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1. 发明申请

WO2023081375A1 DEVICE FOR UNBLOCKING AND REMOVING SECRETIONS FROM AIRWAYS 审中-公开
公开(公告)号：WO2023081375A1
公开(公告)日：2023-05-11
申请号：PCT/US2022/048987
申请日：2022-11-04
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , UNIVERSITY OF CINCINNATI , B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY , MOR RESEARCH APPLICATIONS LTD.
发明人： GUTMARK-LITTLE, Iris , GUTMARK, Ephraim , CAVARI, Yuval , KATOSHEVSKI, David
IPC分类号： A61M16/00
摘要： The present disclosure relates to a device for treating obstructed airways. Specifically, the present disclosure relates to a device for treating the symptoms of diseases that cause persistent airflow limitation by applying air pressure oscillations and acoustic vibrations to the airways of a patient during treatment. The device may be used in a system that allows in- home treatment under remote supervision of a physician.

2. 发明申请

WO2021209999A2 METHODS OF AND APPARATUS FOR ASSESSMENT OF SUBJECTS WITH DISORDERS OF CONSCIOUSNESS 审中-公开
公开(公告)号：WO2021209999A2
公开(公告)日：2021-10-21
申请号：PCT/IL2021/050429
申请日：2021-04-14
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MOR RESEARCH APPLICATIONS LTD.
发明人： SOBEL, Noam , ARZI, Anat , ROZENKRANTZ, Liron , GORODISKY, Lior , HOLTZMAN, Yael , SACHER, Yaron , ROZENKRANTZ, Danit
IPC分类号： A61B5/08 , A61B5/087 , A61B5/00 , A61B5/0205 , A61B5/091 , A61B5/02055 , A61B5/0803 , A61B5/40 , A61B5/4005 , A61B5/4011 , A61B5/4064 , A61B5/4839 , A61B5/4842
摘要： A method of assessing a subject including: measuring a plurality of respirations of the subject; determining one or more respiration parameter from the plurality of respirations; and determining, using the one or more respiration parameter, one or more of: a state of consciousness of the subject; and a prognosis of the subject.

3. 发明申请

WO2021186384A1 URETERAL STENTS 审中-公开
公开(公告)号：WO2021186384A1
公开(公告)日：2021-09-23
申请号：PCT/IB2021/052274
申请日：2021-03-18
申请人： MOR RESEARCH APPLICATIONS LTD. , YEDA RESEARCH AND DEVELOPMENT CO. LTD
发明人： SHILO, Yaniv , BERKOWITZ, Brian
IPC分类号： A61M27/00 , A61M25/04
摘要： Ureteral stents 100 for treatment of partial or full ureteral occlusion by bridging one or more ureteral occlusions, where each stent includes a tubular portion 110, a first spout portion 120 and a second spout portion 130. The stent may have one or more tapered edges by having the smallest diameter of the first and/or the second spout portion smaller than the largest diameter of the tubular portion, and/ or be of an overall length allowing the ureteral stent to be completely located within a patient's ureter once deployed therein.

4. 发明申请

WO2021148929A1 SYSTEMS, DEVICES AND METHODS FOR ADJUSTING FETAL POSITION 审中-公开
公开(公告)号：WO2021148929A1
公开(公告)日：2021-07-29
申请号：PCT/IB2021/050353
申请日：2021-01-18
申请人： MOR RESEARCH APPLICATIONS LTD.
发明人： HADAR, Eran , TRAISTMAN, Idan
IPC分类号： A61B5/00 , A61F5/00 , A61G7/07
摘要： Aspects of embodiments pertain to a fetus positioning device, comprising: a plurality of expandable members that are coupleable with each other; wherein the plurality of selectively expandable members are configured such that when coupled with each other and operably engaged with a pregnant female subject, the plurality of expandable members are arranged relative to female subject allowing to selectively apply, through expansion, forces onto the abdomen of the female subject.

