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1. 发明申请

WO2014041500A2 DOUBLE MUTANT COAGULATION FACTOR VIII AND METHODS THEREOF 审中-公开
标题翻译：双突变凝血因子VIII及其方法
公开(公告)号：WO2014041500A2
公开(公告)日：2014-03-20
申请号：PCT/IB2013058490
申请日：2013-09-12
申请人： CT FOR BIOSEPARATION TECHNOLOGY VIT , CHRISTIAN MEDICAL COLLEGE
发明人： ARUNACHALAM VIJAYALAKSHMI MOOKAMBESWARAN , JOSEPH BILGIMOL CHUVAPPUMKAL , KUTTY SATHEESHKUMAR PADIKKARA , NAIR SUKESH CHANDRAN , SRIVASTAVA ALOK
IPC分类号： C12P21/06
CPC分类号： C07K14/755 , A61K38/00 , C12N9/647
摘要： The present disclosure is in the field of haemophilia therapeutics, particularly recombinant Factor VIII protein products. The present disclosure relates to a double mutant B-domain deleted Factor VIII gene having mutations at Phe309Ser and Asp519Val respectively. The disclosure also relates to the production of double mutant B-domain deleted Factor VIII protein having mutations at Phe309Ser and Asp519Val respectively. The said protein shows enhanced activity and stability and therefore is used in the management of haemophilia.
摘要翻译：本公开内容属于血友病治疗学领域，特别是重组因子VIII蛋白质产品。本公开涉及分别在Phe309Ser和Asp519Val处具有突变的双突变体B结构域缺失的因子VIII基因。本公开还涉及产生分别在Phe309Ser和Asp519Val具有突变的双突变体B结构域缺失的因子VIII蛋白质。所述蛋白质显示增强的活性和稳定性，因此用于血友病的处理。

2. 发明申请

WO2013036445A1 METHODS FOR PROCESSING COAGULATION FACTORS 审中-公开
标题翻译：加工凝血因子的方法
公开(公告)号：WO2013036445A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/053319
申请日：2012-08-31
申请人： MEDIMMUNE LLC , HUNTER, Alan , WANG, Xiangyang , PABST, Timothy , WENDELER, Michaela , WANG, Jihong , CAREY, Kendall , STROUSE, Robert , VARGHESE, Johnson
发明人： HUNTER, Alan , WANG, Xiangyang , PABST, Timothy , WENDELER, Michaela , WANG, Jihong , CAREY, Kendall , STROUSE, Robert , VARGHESE, Johnson
IPC分类号： C12P21/02
CPC分类号： C12N9/6429 , C07K14/745 , C12N9/647
摘要： The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.
摘要翻译：本申请涉及用于纯化重组凝血因子蛋白的方法，包括例如凝血酶原（凝血因子）（因子II）。在实施方案中，所述方法提供显示增加的生物活性和降低凝血酶水平的纯化凝血酶原，从而增加凝血酶原的安全性。还提供了纯化的重组凝血因子蛋白。

3. 发明申请

WO2010140140A1 COMPOSITION DE COMPLEXE PROTHROMBIQUE 审中-公开
标题翻译：丙烯酸复合组合物
公开(公告)号：WO2010140140A1
公开(公告)日：2010-12-09
申请号：PCT/IB2010/052497
申请日：2010-06-04
申请人： LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES , CHABBAT, Jacques
发明人： CHABBAT, Jacques
IPC分类号： C12N9/64 , C12N9/74
CPC分类号： C12N9/644 , C12N9/6429 , C12N9/6432 , C12N9/6437 , C12N9/6464 , C12N9/647 , C12Y304/21005 , C12Y304/21006 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069
摘要： La présente invention concerne un procédé de préparation d'une composition ou concentré de complexe prothrombique comprenant les facteurs de coagulation II, VII, IX et X, ledit procédé comprenant les étapes consistant à fournir un surnageant d'un cryoprécipité de plasma, à appliquer ledit surnageant sur une résine échangeuse d' anions pour obtenir un éluat contenant ledit complexe et des protéines de haut poids moléculaire et à appliquer ledit éluat sur une colonne d' hydroxyapatite pour obtenir un second éluat contenant ledit complexe. L' invention fournit encore une composition susceptible d'être obtenue par ce procédé.
摘要翻译：本发明涉及一种制备包含II，VII，IX和X凝血因子的血栓原因复合物的组合物或浓缩物的方法，其中所述方法包括以下步骤：提供血浆冷沉淀物的上清液，将所述上清液阴离子交换树脂以产生含有所述络合物的洗脱液和具有高分子量的蛋白质，并将所述洗脱液施用在羟基磷灰石柱上以产生含有所述复合物的第二洗脱液。本发明还涉及可通过所述方法生产的组合物。

