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1. 发明申请

WO2016033351A2 DOUBLE ACTION INFUSION SYSTEM 审中-公开
标题翻译：双重作用输液系统
公开(公告)号：WO2016033351A2
公开(公告)日：2016-03-03
申请号：PCT/US2015047240
申请日：2015-08-27
申请人： BOSTON SCIENT LTD , BONNETTE MICHAEL J
发明人： BONNETTE MICHAEL J , UBER ARTHUR E
IPC分类号： A61M5/142
CPC分类号： A61M5/1422 , A61M5/007 , A61M2005/1402 , A61M2005/1403 , A61M2005/3123
摘要： An infusion system includes a double action infusion pump. The pump includes a cylinder and a reciprocating piston received within the cylinder, the reciprocating piston separating a first pump chamber from a second pump chamber of the cylinder. A reciprocating motor is coupled with the reciprocating piston, and the first and second pump chambers alternate between filling and evacuating conditions with reciprocation of the reciprocating piston through operation of the reciprocating motor, and the speed of reciprocation is varied to provide a continuous output of fluid between the first and second pump chambers. A fluid source and a catheter are optionally coupled with the double action infusion pump. The catheter includes one or more infusion ports near a catheter distal portion, and the one or more infusion ports receive and expel the continuous output of fluid from the double action infusion pump.
摘要翻译：输液系统包括双作用输液泵。该泵包括气缸和容纳在气缸内的往复式活塞，往复式活塞将第一泵室与气缸的第二泵室分隔开。往复式马达与往复式活塞联接，并且第一和第二泵室在填充和抽空条件之间交替，通过往复式马达的操作使往复式活塞往复运动，并且往复运动的速度改变以提供流体的连续输出在第一和第二泵室之间。流体源和导管可选地与双作用输液泵连接。导管包括靠近导管远端部分的一个或多个注入端口，并且一个或多个注入端口接收和排出来自双动式输液泵的流体的连续输出。

2. 发明申请

WO2009059085A3 NANO-PATTERNED IMPLANT SURFACES 审中-公开
公开(公告)号：WO2009059085A3
公开(公告)日：2010-05-06
申请号：PCT/US2008081920
申请日：2008-10-31
申请人： BOSTON SCIENT LTD , SCHEUERMANN TOSTEN , KUHLING MICHAEL
发明人： SCHEUERMANN TOSTEN , KUHLING MICHAEL
IPC分类号： A61L31/08 , A61F2/90 , A61L31/10 , A61L31/14
CPC分类号： A61L31/14 , A61F2/91 , A61F2230/0054 , A61L31/148 , A61L2400/12
摘要： A bioerodible endoprosthesis erodes to a desirable geometry that can provide, e.g., improved mechanical properties or degradation characteristics.
摘要翻译：生物腐蚀性内用假体侵蚀到可以提供例如改善的机械性能或降解特性的期望几何形状。

3. 发明申请

WO2009079389A3 DRUG-ELUTING ENDOPROSTHESIS 审中-公开
标题翻译：药物治疗内吞
公开(公告)号：WO2009079389A3
公开(公告)日：2010-04-08
申请号：PCT/US2008086639
申请日：2008-12-12
申请人： BOSTON SCIENT LTD , CLARKE JOHN T , O'CONNOR TIM , XU YIXIN , O'BRIEN BARRY , ARCAND BEN , SHIPPY JAMES LEE III , ATANASOSKA LILIANA , FLANAGAN AIDEN , MCMORROW DAVE , WEBER JAN , KREMER JOHN , KUEHLING MICHAEL , SEIDEL DOMINIQUE
发明人： CLARKE JOHN T , O'CONNOR TIM , XU YIXIN , O'BRIEN BARRY , ARCAND BEN , SHIPPY JAMES LEE III , ATANASOSKA LILIANA , FLANAGAN AIDEN , MCMORROW DAVE , WEBER JAN , KREMER JOHN , KUEHLING MICHAEL , SEIDEL DOMINIQUE
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/45 , A61L2300/61
摘要： A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
摘要翻译：包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。每个离散的沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。所述至少两个生物浸渍金属区域彼此电接触。生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。

