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1. 发明申请

WO2015155606A3 DEVICES AND METHODS FOR CONTROLLED DRUG DELIVERY OF WET AEROSOLS 审中-公开
标题翻译：用于控制药物递送湿敏剂的装置和方法
公开(公告)号：WO2015155606A3
公开(公告)日：2016-03-10
申请号：PCT/IB2015000896
申请日：2015-01-23
申请人： UNIV NEW YORK STATE RES FOUND
发明人： SMALDONE GERALD
IPC分类号： A61M11/00
CPC分类号： A61M11/003 , A61M11/005 , A61M11/06 , A61M15/0016 , A61M15/0018 , A61M15/0021 , A61M15/0085 , A61M15/0086 , A61M15/0091 , A61M16/0495 , A61M2205/0233 , A61M2209/02
摘要： The invention relates to the field of aerosolization by wet nebulizers, and in particular aerosols made by vibrating membranes. A capture chamber moderates the aerosol particle distributions with the primary effect on the larger particles.
摘要翻译：本发明涉及通过湿式喷雾器，特别是由振动膜制成的气溶胶雾化的领域。捕获室缓和气溶胶颗粒分布，对较大颗粒具有主要影响。

2. 发明申请

WO2015066665A2 MODIFIED HYDROPHOBIC SPONGES 审中-公开
标题翻译：改性疏水海绵
公开(公告)号：WO2015066665A2
公开(公告)日：2015-05-07
申请号：PCT/US2014063788
申请日：2014-11-04
申请人： UNIV NEW YORK STATE RES FOUND
发明人： CHU BENJAMIN , HSIAO BENJAMIN , WANG ZHE
IPC分类号： B32B5/18
CPC分类号： B01J20/262 , B01J20/10 , B01J20/28011 , B01J20/28045 , B01J20/28085 , B01J20/3212 , B01J20/3225 , B01J20/3272 , C02F1/285 , C02F1/681 , C02F2101/32 , C08J9/365 , C08J2375/04 , C09K3/32
摘要： Articles are provided for absorbing fluids. In embodiments, the articles of the present disclosure are modified to make them hydrophobic, thereby decreasing their affinity for water and similar liquids, while increasing their affinity for other hydrophobic materials, including oil. After use, the articles, in embodiments polyurethane sponges, may have their absorbed materials removed therefrom, and the articles may then be re¬ used to absorb additional materials.
摘要翻译：提供用于吸收流体的物品。在实施方案中，本公开的制品被修饰以使其疏水，从而降低它们对水和类似液体的亲和力，同时增加它们对其它疏水性材料（包括油）的亲和力。在使用后，在实施方案中，制品聚氨酯海绵可以将其吸收的材料从其中去除，然后制品可以被再次用于吸收额外的材料。

3. 发明申请

WO2014186793A3 ELECTRONIC EXPRESSION OF THE INWARD RECTIFIER IN CARDIOCYTES DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS 审中-公开
标题翻译：来自人类诱导的肺癌细胞的心脏病患者的电子表达的电子表达
公开(公告)号：WO2014186793A3
公开(公告)日：2015-02-05
申请号：PCT/US2014038611
申请日：2014-05-19
申请人： UNIV NEW YORK STATE RES FOUND
发明人： RASMUSSON RANDALL L , BETT GLENNA
IPC分类号： C12N5/00
CPC分类号： C12N13/00 , G01N27/00 , G01N33/48728 , G01N33/5073
摘要： Systems and methods are provided for improving action potential morphology in iPSC- derived cardiac myocytes and utilizing such myocytes. Improved morphology may include, for example, physiological resting membrane potentials. Membrane voltages of the myocyte are measured and a synthetic inward rectifying current is applied to the myocyte based on the membrane voltage.
摘要翻译：提供系统和方法用于改善iPSC衍生的心肌细胞中的动作电位形态并利用这种肌细胞。改进的形态可以包括例如生理休息膜电位。测量肌细胞的膜电压，并根据膜电压向肌细胞施加合成的内向整流电流。