5. 发明申请

WO2018172897A1 OPHTHALMIC INSTRUMENT FOR SECURING AN INTRAOCULAR LENS IMPLANT 审中-公开
公开(公告)号：WO2018172897A1
公开(公告)日：2018-09-27
申请号：PCT/IB2018/051789
申请日：2018-03-18
申请人： MOR RESEARCH APPLICATIONS LTD.
发明人： KLEINMANN, Guy , ELIACHAR, Eliahu
IPC分类号： A61F9/007 , A61B17/068
摘要： An ophthalmic surgical instrument for securing an intraocular lens (IOL) implanted within an eye, the instrument comprising: an elongated handle; a first arm, fixedly disposed at a distal end of the handle; and a second arm, pivotably disposed at a distal end of the handle; wherein the distal end of the instrument is configured to be inserted into a corneal incision of the eye and aligned such that an IOL haptic of the IOL, and the iris of the eye, are positioned between the first arm and the second arm, and wherein the second arm is configured to pivot about a transverse axis of the instrument to clasp the IOL haptic and the iris against the first arm, so as to allow the deployment of a fastener to fasten the clasped IOL haptic to the clasped iris.

6. 发明申请

WO2018109627A1 SINUS LIFT DEVICE AND METHOD 审中-公开
公开(公告)号：WO2018109627A1
公开(公告)日：2018-06-21
申请号：PCT/IB2017/057766
申请日：2017-12-10
申请人： MOR RESEARCH APPLICATIONS LTD.
发明人： MOUTSAFI, Amnon , ELIACHAR, Eliahu , HIRSZOWICZ, Eran
IPC分类号： A61C8/00
CPC分类号： A61C8/0092
摘要： A device for sinus lift following a tearing of the Schneiderian membrane, comprising a biodegradable, multi-lumen balloon. The balloon comprises a first lumen and a second lumen. The first lumen, when inflated, forms a separation barrier and a posterior layer which are substantially perpendicular to one another and extend along a length of the balloon. The second lumen defined by an inferior layer comprising perforations to enable a bone graft formed in the second lumen to mesh with the bony floor of the maxillary sinus. The balloon comprises an inlet cannula in fluid communication with the first lumen, to enable inflation of the first lumen. The balloon comprises at least one connector attached to or integrally formed with the balloon, and adapted or configured to anchor the balloon medially to a rim of a preformed lateral opening in the maxillary sinus.

7. 发明申请

WO2017149530A1 SYSTEM AND METHOD FOR SELECTING OPTIMAL MEDICATIONS FOR A SPECIFIC PATIENT 审中-公开
标题翻译：用于为特定患者选择最佳药物的系统和方法
公开(公告)号：WO2017149530A1
公开(公告)日：2017-09-08
申请号：PCT/IL2017/050246
申请日：2017-02-27
申请人： MOR RESEARCH APPLICATIONS LTD
发明人： NETZER, Doron , NABRISKI, Dan , ROITMAN, Eytan
IPC分类号： G06F19/00
CPC分类号： G16H20/10 , G06F19/3456 , G16H10/60 , G16H50/20
摘要： Embodiments disclosed herein relate to a computerized method of selecting an optimal medication for a patient, comprising: providing a user with communication access to a central server having in memory a database of a rule set associated with a list of medications available, the rules set numerically ranking the suitability of a medication for a patient; allowing upload of at least a portion of an electronic medical record for an identified patient; allowing input of a patient diagnosis, and receiving a search request for a suitable treatment medication; comparing the rules set, with the uploaded electronic medical record; determining (e.g., scoring and calculating) the suitability of medications from the list of medications available; providing a displayable list of medications suited for the patient, wherein the list is ranked according to the preference of the medications for the patient.
摘要翻译：本文公开的实施例涉及为患者选择最佳药物的计算机化方法，包括：向用户提供对中央服务器的通信访问，所述中央服务器在存储器中具有与列表相关联的规则集的数据库的可用药物，规则集合在数字上对药物对患者的适用性进行排序; 允许为识别的患者上载至少一部分电子医疗记录; 允许输入患者诊断，并接收对合适的治疗药物的搜索请求; 将规则集与上传的电子病历进行比较; 从可用药物列表中确定（例如评分和计算）药物的适用性; 提供适合于患者的药物的可显示列表，其中列表根据药物对患者的偏好进行排序。

