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1. 发明申请

WO99047058A2 CATHETER FOR DELIVERY OF ENERGY TO A SURGICAL SITE 审中-公开
标题翻译：为运行领域提供能源的导管
公开(公告)号：WO99047058A2
公开(公告)日：1999-09-23
申请号：PCT/US1999/006092
申请日：1999-03-19
IPC分类号： A61B18/12 , A61B17/00 , A61B17/16 , A61B17/22 , A61B17/28 , A61B17/32 , A61B17/34 , A61B17/88 , A61B18/00 , A61B18/04 , A61B18/08 , A61B18/14 , A61B18/18 , A61B18/24 , A61B19/00 , A61F2/30 , A61F2/44 , A61F7/02 , A61M1/00 , A61M25/00 , A61M25/01 , A61M25/09 , A61N1/06 , A61N1/30 , A61N1/40 , A61N5/04 , A61B17/39
CPC分类号： A61B18/082 , A61B10/02 , A61B17/00491 , A61B17/1671 , A61B17/29 , A61B17/320016 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B18/00 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/32113 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1435 , A61B2018/1455 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2217/007 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0144 , A61M25/0155 , A61M25/0158 , A61M2025/0063 , A61M2025/0064 , A61M2025/0163 , A61N1/06 , A61N1/40
摘要： A catheter for delivering energy to a surgical site is disclosed. The catheter includes at a proximal end a handle and at a distal end a probe. The catheter includes at least one energy delivery device and an activation element. The at least one energy delivery device is located at the distal end of the catheter to deliver energy to portions of the surgical site. The activation element is located at the distal end of the catheter, to transition the probe from a linear to a multi-dimensional shape, within the surgical site. Methods for deploying the probe from the linear to multi-dimensional shape are disclosed. In another embodiment of the invention the catheter includes a heating element fabricated on a substrate by photo-etching to deliver thermal energy to portions of the surgical site. In another embodiment of the invention the catheter includes an energy delivery element, a tip and a blade. The energy delivery element is located at the distal end of the catheter to deliver energy to portions of the intervertebral disc. The blade is positioned within a first lumen of the tip and is extensible beyond the tip, to cut selected portions within the intervertebral disc. In another embodiment of the invention a catheter includes both energy and material transfer elements and an interface on the handle thereof. The interface couples the energy delivery element and the material transfer element to external devices for energy and material transfer to and from the intervertebral disc.
摘要翻译：本发明涉及用于向手术区域供应能量的导管。导管包括在其近端的手柄和在其远端的探针，以及用于提供能量的装置和激活元件。能量输送装置位于导管的远端处以向手术部位提供能量。激活元件设置在导管的远端处，允许探头在手术区内从线性形式移动到多维形状。本发明还提供了用于展开该探针的方法，从而从线性形式传递到多维形式。在本发明的另一个实施例中，所述导管包括通过光刻制造在衬底上的触发体，该触发体用于向所述操作区域的部分提供热能。或者，该导管设置有用于提供能量的元件，尖端和刀片，所述用于提供能量的元件位于导管的远端处以能够为椎间盘的某些部位提供能量。该刀片被放置在尖端内的第一空间中，该刀片可以延伸超过该尖端以便切割椎间盘的一些部分。在本发明的另一个实施例中，导管包括能量和物质转移元件以及在其手柄上的连接器。该连接器连接所述元件以将电力以及材料转移元件提供给外部装置，用于将能量和材料传递到椎间盘或从椎间盘转移。

