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1. 发明申请

WO2023082544A1 一种检测COVID-19抗体的血糖生物传感器审中-公开
公开(公告)号：WO2023082544A1
公开(公告)日：2023-05-19
申请号：PCT/CN2022/087002
申请日：2022-04-15
申请人：福州大学
发明人：李调阳 , 林本慧 , 林美雅
IPC分类号： G01N33/569 , C12Q1/6804 , C12Q1/54 , C12N15/11
摘要：一种检测COVID-19抗体的血糖生物传感器，其包括以下组件：新冠病毒COVID-19抗原（12）、新冠病毒COVID-19抗体（14）、修饰有发夹结构DNA片段H1-DNA的新冠病毒COVID-19二抗（15）、触发DNA片段T-DNA（16）、酶标记的发夹结构DNA片段H2-DNA（18）和血糖生物传感器（113）。生物传感器构筑新冠病毒抗原-COVID-19 IgG/IgM-(H1-DNA-H2-DNA复合物)三明治结构；三明治结构中H2-DNA上标记的酶（110）将糖类底物（111）转化为葡萄糖（112）；将葡萄糖（112）溶液滴加在血糖生物传感器（113）上检测葡萄糖（112）的量，进而检测出COVID-19 IgG/IgM的含量。

2. 发明申请

WO2023277518A1 바이오센서 审中-公开
公开(公告)号：WO2023277518A1
公开(公告)日：2023-01-05
申请号：PCT/KR2022/009217
申请日：2022-06-28
申请人： 동우 화인켐 주식회사
发明人： 이동엽 , 김동옥
IPC分类号： C12Q1/00 , C12Q1/54 , C12Q1/26
摘要： 본 발명은, 일면에 소수성 표면을 가지는 제1 기재; 상기 제1 기재 상에 배치되며, 일면에 친수성 표면을 가지는 제2 기재; 상기 제1 기재의 소수성 표면과 상기 제2 기재의 친수성 표면 사이에 스페이스가 구비되도록 소정의 높이로 형성된 지지층; 상기 제1 기재 상의 상기 스페이스 내에 형성된 하나 이상의 전극층; 및 상기 전극층 상에 형성된 효소반응층을 포함하는 바이오센서에 관한 것이다.

3. 发明申请

WO2022051888A1 生物传感器的成膜组合物及其制备方法审中-公开
公开(公告)号：WO2022051888A1
公开(公告)日：2022-03-17
申请号：PCT/CN2020/113934
申请日：2020-09-08
申请人：三诺生物传感股份有限公司
发明人：高志强
IPC分类号： G01N27/26 , C12Q1/54 , A61B5/145
摘要：一种电化学领域生物传感器的成膜组合物及其制备方法。基于第三代生物传感技术发展起来的葡萄糖生物传感器可以非常有效地和准确地对葡萄糖进行实时活体监测，与此同时，4-乙烯吡啶-乙酰胆碱共聚物薄膜的存在也显著拓展了葡萄糖的可监测范围，并大大提高了传感器的稳定性。初步的活体实验表明该第三代葡萄糖生物传感器具有卓越的生物相容性和超长的工作寿命，是迄今为止，工作寿命最长的可用于植入式持续葡萄糖监测系统的葡萄糖生物传感器。

4. 发明申请

WO2021195656A1 DISPOSABLE INDICATOR COMPONENT FOR MEASURING ANALYTE CONCENTRATION IN BODILY FLUIDS 审中-公开
公开(公告)号：WO2021195656A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/070294
申请日：2021-03-22
申请人： JOHNSON & JOHNSON CONSUMER INC.
发明人： BINNER, Curt , MELLINGER, Justin , PAUNESCU, Alexandru
IPC分类号： A61B5/20 , A61B5/00 , A61B5/103 , A61B5/145 , A61B10/00 , A61B10/007 , A61B2562/0214 , A61B2562/029 , A61B2562/0295 , A61B2562/242 , A61B5/0022 , A61B5/0075 , A61B5/1032 , A61B5/14507 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/207 , A61B5/6808 , A61B5/7275 , A61F13/42 , A61F13/49 , B01L2200/10 , B01L3/502707 , B01L3/502761 , B01L3/502776 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N2021/7756 , G01N2021/7766 , G01N21/31 , G01N21/78 , G01N2201/062 , G01N33/493 , G01N33/52
摘要： A disposable indicator component for use in a system for measuring analyte concentration in a bodily fluid includes an indicator zone comprising at least one colorimetric analyte sensing element, and a coupler for coupling the indicator component to a component having at least one spectrophotometer contained within a housing.

