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1. 发明申请

WO1995014464A1 SSI TYRPHOSTINS AND PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： SSI TYRPHOSTINS和药物组合物
公开(公告)号：WO1995014464A1
公开(公告)日：1995-06-01
申请号：PCT/US1994013535
申请日：1994-11-23
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KUPOT-HOLIM HEALTH INSURANCE INSTITUTE OF THE GENERAL FEDERATION OF LABOUR IN ERETZ-ISRAEL , LEVITZKI, Alexander , NOVOGRODSKY, Abraham , GAZIT, Aviv
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KUPOT-HOLIM HEALTH INSURANCE INSTITUTE OF THE GENERAL FEDERATION OF LABOUR IN ERETZ-ISRAEL
IPC分类号： A61K31/165
CPC分类号： A61K31/275
摘要： SSI thyrphostins are useful in preventing LPS induced toxicity, TNF alpha induced toxicity, LPS induced increases in TNF alpha levels, nitric oxide production, and the treatment of septic shock and various immune disorders. Featured are novel compounds and pharmaceutical compositions, both of which may be used in the methods of prevention and/or treatment described herein, as well as methods for making the novel compounds.
摘要翻译： SSI thyrphostins可用于预防LPS诱导的毒性，TNFα诱导的毒性，LPS诱导的TNFα水平升高，一氧化氮产生以及脓毒性休克和各种免疫疾病的治疗。特征是新颖的化合物和药物组合物，它们都可用于本文所述的预防和/或治疗方法，以及制备新化合物的方法。

2. 发明申请

WO1998006391A1 PHARMACEUTICAL COMPOSITIONS COMPRISING TYRPHOSTINS 审中-公开
标题翻译：包含TYRPHOSTINS的药物组合物
公开(公告)号：WO1998006391A1
公开(公告)日：1998-02-19
申请号：PCT/IL1997000276
申请日：1997-08-14
申请人： MOR-RESEARCH APPLICATIONS LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , NOVOGRODSKY, Abraham , LEVITZKI, Alexander , GAZIT, Aviv
发明人： MOR-RESEARCH APPLICATIONS LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A61K31/275
CPC分类号： A61K31/415 , A61K31/277 , A61K31/427 , A61K31/4406
摘要： Compounds useful for countering undesired toxic effects to cells, tissues or organs having formula (I) wherein: Ar is a group of formulae (i) or (ii), n is O or, when Ar has formula (i) above, then n may also be 1, R is CN, -C(S)NH2, -C(O)NHR3 or, when R1 is 4-NO2 and R2 is H or 3-OH, then R may also be a group of formulae (iii), (iv), (v), (vi) where R3 is H, phenyl, phenyl(lower alkyl) or pyridylmethyl; R1 and R2 are each independently H, OH, NO2 or, when R is CN, also CH3, F, or CF3, provided that both R1 and R2 are not simultaneously H.
摘要翻译：用于对抗具有式（I）的细胞，组织或器官的不期望的毒性作用的化合物，其中：Ar是式（i）或（ii）的基团，n是O或当Ar具有上述式（i）时，则n 也可以是1，R是CN，-C（S）NH 2，-C（O）NHR 3，或者当R 1是4-NO 2且R 2是H或3-OH时，R也可以是式），（iv），（v），（vi）其中R3是H，苯基，苯基（低级烷基）或吡啶基甲基; R 1和R 2各自独立地为H，OH，NO 2，或当R为CN时，R 3，F或CF 3，只要R 1和R 2不同时为H.