4. 发明申请

WO2013040547A3 COMPOUNDS AND METHODS OF IMMUNIZATION WITH TUMOR ANTIGENS 审中-公开
标题翻译：化合物和免疫与肿瘤抗原的方法
公开(公告)号：WO2013040547A3
公开(公告)日：2014-05-08
申请号：PCT/US2012055743
申请日：2012-09-17
申请人： UNIV NEW YORK STATE RES FOUND
发明人： RITTENHOUSE-OLSON KATE , MOREY SUSAN , ABDULLAH JULIA , ALMOGREN ADEL , MOLINARO JAMIE HEIMBURG
IPC分类号： A61K39/00 , A61K38/00 , A61K38/10
CPC分类号： A61K39/0011 , A61K35/18 , A61K38/177 , A61K2039/6006
摘要： Provided are compositions and methods for prophylaxis and/or therapy of cancer. The method involves administering to an individual in need of prophylaxis and/or therapy of cancer a composition which contains tanned mammalian red blood cells complexed with one or more agent(s) that can be a peptide having any of SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3 or SEQ ID NO:4, or asialoglycophorin, or Thomsen-Friedenreich antigen (TF-Ag). Also provided are compositions which contain tanned red blood cells complexes with the peptides, asialoglycophorin, TF-Ag, or combinations thereof.
摘要翻译：提供了用于预防和/或治疗癌症的组合物和方法。该方法涉及对需要预防和/或治疗癌症的个体施用组合物，该组合物含有与可以是具有SEQ ID NO：1，SEQ ID NO：1中任一个的肽的一种或多种药剂复合的鞣制的哺乳动物红细胞 ID NO：2，SEQ ID NO：3或SEQ ID NO：4，或脱唾液酸凝乳酶，或Thomsen-Friedenreich抗原（TF-Ag）。还提供了含有鞣制红细胞与肽，脱唾液酸凝胶素，TF-Ag或其组合的复合物的组合物。

5. 发明申请

WO2014055683A1 SPECTROSCOPIC METHOD FOR ALZHEIMER'S DISEASE DIAGNOSIS 审中-公开
标题翻译：阿尔茨海默病诊断的光谱分析方法
公开(公告)号：WO2014055683A1
公开(公告)日：2014-04-10
申请号：PCT/US2013063118
申请日：2013-10-02
申请人： UNIV NEW YORK STATE RES FOUND
发明人： LEDNEV IGOR K
IPC分类号： G01J3/00 , G01J3/44 , G01N21/00 , G01N21/65
CPC分类号： G01J3/44 , G01N21/65 , G01N21/658 , G01N33/49 , G01N33/6896 , G01N2800/2821
摘要： The present invention relates to a method for detecting Alzheimer's disease in a subject. This method involves providing a sample from the subject, subjecting the sample to a spectroscopic analysis to produce a spectroscopic signature for the sample, determining whether the spectroscopic signature for the sample corresponds to an Alzheimer's disease spectroscopic signature, and identifying a subject as having Alzheimer's disease where the spectroscopic signature for the sample from that subject corresponds to the spectroscopic signature for Alzheimer's disease. Also disclosed is a method for monitoring Alzheimer's disease progression in a subject, involving providing a sample from a subject with Alzheimer's disease, subjecting the sample to a spectroscopic analysis to produce a spectroscopic signature for the sample, comparing the spectroscopic signature for the sample to a prior spectroscopic signature from the subject or to a spectroscopic signature standard for a specific stage of Alzheimer's disease, and determining the progression of Alzheimer's disease in the subject based on said comparing.
摘要翻译：本发明涉及用于检测受试者中的阿尔茨海默氏病的方法。该方法包括提供来自受试者的样品，对样品进行光谱分析以产生样品的光谱学标记，确定样品的光谱学标记是否对应于阿尔茨海默病光谱学标记，并且将受试者鉴定为患有阿尔茨海默氏病其中来自该受试者的样品的光谱特征对应于阿尔茨海默病的光谱特征。还公开了用于监测受试者中阿尔茨海默氏病进展的方法，涉及提供来自患有阿尔茨海默病的受试者的样品，对样品进行光谱分析以产生样品的光谱特征，将样品的光谱特征与基于所述比较确定来自受试者的先验光谱签名或针对阿尔茨海默病的特定阶段的光谱签名标准，以及确定受试者中阿尔茨海默病的进展。