8. 发明申请

WO2017098514A1 NUPHARIDINE COMPOUNDS AND DERIVATIVES THEREOF FOR THE TREATMENT OF CYSTEINE PROTEASE RELATED DISEASES 审中-公开
标题翻译： NUPHARIDINE化合物及其衍生物用于治疗半胱氨酸蛋白酶相关疾病
公开(公告)号：WO2017098514A1
公开(公告)日：2017-06-15
申请号：PCT/IL2016/051316
申请日：2016-12-08
申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY , MOR RESEARCH APPLICATIONS LTD.
发明人： GOLAN-GOLDHIRSH, Avi , GOPAS, Jacob , ZURGIL, Udi
IPC分类号： A61K36/62 , A61K31/438 , A61P25/00 , A61P29/00 , A61P33/00 , A61P35/00 , C07D495/20 , C07D495/22 , C07D495/10
CPC分类号： A61K31/438 , A61K36/62 , C12Q1/37 , G01N2333/96466
摘要： Disclosed a method of treating a disease or a disorder characterized by protease activity. A pharmaceutical composition for treating a disease or a disorder characterized by protease activity is further disclosed. A method of detecting a cysteine protease from a biological sample is also disclosed.
摘要翻译：公开了一种治疗以蛋白酶活性为特征的疾病或病症的方法。还公开了用于治疗以蛋白酶活性为特征的疾病或病症的药物组合物。还公开了检测来自生物样品的半胱氨酸蛋白酶的方法。

9. 发明申请

WO2017006321A1 DEVICE AND METHOD FOR SUTURING 审中-公开
标题翻译：装置和方法
公开(公告)号：WO2017006321A1
公开(公告)日：2017-01-12
申请号：PCT/IL2016/050722
申请日：2016-07-06
申请人： MOR RESEARCH APPLICATIONS LTD.
发明人： NESHER, Eviatar , SEGAL, Shmuel
IPC分类号： A61B17/04 , A61B17/86
CPC分类号： A61B17/06114 , A61B17/0401 , A61B17/0466 , A61B17/0491 , A61B17/06123 , A61B2017/0409 , A61B2017/0414 , A61B2017/0417 , A61B2017/0437 , A61B2017/045 , A61B2017/0462 , A61B2017/0464 , A61B2017/06142 , A61B2017/06157 , A61B2017/06176
摘要： The present disclosure provides a system, a device, a cassette for use therein and method for suturing two tissue sections, for example two sections of a tissue, by using a plurality of consecutively-arranged anchoring units.
摘要翻译：本公开提供了一种系统，装置，其中使用的盒以及通过使用多个连续布置的锚固单元来缝合两个组织部分，例如组织的两个部分的方法。

10. 发明申请

WO2015151091A1 METHODS OF USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT AND PREVENTION OF AGENT-INDUCED GONADAL OR UTERINE TOXICITY 审中-公开
标题翻译：使用色素上皮衍生因子（PEDF）治疗和预防代谢诱发性腺瘤或子宫毒性的方法
公开(公告)号：WO2015151091A1
公开(公告)日：2015-10-08
申请号：PCT/IL2015/050340
申请日：2015-03-30
申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD. , MOR RESEARCH APPLICATIONS LTD.
发明人： SHALGI, Ruth , CHUDERLAND, Dana , BAR-JOSEPH, Hadas , GOLDBERG, Keren , BEN-AHARON, Irit , STEMMER, Salomon M.
IPC分类号： A61K38/18 , A61P15/08 , A61K31/138
CPC分类号： A61K38/18 , A61K31/138 , A61K31/704 , C12N5/0609 , C12N2501/10 , G01N33/74 , G01N2333/475 , G01N2800/34 , G01N2800/36 , G01N2800/52 , G01N2800/709 , A61K2300/00
摘要： A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium- derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject; and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo.
摘要翻译：提供了治疗或预防由受试者中的药剂引起的性腺或子宫中毒的方法。因此，提供了一种方法，其包括向受试者施用治疗有效量的色素上皮衍生因子（PEDF），由此治疗或预防由所述药剂引起的性腺毒性。还提供了一种方法，其包括确定受试者中的性腺功能; 并向受试者施用治疗有效量的PEDF，从而治疗或预防由该药剂引起的性腺毒性。还提供了用于治疗或预防受试者中的药剂引起的性腺毒性的PEDF。还提供了细胞培养，培养基，试剂盒和离体提高卵母细胞质量的方法。

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