5. 发明申请

WO2021049797A1 요당 검출용 조성물 및 이를 이용한 요당 확인 시스템 审中-公开
公开(公告)号：WO2021049797A1
公开(公告)日：2021-03-18
申请号：PCT/KR2020/011611
申请日：2020-08-31
申请人： 김영욱
发明人： 김영욱 KIM, Young Wook
IPC分类号： C12Q1/26 , C12Q1/54 , A61B10/00 , E03D11/00
摘要： 본 발명은 고정제; 지시약; 및 글루코스 옥시다아제(Glucose Oxidase)를 포함하며, 상기 고정제는, 비누 베이스, 젤라틴, 및 천연 지방산으로 구성된 군에서 선택된 하나 이상으로 이루어진 것을 특징으로 하는 요당 검출용 조성물을 제공할 수 있다.

6. 发明申请

WO2019083939A1 PRE-CONNECTED ANALYTE SENSORS 审中-公开
公开(公告)号：WO2019083939A1
公开(公告)日：2019-05-02
申请号：PCT/US2018/057011
申请日：2018-10-23
申请人： DEXCOM, INC.
发明人： HALAC, Jason , BARRY, John Charles , CLARK, Becky L. , DRING, Chris W. , GRAY, John Michael , HIGLEY, Kris Elliot , JACKSON, Jeff , KELLER, David A. , LEE, Ted Tang , MITCHELL, Jason , PIRONDINI, Kenneth , REGO, David , SCHOONMAKER, Ryan Everett , SIMPSON, Peter C. , GADD, Craig Thomas , STEWART, Kyle Thomas
IPC分类号： A61B5/05 , A61B5/145 , A61B5/1468 , C12Q1/54 , G01N27/327
摘要： Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

7. 发明申请

WO2018062830A1 포도당 검출용 복합체 및 이를 포함하는 눈물 내 포도당 검출을 위한 콘택트렌즈형 센서 审中-公开
标题翻译：用于检测葡萄糖的复合物和用于检测含有葡萄糖的泪液葡萄糖的隐形眼镜型传感器
公开(公告)号：WO2018062830A1
公开(公告)日：2018-04-05
申请号：PCT/KR2017/010680
申请日：2017-09-27
申请人： 한양대학교 산학협력단
发明人： 이동윤 , 배우리 , 박시진
IPC分类号： G01N33/64 , C12Q1/00 , C12Q1/54
摘要： 본 발명은 포도당 검출용 복합체 및 이를 포함하는 눈물 내 포도당 검출을 위한 콘택트렌즈형 센서에 관한 것이다. 본 발명에 따른 포도당 검출용 콘택트렌즈형 센서는, 산화세륨 나노입자에 포도당 산화효소가 결합된 복합체를 포함하며, 이러한 구성을 통해, 더욱 간단하고 경제적인 방법으로 포도당의 농도 변화를 시각화하고, 정량적으로 측정할 수 있다. 또한, 종래의 혈당 측정법과 비교하여, 혈액이 아닌, 눈물 내 포도당 농도를 측정함으로써, 비침습적인 방법으로 포도당의 농도를 실시간으로 모니터링할 수 있는바, 당뇨병의 조기 진단 및 예방을 위한 기술 분야에 폭넓게 적용될 수 있을 것이다.
摘要翻译：本发明涉及用于检测葡萄糖的复合物和用于检测含有葡萄糖的泪液葡萄糖的隐形眼镜型传感器。根据本发明葡萄糖检测接触透镜型传感器，包括耦合到所述铈纳米氧化物颗粒复合物中的葡萄糖氧化酶，通过这样的结构，更简单和可视化以经济的方式在葡萄糖浓度的变化，定量。“ 此外，与以往的血糖测量的比较，通过测量比血液，撕裂葡萄糖水平，本领域的早期诊断和预防的非侵入性的方式，在葡萄糖浓度的条能够被实时监控，糖尿病它可能被广泛应用。