6. 发明申请

WO2014005089A3 POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES 审中-公开
标题翻译：多酚锌结合剂（PEZBINS）促进癌症干细胞和潜在的细胞毒性抗肿瘤药物灭活
公开(公告)号：WO2014005089A3
公开(公告)日：2014-04-10
申请号：PCT/US2013048710
申请日：2013-06-28
申请人： UNIV NEW YORK STATE RES FOUND , CHEM MASTER INTERNATIONAL INC , GOLUB LOME M , JOHNSON FRANCIS , BOTCHKINA GALINA I , OJIMA IWAO
发明人： GOLUB LOME M , JOHNSON FRANCIS , BOTCHKINA GALINA I , OJIMA IWAO
IPC分类号： A61K31/121
CPC分类号： A61K31/216 , A61K31/136 , A61K31/167 , A61K31/337 , A61K31/444 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound of the invention, including CMC2.24, or a pharmaceutically acceptable salt thereof. The present invention also provides a method of down-regulating cancer stem cell-relevant transcription factors comprising contacting the cancer stem cells with a compound of the invention, including CMC2.24, or a pharmaceutically acceptable
摘要翻译：本发明提供抑制癌干细胞（CSCs）生长或促进分化和破坏的方法，包括使癌干细胞与本发明化合物（包括CMC2.24）或其药学上可接受的盐接触。本发明还提供了一种降低癌症干细胞相关转录因子的方法，包括使癌症干细胞与本发明化合物（包括CMC2.24）或其药学上可接受的

7. 发明申请

WO2014012042A8 INTRALIPID AS A CONTRAST AGENT TO ENHANCE SUBSURFACE BLOOD FLOW IMAGING 审中-公开
标题翻译：作为对比剂的INTRALIPID，以增强表面血液流动成像
公开(公告)号：WO2014012042A8
公开(公告)日：2014-03-06
申请号：PCT/US2013050348
申请日：2013-07-12
申请人： UNIV NEW YORK STATE RES FOUND , US HEALTH , PAN YINGTIAN , DU CONGWU , REN HUGANG , VOLKOW NORA
发明人： PAN YINGTIAN , DU CONGWU , REN HUGANG , VOLKOW NORA
IPC分类号： A61B5/026 , A61B5/0275 , A61K49/06
CPC分类号： A61K49/00 , A61B5/004 , A61B5/0059 , A61B5/0261 , A61B5/0275 , A61B5/0285 , A61K49/0004
摘要： The present invention provides a method of imaging blood vessels or blood flow in blood vessels in an animal comprising: (i) injecting a lipid solution into the bloodstream of the animal; (ii) imaging the blood vessels by an imaging method; and (iii) calculating the blood flow velocity in the blood vessels.
摘要翻译：本发明提供了一种对动物血管或血液流动进行成像的方法，包括：（i）将脂质溶液注射到动物的血液中; （ii）通过成像方法对血管成像; 和（iii）计算血管中的血流速度。

8. 发明申请

WO2012021415A3 ORAL COMPOSITIONS COMPRISING A ZINC COMPOUND AND AN ANTI-MICROBIAL AGENT 审中-公开
标题翻译：包含锌化合物和抗微生物剂的口服组合物
公开(公告)号：WO2012021415A3
公开(公告)日：2012-12-13
申请号：PCT/US2011046831
申请日：2011-08-05
申请人： UNIV NEW YORK STATE RES FOUND , COHEN MARVIN , COHEN SUSANNE , FLYNN BOB
发明人： COHEN MARVIN , COHEN SUSANNE , FLYNN BOB
IPC分类号： A61K9/00
CPC分类号： A61K8/27 , A61K8/19 , A61K8/20 , A61K8/22 , A61K8/345 , A61K8/36 , A61K8/368 , A61K8/4926 , A61K8/922 , A61K9/0063 , A61K9/08 , A61K31/435 , A61K31/4425 , A61K33/20 , A61K33/30 , A61K33/40 , A61K45/06 , A61K47/02 , A61K47/10 , A61K2800/882 , A61K2800/92 , A61Q11/00 , A61K2300/00
摘要： Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.
摘要翻译：本文提供了口服组合物及其使用方法。口服组合物包含包含至少一种升高化合物和药学上可接受的载体的第一组分和包含至少一种锌化合物，抗微生物剂和药学上可接受的载体的第二组分。

