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1. 发明申请

WO2010041256A3 A COMPOSITION OF MATTER COMPRISING LIPOSOMES EMBEDDED IN A POLYMERIC MATRIX AND METHODS OF USING SAME 审中-公开
公开(公告)号：WO2010041256A3
公开(公告)日：2010-04-15
申请号：PCT/IL2009/000967
申请日：2009-10-11
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. , BARENHOLZ, Yechezkel , COHEN, Rivka
发明人： BARENHOLZ, Yechezkel , COHEN, Rivka
IPC分类号： A61K9/127 , A61K9/16 , A61K31/445 , A61K31/573
摘要： The present disclosure provides a composition of matter comprising liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the liposomes having a diameter of at least 200nm and being embedded in a water insoluble, water absorbed cross-linked polymeric matrix. In one embodiment, the composition of matter is held within an aqueous medium, preferably being in iso-osmotic equilibrium with the intraliposomal aqueous compartments of the liposomes. The present disclosure also provides a method of removal of non-encapsulated active agent from the composition of matter, a method of preparing said composition of matter, a pharmaceutical composition comprising said composition of matter, use of such composition of matter; a method of providing prolonged delivery of a active agent to a subject in need thereof by administering to said subject the composition of matter disclosed herein as well as a package comprising said composition of matter held within said aqueus medium and instructions for use thereof.

2. 发明申请

WO2010041255A2 LIPOSOMAL SYSTEMS COMPRISING SPHINGOMYELIN 审中-公开
标题翻译：包含SPHINGOMYELIN的脂质体系
公开(公告)号：WO2010041255A2
公开(公告)日：2010-04-15
申请号：PCT/IL2009/000966
申请日：2009-10-11
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. , BARENHOLZ, Yechezkel , COHEN, Rivka
发明人： BARENHOLZ, Yechezkel , COHEN, Rivka
IPC分类号： A61K9/127 , A61K31/445
CPC分类号： A61K9/127 , A61K31/445 , A61K31/573
摘要： The present disclosure provides a liposomal system comprising an aqueous medium having dispersed therein liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the aqueous medium being in iso-osmotic equilibrium with said intraliposomal aqueous compartment, the liposomes having a membrane comprising a liposome forming lipids, at least one of which being sphingomyelin (SPM), the liposomal system having increased stability as compared to the same liposomes free of SPM, and in one embodiment being stable during long-term storage, said stability being characterized in that no more than 30% of the at least one active agent is present in the aqueous medium after said storage. Further provided by the present disclosure are a method for storage of liposomes making use of the liposomal system; use of the liposomal system for the treatment of a medical condition or for the diagnostic of a medical condition; a pharmaceutical or diagnostic composition comprising the liposomal system, and a method of treating or diagnosing of a medical condition comprising administering to a subject an amount of the liposomal system.
摘要翻译：本公开提供了一种脂质体系统，其包含水分介质，其中分散有脂质体，其脂质体包封在其脂质体内水性隔室中至少一种活性剂，所述水性介质与所述脂质体内水性隔室处于等渗平衡，所述脂质体具有包含脂质体的膜形成脂质，其中至少一种是鞘磷脂（SPM），与没有SPM的相同脂质体相比，脂质体系统具有增加的稳定性，并且在一个实施方案中在长期储存期间是稳定的，所述稳定性的特征在于不再有在所述储存之后，至少一种活性剂的30％以上存在于水性介质中。本公开进一步提供的是利用脂质体系统储存脂质体的方法; 使用脂质体系统治疗医疗状况或诊断医疗状况; 包含脂质体系统的药物或诊断组合物，以及治疗或诊断医学病症的方法，其包括向受试者施用一定量的脂质体系统。