3. 发明申请

WO1995028922A1 USE OF BENZYLIDENE-MALONONITRILE DERIVATES FOR THE TREATMENT OF LEUKEMIA 审中-公开
标题翻译：苯二酚 - 马来酸衍生物用于治疗白血病的用途
公开(公告)号：WO1995028922A1
公开(公告)日：1995-11-02
申请号：PCT/US1995004939
申请日：1995-04-20
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , THE HOSPITAL FOR SICK CHILDREN RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP , LEVITZKI, Alexander , GAZIT, Aviv , ROIFMAN, Chaim
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , THE HOSPITAL FOR SICK CHILDREN RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP
IPC分类号： A61K31/275
CPC分类号： A61K31/275
摘要： The present invention relates to products and methods useful for treating leukemia, in particular acute lymphoblastomic leukemias. Compounds described herein are effective in inhibiting activities associated with ALL both in vitro and in vivo. Methods for modifying such compounds and screening other compounds are also provided in order to identify additional compounds with similar or better inhibition properties.
摘要翻译：本发明涉及用于治疗白血病，特别是急性淋巴细胞白血病的产品和方法。本文所述的化合物在体外和体内均有效抑制与ALL相关的活性。还提供了修饰这些化合物和筛选其它化合物的方法，以便鉴定具有相似或更好抑制性质的其它化合物。

4. 发明申请

WO1998009641A1 SEMIPEPTOID FARNESYL PROTEIN TRANSFERASE INHIBITORS AND ANALOGS THEREOF 审中-公开
标题翻译： SEMIPEPTOID FARNESYL蛋白转移酶抑制剂及其类似物
公开(公告)号：WO1998009641A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015157
申请日：1997-08-28
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , FRIEDMAN, Mark, M. , LEVITZKI, Alexander , GILON, Chaim , REUVENI, Hadas
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , FRIEDMAN, Mark, M.
IPC分类号： A61K38/06
CPC分类号： C07K5/1013 , A61K38/00
摘要： A farnesyl protein transferase (i.e., farnesyltransferase) inhibitors formed as peptoid and semipeptoid peptidomimetic compounds derived from a farnesyltransferase universal recognition tetrapeptide sequence CAAX (i.e., CAAX motif) and analogs thereof, and to the use of these compounds and analogs and ester derivatives thereof as chemotherapeutic agents in oncogenic or non-oncogenic Ras associated cancers and proliferative diseases.
摘要翻译：由法呢基转移酶通用识别四肽序列CAAX（即CAAX基序）及其类似物衍生的拟胆碱和半皮下模拟肽化合物形成的法呢基蛋白转移酶（即法呢基转移酶）抑制剂以及这些化合物及其类似物和酯衍生物作为致癌或非致癌性Ras相关癌症和增殖性疾病中的化学治疗剂。

