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1. 发明申请

WO2004017102A3 SCANNING MAGNETIC MICROSCOPE HAVING IMPROVED MAGNETIC SENSOR 审中-公开
标题翻译：扫描磁性显微镜具有改进的磁传感器
公开(公告)号：WO2004017102A3
公开(公告)日：2004-04-29
申请号：PCT/US0325390
申请日：2003-08-14
申请人： UNIV BROWN RES FOUND , XIAO GANG
发明人： XIAO GANG
IPC分类号： G01R33/038 , H01J47/00 , H01J47/252
CPC分类号： G01Q60/54 , G01Q10/04 , G01Q30/04 , G01R33/0385
摘要： A scanning magnetic microscope SMM (20) includes a sensor (10) for sensing a magnetic field generated by a specimen (78), the sensor including one of a MTJ, a GMR, or an EHE sensor; translation apparatus (22A-C, 52) for translating the sensor relative to a surface of sad specimen; and a data processor (50), having an input coupled to an output of said sensor, for constructing an image of said magnetic field. The sensor preferably includes one to three sensing units each defining a sensing axis for sensing a component of a magnetic field from a specimen, the sensing units disposed such that the sensing axes are orthogonal to one another. Pluralities of such sensors can be disposed in two or three dimensional arrays. The SMM can be used for examining the current flow in ICs, electromigration, magnetic data storage media, biomagnetic systems and magnetic ink used to print currency.
摘要翻译：扫描型磁性显微镜SMM（20）包括用于感测由样本（78）产生的磁场的传感器（10），所述传感器包括MTJ，GMR或EHE传感器中的一个; 平移装置（22A-C，52），用于相对于伤心样本的表面平移传感器; 和数据处理器（50），具有耦合到所述传感器的输出的输入，用于构建所述磁场的图像。传感器优选地包括一个至三个感测单元，每个感测单元限定用于感测来自样本的磁场的分量的感测轴，感测单元布置成使得感测轴彼此正交。多个这种传感器可以布置成二维或三维阵列。 SMM可用于检查IC，电子迁移，磁性数据存储介质，生物磁性系统和用于印刷货币的磁性墨水中的电流。

2. 发明申请

WO03083910B1 REDUCTION OF NOISE, AND OPTIMIZATION OF MAGNETIC FIELD SENSITIVITY AND ELECTRICAL PROPERTIES IN MAGNETIC TUNNEL JUNCTION DEVICES 审中-公开
标题翻译：降低噪声，优化磁隧道结器件的磁场灵敏度和电学性能
公开(公告)号：WO03083910B1
公开(公告)日：2003-12-18
申请号：PCT/US0305663
申请日：2003-02-26
申请人： UNIV BROWN RES FOUND
发明人： XIAO GANG , LIU XIAOYONG
IPC分类号： H01F10/32 , H01F41/30 , H01L43/12 , H01L21/00
CPC分类号： B82Y25/00 , B82Y40/00 , H01F10/3254 , H01F10/3268 , H01F41/302 , H01L43/12
摘要： Magnetic tunneling junction devices (MTJ) useful for sensing and memory applications and characterized by reduced resistance, magnetic noise, increased sensitivity, and increased magnetoresistance are disclosed herein. A method for fabrication of said MTJ is also disclosed wherein a series of materials are layered upon a substrate under controlled conditions, patterned and subjected to a period of annealing for simultaneously optimizing a plurality of performance parameters.
摘要翻译：本文公开了可用于感测和存储器应用并以降低的电阻，磁噪声，增加的灵敏度和增加的磁阻为特征的磁隧道结器件（MTJ）。还公开了一种用于制造所述MTJ的方法，其中在受控条件下将一系列材料层叠在衬底上，将其图案化并经历一段退火时间以同时优化多个性能参数。

