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1. 发明申请

WO2009132176A2 MEDICAL DEVICES HAVING INORGANIC PARTICLE LAYERS 审中-公开
标题翻译：具有无机颗粒层的医疗器械
公开(公告)号：WO2009132176A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041520
申请日：2009-04-23
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KUEHLING, Michael , SEIDEL, Dominique , SCHEUERMANN, Torsten , WEBER, Jan
发明人： KUEHLING, Michael , SEIDEL, Dominique , SCHEUERMANN, Torsten , WEBER, Jan
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L31/16 , A61L31/08 , A61L2300/61 , A61L2300/62 , A61L2420/02
摘要： An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles.
摘要翻译：一种可膨胀医疗装置，其具有设置在含有治疗剂的贮器上方的颗粒层。当医疗装置处于未膨胀构型时，颗粒层具有第一孔隙度，并且当医疗装置处于膨胀构型时具有第二孔隙率。颗粒层包含多个微米级或纳米尺寸的颗粒。在某些实施方案中，颗粒彼此不连接，因此，当医疗装置膨胀/未膨胀时，由颗粒之间的间隔的变化提供不同的孔隙度。还公开了具有颗粒层的医疗装置，其中所述颗粒层包含多个包封的颗粒，以及用颗粒涂覆医疗装置的方法。

2. 发明申请

WO2009079389A2 DRUG-ELUTING ENDOPROSTHESIS 审中-公开
标题翻译：药物治疗内吞
公开(公告)号：WO2009079389A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/086639
申请日：2008-12-12
申请人： BOSTON SCIENTIFIC LIMITED , CLARKE, John T. , O'CONNOR, Tim , XU, Yixin , O'BRIEN, Barry , ARCAND, Ben , SHIPPY, James Lee, III , ATANASOSKA, Liliana , FLANAGAN, Aiden , MCMORROW, Dave , WEBER, Jan , KREMER, John , KUEHLING, Michael , SEIDEL, Dominique
发明人： CLARKE, John T. , O'CONNOR, Tim , XU, Yixin , O'BRIEN, Barry , ARCAND, Ben , SHIPPY, James Lee, III , ATANASOSKA, Liliana , FLANAGAN, Aiden , MCMORROW, Dave , WEBER, Jan , KREMER, John , KUEHLING, Michael , SEIDEL, Dominique
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/45 , A61L2300/61
摘要： A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
摘要翻译：包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。每个离散的沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。所述至少两个生物浸渍金属区域彼此电接触。生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。

3. 发明申请

WO2010022226A2 MEDICAL DEVICES HAVING A COATING FOR ELECTROMAGNETICALLY-CONTROLLED RELEASE OF THERAPEUTIC AGENTS 审中-公开
标题翻译：具有用于电磁控制释放治疗剂的涂层的医疗装置
公开(公告)号：WO2010022226A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/054442
申请日：2009-08-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , PRIEBE, Tom , ANAND, Umang , GIBSON, Lance , CLAPP, Les , KUEHLING, Michael
发明人： PRIEBE, Tom , ANAND, Umang , GIBSON, Lance , CLAPP, Les , KUEHLING, Michael
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L27/34 , A61L27/50 , A61L27/54 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/606 , C08L101/12
摘要： Medical devices having a coating comprising an ionic polymer for electromagnetically- controlled release of a therapeutic agent. Release of the therapeutic agent from the coating is facilitated or modulated by the application of an electromagnetic field to the medical device. Exposure to the electromagnetic field may cause the release of the therapeutic agent in various ways, including electrochemical changes in the ionic polymer, structural changes in the coating and/or ionic polymers, changes in the permeability of the coating, changes in the orientation of the ionic polymers, or motion of the ionic polymers. Also disclosed are methods for delivering a therapeutic agent using electromagnetic fields.
摘要翻译：具有涂层的医疗装置，所述涂层包含用于电磁控制释放治疗剂的离子聚合物。治疗剂从涂层中的释放通过向医疗装置施加电磁场而促进或调节。暴露于电磁场可以以各种方式引起治疗剂的释放，包括离子聚合物中的电化学变化，涂层和/或离子聚合物中的结构变化，涂层渗透性的变化，离子聚合物或离子聚合物的运动。还公开了使用电磁场递送治疗剂的方法。