9. 发明申请

WO2012100038A3 PHOTOVOLTAIC CELLS WITH QUANTUM DOTS WITH BUILT-IN-CHARGE AND METHODS OF MAKING SAME 审中-公开
标题翻译：具有内置量子点的光伏电池及其制造方法
公开(公告)号：WO2012100038A3
公开(公告)日：2012-12-06
申请号：PCT/US2012021847
申请日：2012-01-19
申请人： UNIV NEW YORK STATE RES FOUND , US ARMY RES LAB , MITIN VLADIMIR , SERGEYEV ANDREI , VAGIDOV NIZAMI , LITTLE JOHN W , REINHARDT KITT , SABLON KIMBERLY
发明人： MITIN VLADIMIR , SERGEYEV ANDREI , VAGIDOV NIZAMI , LITTLE JOHN W , REINHARDT KITT , SABLON KIMBERLY
IPC分类号： H01L31/06 , H01L31/042 , H01L31/18
CPC分类号： H01L21/0237 , H01L21/02395 , H01L21/02463 , H01L21/02505 , H01L21/02521 , H01L21/02546 , H01L21/02576 , H01L21/02584 , H01L21/0259 , H01L31/035218 , H01L31/0693 , H01L31/184 , Y02E10/544 , Y02P70/521
摘要： Devices (e.g., photovoltaic devices) with quantum dots with built-in charge and methods of making such devices. The quantum dots are in a layer of n-doped semiconductor material. The devices can exhibit improved conversion and electrical properties as compared to devices without such quantum dots and n-doping.
摘要翻译：具有内置电荷的量子点的器件（例如，光伏器件）以及制造这种器件的方法。量子点位于一层n掺杂半导体材料中。与没有这种量子点和n掺杂的器件相比，器件可以表现出改善的转换和电学性质。

10. 发明申请

WO2012106693A3 COMPOSITIONS AND METHODS FOR REMOVING ASCITIC FLUID FROM THE ABDOMEN 审中-公开
标题翻译：从ABDOMEN中除去流体液的组合物和方法
公开(公告)号：WO2012106693A3
公开(公告)日：2012-11-01
申请号：PCT/US2012023902
申请日：2012-02-04
申请人： UNIV NEW YORK STATE RES FOUND , NIEMAN GARY F , SYNDER KATHLEEN P , GATTO LOUIS , ROY SHREYUS , SADOWITZ BENJAMIN
发明人： NIEMAN GARY F , SYNDER KATHLEEN P , GATTO LOUIS , ROY SHREYUS , SADOWITZ BENJAMIN
IPC分类号： A61M1/00 , A61F2/958 , A61M27/00 , A61M39/08
CPC分类号： A61M1/008 , A61M1/0084 , A61M39/08 , A61M2202/0401
摘要： The present invention features devices that can be used to extract ascites and other fluids from the body with a minimally invasive procedure and, if desired, can also be used to flush the cavity (e.g., the abdominal cavity) from which the fluids were removed. The devices also permit characterization of the fluids in that a surgeon or other health care provider can conveniently obtain a sample of the fluids to assess their composition. The amount of fluid removed from a cavity can also be determined. While the present devices and procedures are not limited to those that bring about any particular physiological response, we believe they will help maintain blood flow and prevent the accumulation of toxins and inflammatory cytokines in bodily cavities, such as the abdominal cavity. We may refer to the devices of the invention as MIST, as they allow for minimally invasive suction and treatment.
摘要翻译：本发明的特征在于可以用微创程序从体内提取腹水和其它流体的装置，并且如果需要，也可以用于冲洗除去流体的空腔（例如，腹腔）。这些装置还允许表征流体，因为外科医生或其他保健提供者可以方便地获得流体样本以评估其组成。还可以确定从空腔移除的流体的量。虽然本发明的装置和程序不限于那些产生任何特定生理反应的装置和程序，但是我们相信它们将有助于维持血液流动并防止毒素和炎性细胞因子在诸如腹腔的体腔中积累。我们可以将本发明的装置称为MIST，因为它们允许微创的吸入和治疗。

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