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1. 发明申请

WO2009067397A2 TREATMENT FOR SOLID TUMORS 审中-公开
标题翻译：固体肿瘤治疗
公开(公告)号：WO2009067397A2
公开(公告)日：2009-05-28
申请号：PCT/US2008083750
申请日：2008-11-17
申请人： ORE PHARMACEUTICALS INC , WHITE DAVID WILLIAM , SHENGFANG JIN , COOPERSMITH ROBERT MARK , MALSTROM SCOTT EDWARD , NGUYEN THI T
发明人： WHITE DAVID WILLIAM , SHENGFANG JIN , COOPERSMITH ROBERT MARK , MALSTROM SCOTT EDWARD , NGUYEN THI T
IPC分类号： A61K31/00 , A61P35/00
CPC分类号： A61K31/00 , A61K31/255 , A61K31/47
摘要： A method for treating a solid tumor in a subject comprises administering to the subject an ACAT inhibitory compound or a prodrug thereof, for example avasimibe, wherein (a) the solid tumor is at least about 2 mm in diameter and (b) the compound or prodrug thereof is administered in an amount that is therapeutically effective, but ineffective to cause unacceptable toxicity to normoxic tissues.
摘要翻译：用于治疗受试者中的实体肿瘤的方法包括向受试者施用ACAT抑制化合物或其前药，例如阿伐他米，其中（a）实体瘤直径至少约2mm，和（b）化合物或其前药以治疗有效的量施用，但对于对正常氧组织引起不可接受的毒性无效。

2. 发明申请

WO2009049022A1 METHOD FOR TREATMENT OF PANCREATITIS 审中-公开
标题翻译：治疗胰腺癌的方法
公开(公告)号：WO2009049022A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079304
申请日：2008-10-09
申请人： ORE PHARMACEUTICALS INC. , TARTAGLIA, Louis, Anthony , BARNES, Thomas, Michael , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward , WHITE, David, William , GUZMAN, Luz-maria
发明人： TARTAGLIA, Louis, Anthony , BARNES, Thomas, Michael , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward , WHITE, David, William , GUZMAN, Luz-maria
IPC分类号： A61K31/415 , A61K31/4172 , A61K31/4174 , A61K31/426 , A61P3/00
CPC分类号： A61K31/415 , A61K31/4172 , A61K31/4174 , A61K31/426
摘要： A method for treating acute or chronic pancreatitis in a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor.
摘要翻译：用于治疗受试者的急性或慢性胰腺炎的方法包括向受试者施用治疗有效量的ACE2抑制剂。

3. 发明申请

WO2009067397A3 TREATMENT FOR SOLID TUMORS 审中-公开
公开(公告)号：WO2009067397A3
公开(公告)日：2009-05-28
申请号：PCT/US2008/083750
申请日：2008-11-17
申请人： ORE PHARMACEUTICALS INC. , WHITE, David, William , SHENGFANG, Jin , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward , NGUYEN, Thi, T.
发明人： WHITE, David, William , SHENGFANG, Jin , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward , NGUYEN, Thi, T.
IPC分类号： A61K31/47 , A61K31/255 , A61K31/00 , A61P35/00
摘要： A method for treating a solid tumor in a subject comprises administering to the subject an ACAT inhibitory compound or a prodrug thereof, for example avasimibe, wherein (a) the solid tumor is at least about 2 mm in diameter and (b) the compound or prodrug thereof is administered in an amount that is therapeutically effective, but ineffective to cause unacceptable toxicity to normoxic tissues.

4. 发明申请

WO2008060899A3 BREAST CANCER SCREENING AND TREATMENT METHODS 审中-公开
公开(公告)号：WO2008060899A3
公开(公告)日：2008-05-22
申请号：PCT/US2007/083778
申请日：2007-11-06
申请人： GENE LOGIC INC. , COOPERSMITH, Robert, Mark , WHITE, David , JIN, Shengfang , FERNANDES, Denzyl , LIN, Xuena
发明人： COOPERSMITH, Robert, Mark , WHITE, David , JIN, Shengfang , FERNANDES, Denzyl , LIN, Xuena
IPC分类号： G01N33/574
摘要： A method for selecting a female breast cancer patient for AT 1 receptor antagonist therapy comprises (a) determining whether the cancer comprises a tumor that is ER+ and/or PR+; and (b) selecting the patient for AT 1 receptor antagonist therapy only if the cancer is determined to comprise an ER+ and/or PR+ tumor. A method for treating breast cancer in a female patient further comprises (c) administering to the patient, if so selected, an AT 1 receptor antagonist according to a regimen effective to reduce growth, invasiveness and/or metastasis of the tumor.