3. 发明申请

WO2006027786A3 USE OF LIPOSOMAL GLUOCOCORTICOIDS FOR TREATING INFLAMMATORY STATES 审中-公开
公开(公告)号：WO2006027786A3
公开(公告)日：2006-03-16
申请号：PCT/IL2005/000962
申请日：2005-09-11
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED , BARENHOLZ, Yechezkel , NAPARSTEK, Yaakov , AVNIR, Yuval , ULMANSKY, Rina
发明人： BARENHOLZ, Yechezkel , NAPARSTEK, Yaakov , AVNIR, Yuval , ULMANSKY, Rina
IPC分类号： A61K9/127 , A61K31/573
摘要： The present invention provides the use of a glucocorticoid (GC) or of a GC derivative encapsulated in a liposome for the preparation of a pharmaceutical composition for the treatment of an inflammatory associated condition in a subject, provided that said condition is not associated with a neurodegenerative disease or disorder. A specific use concerns a liposomal formulation comprising methylprednisolone sodium hemisuccinate (MPS) for the treatment of rheumatoid arthritis.

4. 发明申请

WO2005046643A3 METHOD FOR DRUG LOADING IN LIPOSOMES 审中-公开
标题翻译：药物中的药物加载方法
公开(公告)号：WO2005046643A3
公开(公告)日：2005-06-23
申请号：PCT/IL2004001041
申请日：2004-11-14
申请人： YISSUM RES DEV CO , BARENHOLZ YECHEZKEL , GABIZON ALBERTO A
发明人： BARENHOLZ YECHEZKEL , GABIZON ALBERTO A
IPC分类号： A61K9/127 , A61K31/704
CPC分类号： A61K9/127 , A61K31/704
摘要： A liposome composition having a protonatable therapeutic agent entrapped in the form of a salt with an glucuronate anion is disclosed. Methods for preparing the composition using an ammonium ion transmembrane gradient having glucuronate as the counterion are also disclosed. In one embodiment where the protonatable agent is doxorubicin, the method of the invention has comparable loading efficiency, faster release rate, without compromising the therapeutic efficacy compared to loading with an ammonium ion gradient having sulfate as the counterion.
摘要翻译：公开了一种具有以葡萄糖醛酸盐阴离子盐形式包埋的可质子治疗剂的脂质体组合物。还公开了使用具有葡萄糖醛酸盐作为抗衡离子的铵离子跨膜梯度制备组合物的方法。在可质子化剂是多柔比星的一个实施方案中，与用硫酸盐作为抗衡离子的铵离子梯度负载相比，本发明的方法具有相当的加载效率，更快的释放速率，而不会降低治疗功效。

5. 发明申请

WO02064110A3 CAROTENOID-LOADED LIPOSOMES 审中-公开
标题翻译： CAROTENOID装载脂质体
公开(公告)号：WO02064110A3
公开(公告)日：2003-01-09
申请号：PCT/IB0200417
申请日：2002-02-13
申请人： YISSUM RES DEV CO , BARENHOLZ YECHEZKEL , DIMINSKY DVORAH , COHEN RIVKA
发明人： BARENHOLZ YECHEZKEL , DIMINSKY DVORAH , COHEN RIVKA
IPC分类号： A61K9/06 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/11 , A61K8/14 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/55 , A61K8/58 , A61K8/96 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/127 , A61K9/48 , A61K31/01 , A61K31/015 , A61K31/045 , A61K31/047 , A61K31/122 , A61K47/44 , A61P17/00 , A61P17/02 , A61P39/06 , A61Q17/00 , A61Q17/04 , A61Q19/00
CPC分类号： A61K9/127 , A61K8/14 , A61K8/31 , A61K31/01 , A61K31/015 , A61K31/045 , A61K31/047 , A61K31/122 , A61K2800/522 , A61Q17/00 , A61Q17/04 , A61Q19/00
摘要： The present invention is based on a novel method for encapsulating in liposomes substantialy water immiscible carotenoids. Therefore, there are provided by the present invention formulations comprising liposomes loaded with an amount of at least one water immiscible carotenoid. Pharmaceutical compositions comprising such a formulation, and a method for preparing the liposomes loaded with said carotenoid.
摘要翻译：本发明是基于一种用于将脂质体封装在大体上与水不混溶的类胡萝卜素的新方法。因此，本发明提供的制剂包含负载量至少一种与水不混溶的类胡萝卜素的脂质体。包含这种制剂的药物组合物，以及用于制备负载有所述类胡萝卜素的脂质体的方法。