8. 发明申请

WO2018049170A1 SENSORS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：传感器及其制造和使用方法
公开(公告)号：WO2018049170A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050692
申请日：2017-09-08
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： CHIAO, Jung-Chih , TJIA, Maggie , YANG, Xuesong , O'GRADY, Gregory
IPC分类号： C12Q1/25 , C12Q1/54 , C12Q1/58 , C12Q1/60 , C12Q1/61 , C12Q1/62 , G01N27/327
摘要： The present invention is directed to a sensor for detecting an analyte. The sensor comprises the following components: (1) an electrode; (2) a continuous, amorphous, sol-gel metal oxide layer or a patterned metal oxide layer deposited on the electrode; and (3) a redox catalyst in direct contact with an exterior surface of the metal oxide layer. The redox catalyst is a catalyst for oxidation or reduction of the analyte. The present invention is also directed to a sensing system comprising one or more of the sensors and a method of sensing comprising depositing the sensor in a chemical or biological environment.
摘要翻译：本发明涉及用于检测分析物的传感器。该传感器包括以下部件：（1）电极; （2）沉积在电极上的连续的无定形溶胶 - 凝胶金属氧化物层或图案化金属氧化物层; 和（3）与金属氧化物层的外表面直接接触的氧化还原催化剂。氧化还原催化剂是分析物氧化或还原的催化剂。本发明还涉及一种包括一个或多个传感器的传感系统和一种传感方法，包括将传感器沉积在化学或生物环境中。

9. 发明申请

WO2017013495A3 COMPOSITIONS AND METHODS FOR MEASURING BLOOD GLUCOSE LEVELS 审中-公开
公开(公告)号：WO2017013495A3
公开(公告)日：2017-01-26
申请号：PCT/IB2016/001150
申请日：2016-07-22
申请人： SMARTZYME BIOPHARMA LTD.
发明人： GUTTMAN, Chen, Haim , BARAM, David , GOFBERG, Itamar Oz , OMER, Dotan
IPC分类号： C12N9/06 , C12Q1/54
摘要： In some embodiments, the present invention a mutated FAD-GDHa protein, wherein the mutated FAD-GDHa protein is mutated from a wild-type first species to contain at least one point mutation, wherein the mutated FAD-GDHα protein comprises: P(X) n=8 X4(X) n=16 V(X) n=6 RN(X) n=3 YDXRPXCXGX 3 NNCMP(X) n=1 CP(X) n=2 A(X) n=1 Y(X) n=1 G(X) n=6 A(X) n=2 AG(X) n=6 AVV(X) n=3 E(X) n=8-9 A(X) n=2 Y(X) n=1 D(X) n=5 HRV(X) n=5 V(X) n=2 A(X) n=3 E(X) n=2 K(X) n=4 S(X) n=5 P(X) n=1 G(X) n=2 N(X) n=4 GRN(X) n=1 MDH(X) n=4 V(X) n=1 F(X) n=6-7 W(X) n=1 GRGP(X) n=9 RDGXX 5 R(X) n=19 T(X) n=14 L(X) n=14 X 2 (X) n=1 X 1 (X) n=1 E(X) n=4 P(X) n=1 NR(X) n=3 S(X)n=4D(X) n=2 G(X) n=7 Y(X) n=4 Y(X) n=32-35 , wherein each X represents a wild-type amino acid residue of the first species and n indicates the number of the wild-type amino acid residues of the first species represented by a respective parenthetical at that position, wherein: a) X 1 is selected from the group consisting of X, S, C, T, M, V, Y, N, P, L, G, Q, A, I, D, W, H, and E, wherein if X 1 is L, H or V, then X 2 is D; b) X 3 is selected from the group consisting of G, H, D, Y, S, and X; c) X 4 is selected from the group consisting of S and X; and d) X 5 is selected from the group consisting of S and X.