4. 发明申请

WO2009009627A3 ENDOPROSTHESIS COATING 审中-公开
标题翻译：内部涂层
公开(公告)号：WO2009009627A3
公开(公告)日：2010-01-14
申请号：PCT/US2008069579
申请日：2008-07-10
申请人： BOSTON SCIENT LTD , KUEHLING MICHAEL
发明人： KUEHLING MICHAEL
IPC分类号： A61L31/18 , A61F2/06 , A61F2/82 , A61L31/02 , A61L31/10 , A61L31/16
CPC分类号： A61F2/06 , A61L31/026 , A61L31/10
摘要： An endoprosthesis, such as a stent, includes anchoring regions formed of polymer that enhance adherence of a coating, e.g. a drug eluting polymer coating, to a stent surface, e.g. made of ceramic. The anchoring regions can be formed using stamping processes.
摘要翻译：内置假体，例如支架，包括由聚合物形成的锚定区域，其增强涂层的附着力，例如，药物洗脱聚合物涂层，例如支架表面。陶瓷制成。锚定区域可以使用冲压工艺形成。

5. 发明申请

WO2008124513A3 STENTS WITH DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：具有药物储存层的方法及其制备和使用方法
公开(公告)号：WO2008124513A3
公开(公告)日：2009-12-23
申请号：PCT/US2008059280
申请日：2008-04-03
申请人： BOSTON SCIENT LTD , ATANASOSKA LILIANA , WEBER JAN , WARNER ROBERT W
发明人： ATANASOSKA LILIANA , WEBER JAN , WARNER ROBERT W
IPC分类号： A61L31/02 , A61L31/08 , A61L31/16
CPC分类号： A61L31/082 , A61L31/022 , A61L31/16 , A61L2300/608 , A61L2420/08
摘要： A method of making drug eluting stents comprises forming ceramic surface coatings of two or more levels of porosity on a stent body. The less porous coating is more conducive to endothelial cell growth, while the more porous coating is better suited for storing and releasing drugs. The surface coatings of different porosities can be produced by coating stent body surface of differing roughness with coatings made by sol-gel method. Differing roughness of the stent body surface can be produced by selective etching of the stent body surface.
摘要翻译：制备药物洗脱支架的方法包括在支架主体上形成两个或多个孔隙度水平的陶瓷表面涂层。多孔涂层更有利于内皮细胞生长，而多孔涂层更适合于储存和释放药物。不同孔隙度的表面涂层可以通过使用溶胶 - 凝胶法制成的涂层涂覆不同粗糙度的支架体表面来生产。可以通过选择性蚀刻支架体表面来产生支架体表面的不同粗糙度。

6. 发明申请

WO2008088536A3 DIFFERENTIAL DRUG RELEASE FROM A MEDICAL DEVICE 审中-公开
标题翻译：来自医疗器械的差别药物释放
公开(公告)号：WO2008088536A3
公开(公告)日：2009-10-01
申请号：PCT/US2007025346
申请日：2007-12-11
申请人： BOSTON SCIENT LTD , GREGORICH DANIEL J , MEYER MIKE
发明人： GREGORICH DANIEL J , MEYER MIKE
IPC分类号： A61L31/10 , A61L31/02 , A61L31/04 , A61L31/14 , A61L31/16
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/45 , A61L2300/602
摘要： The invention relates to a medical device, such as an intravascular stent, useful for delivering two or more therapeutic agents to a body tissue of a patient at different rates, and methods for making and using such medical device. The medical device includes a substrate and/or coating having a plurality of pores, dispersed in said pores are a plurality of a first and a second therapeutic agents, wherein said first therapeutic agent is bonded to one or more molecule(s) of a first material and the second therapeutic agent bonded to one or more molecule(s) of a second material, such that when the medical device, is in use (e.g., implanted into a body lumen such as a blood vessel), bonded first therapeutic agent is released from the medical device at a rate that is slower than the rate at which the bonded second therapeutic agent is released from the medical device.
摘要翻译：本发明涉及可用于将两种或更多种治疗剂以不同速率递送到患者的身体组织的医疗装置，例如血管内支架，以及制造和使用该医疗装置的方法。医疗装置包括具有多个孔的基底和/或涂层，分散在所述孔中是多个第一和第二治疗剂，其中所述第一治疗剂与一个或多个第一材料和第二治疗剂结合到第二材料的一个或多个分子，使得当使用医疗装置（例如，植入体腔诸如血管）时，结合的第一治疗剂是以比从粘合的第二治疗剂从医疗装置释放的速度慢的速度从医疗装置释放。

