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1. 发明申请

WO2013025839A3 DYNAMIC LEVEL ASSESSMENT 审中-公开
标题翻译：动态水平评估
公开(公告)号：WO2013025839A3
公开(公告)日：2013-05-16
申请号：PCT/US2012050998
申请日：2012-08-15
申请人： VISA INT SERVICE ASS , OLSON RAY , WHITE DAVID , BODINGTON SHAUN , FENG JIE
发明人： OLSON RAY , WHITE DAVID , BODINGTON SHAUN , FENG JIE
IPC分类号： G06Q20/16 , G06Q40/02
CPC分类号： G06Q20/0855 , G06Q20/34 , G06Q20/405 , G06Q30/06
摘要： Embodiments of the present invention include a dynamic and auditable rules-based spend requirement management (SRM) server configured to receive transaction data associated with a payment transaction involving an issuer of an account, where the account is associated with a first set of account level requirements (e.g., a minimum spend requirement) and a first interchange rate. The SRM is further configured to determine that the transaction data is not within the first set of account level requirements, but is within a second set of account level requirements associated with a second interchange rate, and associate the account to the second set of account level requirements by way of a final product identifier stored in a database accessible by a payment processing network (PPN).
摘要翻译：本发明的实施例包括动态和可审计的基于规则的花费需求管理（SRM）服务器，其被配置为接收与涉及帐户的发行者的支付交易相关联的交易数据，其中所述帐户与第一组帐户级别要求相关联（例如，最低支出要求）和第一个交换费率。 SRM还被配置为确定交易数据不在第一组帐户级别要求内，但是处于与第二交换费用相关联的第二组帐户级别要求中，并且将帐户与第二组帐户级别相关联通过存储在可由支付处理网络（PPN）访问的数据库中的最终产品标识符的要求。

2. 发明申请

WO2008060899A2 BREAST CANCER SCREENING AND TREATMENT METHODS 审中-公开
标题翻译：乳腺癌筛查和治疗方法
公开(公告)号：WO2008060899A2
公开(公告)日：2008-05-22
申请号：PCT/US2007083778
申请日：2007-11-06
申请人： GENE LOGIC INC , COOPERSMITH ROBERT MARK , WHITE DAVID , JIN SHENGFANG , FERNANDES DENZYL , LIN XUENA
发明人： COOPERSMITH ROBERT MARK , WHITE DAVID , JIN SHENGFANG , FERNANDES DENZYL , LIN XUENA
CPC分类号： G01N33/57415
摘要： A method for selecting a female breast cancer patient for AT 1 receptor antagonist therapy comprises (a) determining whether the cancer comprises a tumor that is ER+ and/or PR+; and (b) selecting the patient for AT 1 receptor antagonist therapy only if the cancer is determined to comprise an ER+ and/or PR+ tumor. A method for treating breast cancer in a female patient further comprises (c) administering to the patient, if so selected, an AT 1 receptor antagonist according to a regimen effective to reduce growth, invasiveness and/or metastasis of the tumor.
摘要翻译：用于选择AT＆gt;受体拮抗剂治疗的女性乳腺癌患者的方法包括（a）确定癌症是否包括ER +和/或PR +的肿瘤; 和（b）仅当确定癌症包含ER +和/或PR +肿瘤时才选择患者进行AT 1受体拮抗剂治疗。用于治疗女性患者乳腺癌的方法还包括（c）根据有效减少生长，侵袭和/或转移的方案向患者施用（如果这样选择）AT 1受体拮抗剂的肿瘤。

3. 发明申请

WO0159116A2 19459 PROTEIN, A NOVEL SEVEN TRANSMEMBRANE PROTEIN 审中-公开
标题翻译： 19459蛋白质，一种新的七代转录蛋白
公开(公告)号：WO0159116A2
公开(公告)日：2001-08-16
申请号：PCT/US0104446
申请日：2001-02-09
申请人： MILLENNIUM PHARM INC , GLUCKSMANN MARIA ALEXANDRA , WHITE DAVID
发明人： GLUCKSMANN MARIA ALEXANDRA , WHITE DAVID
IPC分类号： C07K14/705 , C07K14/72 , C12N15/12 , A61K39/395 , C07K16/28 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： The present invention relates to a newly identified seven-transmembrane protein, potentially a receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the protein. The invention further relates to methods using the polypeptides and polynucleotides as a target for diagnosis and treatment in 19459 protein-mediated or -related disorders. The invention further relates to drug-screening methods using the polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the polypeptides and polynucleotides. The invention further relates to procedures for producing the polypeptides and polynucleotides.
摘要翻译：本发明涉及新鉴定的七跨膜蛋白，潜在地是属于G蛋白偶联受体的超家族的受体。本发明还涉及编码该蛋白质的多核苷酸。本发明还涉及使用多肽和多核苷酸作为在19459蛋白介导或相关疾病中进行诊断和治疗的靶标的方法。本发明还涉及使用多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生多肽和多核苷酸的方法。