4. 发明申请

WO2008134665A8 RECOMBINANT VITAMIN K DEPENDENT PROTEINS WITH HIGH SIALIC ACID CONTENT AND METHODS OF PREPARING SAME 审中-公开
标题翻译：具有高酸度含量的重组维生素K依赖性蛋白质及其制备方法
公开(公告)号：WO2008134665A8
公开(公告)日：2009-09-03
申请号：PCT/US2008061822
申请日：2008-04-28
申请人： INSPIRATION BIOPHARMACEUTICALS , GRIFFITH MICHAEL J , DROHAN MARIAN J
发明人： GRIFFITH MICHAEL J , DROHAN MARIAN J , DROHAN WILLIAM N
IPC分类号： A61K35/14 , A23J1/00 , C07K1/00
CPC分类号： C12N9/644 , A61K38/00 , C07K14/745 , C12N9/647 , C12P21/005 , C12Y304/21022
摘要： Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N- glycosylation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties.
摘要翻译：描述了通过色谱法分离高度唾液酸化的重组维生素K依赖性蛋白质，特别是因子IX的方法。表征高度唾液酸化的重组蛋白。改进的因子IX具有至少62％的N-糖基化，具有3或4个唾液酸残基和改善的生物利用度和药物动力学性质。

5. 发明申请

WO2008015339A3 RECOMBINANT FACTOR VII COMPOSITION 审中-公开
标题翻译：重组因子VII组成
公开(公告)号：WO2008015339A3
公开(公告)日：2008-04-17
申请号：PCT/FR2007001324
申请日：2007-07-31
申请人： LFB BIOTECHNOLOGIES , CHTOUROU ABDESSATAR SAMI , NONY EMMANUEL , BIHOREAU NICOLAS
发明人： CHTOUROU ABDESSATAR SAMI , NONY EMMANUEL , BIHOREAU NICOLAS
IPC分类号： A61K38/36 , A61K38/48 , C07K14/745 , C12P21/00
CPC分类号： C12N9/50 , A01K2217/05 , A01K2227/107 , A01K2267/01 , A61K38/00 , C07K14/745 , C12N9/6437 , C12N9/647 , C12Y304/21021
摘要： The present invention concerns a recombinant or transgenic factor VII composition, each factor VII molecule of the composition having glycan forms linked to N-glycosylation sites, wherein among all the factor VII molecules in said composition, glycan, biantennary, bisialylated, and non-fucosylated forms are in the majority. The invention also concerns such a composition for use as a medication, and a method for preparing said composition, among others.
摘要翻译：本发明涉及重组或转基因因子VII组合物，组合物的每个因子VII分子具有与N-糖基化位点连接的聚糖形式，其中在所述组合物中的所有因子VII分子中，聚糖，双天冬氨酸，双唾液酸化和非岩藻糖基化形式多数。本发明还涉及用作药物的这种组合物，以及用于制备所述组合物的方法等。

6. 发明申请

WO2004101739A2 METHODS FOR CHEMICALLY SYNTHESIZING IMMUNOGLOBULIN CHIMERIC PROTEINS 审中-公开
标题翻译：化学合成免疫蛋白质半胱氨酸蛋白质的方法
公开(公告)号：WO2004101739A2
公开(公告)日：2004-11-25
申请号：PCT/US2004013939
申请日：2004-05-06
申请人： SYNTONIX INC , MEZO ADAM R , PETERS ROBERT T
发明人： MEZO ADAM R , PETERS ROBERT T
IPC分类号： A61K39/395 , C07H21/04 , C07K1/02 , C07K1/06 , C07K1/10 , C07K1/107 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K16/00 , C07K16/44 , C07K16/46 , C12N20060101 , C12N5/06 , C12N9/64 , C12P21/00 , C12P21/04 , C12N
CPC分类号： C07K14/755 , A61K38/00 , A61K47/48215 , A61K47/48369 , A61K47/48415 , A61K47/48423 , A61K47/4843 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.
摘要翻译：本发明提供了化学合成包含免疫球蛋白恒定区和生物活性分子的至少一部分的嵌合蛋白的方法。