5. 发明申请

WO1998026062A2 SYNTHETIC ANTISENSE OLIGODEOXYNUCLEOTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：合成抗体寡糖氧化酶和含有它们的药物组合物
公开(公告)号：WO1998026062A2
公开(公告)日：1998-06-18
申请号：PCT/US1997023598
申请日：1997-12-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , SOREQ, Hermona , SEIDMAN, Shlomo , ECKSTEIN, Fritz , FRIEDMAN, Alon , KAUFER, Daniela
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： C12N15/00
CPC分类号： C12Y301/01007 , A01K2217/05 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/53 , C12N2310/3521
摘要： A synthetic nuclease resistant antisense oligodeoxynucleotide (AS-ODN) capable of selectively modulating human acetylcholinesterase (AChE) production and a pharmaceutical or medical composition comprising at least one AD-ODN as an active ingredient. In an embodiment the AS-ODN can be selected from 5'ACGCTTTCTTGAGGC 3' (SEQ ID NO.1), 5'GGCACCCTGGGCAGC 3' (SEQ ID NO.2); 5'CCACGTCCTCCTGCACCGTC 3' (SEQ ID NO.6); 5'ATGAACTCGATCTCGTAGCC 3' (SEQ ID NO.7); 5'GCCAGAGGAGGAGGAGAAGG 3' (SEQ ID NO.4); 5'TAGCGTCTACCACCCCTGAC 3' (SEQ ID NO.5), 5'TCTGTGTTATAGCCCAGCCC 3' (SEQ ID NO.17); and 5'GGCCTGTAACAGTTTATTT 3' (SEQ ID NO.18). A nuclease resistant antisense targeted against the splice junction in the AChEmRNA post splice message is disclosed. In an embodiment, a nuclease resistant AS-ODN targeted against the E4-E6 junction in the E1-E4-E6 splice variant AChEmRNA is disclosed as being highly specific for the muscle and central nervous system splice variant of AChE. The synthetic nuclease resistant AS-ODNs are capable of selectively modulating human AChE production in the central nervous system or capable of selectively reducing human AChE deposition in the neuromuscular junction. The present invention also provides a method to restore balanced cholinergic signaling in the brain and spinal cord or reduce AChE in the neuromuscular junction in patients in need of such treatment comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one of the synthetic nuclease resistant AS-ODN capable of selectively modulating human AChE production.
摘要翻译：能够选择性调节人乙酰胆碱酯酶（AChE）生产的合成核酸酶抗性反义寡脱氧核苷酸（AS-ODN）和包含至少一种AD-ODN作为活性成分的药物或医药组合物。在一个实施方案中，AS-ODN可以选自5'ACGCTTTCTTGAGGC 3'（SEQ ID NO.1），5'GGCACCCTGGGCAGC 3'（SEQ ID NO.2）; 5'CCACGTCCTCCTGCACCGTC 3'（SEQ ID NO.6）; 5'ATGAACTCGATCTCGTAGCC 3'（SEQ ID NO.7）; 5'GCCAGAGGAGGAGGAGAAGG 3'（SEQ ID NO.4）; 5'TAGCGTCTACCACCCCTGAC 3'（SEQ ID NO.5），5'TCTGTGTTATAGCCCAGCCC 3'（SEQ ID NO.17）; 和5'GGCCTGTAACAGTTTATTT 3'（SEQ ID NO.18）。公开了针对针对AChEmRNA后剪接消息中的剪接连接的核酸酶抗性反义。在一个实施方案中，公开了针对E1-E4-E6剪接变体AChEmRNA中的E4-E6连接的核酸酶抗性AS-ODN作为AChE的肌肉和中枢神经系统剪接变体的高度特异性。合成的核酸酶抗性AS-ODNs能够选择性调节中枢神经系统中的人AChE产生或能够选择性地降低神经肌肉接头中的人类AChE沉积。本发明还提供一种在需要这种治疗的患者中恢复脑和脊髓中的平衡胆碱能信号传导或减少神经肌肉接头中的AChE的方法，包括向需要这种治疗的患者施用治疗有效量的至少一种的能够选择性调节人AChE生产的合成核酸酶抗性AS-ODN。

6. 发明申请

WO1998024300A1 CAROTENOID-ASSOCIATED PROTEINS USEFUL FOR HIGH CAROTENOID ACCUMULATION AND PRODUCTION IN PLANTS AND OTHER ORGANISMS 审中-公开
标题翻译：与植物和其他有机体相关的高碳毛虫积累和生产有关的CAROTENOID相关蛋白
公开(公告)号：WO1998024300A1
公开(公告)日：1998-06-11
申请号：PCT/IL1997000399
申请日：1997-12-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , VAINSTEIN, Alexander , VISHNEVETSKY, Michael , OVADIS, Marianna , ITZHAKI, Hanan
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A01H01/00
CPC分类号： C12N15/8237 , C07K14/415 , C12N15/823 , C12N15/8238 , C12N15/825
摘要： A method for production of high amounts of carotenoids in plants, bacteria or cells. Carotenoid-associated proteins CHRC and CHRD isolated from corollas of Cucumis sativus, chrc gene, CHRC deduced sequence, the molecular cloning, cDNA and RNA. A new CHRC promoter able to direct expression for foreign genes. The cloned promoter comprising approximately 3.5 kb of the CHRC upstream region.
摘要翻译：用于在植物，细菌或细胞中产生大量类胡萝卜素的方法。从Cucumis sativus，chrc基因，CHRC推导序列，分子克隆，cDNA和RNA的花冠分离的类胡萝卜素相关蛋白CHRC和CHRD。一个能够引导外源基因表达的新型CHRC启动子。克隆的启动子包含大约3.5kb的CHRC上游区。