4. 发明申请

WO2005118567A3 MAGNESIUM COMPLEXES OF S-OMEPRAZOLE 审中-公开
标题翻译： S-OMEPRAZOLE的镁复合物
公开(公告)号：WO2005118567A3
公开(公告)日：2006-09-28
申请号：PCT/US2005018754
申请日：2005-05-27
申请人： AAIPHARMA INC , WHITTLE ROBERT R , WHITTALL LINDA , WHITE DAVID , STOWELL GRAYSON W
发明人： WHITTLE ROBERT R , WHITTALL LINDA , WHITE DAVID , STOWELL GRAYSON W
IPC分类号： C07D401/12 , A61K31/435 , A61K31/4439 , A61P1/04 , C07F3/00 , C07F3/02
CPC分类号： C07F3/003 , C07D401/12
摘要： The invention provides magnesium S-omeprazolato coordination compounds according to formula (I): [Mg(solv a )
摘要翻译：本发明提供了根据式（I）的S-巯基配位化合物：[Mg（solv）

5. 发明申请

WO0159116A9 19459 PROTEIN, A HUMAN G-PROTEIN COUPLED SEVEN TRANSMEMBRANE RECEPTOR 审中-公开
标题翻译： 19459蛋白质，人类G蛋白偶联第七代转录受体
公开(公告)号：WO0159116A9
公开(公告)日：2002-10-17
申请号：PCT/US0104446
申请日：2001-02-09
申请人： MILLENNIUM PHARM INC , GLUCKSMANN MARIA ALEXANDRA , WHITE DAVID
发明人： GLUCKSMANN MARIA ALEXANDRA , WHITE DAVID
IPC分类号： C07K14/705 , C07K14/72 , C12N15/12 , A61K39/395 , C07K16/28 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： The present invention relates to a newly identified seven-transmembrane protein, potentially a receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the protein. The invention further relates to methods using the polypeptides and polynucleotides as a target for diagnosis and treatment in 19459 protein-mediated or -related disorders. The invention further relates to drug-screening methods using the polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the polypeptides and polynucleotides. The invention further relates to procedures for producing the polypeptides and polynucleotides.
摘要翻译：本发明涉及新鉴定的七跨膜蛋白，潜在地是属于G蛋白偶联受体的超家族的受体。本发明还涉及编码该蛋白质的多核苷酸。本发明还涉及使用多肽和多核苷酸作为在19459蛋白质介导或相关疾病中进行诊断和治疗的靶标的方法。本发明还涉及使用多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生多肽和多核苷酸的方法。

6. 发明申请

WO0136605A3 2786, A HUMAN AMINOPEPTIDASE 审中-公开
标题翻译： 2786，人类氨基酸
公开(公告)号：WO0136605A3
公开(公告)日：2002-01-31
申请号：PCT/US0031873
申请日：2000-11-20
申请人： MILLENNIUM PHARM INC , KAPELLER LIBERMANN ROSANA , WHITE DAVID , MACBETH KYLE J
发明人： KAPELLER-LIBERMANN ROSANA , WHITE DAVID , MACBETH KYLE J
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/76 , A61K38/46 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/02 , A61P7/02 , A61P7/04 , A61P9/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/08 , A61P15/08 , A61P15/14 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/28 , A61P25/32 , A61P31/04 , A61P31/06 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/06 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N15/09 , C12Q1/02 , C12Q1/37 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N9/00 , A61K38/40 , C12N5/06 , C12N15/11 , C12N15/57
CPC分类号： C12N9/48
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
摘要翻译：本发明涉及新鉴定的人类氨基肽酶。本发明还涉及编码氨基肽酶的多核苷酸。本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。

