE, Kenneth
IPC分类号： A61B5/1468 , A61B5/1473 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/14532 , A61B5/14546 , A61B5/14735 , A61B5/15105 , A61B5/6849 , A61B5/742 , A61B2560/045 , A61B2560/063 , A61B2562/125 , A61B2562/16
摘要： An electrochemical sensing system includes a working electrode and a reference electrode, which can at least partially be disposed in a housing. At least a portion of the working electrode includes rhodium metal. An electrical circuit is disposed in the housing and configured to be electronically coupled to the electrodes. The electrical circuit is operative to: (a) bias the working electrode at a voltage of less than about 0.4 V, and (b) measure a current corresponding to the concentration of the target analyte. A communications module is electrically coupled to the electrical circuit and configured to display a concentration of the target analyte, and/or communicate data between the electrical circuit and an external device. The electrodes are movable between a first configuration in which the electrodes are substantially disposed inside the housing, and a second configuration in which at least a portion of the electrodes is disposed outside the housing.
摘要翻译：电化学感测系统包括工作电极和参考电极，其可以至少部分地布置在壳体中。工作电极的至少一部分包括铑金属。电路设置在壳体中并且被配置为电连接到电极。该电路可操作以：（a）将工作电极偏置在小于约0.4V的电压下，和（b）测量与目标分析物的浓度相对应的电流。通信模块电耦合到电路并且被配置为显示目标分析物的浓度，和/或在电路和外部设备之间传送数据。电极可以在其中电极基本上设置在壳体内部的第一构造和第二构造之间移动，其中至少一部分电极设置在壳体外部。

9. 发明申请

WO2015073876A1 FLUORESCENCE-BASED SENSOR WITH MULTIPLE INDICATOR GRAFTS 审中-公开
标题翻译：基于荧光的传感器与多个指示器
公开(公告)号：WO2015073876A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065782
申请日：2014-11-14
申请人： SENSEONICS, INCORPORATED
发明人： EMKEN, Jeremy , HUFFSTETLER, Philip , WHITEHURST, Todd
IPC分类号： A61B5/145 , G01N21/63 , G01N21/64
CPC分类号： A61B5/14503 , A61B5/0031 , A61B5/1451 , A61B5/14532 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/14735 , A61B5/6861 , A61B2560/0219 , A61B2560/0247 , G01N21/27 , G01N21/645 , G01N2021/6421 , G01N2021/6441
摘要： A system including a sensor and a transceiver and configured to determine a concentration of an analyte in a medium of a living animal. The sensor may include first and second signal photodetectors and first and second reference photodetectors, which may each be covered by an associate filter. The first photodetector may receive light emitted from first and second grafts, respectively. The grafts may receive excitation light from one or more light sources. The transceiver may receive signals from the photodetectors of the sensor and may determine the analyte concentration based on the received signals.
摘要翻译：一种包括传感器和收发器并且被配置为确定活动物体的介质中的分析物的浓度的系统。传感器可以包括第一和第二信号光电检测器以及可以由关联滤波器覆盖的第一和第二参考光电探测器。第一光电检测器可以分别接收从第一和第二移植物发射的光。移植物可以接收来自一个或多个光源的激发光。收发器可以从传感器的光电检测器接收信号，并且可以基于接收到的信号来确定分析物浓度。

10. 发明申请

WO2014140164A1 METHODS OF USING INFORMATION FROM RECOVERY PULSES IN ELECTROCHEMICAL ANALYTE MEASUREMENTS AS WELL AS DEVICES, APPARATUSES AND SYSTEMS INCORPORATING THE SAME 审中-公开
标题翻译：在电化学分析测量中使用来自恢复脉冲的信息的方法，作为装置，装置和系统的装置
公开(公告)号：WO2014140164A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054943
申请日：2014-03-13
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： Carpenter, Scott E.
IPC分类号： G01N27/327 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/145
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14735 , A61B5/1486 , A61B5/1495 , A61B2560/0223 , A61B2560/0252
摘要： Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods allow one to correct and/or compensate for confounding variables such as temperature before providing an analyte concentration. The measurement methods use response information from a test sequence having at least one DC block, where the DC block includes at least one excitation pulse and at least one recovery pulse, and where a closed circuit condition of an electrode system is maintained during the at least one recovery pulse. Information encoded in the at least one recovery pulse is used to correct/compensate for temperature effects on the analyte concentration. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods.
摘要翻译：公开了用于测量流体样品中的分析物浓度的方法。这样的方法允许在提供分析物浓度之前校正和/或补偿混杂变量，例如温度。测量方法使用来自具有至少一个DC块的测试序列的响应信息，其中DC块包括至少一个激励脉冲和至少一个恢复脉冲，并且其中在至少保持电极系统的闭合状态一个恢复脉冲。在至少一个恢复脉冲中编码的信息用于校正/补偿对分析物浓度的温度影响。还公开了结合各种测量方法的装置，装置和系统。

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