4. 发明申请

WO2010011515A2 MEDICAL DEVICES HAVING INORGANIC BARRIER COATINGS 审中-公开
标题翻译：具有无机屏障涂层的医疗器械
公开(公告)号：WO2010011515A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/050365
申请日：2009-07-13
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SCHEUERMANN, Torsten , KUEHLING, Michael , WEBER, Jan , SEIDEL, Dominique
发明人： SCHEUERMANN, Torsten , KUEHLING, Michael , WEBER, Jan , SEIDEL, Dominique
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/082 , A61L31/146 , A61L2300/608 , A61L2420/08
摘要： Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask.
摘要翻译：具有包含无机材料的阻挡层的医疗装置。医疗装置具有含有治疗剂的储液器，并且阻挡层设置在贮存器的上方。在一个方面，阻挡层在医疗装置的一部分处具有对治疗剂的一种渗透性，并且在医疗装置的另一部分具有不同的渗透性。另一方面，医疗器械的一部分处的储存器中的治疗剂的剂量与医疗器械的另一部分处的储存器中的治疗剂的剂量不同。在另一方面，生物可再吸收层设置在医疗装置的一个或多个部分的阻挡层之上，其中生物可再吸收层包括生物可再吸收材料。此外，公开了涂覆医疗装置的方法，其中使用光刻蚀刻工艺形成医疗装置上的阻挡层，其中多个颗粒用作蚀刻掩模。

5. 发明申请

WO2009009627A2 ENDOPROSTHESIS COATING 审中-公开
标题翻译：内部涂层
公开(公告)号：WO2009009627A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/069579
申请日：2008-07-10
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KUEHLING, Michael
发明人： KUEHLING, Michael
IPC分类号： A61L31/02 , A61L31/10
CPC分类号： A61F2/06 , A61L31/026 , A61L31/10
摘要： An endoprosthesis, such as a stent, includes anchoring regions formed of polymer that enhance adherence of a coating, e.g. a drug eluting polymer coating, to a stent surface, e.g. made of ceramic. The anchoring regions can be formed using stamping processes.
摘要翻译：内置假体，例如支架，包括由聚合物形成的锚定区域，其增强涂层的附着力，例如，药物洗脱聚合物涂层，例如支架表面。陶瓷制成。锚定区域可以使用冲压工艺形成。

6. 发明申请

WO2008034007A3 MEDICAL DEVICES 审中-公开
标题翻译：医疗设备
公开(公告)号：WO2008034007A3
公开(公告)日：2008-05-15
申请号：PCT/US2007078407
申请日：2007-09-13
申请人： BOSTON SCIENT SCIMED INC , BOISMIER DENNIS A , MILLER MATTHEW , KUEHLING MICHAEL
发明人： BOISMIER DENNIS A , MILLER MATTHEW , KUEHLING MICHAEL
IPC分类号： A61F2/90
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61F2002/91575 , A61F2210/0004 , A61F2230/0054 , A61F2250/003 , A61F2250/0054 , A61F2250/0068 , A61F2250/0071 , A61L31/128 , A61L31/146 , A61L31/16 , A61L2300/00
摘要： A tubular endoprothesis, comprising a generally tubular member comprising biodegradable metal foam. The pores can be used as drug reservoir. Methods for producing are described.
摘要翻译：一种管状内支承，其包括包含可生物降解金属泡沫的大体管状构件。毛孔可用作药物储库。描述生产方法。

7. 发明申请

WO2008034007A2 MEDICAL DEVICES 审中-公开
标题翻译：医疗设备
公开(公告)号：WO2008034007A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/078407
申请日：2007-09-13
申请人： BOSTON SCIENTIFIC SCIMED, INC. , BOISMIER, Dennis A. , MILLER, Matthew , KUEHLING, Michael
发明人： BOISMIER, Dennis A. , MILLER, Matthew , KUEHLING, Michael
IPC分类号： A61L31/14 , A61L31/16 , A61L31/12 , A61L31/02
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61F2002/91575 , A61F2210/0004 , A61F2230/0054 , A61F2250/003 , A61F2250/0054 , A61F2250/0068 , A61F2250/0071 , A61L31/128 , A61L31/146 , A61L31/16 , A61L2300/00
摘要： Medical devices, such as endoprostheses, and methods of making the devices are disclosed.
摘要翻译：公开了医疗装置，例如内用假体，以及制造装置的方法。