7. 发明申请

WO1997049423A2 LIPOSOMAL INFLUENZA VACCINE COMPOSITION AND METHOD 审中-公开
标题翻译：脂肪流感疫苗组合物和方法
公开(公告)号：WO1997049423A2
公开(公告)日：1997-12-31
申请号：PCT/IL1997000210
申请日：1997-06-24
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KEDAR, Eliezer , BABAI, Ilan , BARENHOLZ, Yechezkel
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/55505 , A61K2039/55522 , A61K2039/55533 , A61K2039/55555 , C12N2760/16134 , Y10S436/829 , A61K38/2013 , A61K38/193 , A61K2300/00
摘要： Subunit influenza vaccines containing an influenza H/N antigen and a cytokine immunopotentiator, where at least one and preferably both are encapsulated in liposomes, are described. The vaccines stimulate a strong humoral and CTL response. Also described are methods of immunization using such vaccines.
摘要翻译：描述了含有流感H / N抗原的亚单位流感疫苗和细胞因子免疫增强剂，其中至少一个并且优选二者被包封在脂质体中。疫苗刺激强烈的体液和CTL反应。还描述了使用这种疫苗免疫的方法。

8. 发明申请

WO1997037008A1 MEANS AND PROCESS FOR NITRATE REMOVAL 审中-公开
标题翻译：硝酸盐去除的手段和方法
公开(公告)号：WO1997037008A1
公开(公告)日：1997-10-09
申请号：PCT/IL1997000116
申请日：1997-04-01
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , VAN RIJN , Jaap , NUSSINOVITCH, Amos , TAL, Joseph
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： C12N11/10
CPC分类号： C02F3/108 , C02F3/2806 , C02F3/30 , C02F3/302 , C02F3/34 , C12N11/04 , Y02W10/15 , Y10S435/821
摘要： A system for nitrate removal from aquariums, both fresh water and marine aquariums, by means of permeable polymeric beads which contain a combination of fermentative and denitrifying bacteria and a carbon source. Preferred beads are beads made from sodium alginate or chitosan. The bacteria, in the presence of the carbon source, are able to reduce nitrate to nitrogen gas. Bacteria which are not harmful to fish are used. The porous beads used in the process are novel and part of the invention.
摘要翻译：通过含有发酵和反硝化细菌和碳源的组合的可渗透聚合物珠子，从水族馆，淡水和海洋水族箱中去除硝酸盐的系统。优选的珠粒是由藻酸钠或壳聚糖制成的珠粒。在碳源的存在下，细菌能够将硝酸盐还原成氮气。使用对鱼无害的细菌。在该方法中使用的多孔珠是新颖的和本发明的一部分。

9. 发明申请

WO1997035808A3 AN ELECTRO-FLOCCULATION PROCESS 审中-公开
公开(公告)号：WO1997035808A3
公开(公告)日：1997-10-02
申请号：PCT/GB1997000821
申请日：1997-03-24
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , RITTER, Stephen, David , ADIN, Avner , VESCAN, Nicholas
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , RITTER, Stephen, David
IPC分类号： C02F01/463

10. 发明申请

WO1997004314A3 DETERMINATION OF AN ANALYTE IN A LIQUID MEDIUM 审中-公开
公开(公告)号：WO1997004314A3
公开(公告)日：1997-02-06
申请号：PCT/IL1996000049
申请日：1996-07-16
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WILLNER, Itamar , LEVI, Shlomo , COHEN, Yael , KATZ, Eugenii , DAGAN, Arie
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： G01N33/543

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