6. 发明申请

WO2003000227A3 A METHOD FOR PREPARATION OF VESICLES LOADED WITH BIOLOGICAL MATERIAL AND DIFFERENT USES THEREOF 审中-公开
公开(公告)号：WO2003000227A3
公开(公告)日：2003-01-03
申请号：PCT/IL2002/000506
申请日：2002-06-25
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , BARENHOLZ, Yechezkel , KEDAR, Eliezer
发明人： BARENHOLZ, Yechezkel , KEDAR, Eliezer
IPC分类号： A61K9/127
摘要： The present invention discloses a method for an efficient entrapment of active biological material in liposomes. The method is based on the steps of drying a suspension of liposome-forming lipids and then hydrating the dry composition obtained with an aqueous solution containing a biologically active material to be entrapped in high yield in the liposomes thus formed. The invention also concerns liposomal formulations produced by the method of the invention and their uses.

7. 发明申请

WO1997049423A2 LIPOSOMAL INFLUENZA VACCINE COMPOSITION AND METHOD 审中-公开
标题翻译：脂肪流感疫苗组合物和方法
公开(公告)号：WO1997049423A2
公开(公告)日：1997-12-31
申请号：PCT/IL1997000210
申请日：1997-06-24
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KEDAR, Eliezer , BABAI, Ilan , BARENHOLZ, Yechezkel
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/55505 , A61K2039/55522 , A61K2039/55533 , A61K2039/55555 , C12N2760/16134 , Y10S436/829 , A61K38/2013 , A61K38/193 , A61K2300/00
摘要： Subunit influenza vaccines containing an influenza H/N antigen and a cytokine immunopotentiator, where at least one and preferably both are encapsulated in liposomes, are described. The vaccines stimulate a strong humoral and CTL response. Also described are methods of immunization using such vaccines.
摘要翻译：描述了含有流感H / N抗原的亚单位流感疫苗和细胞因子免疫增强剂，其中至少一个并且优选二者被包封在脂质体中。疫苗刺激强烈的体液和CTL反应。还描述了使用这种疫苗免疫的方法。

8. 发明申请

WO1995004523A1 A METHOD FOR PREPARATION OF VESICLES LOADED WITH BIOLOGICAL STRUCTURES, BIOPOLYMERS AND/OR OLIGOMERS 审中-公开
标题翻译：一种用生物结构，生物聚合物和/或低聚物负载的VESICLES的制备方法
公开(公告)号：WO1995004523A1
公开(公告)日：1995-02-16
申请号：PCT/EP1994002242
申请日：1994-07-08
申请人： OPPERBAS HOLDING B.V. , BARENHOLZ, Yechezkel , NUR, Israel
发明人： OPPERBAS HOLDING B.V.
IPC分类号： A61K09/127
CPC分类号： A61K9/127 , A61K9/1277
摘要： A method for preparation of vesicles loaded with biological structures, biopolymers and/or -oligomers comprising the step of co-drying a fraction of amphiphatic material and a fraction of biological structures, biopolymers and/or -oligomers wherein said fraction of amphiphatic material is present in an organic solvent which is miscible with water and said fraction of biological structures, biopolymers and/or -oligomers is present in an aqueous medium.
摘要翻译：一种制备装载有生物结构，生物聚合物和/或多元醇的囊泡的方法，包括共同干燥一部分的亲脂性物质和一部分生物结构，生物聚合物和/或 - 寡聚体的步骤，其中所述的两性脂族物质部分存在在与水混合并且所述生物结构部分的有机溶剂中，生物聚合物和/或 - 低聚物存在于水性介质中。