2. 发明申请

WO1996029943A1 PHOTODYNAMIC THERAPY SYSTEM AND METHOD 审中-公开
标题翻译：光动力治疗系统及方法
公开(公告)号：WO1996029943A1
公开(公告)日：1996-10-03
申请号：PCT/US1996004252
申请日：1996-03-27
申请人： ELI LILLY AND COMPANY
发明人： ELI LILLY AND COMPANY , AITA, Michael , BUCHIN, Michael
IPC分类号： A61B17/22
CPC分类号： A61N5/062 , A61B18/245 , A61B2017/22038 , A61B2017/22051 , A61B2017/22059 , A61B2017/22074 , A61B2017/22078 , A61B2017/22087 , A61N5/0601
摘要： A method and catheter system for irradiating a body lumen wall which comprises providing an elongated, flexible radiation transmission member having an emitting portion at its distal end, advancing the emitting portion to an area adjacent the wall defining the patient's body lumen to be treated by irradiation, and directing radiation through the transmission member while moving the transmission member to cause the emitting portion to irradiate a length of the wall of the body lumen. The transmission member may be rotated independently or in conjunction with longitudinal movement to achieve either selective or uniform irradiation of the wall defining the body lumen. In one embodiment, this invention comprises an elongated flexible shaft, having an inflatable member disposed at the distal end. A radiation transmission member having an emitting portion on its distal end is slidably disposed within the elongated shaft so that the emitting portion resides within the inflatable member. The system is configured so that the emitting portion may travel at least along the length of the inflatable member by longitudinally moving the transmission member. Optionally, the emitting portion may be configured to transmit radiation in a particular radial direction and the transmission member may be configured to rotate axially within the lumen.
摘要翻译：一种用于照射体腔壁的方法和导管系统，其包括提供细长的柔性辐射透射构件，其在其远端具有发射部分，将发射部分推进到邻近限定患者体腔的区域以通过照射进行治疗并且在移动所述透射构件的同时引导辐射通过所述透射构件，以使所述发射部分照射所述体腔的壁的一定长度。透射构件可以独立地或与纵向运动相结合地旋转，以实现限定体腔的壁的选择性或均匀照射。在一个实施例中，本发明包括细长的柔性轴，其具有设置在远端的可充气构件。在其远端具有发射部分的辐射传递构件可滑动地设置在细长轴内，使得发射部分位于可充气构件内。该系统构造成使得发射部分可以通过纵向移动传播构件至少沿着可充气构件的长度行进。可选地，发射部分可以被配置成在特定径向方向上透射辐射，并且透射构件可以构造成在腔内轴向旋转。

3. 发明申请

WO9947058A3 CATHETER FOR DELIVERY OF ENERGY TO A SURGICAL SITE 审中-公开
标题翻译：将能量输送到外科手术台的导管
公开(公告)号：WO9947058A3
公开(公告)日：1999-11-11
申请号：PCT/US9906092
申请日：1999-03-19
申请人： ORATEC INTERVENTIONS INC , ASHLEY JOHN E , SHARKEY HUGH R , SAAL JOEL , SAAL JEFFREY
发明人： ASHLEY JOHN E , SHARKEY HUGH R , SAAL JOEL , SAAL JEFFREY
IPC分类号： A61B18/12 , A61B17/00 , A61B17/16 , A61B17/22 , A61B17/28 , A61B17/32 , A61B17/34 , A61B17/88 , A61B18/00 , A61B18/04 , A61B18/08 , A61B18/14 , A61B18/18 , A61B18/24 , A61B19/00 , A61F2/30 , A61F2/44 , A61F7/02 , A61M1/00 , A61M25/00 , A61M25/01 , A61M25/09 , A61N1/06 , A61N1/30 , A61N1/40 , A61N5/04 , A61B17/39
CPC分类号： A61B18/082 , A61B10/02 , A61B17/00491 , A61B17/1671 , A61B17/29 , A61B17/320016 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B18/00 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/32113 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1435 , A61B2018/1455 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2217/007 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0144 , A61M25/0155 , A61M25/0158 , A61M2025/0063 , A61M2025/0064 , A61M2025/0163 , A61N1/06 , A61N1/40
摘要： A catheter for delivering energy to a surgical site is disclosed. The catheter includes at a proximal end a handle and at a distal end a probe. The catheter includes at least one energy delivery device and an activation element. The at least one energy delivery device is located at the distal end of the catheter to deliver energy to portions of the surgical site. The activation element is located at the distal end of the catheter, to transition the probe from a linear to a multi-dimensional shape, within the surgical site. Methods for deploying the probe from the linear to multi-dimensional shape are disclosed. In another embodiment of the invention the catheter includes a heating element fabricated on a substrate by photo-etching to deliver thermal energy to portions of the surgical site. In another embodiment of the invention the catheter includes an energy delivery element, a tip and a blade. The energy delivery element is located at the distal end of the catheter to deliver energy to portions of the intervertebral disc. The blade is positioned within a first lumen of the tip and is extensible beyond the tip, to cut selected portions within the intervertebral disc. In another embodiment of the invention a catheter includes both energy and material transfer elements and an interface on the handle thereof. The interface couples the energy delivery element and the material transfer element to external devices for energy and material transfer to and from the intervertebral disc.
摘要翻译：公开了一种用于向外科手术部位输送能量的导管。导管在近端处包括手柄，并且在远端处包括探针。导管包括至少一个能量输送装置和激活元件。所述至少一个能量输送装置位于所述导管的远端，以将能量传递到手术部位的部分。激活元件位于导管的远端，以将探针从线性过渡到多维形状，在手术部位内。公开了将探针从线性展开到多维形状的方法。在本发明的另一个实施例中，导管包括通过光蚀刻在衬底上制造的加热元件，以将热能传递到手术部位的部分。在本发明的另一个实施例中，导管包括能量输送元件，尖端和刀片。能量输送元件位于导管的远端，以将能量传递给椎间盘的部分。刀片定位在尖端的第一内腔内并且可延伸超过尖端，以切割椎间盘内的所选部分。在本发明的另一个实施例中，导管包括能量和材料转移元件以及其手柄上的界面。界面将能量输送元件和材料转移元件耦合到外部装置，以将能量和材料传递到椎间盘和从椎间盘传递。