7. 发明申请

WO2005086960A3 NARCOTIC-NSAID ION PAIRS 审中-公开
公开(公告)号：WO2005086960A3
公开(公告)日：2009-04-09
申请号：PCT/US2005008209
申请日：2005-03-10
申请人： AAIPHARMA INC , SANCILIO FREDERICK D , STOWELL GRAYSON W , WHITTALL LINDA B , WHITE DAVID , WHITTLE ROBERT R
发明人： SANCILIO FREDERICK D , STOWELL GRAYSON W , WHITTALL LINDA B , WHITE DAVID , WHITTLE ROBERT R
IPC分类号： A61K31/19 , A01N43/00 , A61K31/00 , A61K31/192 , A61K31/205 , A61K31/33 , A61K31/445 , A61K31/485 , C07D489/02
CPC分类号： C07D489/02 , C07C57/30 , C07C57/58 , C07C59/64 , C07C59/84 , C07C65/10 , C07C69/157 , C07C219/22 , C07C225/16 , C07C225/20 , C07C229/42 , C07C309/35 , C07C317/44 , C07D489/04
摘要： The present invention provides an ion pair compound of the formula [narcotic]+[A]-, wherein [narcotic]+ represents at least one cation of at least one narcotic agent or one or more stereochemical isomers thereof and [A]- represents at least one anion of at least one NSAID or one or more stereochemical isomers thereof. An example of the ion pair compound is propoxyphene diclofenate. The ion pair compounds, or their pharmaceutical compositions, are useful in methods of treating a wide variety of conditions that indicate analgesics, anti-inflammatory agents, or both. Under the conditions prescribed for their use, the ion pair compounds exhibit poor or complete insolubility but excellent chemical stability in low pH environments, such as those found in the stomach. The ion pair compounds readily dissolve and dissociate in higher pH environments such as the small intestine to release the constituent narcotic and NSAID.
摘要翻译：本发明提供式[麻醉] + [A] - 的离子对化合物，其中[麻醉] +代表至少一种麻醉剂或其一种或多种立体化学异构体的阳离子，[A] - 表示至少一种至少一种NSAID阴离子或其一种或多种立体化学异构体。离子对化合物的实例是丙氧芬双氯芬酸酯。离子对化合物或其药物组合物可用于治疗指示止痛剂，抗炎剂或两者的多种病症的方法。在其使用条件下，离子对化合物在低pH环境（例如胃中发现的那些）环境中表现出差的或完全的不溶性，但具有优异的化学稳定性。离子对化合物在较高的pH环境如小肠中容易溶解和解离，以释放组分麻醉剂和NSAID。

8. 发明申请

WO2006131748A3 METHOD FOR MODELING EPG DATA AT A HEADEND 审中-公开
标题翻译： EPG数据建模方法
公开(公告)号：WO2006131748A3
公开(公告)日：2007-07-12
申请号：PCT/GB2006002113
申请日：2006-06-09
申请人： NDS LTD , WHITE DAVID , BASTABLE IAN , GOLD MARTIN
发明人： WHITE DAVID , BASTABLE IAN , GOLD MARTIN
IPC分类号： H04N7/16
CPC分类号： H04N21/23109 , H04N7/165 , H04N21/26283
摘要： A data modeling method for modeling data for an electronic program guide (EPG) at a broadcast headend is described. The method includes grouping receiver types according to a first set of characteristics associated with a receiver type, thereby producing a plurality of groups of receivers, assigning a bit- number to each group of receivers, providing EPG data, the EPG data including data for display at an EPG, the EPG data being included in a data fragment, evaluating the data fragment and the EPG data included therein according to at least one characteristic from a second set of characteristics, thereby producing a result, adding metadata to the data fragment, the metadata including a bit field including the assigned bit number, the bit number being determined in accordance with the result, the metadata being indicative of at least one characteristic from the first set of characteristics with which a data container and EPG data included therein are associated, and broadcasting the data fragment in the data container. Related methods and apparatus are also described.
摘要翻译：描述了一种用于在广播前端对电子节目指南（EPG）建模数据的数据建模方法。该方法包括根据与接收器类型相关联的第一组特征对接收器类型进行分组，从而产生多组接收器，向每组接收器分配位数，提供EPG数据，EPG数据包括用于显示的数据在EPG中，EPG数据被包括在数据片段中，根据来自第二组特征的至少一个特征来评估其中包括的数据片段和EPG数据，从而产生结果，向数据片段添加元数据，包括包括所分配的比特数的比特字段的元数据，根据结果确定的比特数，所述元数据指示与其中包括的数据容器和EPG数据相关联的第一组特征中的至少一个特征，并在数据容器中广播数据片段。还描述了相关方法和装置。