3. 发明申请

WO03015615A9 TREATMENT OF MUSCULAR DYSTROPHIES AND RELATED DISORDERS 审中-公开
标题翻译：治疗肌瘤和相关疾病
公开(公告)号：WO03015615A9
公开(公告)日：2003-08-07
申请号：PCT/US0226201
申请日：2002-08-15
申请人： UNIV BROWN RES FOUND , FALLON JUSTIN R , RAFII MICHAEL
发明人： FALLON JUSTIN R , RAFII MICHAEL
IPC分类号： A61K38/17 , A61K38/39 , A61P21/00 , A61K38/00 , A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： A61K38/1709 , A61K38/1703 , A61K38/39
摘要： The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; diseases or conditions associated with an abnormal level or activity of collagen VI; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); and disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation.
摘要翻译：本发明尤其提供了用于治疗，预防和诊断与双糖链蛋白聚糖异常水平或活性相关的疾病或病症的组合物和方法; 与胶原蛋白VI的异常水平或活性相关的疾病或病症; 与不稳定的细胞质膜相关的病症，例如由于不稳定的肌营养不良蛋白相关蛋白复合物（DAPC）引起; 以及与异常突触或神经肌肉接头相关的疾病，包括由异常的MuSK激活或乙酰胆碱受体（AChR）聚集而产生的疾病。

4. 发明申请

WO0136475A9 BIGLYCAN AND RELATED THERAPEUTICS AND METHODS OF USE 审中-公开
标题翻译： BIGLYCAN及相关的治疗方法和使用方法
公开(公告)号：WO0136475A9
公开(公告)日：2002-11-21
申请号：PCT/US0031661
申请日：2000-11-17
申请人： UNIV BROWN RES FOUND
发明人： FALLON JUSTIN , MCKECHNIE BETH , RAFII MICHAEL , CREELY HILLIARY , BOWE MARK , FERRI RAYMOND
IPC分类号： A61K38/17 , G01N33/68 , C07K14/47 , C07K14/46 , C12P21/02 , G01N33/50
CPC分类号： A61K38/1709 , G01N33/6887 , G01N2400/12 , G01N2800/2878 , G01N2800/2885
摘要： The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.
摘要翻译：本发明提供了用于治疗，预防和诊断与双糖链蛋白聚糖异常水平或活性相关的疾病或病症的组合物和方法; 由于例如不稳定的肌营养不良蛋白复合体（DAPC）而与不稳定的细胞质膜相关的病症; 与异常突触或神经肌肉接头有关的疾病，包括由异常MuSK激活或乙酰胆碱受体（AChR）聚集引起的疾病。疾病的实例包括肌营养不良，例如杜兴氏肌营养不良，贝克氏肌营养不良，神经肌肉疾病和神经障碍。

5. 发明申请

WO02057841A3 ELECTRICALLY CONTROLLABLE VARIABLE REFLECTING ELEMENT 审中-公开
标题翻译：电气可控变量反射元件
公开(公告)号：WO02057841A3
公开(公告)日：2002-09-12
申请号：PCT/US0201972
申请日：2002-01-17
申请人： UNIV BROWN RES FOUND , REVEO CORP
发明人： CRAWFORD GREGORY P , BOWLEY CHRISTOPHER C , FARIS SADEG M
IPC分类号： G02F1/1334 , G02F1/31
CPC分类号： G02F1/13342 , G02F1/31 , G02F2201/346
摘要： A reflecting device having electrically controllable variable reflection is provided having a periodic array of liquid crystals disposed in a polymer matrix (76), the liquid crystal having an index of refraction variable in response to an applied electric field, and means (74, 80) for applying an electric field across the device to provide first and second applied electric field strengths. The index of refraction of the liquid crystal and the index of refraction of the polymer matrix, np, are mismatched at the first and second applied electric field strengths to provide differing peak reflective wavelengths (500, 512).
摘要翻译：提供具有电可控可变反射的反射装置，其具有设置在聚合物基体（76）中的周期性液晶阵列，所述液晶具有响应于所施加的电场而可变的折射率，以及装置（74,80）用于在装置上施加电场以提供第一和第二施加的电场强度。液晶的折射率和聚合物基体的折射率np在第一和第二施加的电场强度处不匹配，以提供不同的峰值反射波长（500,512）。