4. 发明申请

WO98048882A1 LIGHT DELIVERY CATHETER AND METHOD FOR THE USE THEREOF 审中-公开
标题翻译：光输送管及其使用方法
公开(公告)号：WO98048882A1
公开(公告)日：1998-11-05
申请号：PCT/US1998/008836
申请日：1998-04-30
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/20 , A61B18/24 , A61B19/00 , A61M25/00 , A61M25/14 , A61M31/00
CPC分类号： A61B18/245 , A61B18/24 , A61B2017/00973 , A61B2017/22014 , A61B2017/22038 , A61B2017/22074 , A61B2017/22084 , A61B2017/22087 , A61B2018/00642 , A61B2018/206 , A61B2090/3933 , A61M25/003 , A61M2025/0037
摘要： This invention is a light delivery catheter (10) having a two lumen proximal shaft (14) and a single lumen distal shaft (12). A guide wire (28) and light guide (30) received in the first and second lumens of the proximal shaft may individually extend into the single lumen of the distal shaft (12). A hub (16) has ports to introduce fluids to the lumens. To remove a blood clot, the guide wire (28) is extended through the single lumen to position the catheter (10) at the clot. The guide wire (28) is then retracted, the light guide (30) extended, and contrast fluid is preferably flowed through the light guide's lumen before light energy is applied. The catheter (10) may be repositioned before subsequent applications of light energy, and a clot busting drug may be applied. Alternatively, the catheter (10) may be passed through the clot and then retracted as light energy and contrast fluid are applied.
摘要翻译：本发明是具有两腔近端轴（14）和单腔远侧轴（12）的光输送导管（10）。容纳在近侧轴的第一和第二腔中的导丝（28）和导光体（30）可以单独地延伸到远侧轴（12）的单个内腔中。轮毂（16）具有向流体引入流体的端口。为了去除血块，引导线（28）延伸穿过单个腔以将导管（10）定位在血块处。引导线（28）然后缩回，导光体（30）延伸，并且对比流体优选在施加光能之前流过光导管的内腔。导管（10）可以在随后的光能施加之前重新定位，并且可以施用凝块破坏药物。或者，导管（10）可以通过凝块，然后随着光能和对比度流体被施加而缩回。

5. 发明申请

WO1995028135A1 COLLAGEN TREATMENT APPARATUS 审中-公开
标题翻译：胶原治疗装置
公开(公告)号：WO1995028135A1
公开(公告)日：1995-10-26
申请号：PCT/US1994004183
申请日：1994-04-15
申请人： SUNRISE TECHNOLOGIES, INC.
发明人： SUNRISE TECHNOLOGIES, INC. , SAND, Bruce, J.
IPC分类号： A61F09/00
CPC分类号： A61F9/008 , A61B2017/22082 , A61B2017/22087 , A61F2009/00853 , A61F2009/00872
摘要： A method and apparatus for controlled thermal shrinkage of collagen tissue by irradiation with coherent energy in the wavelength band of 1.80 to 2.55 microns as generated by a laser. A specific application to ophthalmological corneal reshaping is described. A method for shrinkage of collagen tissue by application of coherent infrared energy, in which the threshold shrinkage temperature is substantially reduced by application of a reagent such as lysozyme to the tissue prior to heating. The method is especially useful in ophthalmology for shape modification of a cornea, and is enhanced by using a corneal collagen shield as a carrier and delivery agent for the reagent and an admixed anaesthetic.
摘要翻译：通过用激光产生的1.80〜2.55微米的波长范围内的相干能量照射，可以控制胶原组织热收缩的方法和装置。描述了对眼科角膜重塑的具体应用。通过施加相干红外能量来收缩胶原组织的方法，其中通过在加热之前向组织施加诸如溶菌酶的试剂，阈值收缩温度显着降低。该方法在用于角膜形状修饰的眼科中特别有用，并且通过使用角膜胶原屏蔽作为载体和用于试剂的输送剂和混合麻醉剂来增强。