8. 发明申请

WO2009135008A3 DRUG-LOADED MEDICAL DEVICES AND METHODS FOR MANUFACTURING DRUG-LOADED MEDICAL DEVICES 审中-公开
标题翻译：药物装载医疗装置及其制造装载药物的方法
公开(公告)号：WO2009135008A3
公开(公告)日：2010-12-02
申请号：PCT/US2009042319
申请日：2009-04-30
申请人： BOSTON SCIENT SCIMED INC , KUEHLING MICHAEL , XU YIXIN
发明人： KUEHLING MICHAEL , XU YIXIN
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/606
摘要： Drug-loaded medical devices such as stents and methods for manufacturing them are provided. In certain embodiments, the therapeutic agent is loaded only in or on areas of the medical device that do not undergo substantial deformation during expansion. The medical device may be provided with reservoirs in or on the first portions of the medical device that do not undergo substantial deformation during expansion, and the therapeutic agent may be loaded in these reservoirs. The reservoirs may be covered with a porous coating which may be a non- polymeric coating. In other embodiments, a non-polymeric coating is provided in a discontinuous manner in or on the medical device. A method includes the steps of providing a transfer member that includes a translucent substrate and a layer of transfer material such as a film or foil; attaching reservoirs to the transfer material; positioning the transfer member with the reservoirs adjacent a medical device, such as a stent, with the reservoirs facing the medical device; and directing a laser beam at the transfer member such that the laser beam passes through the translucent substrate to vaporize a portion of the transfer material, creating a pocket of trapped gas between the translucent substrate and reservoir, thereby forcing the reservoir from the transfer member to the medical device. The reservoirs may be formed of a non-polymeric material.
摘要翻译：提供诸如支架的药物装载的医疗装置及其制造方法。在某些实施方案中，治疗剂仅在扩张期间不经历基本变形的医疗装置的区域中或其上加载。医疗装置可以在医疗装置的第一部分中或其上设置有在膨胀期间不经历实质变形的第一部分上的储存器，并且治疗剂可以装载在这些储存器中。储存器可以用可以是非聚合物涂层的多孔涂层覆盖。在其它实施方案中，在医疗装置中或其上以不连续的方式提供非聚合物涂层。一种方法包括提供包括透光性基板和转印材料层例如膜或箔的转印部件的步骤; 将储存器附接到转印材料上; 将所述转移构件与所述储存器邻近医疗装置（例如支架）定位，所述储存器面向所述医疗装置; 并且将激光束引导在转印部件处，使得激光束通过透光性基板以蒸发转印材料的一部分，从而在透光性基板和储存器之间形成捕获气体的袋状物，从而迫使储存器从转印部件医疗器械。储存器可以由非聚合材料形成。

9. 发明申请

WO2010022226A3 MEDICAL DEVICES HAVING A COATING FOR ELECTROMAGNETICALLY-CONTROLLED RELEASE OF THERAPEUTIC AGENTS 审中-公开
标题翻译：具有用于电磁控制释放治疗剂的涂层的医疗装置
公开(公告)号：WO2010022226A3
公开(公告)日：2010-11-25
申请号：PCT/US2009054442
申请日：2009-08-20
申请人： BOSTON SCIENT SCIMED INC , PRIEBE TOM , ANAND UMANG , GIBSON LANCE , CLAPP LES , KUEHLING MICHAEL
发明人： PRIEBE TOM , ANAND UMANG , GIBSON LANCE , CLAPP LES , KUEHLING MICHAEL
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L27/34 , A61L27/50 , A61L27/54 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/606 , C08L101/12
摘要： Medical devices having a coating comprising an ionic polymer for electromagnetically- controlled release of a therapeutic agent. Release of the therapeutic agent from the coating is facilitated or modulated by the application of an electromagnetic field to the medical device. Exposure to the electromagnetic field may cause the release of the therapeutic agent in various ways, including electrochemical changes in the ionic polymer, structural changes in the coating and/or ionic polymers, changes in the permeability of the coating, changes in the orientation of the ionic polymers, or motion of the ionic polymers. Also disclosed are methods for delivering a therapeutic agent using electromagnetic fields.
摘要翻译：具有包含用于电磁控制释放治疗剂的离子聚合物的涂层的医疗装置。通过向医疗装置施加电磁场来促进或调节治疗剂从涂层的释放。暴露于电磁场可能导致治疗剂以各种方式释放，包括离子聚合物的电化学变化，涂层和/或离子聚合物的结构变化，涂层渗透性的变化，离子聚合物或离子聚合物的运动。还公开了使用电磁场递送治疗剂的方法。

10. 发明申请

WO2010011515A3 MEDICAL DEVICES HAVING INORGANIC BARRIER COATINGS 审中-公开
标题翻译：具有无机屏障涂层的医疗设备
公开(公告)号：WO2010011515A3
公开(公告)日：2010-11-25
申请号：PCT/US2009050365
申请日：2009-07-13
申请人： BOSTON SCIENT SCIMED INC , SCHEUERMANN TORSTEN , KUEHLING MICHAEL , WEBER JAN , SEIDEL DOMINIQUE
发明人： SCHEUERMANN TORSTEN , KUEHLING MICHAEL , WEBER JAN , SEIDEL DOMINIQUE
IPC分类号： A61L31/14 , A61L31/08 , A61L31/16
CPC分类号： A61L31/16 , A61L31/082 , A61L31/146 , A61L2300/608 , A61L2420/08
摘要： Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask.
摘要翻译：具有包含无机材料的阻挡层的医疗装置。医疗装置具有容纳治疗剂的储存器，并且阻挡层设置在储存器上方。在一个方面，阻隔层在医疗装置的一部分具有对治疗剂的一种渗透性，并且在医疗装置的另一部分具有不同的渗透性。在另一方面，医疗装置的一部分处的储器中的治疗剂的剂量与医疗装置的另一部分处的储器中的治疗剂的剂量不同。另一方面，生物可再吸收层在医疗装置的一个或多个部分处设置在阻隔层上，其中生物可吸收层包含生物可吸收材料。而且，公开了涂覆医疗装置的方法，其中使用平版印刷蚀刻工艺形成医疗装置上的阻挡层，其中多个颗粒用作蚀刻掩模。

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