7. 发明申请

WO2008108987A3 MEDICAL DEVICE WITH A POROUS SURFACE FOR DELIVERY OF A THERAPEUTIC AGENT 审中-公开
标题翻译：具有用于递送治疗剂的多孔表面的医疗装置
公开(公告)号：WO2008108987A3
公开(公告)日：2009-09-03
申请号：PCT/US2008002711
申请日：2008-02-29
申请人： BOSTON SCIENT LTD , FLANAGAN AIDEN , MCMORROW DAVID , MALONE ANTHONY , O'CONNOR TIM
发明人： FLANAGAN AIDEN , MCMORROW DAVID , MALONE ANTHONY , O'CONNOR TIM
IPC分类号： A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61F2/06 , A61L31/082 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.
摘要翻译：本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置和用于制造这种医疗装置的方法。特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包括多个空腔的表面和多个孔以及设置在孔和/或空腔中的组合物，以及植入式医疗装置，例如血管内支架，其具有设置在表面上的涂层组合物的表面，其中所述涂层组合物包括多个空腔和多个孔以及设置在孔和/或空腔中的另一涂层组合物。

8. 发明申请

WO2008091835A3 IMPLANTABLE MEDICAL ENDOPROSTHESES 审中-公开
标题翻译：可植入医学内吞
公开(公告)号：WO2008091835A3
公开(公告)日：2009-08-06
申请号：PCT/US2008051607
申请日：2008-01-22
申请人： BOSTON SCIENT LTD , ATANASOSKA LILIANA , WEBER JAN , SCHEWE SCOTT R , WARNER ROBERT W
发明人： ATANASOSKA LILIANA , WEBER JAN , SCHEWE SCOTT R , WARNER ROBERT W
IPC分类号： A61L31/02 , A61F2/82 , A61F2/90 , A61L31/08 , A61L31/14
CPC分类号： A61L31/022 , A61F2/12 , A61F2/82 , A61F2/88 , A61F2/90 , A61F2/91 , A61L31/08 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/62
摘要： Implantable medical endoprostheses, as well as related systems and methods are disclosed.
摘要翻译：公开了可植入医疗内用假体，以及相关系统和方法。

9. 发明申请

WO2009059196A2 ENDOPROSTHESIS WITH COATING 审中-公开
标题翻译：涂层涂层
公开(公告)号：WO2009059196A2
公开(公告)日：2009-05-07
申请号：PCT/US2008082074
申请日：2008-10-31
申请人： BOSTON SCIENT LTD , FOSS AARON , RIZQ RAED , VANCAMP DANIEL
发明人： FOSS AARON , RIZQ RAED , VANCAMP DANIEL
IPC分类号： A61L31/08 , A61L31/14
CPC分类号： A61L31/088 , A61L31/14
摘要： An endoprosthesis such as a coronary stent includes a surface region that defines a depression in the form of a channel, the depression having an interior surface, and an enhanced roughness on the interior surface.
摘要翻译：诸如冠状动脉支架的内假体包括限定通道形式的凹陷的表面区域，凹陷具有内表面，并且在内表面上具有增强的粗糙度。

10. 发明申请

WO2009059086A2 DEFORMABLE UNDERLAYER FOR STENT 审中-公开
标题翻译：不可逆转的底层
公开(公告)号：WO2009059086A2
公开(公告)日：2009-05-07
申请号：PCT/US2008081921
申请日：2008-10-31
申请人： BOSTON SCIENT LTD , GREGORICH DANIEL J , SORENSON SHAWN
发明人： GREGORICH DANIEL J , SORENSON SHAWN
IPC分类号： A61L31/02 , A61L31/08 , A61L31/10
CPC分类号： A61F2/06 , A61L31/088 , A61L31/16 , A61L31/18 , A61L2300/00
摘要： An endoprosthesis includes a brittle layer, e.g. a ceramic and an underlayer to accommodate dimensional changes as the endoprosthesis is flexed.
摘要翻译：内置假体包括脆性层，例如陶瓷和底层，以容纳尺寸变化，因为内置假体弯曲。

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