9. 发明申请

WO2010041255A3 LIPOSOMAL SYSTEMS COMPRISING SPHINGOMYELIN 审中-公开
标题翻译：包含SPHINGOMYELIN的脂质体系
公开(公告)号：WO2010041255A3
公开(公告)日：2011-04-07
申请号：PCT/IL2009000966
申请日：2009-10-11
申请人： YISSUM RES DEV CO , BARENHOLZ YECHEZKEL , COHEN RIVKA
发明人： BARENHOLZ YECHEZKEL , COHEN RIVKA
IPC分类号： A61K9/127 , A61K31/445
CPC分类号： A61K9/127 , A61K31/445 , A61K31/573
摘要： The present disclosure provides a liposomal system comprising an aqueous medium having dispersed therein liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the aqueous medium being in iso-osmotic equilibrium with said intraliposomal aqueous compartment, the liposomes having a membrane comprising a liposome forming lipids, at least one of which being sphingomyelin (SPM), the liposomal system having increased stability as compared to the same liposomes free of SPM, and in one embodiment being stable during long-term storage, said stability being characterized in that no more than 30% of the at least one active agent is present in the aqueous medium after said storage. Further provided by the present disclosure are a method for storage of liposomes making use of the liposomal system; use of the liposomal system for the treatment of a medical condition or for the diagnostic of a medical condition; a pharmaceutical or diagnostic composition comprising the liposomal system, and a method of treating or diagnosing of a medical condition comprising administering to a subject an amount of the liposomal system.
摘要翻译：本公开提供了一种脂质体系统，其包含水分介质，其中分散有脂质体，其脂质体包封在其脂质体内水性隔室中至少一种活性剂，所述水性介质与所述脂质体内水性隔室处于等渗平衡，所述脂质体具有包含脂质体的膜形成脂质，其中至少一种是鞘磷脂（SPM），与没有SPM的相同脂质体相比，脂质体系统具有增加的稳定性，并且在一个实施方案中在长期储存期间是稳定的，所述稳定性的特征在于不再有在所述储存之后，至少一种活性剂的30％以上存在于水性介质中。本公开进一步提供的是利用脂质体系统储存脂质体的方法; 使用脂质体系统治疗医疗状况或诊断医疗状况; 包含脂质体系统的药物或诊断组合物，以及治疗或诊断医学病症的方法，其包括向受试者施用一定量的脂质体系统。

10. 发明申请

WO2010004568A1 DEVICE, METHOD AND KIT FOR IN VIVO DETECTION OF A BIOMARKER 审中-公开
标题翻译：用于生物标记物检测的装置，方法和工具包
公开(公告)号：WO2010004568A1
公开(公告)日：2010-01-14
申请号：PCT/IL2009/000691
申请日：2009-07-09
申请人： GIVEN IMAGING LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , RABINOVITZ, Elisha , RUBINSTEIN, Abraham , BARENHOLZ, Yechezkel , KHAZANOV, Elena , AZAB, Abdel, Kareem , EMMANUEL, Noam , YAVIN, Eylon
发明人： RABINOVITZ, Elisha , RUBINSTEIN, Abraham , BARENHOLZ, Yechezkel , KHAZANOV, Elena , AZAB, Abdel, Kareem , EMMANUEL, Noam , YAVIN, Eylon
IPC分类号： A61B1/05 , A61B5/00 , A61L29/08 , G01N33/48 , A61K49/00 , A61K39/00 , C12M1/26
CPC分类号： A61B1/041 , A61B1/043 , A61B5/0071 , A61B5/0084 , A61B5/6861
摘要： The invention relates to a device and a system for in-vivo detection of a biomarker in the gastrointestinal tract. The invention further relates to a method for the in-vivo detection of a biomarker in the gastrointestinal tract such as e.g., the α1-antitrypsin precursor (A1AT biomarker), by using the recognition factor, e.g., trypsin immobilized to a solid surface. The invention further relates to a kit for the in-vivo detection of a biomarker in the gastrointestinal system.
摘要翻译：本发明涉及用于体内检测胃肠道生物标志物的装置和系统。本发明还涉及通过使用识别因子例如固定在固体表面上的胰蛋白酶来体内检测胃肠道中的生物标志物例如α-抗胰蛋白酶前体（A1AT生物标志物）的方法。本发明还涉及用于体内检测胃肠系统中生物标志物的试剂盒。

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