10. 发明申请

WO2017013495A2 COMPOSITIONS AND METHODS FOR MEASURING BLOOD GLUCOSE LEVELS 审中-公开
标题翻译：用于测量血液葡萄糖水平的组合物和方法
公开(公告)号：WO2017013495A2
公开(公告)日：2017-01-26
申请号：PCT/IB2016/001150
申请日：2016-07-22
申请人： SMARTZYME BIOPHARMA LTD.
发明人： GUTTMAN, Chen, Haim , BARAM, David , GOFBERG, Itamar Oz , OMER, Dotan
IPC分类号： C12Q1/54 , C12N9/04
CPC分类号： C12Y101/05 , C12N9/0006 , C12Q1/006 , C12Q1/32
摘要： In some embodiments, the present invention a mutated FAD-GDHa protein, wherein the mutated FAD-GDHa protein is mutated from a wild-type first species to contain at least one point mutation, wherein the mutated FAD-GDHα protein comprises: P(X) n=8 X4(X) n=16 V(X) n=6 RN(X) n=3 YDXRPXCXGX 3 NNCMP(X) n=1 CP(X) n=2 A(X) n=1 Y(X) n=1 G(X) n=6 A(X) n=2 AG(X) n=6 AVV(X) n=3 E(X) n=8-9 A(X) n=2 Y(X) n=1 D(X) n=5 HRV(X) n=5 V(X) n=2 A(X) n=3 E(X) n=2 K(X) n=4 S(X) n=5 P(X) n=1 G(X) n=2 N(X) n=4 GRN(X) n=1 MDH(X) n=4 V(X) n=1 F(X) n=6-7 W(X) n=1 GRGP(X) n=9 RDGXX 5 R(X) n=19 T(X) n=14 L(X) n=14 X 2 (X) n=1 X 1 (X) n=1 E(X) n=4 P(X) n=1 NR(X) n=3 S(X)n=4D(X) n=2 G(X) n=7 Y(X) n=4 Y(X) n=32-35 , wherein each X represents a wild-type amino acid residue of the first species and n indicates the number of the wild-type amino acid residues of the first species represented by a respective parenthetical at that position, wherein: a) X 1 is selected from the group consisting of X, S, C, T, M, V, Y, N, P, L, G, Q, A, I, D, W, H, and E, wherein if X 1 is L, H or V, then X 2 is D; b) X 3 is selected from the group consisting of G, H, D, Y, S, and X; c) X 4 is selected from the group consisting of S and X; and d) X 5 is selected from the group consisting of S and X.
摘要翻译：在一些实施方案中，本发明是突变的FAD-GDHα蛋白，其中突变的FAD-GDHα蛋白从野生型第一物种突变为含有至少一个点突变，其中所述突变的FAD-GDHα蛋白包含：P（X ）N = 8X4（X）N = 16V（X）N = 6RN（X）N = 3YDXRPXCXGX3NNCMP（X）N = 1CP（X）N = 2A（X）N = 1Y（X）N = 1G（X）N = 6A（X）N = 2AG（X）N = 6AVV（X）N = 3E（X）N = 8-9A（X）N = 2Y（X）N = 1D（X）N = 5HRV（X）N = 5V（X）N = 2A（X）N = 3E（X）N = 2K（X）N = 4S（X）N = 5P（X）N = 1G（X）N = 2 N（X）N = 4GRN （X）N = 1MDH（X）N = 4V（X）N = 1F（X）N = 6-7W（X）N = 1GRGP（X）N = 9RDGXX5R（X）N = 19T（X）N = 14L （X）N = 14X2（X）N = 1X1（X）N = 1E（X）N = 4P（X）N = 1NR（X）N = 3S（X）N = 4D（X）N = 2G（X ）n = 7Y（X）n = 4Y（X）n = 32-35，其中每个X表示第一种的野生型氨基酸残基，n表示第一种的野生型氨基酸残基的数目其中：a）X1选自X，S，C，T，M，V，Y，N，P，L，G，Q，A，I， D，W，H和E，其中如果X1是L，H或V，则X2是D; b）X3选自G，H，D，Y，S和X; c）X4选自S和X; 和d）X5选自S和X组成的组。

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