7. 发明申请

WO02063025A8 MUSCLE-DIRECTED GENE THERAPY WITH AAV-1 AND AAV-6 VECTORS 审中-公开
标题翻译：带有AAV-1和AAV-6载体的肌肉指导基因治疗
公开(公告)号：WO02063025A8
公开(公告)日：2004-05-21
申请号：PCT/US0203195
申请日：2002-02-01
申请人： AVIGEN INC
发明人： MCCLELLAND ALAN , ALLEN JAMES
IPC分类号： A61K48/00 , A61P7/00 , C12N9/64 , C12N15/864 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C12N9/647 , C12N2750/14143 , C12N2750/14145 , C12N2810/60
摘要： Methods for using novel recombinant adeno-associated virus (rAAV) virion serotypes are disclosed. The methods enable an increase in transduction efficiency of rAAV virions in mammalian muscle cells or tissue. Specifically, the methods described herein employ rAAV-1 and rAAV-6 serotype virions to deliver heterologous nucleic acid molecules of interest to muscle cells or tissue of a mammal. The disclosed methods describe direct injection into muscle tissue, intravascular administration of rAAV virions, and limb perfusion to deliver heterologous nucleic acid molecules of interest to at least one muscle cell of a mammal. The disclosed methods also describe the treatment of hemophilia, using the rAAV virions of the invention, by administering the rAAV virions to a mammalian subject with hemophilia so that blood coagulation proteins, such as Factor VIII or Factor IX, are expressed at levels greater than those achieved using the rAAV-2 serotype.
摘要翻译：公开了使用新型重组腺相关病毒（rAAV）病毒粒子血清型的方法。该方法能够增加哺乳动物肌肉细胞或组织中rAAV病毒粒子的转导效率。具体来说，本文描述的方法使用rAAV-1和rAAV-6血清型病毒体将哺乳动物的肌肉细胞或组织感兴趣的异源核酸分子递送。所公开的方法描述了直接注射到肌肉组织中，血管内施用rAAV病毒粒子和肢体灌注，以将哺乳动物的至少一个肌肉细胞感兴趣的异源核酸分子递送。所公开的方法还描述了使用本发明的rAAV病毒粒子治疗血友病，通过将血管紧张素血症患者的rAAV病毒粒子施用于哺乳动物受试者，使得凝血蛋白，例如因子VIII或因子IX以高于那些使用rAAV-2血清型实现。

8. 发明申请

WO0170968A3 PRODUCTION OF RECOMBINANT BLOOD CLOTTING FACTORS IN HUMAN CELL LINES 审中-公开
标题翻译：人类细胞系中重组血液凝固因子的产生
公开(公告)号：WO0170968A3
公开(公告)日：2001-12-13
申请号：PCT/EP0103220
申请日：2001-03-21
申请人： OCTAGENE GMBH , HAUSER CHARLOTTE , HOERSTER ANDREA , SCHROEDER CAROLA , LEHNERER MICHAEL
发明人： HAUSER CHARLOTTE , HOERSTER ANDREA , SCHROEDER CAROLA , LEHNERER MICHAEL
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P7/04 , C07K14/47 , C07K14/745 , C07K14/755 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N9/64 , C12N15/12 , C12N15/57 , C12P21/02 , A61K38/36 , A61K38/37 , A61K38/43
CPC分类号： C12N9/6437 , A61K38/00 , A61K48/00 , C07K14/745 , C07K14/755 , C12N9/644 , C12N9/647 , C12Y304/21021 , C12Y304/21022
摘要： The present invention relates to a method for the production of recombinant human blood clotting factors, in particular of factor VIII and factor IX, utilizing an immortalized human cell line stably expressing viral transcription activator proteins and carrying a vector having a promoter functionally linked to a DNA sequence coding for a blood coagulating factor, provided that said promoter is not a viral promoter which is stimulated by said viral transcription activator proteins; an immortalized human cell line carrying said vector; factor VIII muteins particularly suitable for the above production method; pharmaceutical compositions comprising such factor VIII muteins and the use of such factor VIII muteins for preparing a medicament for treating hemophilia.
摘要翻译：本发明涉及使用稳定表达病毒转录激活蛋白的永生化人细胞系和携带具有与DNA功能连接的启动子的载体来生产重组人凝血因子，特别是因子VIII和因子IX的方法前提是所述启动子不是由所述病毒转录激活蛋白刺激的病毒启动子; 携带所述载体的永生化人类细胞系; 因子VIII突变蛋白特别适合上述生产方法; 包含这种因子VIII突变蛋白的药物组合物以及这种因子VIII突变蛋白用于制备治疗血友病的药物的用途。