6. 发明申请

WO1994020038A1 METHODS OF LASER INDUCED TISSUE NECROSIS 审中-公开
标题翻译：激光诱导组织坏死的方法
公开(公告)号：WO1994020038A1
公开(公告)日：1994-09-15
申请号：PCT/US1994002649
申请日：1994-03-11
申请人： GREEN, Howard, A.
IPC分类号： A61B17/36
CPC分类号： A61B18/203 , A61B18/22 , A61B2017/00761 , A61B2017/22087 , A61B2018/00452
摘要： A method for treating dermatological organ disorders and skin lesions in a mammal through the use of directed, pulsed laser light is described. The dermatological disorders are characterized by an increase in concentration of potential photodynamic chemical compounds like carotenoid compounds, and especially the carotenoid beta-carotene, compared to normal skin. Pulsed dye laser light of a time and duration specific for maximal absorption by a carotenoid compound like beta-carotene is directed at the regions of carotenoid accumulation within a skin disorder. Thermal coagulation necrosis of the carotenoid-accumulation skin region results, though thermal damage to surrounding tissue is limited in amount.
摘要翻译：描述了通过使用有针对性的脉冲激光治疗哺乳动物皮肤病症和皮肤病变的方法。皮肤病的特征是与正常皮肤相比，潜在的光动力学化合物如类胡萝卜素化合物，特别是类胡萝卜素β-胡萝卜素的浓度增加。脉冲染料激光具有针对类胡萝卜素化合物如β-胡萝卜素最大吸收的时间和持续时间，指向皮肤病中类胡萝卜素积累的区域。类胡萝卜素积累皮肤区域的热凝固性坏死导致周围组织的热损伤受到限制。

7. 发明申请

WO1992017243A2 APPARATUS USING A LASER LUCENT NEEDLE 审中-公开
标题翻译：使用激光针的装置
公开(公告)号：WO1992017243A2
公开(公告)日：1992-10-15
申请号：PCT/US1992002385
申请日：1992-03-24
申请人： ARIA CORPORATION
发明人： ARIA CORPORATION , CONN, Richard, L. , LOREE, Thomas, Robert , BIGIO, Irving, Joseph , STROBL, Karlheinz
IPC分类号： A61N05/06
CPC分类号： A61N5/062 , A61B18/22 , A61B2017/22072 , A61B2017/22087 , A61B2018/00011 , A61B2018/2261 , A61N5/0601 , A61N2005/067
摘要： Apparatus formed of a laser lucent hollow, transparent needle (10) with an optical fiber (12) disposed within its interior. Means such as a spacer (14) can be used to retain the fiber in position within the needle. In a particular embodiment, the end of the needle adjacent to the energy transmitting end of the fiber is closed, and energy scatterers or diffusers (18) may be provided to alter the characteristics of the transmitted energy. In further embodiments, scattering or diffusing materials (32) are disposed within the walls and the closed end (16) of the needle to form a laser lucent apparatus customized to specific hyperthermia requirements. In other embodiments, the needle is open-ended for insertion of a specialized instrument for such uses as biopsies and spectroscopic tissue analyses. These procedures can be conducted before or after hyperthermia treatment of the tissue by replacing fiber in the needle casing with such a specialized instrument or vice-versa. A particular application facilitates the use of laser-induced hyperthermia to treat benign prostatic hypertrophy.
摘要翻译：由激光透明中空透明针（10）形成的装置，其具有设置在其内部的光纤（12）。诸如间隔物（14）的装置可用于将纤维保持在针内的适当位置。在特定实施例中，与光纤的能量传输端相邻的针的端部是封闭的，并且可以提供能量散射体或扩散器（18）来改变传输能量的特性。在另外的实施例中，散射或扩散材料（32）设置在针的壁和封闭端（16）内，以形成根据具体的热疗要求定制的激光透明装置。在其他实施例中，针是开放式的，用于插入专用仪器用于活检和分光组织分析。这些方法可以在用这种专门的仪器替代针套管中的纤维之前或之后进行组织的热疗，反之亦然。特定的应用有助于激光诱导的高热治疗良性前列腺肥大。