6. 发明申请

WO0168745A8 LIQUID CRYSTALLINE POLYMERS 审中-公开
标题翻译：液晶聚合物
公开(公告)号：WO0168745A8
公开(公告)日：2001-11-01
申请号：PCT/US0107386
申请日：2001-03-08
申请人： UNIV BROWN RES FOUND
发明人： MATHIOWITZ EDITH , JACOB JULES S , JONG YONG S , CHICKERING DONALD E III , EDWARDS EDWIN E
IPC分类号： A61K9/40 , B29C55/00 , B29C55/18 , C09K19/38 , C08J3/00
CPC分类号： C09K19/38 , B29C55/00 , B29C55/18 , B29K2105/0079
摘要： Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in , preferably between about 2 and 10 metric tons/in , preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics. The liquid crystalline polymers can be used in the controlled release or retention of substances encapsulated in the polymers. The polymer can be in a variety of forms including films, film laminants, and microparticles. In a preferred embodiment, the LC polymers are used to encapsulate therapeutic, diagnostic, or prophylactic agenst for use in medical or pharmaceutical applications.
摘要翻译：已经开发了用于诱导可以是非介晶的热塑性聚合物呈现液晶性质的方法。该方法包括以下步骤：（a）将聚合物从低于其玻璃化转变温度（Tg）的初始温度加热至高于其Tg并低于其熔融温度（Tm）的温度; （b）使聚合物暴露于大于约2公吨/英寸2，优选约2至10公吨/英寸2的压力下，优选至少约1分钟，同时保持温度高于其温度 TG; 和（c）在保持升高的压力的同时将聚合物冷却到Tg以下。与许多可逆的现有技术转换过程不同，该过程提供了可在环境条件下保持多年的液晶状态。在一个优选的实施方案中，塑料是可生物侵蚀的热塑性聚合物，例如聚酐，一些聚酯，聚酰胺和聚芳族化合物。液晶聚合物可用于控制释放或保留包封在聚合物中的物质。聚合物可以有多种形式，包括薄膜，薄膜层压材料和微粒。在一个优选的实施方案中，LC聚合物用于包封用于医疗或药物应用的治疗，诊断或预防剂。

7. 发明申请

WO9015637A3 NEUROLOGICAL THERAPY SYSTEM 审中-公开
标题翻译：神经治疗系统
公开(公告)号：WO9015637A3
公开(公告)日：1991-04-04
申请号：PCT/US9003492
申请日：1990-06-20
申请人： UNIV BROWN RES FOUND
发明人： AEBISCHER PATRICK , WINN SHELLEY R
IPC分类号： A61F2/02 , A61K9/00 , A61K9/20 , A61K9/22 , A61M31/00
CPC分类号： A61M31/002 , A61F2/022 , A61K9/0085 , A61M2210/0687 , A61M2210/0693 , A61M2230/005
摘要： Neurological therapy devices are disclosed for the local and controlled delivery of a neurotransmitter to the brain of a subject suffering from neurotransmitter deficiency or dysfunction. In one embodiment the device (100) includes a biocompatible, implantable, and retrievable polymeric insert (30) including a source of neurotransmitter embedded therein. In another embodiment, the device (200) includes a retrievable source of neurotransmitter including at least one neurotransmitter-secreting cell (52) encapsulated within a semipermeable membrane allowing the diffusion therethrough of the neurotransmitter, and further includes a source of growth factor in close proximity to the neurotransmitter-secreting cells.

8. 发明申请

WO2004003598A2 METHOD AND APPARATUS FOR DETECTING MULTIPLE OPTICAL WAVE LENGTHS 审中-公开
标题翻译：用于检测多个光波长的方法和装置
公开(公告)号：WO2004003598A2
公开(公告)日：2004-01-08
申请号：PCT/US0320237
申请日：2003-06-27
申请人： UNIV BROWN RES FOUND
发明人： LEVNER DANIEL , FAY MARTIN F , XU JINGMING
IPC分类号： G02B6/02 , G02B6/12 , G02B6/34 , G02F1/025 , G02F1/065 , G02B
CPC分类号： G02B6/29323 , G02B6/02061 , G02B6/02085 , G02B6/02147 , G02B6/02152 , G02B6/02195 , G02B6/12007 , G02B6/29319 , G02B6/29322 , G02B6/29334 , G02B6/29383 , G02B6/29391 , G02B6/29395 , G02F1/025 , G02F1/065 , G02F2201/307
摘要： Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide to another, controllable gratings that operate on different wavelengths in response to external control signals.
摘要翻译：通过在波长带内保留光谱信息的各种方法形成在各种波长下执行多个功能的光栅，其功能包括：将来自一个波导的辐射耦合到另一个波导，响应外部控制信号在不同波长上工作的可控光栅。