9. 发明申请

WO01070968A2 PRODUCTION OF RECOMBINANT BLOOD CLOTTING FACTORS IN HUMAN CELL LINES 审中-公开
标题翻译：重组人血细胞凝集因子的制备
公开(公告)号：WO01070968A2
公开(公告)日：2001-09-27
申请号：PCT/EP2001/003220
申请日：2001-03-21
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P7/04 , C07K14/47 , C07K14/745 , C07K14/755 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N9/64 , C12N15/12 , C12N15/57 , C12P21/02 , A61K38/36 , A61K38/37 , A61K38/48
CPC分类号： C12N9/6437 , A61K38/00 , A61K48/00 , C07K14/745 , C07K14/755 , C12N9/644 , C12N9/647 , C12Y304/21021 , C12Y304/21022
摘要： The present invention relates to a method for the production of recombinant human blood clotting factors, in particular of factor VIII and factor IX, utilizing an immortalized human cell line stably expressing viral transcription activator proteins and carrying a vector having a promoter functionally linked to a DNA sequence coding for a blood coagulating factor, provided that said promoter is not a viral promoter which is stimulated by said viral transcription activator proteins; an immortalized human cell line carrying said vector; factor VIII muteins particularly suitable for the above production method; pharmaceutical compositions comprising such factor VIII muteins and the use of such factor VIII muteins for preparing a medicament for treating hemophilia.
摘要翻译：本发明涉及使用永生化人细胞系生产重组人凝血因子，特别是因子VIII和IX的改进方法，所述永生化人细胞系稳定表达病毒转录激活因子蛋白并携带具有如果所述启动子不是由所述病毒转录激活蛋白刺激的病毒启动子，则所述启动子可操作地连接至编码血液凝固因子的DNA序列; 并进一步涉及携带所述因子的永生化人细胞系; 因子VIII突变蛋白，特别适用于上述生产过程; 包含因子VIII突变蛋白的药物组合物，以及因子VIII突变蛋白在制备用于治疗血友病的药物中的各种用途。

10. 发明申请

WO9961475A8 METHOD FOR SEPARATING AND/OR ISOLATING PLASMA PROTEINS BY ANNULARCHROMATOGRAPHY 审中-公开
标题翻译：分离和/或分离的血浆蛋白与环形色谱法测定
公开(公告)号：WO9961475A8
公开(公告)日：2000-02-03
申请号：PCT/EP9903659
申请日：1999-05-27
申请人： OCTAPHARMA AG , BUCHACHER ANDREA , JOSIC DJURO , GRUBER GERHARD , PRIOR ADALBERT , WOLFGANG JUERGEN
发明人： BUCHACHER ANDREA , JOSIC DJURO , GRUBER GERHARD , PRIOR ADALBERT , WOLFGANG JUERGEN
IPC分类号： C07K1/16 , C07K14/755 , C07K14/765 , C07K14/81 , C07K16/06 , C12N9/64 , C12N9/74 , G01N30/60
CPC分类号： C12N9/644 , C07K14/755 , C07K14/765 , C07K14/8125 , C07K16/065 , C12N9/6429 , C12N9/647 , C12Y304/21005 , C12Y304/21022
摘要： The invention relates to a method for separating and/or isolating especially human plasma proteins from a mixture containing plasma proteins. According to said method the mixture is deposited on an annular separating medium; the annular separating medium is rotated substantially vertically about an axis defined in the direction of flow of the mixture through the annular separating medium; an eluant is fed through the annular separating medium; and the fractions emerging at the end of the annular separating medium are collected.
摘要翻译：一种用于从含蛋白质的血浆混合物，其中所述混合物被施加到一个环形设计布置分离介质的分离和/或人血浆蛋白的分离，特别是过程; 基本上垂直旋转环形设计分离介质在通过环形设计的分离介质轴的混合物的流动方向的定义; 洗脱液通过环形设计分离介质通过; 并且在环形设计分离介质新兴馏分的结束时收集。

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