8. 发明申请

WO2016147191A1 PERCUTANEOUS MODIFICATION OF VASCULAR EXTRACELLULAR MATRIX TO PREVENT AND TREAT VASCULAR RESTENOSIS 审中-公开
标题翻译：血管外细胞基质修复以预防和治疗血管内皮生长因子
公开(公告)号：WO2016147191A1
公开(公告)日：2016-09-22
申请号：PCT/IL2016/050296
申请日：2016-03-17
申请人： MOR RESEARCH APPLICATIONS LTD.
发明人： HARARI, Emanuel
IPC分类号： A61M25/10 , A61L29/08 , A61L29/16
CPC分类号： A61N5/062 , A61B17/22031 , A61B2017/22002 , A61B2017/22051 , A61B2017/22087 , A61L29/08 , A61L29/14 , A61L29/16 , A61M25/104 , A61M2025/105 , A61N5/0601 , A61N2005/0602 , A61N2005/063 , A61N2005/0643 , A61N2005/0651 , A61N2005/0652 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/067
摘要： Aspects of disclosed embodiments relate to systems, devices and methods for treating and preventing restenosis by cross-linking collagen fibrils of the vessel wall at the intervention site. The devices described are drug-eluting devices comprising: an expandable member or a balloon; a cross-linking agent; and a photoactivating light source. Upon the inflation of the expandable member or the balloon the cross linking agent is released and photoactivated in a therapeutically effective amount for cross-linking collagen fibrils.
摘要翻译：所公开的实施方案涉及用于通过在介入部位交联血管壁的胶原原纤维来治疗和预防再狭窄的系统，装置和方法。所描述的装置是药物洗脱装置，包括：可膨胀构件或气囊; 交联剂; 和光活化光源。在可膨胀构件或球囊膨胀时，交联剂以治疗有效量释放和光活化以交联胶原原纤维。

9. 发明申请

WO2003017846A1 PORPHYRINS WITH ENHANCED MULTI-PHOTON ABSORPTION CROSS-SECTIONS FOR PHOTODYNAMIC THERAPY 审中-公开
标题翻译：具有增强的多光子吸收的磷光体用于光动力治疗的交叉部分
公开(公告)号：WO2003017846A1
公开(公告)日：2003-03-06
申请号：PCT/US2002/026626
申请日：2002-08-22
申请人： MONTATA STATE UNIVERSITY-BOZEMAN , NICKEL, Eric , SPANGLER, Charles, W. , REBANE, Aleksander
发明人： NICKEL, Eric , SPANGLER, Charles, W. , REBANE, Aleksander
IPC分类号： A61B10/00
CPC分类号： A61K41/008 , A61B2017/22087
摘要： A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin structure of the porphyrin-based photosensitizer, and at least one intersystem crossing enhancing substituent to meso- or beta-positions of a porphyrin structure of the porphyrin-based photosensitizer, to thereby increase multi-photon absorption cross-section of the porphyrin-based photosensitizer to at least about 30 GM units at about its maximum wavelength for two-photon absorption. The TPA-chromophore is selected from a group of p-conjugated structures. The resulting porphyrin-based photosensitizer absorbs two photons of radiation in the range of about 700 nm to about 1300 nm. (Figure 2) discloses the molecular structures of three porphyrins.
摘要翻译：通过在卟啉基光敏剂的卟啉结构的中间位置或β-位置附着至少一个TPA发色团，以及至少一个系统间相互作用来增加卟啉基光敏剂的多光子吸收横截面的方法将卟啉基光敏剂的卟啉结构的中间或β-位交叉增强取代基，从而将卟啉基光敏剂的多光子吸收横截面增加至约大约30个GM单位，其大约其最大波长为双光子吸收。 TPA发色团选自一组p-共轭结构。所得的卟啉基光敏剂吸收约700nm至约1300nm范围内的两个辐射光子。（图2）公开了三种卟啉的分子结构。

10. 发明申请

WO01072370A1 CATHETER FOR DELIVERING ELECTROMAGNETIC ENERGY FOR ENHANCED PERMEATION OF SUBSTANCES 审中-公开
标题翻译：用于提供电磁能量的导管，用于增强物质的渗透
公开(公告)号：WO01072370A1
公开(公告)日：2001-10-04
申请号：PCT/US2001/009243
申请日：2001-03-23
IPC分类号： A61B17/22 , A61B18/24 , A61M31/00
CPC分类号： A61B17/22 , A61B18/24 , A61B2017/22082 , A61B2017/22084 , A61B2017/22087 , A61M31/00 , A61M2025/105
摘要： The present invention provides a catheter device (3) and method for enhancing local administration of pharmaceutical compounds. Such device (3) and method are used for various situations which require high concentrations of drugs that are delivered locally.
摘要翻译：本发明提供一种用于增强药物化合物的局部给药的导管装置（3）和方法。这种装置（3）和方法用于需要局部递送的高浓度药物的各种情况。

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