9. 发明申请

WO0120406A9 HOLOGRAPHICALLY-FORMED POLYMER DISPERSED LIQUID CRYSTALS WITH MULTIPLE GRATINGS 审中-公开
标题翻译：具有多层结构的全自动聚合物分散液晶
公开(公告)号：WO0120406A9
公开(公告)日：2002-09-12
申请号：PCT/US0024164
申请日：2000-09-05
申请人： UNIV BROWN RES FOUND , REVEO INC
发明人： BOWLEY CHRISTOPHER C , FONTECCHIO ADAM K , LIN JAUJENG , CRAWFORD GREGORY P , FARIS SADEG M , LI LE
IPC分类号： G02B5/32 , G02F1/1334 , G03H1/04 , G03H1/28 , G03H1/02
CPC分类号： G03H1/28 , G02B5/203 , G02B5/32 , G02F1/13342 , G03H1/0236 , G03H1/0248 , G03H1/04 , G03H1/265 , G03H2001/2231 , G03H2223/12 , G03H2223/18 , G03H2260/12 , G03H2260/33
摘要： A multicolored reflection liquid crystal display device includes a pair of substrates (24, 26) having a reflective holographic polymer dispersed liquid crystal (H-PDLC) film (22) disposed therebetween. The H-PDLC film contains at least two different reflection gratings (30, 33) capable of reflecting two different wavelengths of light. A multicolored reflection H-PDLC is obtained by simultaneously illuminating a plurality of regions of a film comprised of a mixture of a liquid crystal and a photo-polymerizable monomer with a plurality of holographic light patterns capable of providing liquid crystal layers of different spacings so as to obtain different reflection gratings in each of the regions.
摘要翻译：多彩反射液晶显示装置包括一对具有设置在其间的反射全息聚合物分散液晶（H-PDLC）膜（22）的基板（24,26）。 H-PDLC膜包含能够反射两种不同波长的光的至少两种不同的反射光栅（30,33）。通过同时用能够提供不同间隔的液晶层的多个全息光图案同时照射由液晶和可光聚合单体的混合物组成的膜的多个区域来获得多色反射H-PDLC，从而以在每个区域中获得不同的反射光栅。

10. 发明申请

WO0192843A3 REFLECTIVE STRAIN GAUGE AND POLARIZATION-SENSITIVE DEVICE 审中-公开
标题翻译：反射应变计和偏振敏感器件
公开(公告)号：WO0192843A3
公开(公告)日：2002-06-27
申请号：PCT/US0117377
申请日：2001-05-30
申请人： UNIV BROWN RES FOUND , REVEO INC
发明人： CRAWFORD GREGORY C , CAIRNS DARRAN R , BOWLEY CHRISTOPHER C , DANWORAPHONG SORASAK , FONTECCHIO ADAM K , FARIS SADEG M , LI LE
IPC分类号： G01B11/16 , G01L1/24 , G02F1/1334
CPC分类号： G01B11/165 , G01B11/18 , G01L1/241 , G02F1/13342
摘要： A reflective strain gauge includes an holographically-formed polymer dispersed liquid crystal (H-PDLC) film comprising layers of liquid crystal (LC) droplets in a matrix polymer, the H-PDLC film having a reflection or transmission grating capable of reflecting or transmitting light of a selected wavelength, and means for adhering the film to a surface of a workpiece for monitoring the strain at said surface. A change in the nature of the reflected light is an indication of strain. Also included is a polarizing material having an holographically-formed polymer dispersed liquid crystal (H-PDLC) film comprising layers of liquid crystal (LC) droplets in a matrix polymer, the H-PDLC film having a reflection grating capable of reflecting light of a selected wavelength, wherein the reflection grating of the H-PDLC film is oriented, such that the refractive index parallel to said axis of orientation (ne) is greater than the refractive index perpendicular to said axis no).
摘要翻译：反射应变计包括在基质聚合物中包含液晶（LC）液滴层的全息形成的聚合物分散液晶（H-PDLC）膜，该H-PDLC膜具有能够反射或透射光的反射或透射光栅以及用于将膜粘附到工件的表面以用于监测所述表面处的应变的装置。反射光的性质的变化表明了应变。还包括具有在基体聚合物中包含液晶（LC）液滴层的全息形成的聚合物分散液晶（H-PDLC）膜的偏振材料，该H-PDLC膜具有能够反射光的反射光栅选择的波长，其中H-PDLC膜的反射光栅被定向，使得平行于所述取向轴（ne）的折射率大于垂直于所述轴线no）的折射率。

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