9. 发明申请

WO2006131754A3 DATA CAROUSEL DELIVERY 审中-公开
标题翻译：数据卡车送货
公开(公告)号：WO2006131754A3
公开(公告)日：2007-05-31
申请号：PCT/GB2006002127
申请日：2006-06-09
申请人： NDS LTD , WHITE DAVID , BASTABLE IAN , GOLD MARTIN
发明人： WHITE DAVID , BASTABLE IAN , GOLD MARTIN
IPC分类号： H04N7/16
CPC分类号： H04N21/23109 , H04N7/165 , H04N21/26283
摘要： A method is described for updating electronic program guide (EPG) data in a system including a plurality of transponders, at least one of the transponders being at least partially dedicated to broadcasting EPG data and at least one of the transponders not being dedicated to broadcasting EPG data, the method including receiving a broadcast stream, the broadcast stream including a data carousel, the data carousel including a plurality of data containers sent from a transponder not dedicated to broadcasting EPG data, each individual data container of the plurality of data containers including updates to the EPG data, downloading each of the data containers included in the data carousel, extracting the updates to the EPG data from each downloaded data container, and updating a cache of EPG data according to the extracted updates to the EPG data. Related methods and apparatus are also described.
摘要翻译：描述了一种用于在包括多个转发器的系统中更新电子节目指南（EPG）数据的方法，至少一个转发器至少部分专用于广播EPG数据，并且至少一个转发器不专用于广播EPG 数据，所述方法包括接收广播流，所述广播流包括数据轮播，所述数据轮播包括从不专用于广播EPG数据的转发器发送的多个数据容器，所述多个数据容器中的每个单独数据容器包括更新 EPG数据，下载数据轮播中包含的每个数据容器，从每个下载的数据容器中提取对EPG数据的更新，以及根据所提取的对EPG数据的更新来更新EPG数据的缓存。还描述了相关方法和装置。

10. 发明申请

WO0149847A9 26904, 38911, AND 39404, SEVEN-TRANSMEMBRANE PROTEINS/G-PROTEIN COUPLED RECEPTORS 审中-公开
标题翻译： 26904,38911和39404，SEVEN-TRANSMEMBRANE蛋白/ G蛋白偶联受体
公开(公告)号：WO0149847A9
公开(公告)日：2002-06-27
申请号：PCT/US0035309
申请日：2000-12-22
申请人： MILLENNIUM PHARM INC , GLUCKSMANN MARIA ALEXANDRA , WHITE DAVID
发明人： GLUCKSMANN MARIA ALEXANDRA , WHITE DAVID
IPC分类号： A61K38/00 , C07K14/72 , C12N15/12 , A61K38/17 , C07K16/28 , C07K19/00 , C12N15/11 , C12N15/62 , C12Q1/68 , G01N33/50 , G01N33/566
CPC分类号： C07K14/723 , A61K38/00 , C07K2319/00
摘要： The present invention relates to seven-transmembrane proteins, including proteins that function as receptors belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the seven-transmembrane proteins/receptors. The invention further relates to methods using the seven-transmembrane protein/receptor polypeptides and polynucleotides as a target for diagnosis and treatment in seven-transmembrane protein/receptor-mediated and related disorders. The invention further relates to drug-screening methods using the seven-transmembrane protein/receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the seven-transmembrane protein/receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
摘要翻译：本发明涉及七跨膜蛋白，其包括用作属于G蛋白偶联受体的超家族的受体的蛋白质。本发明还涉及编码七跨膜蛋白/受体的多核苷酸。本发明还涉及使用七跨膜蛋白/受体多肽和多核苷酸作为七跨膜蛋白/受体介导和相关病症中的诊断和治疗的靶标的方法。本发明还涉及使用七跨膜蛋白/受体多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于七跨膜蛋白/受体多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生受体多肽和多核苷酸的方法。

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