5. 发明申请

WO2009114516A1 THERAPY FOR DISORDERS OF THE PROXIMAL DIGESTIVE TRACT 审中-公开
标题翻译：治疗接触性消化道疾病的治疗方法
公开(公告)号：WO2009114516A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/036642
申请日：2009-03-10
申请人： ORE PHARMACEUTICALS INC. , DONAHUE, Stephen, Richard , JACOBSON, Michael, David , BYRNES, John, Joseph , GUZMAN, Luz-maria , BARNES, Thomas, Michael , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward
发明人： DONAHUE, Stephen, Richard , JACOBSON, Michael, David , BYRNES, John, Joseph , GUZMAN, Luz-maria , BARNES, Thomas, Michael , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward
IPC分类号： A61K31/00 , A61K31/196 , A61K31/405 , A61K31/415 , A61K31/4172 , A61K31/4174 , A61K31/426 , A61K45/06 , A61P1/00 , A61P1/04
CPC分类号： A61K31/196 , A61K31/00 , A61K31/405 , A61K31/415 , A61K31/4172 , A61K31/4174 , A61K31/426 , A61K45/06 , A61K2300/00
摘要： A method for managing or treating an inflammatory, erosive, dyspeptic or reflux disorder of the proximal digestive tract of a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor. A therapeutic combination, useful to treat any disease or condition in which an NSAID is indicated, comprises an NSAID in an anti-inflammatory, analgesic or antipyretic effective amount and a gastroprotective agent that comprises an ACE2 inhibitor in an amount effective to protect mucosal surfaces of the proximal digestive tract from erosion or ulceration induced by the NSAID.
摘要翻译：用于管理或治疗受试者的近端消化道的炎性，侵蚀性，消化不良或回流障碍的方法包括向受试者施用治疗有效量的ACE2抑制剂。用于治疗其中指示NSAID的任何疾病或病症的治疗组合包含抗炎，镇痛或解热有效量的NSAID和包含ACE2抑制剂的胃保护剂，其有效保护粘膜表面的近端消化道由NSAID引起的侵蚀或溃疡。

6. 发明申请

WO2008060899A2 BREAST CANCER SCREENING AND TREATMENT METHODS 审中-公开
标题翻译：乳腺癌筛查和治疗方法
公开(公告)号：WO2008060899A2
公开(公告)日：2008-05-22
申请号：PCT/US2007083778
申请日：2007-11-06
申请人： GENE LOGIC INC , COOPERSMITH ROBERT MARK , WHITE DAVID , JIN SHENGFANG , FERNANDES DENZYL , LIN XUENA
发明人： COOPERSMITH ROBERT MARK , WHITE DAVID , JIN SHENGFANG , FERNANDES DENZYL , LIN XUENA
CPC分类号： G01N33/57415
摘要： A method for selecting a female breast cancer patient for AT 1 receptor antagonist therapy comprises (a) determining whether the cancer comprises a tumor that is ER+ and/or PR+; and (b) selecting the patient for AT 1 receptor antagonist therapy only if the cancer is determined to comprise an ER+ and/or PR+ tumor. A method for treating breast cancer in a female patient further comprises (c) administering to the patient, if so selected, an AT 1 receptor antagonist according to a regimen effective to reduce growth, invasiveness and/or metastasis of the tumor.
摘要翻译：用于选择AT＆gt;受体拮抗剂治疗的女性乳腺癌患者的方法包括（a）确定癌症是否包括ER +和/或PR +的肿瘤; 和（b）仅当确定癌症包含ER +和/或PR +肿瘤时才选择患者进行AT 1受体拮抗剂治疗。用于治疗女性患者乳腺癌的方法还包括（c）根据有效减少生长，侵袭和/或转移的方案向患者施用（如果这样选择）AT 1受体拮抗剂的肿瘤。

7. 发明申请

WO2008031014A1 METHOD FOR REDUCING OR ALLEVIATING INFLAMMATION IN THE DIGESTIVE TRACT 审中-公开
标题翻译：用于减少或消除污染物中的炎症的方法
公开(公告)号：WO2008031014A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/077857
申请日：2007-09-07
申请人： GENE LOGIC INC. , TARTAGLIA, Louis, Anthony , BARNES, Thomas, Michael , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward , WHITE, David, William , PICARELLA, Dominic
发明人： TARTAGLIA, Louis, Anthony , BARNES, Thomas, Michael , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward , WHITE, David, William , PICARELLA, Dominic
IPC分类号： A61K31/00 , A61K31/40 , A61P1/00 , A61P1/04
CPC分类号： A61K31/00 , A61K31/40 , A61K2300/00
摘要： A method is provided for reducing or alleviating inflammation or a pathological process associated therewith or secondary thereto in a subject having an inflammatory disease of the digestive tract. The method comprises administering to the subject an anti-inflammatorily effective amount of an ACE2 inhibitor.
摘要翻译：提供了一种减轻或缓解具有消化道炎性疾病的受试者的炎症或与其相关的或与之相关的病理过程的方法。该方法包括向受试者施用抗炎剂有效量的ACE2抑制剂。

8. 发明申请

WO2008031013A1 METHOD FOR TREATING INFLAMMATORY DISEASES OF THE DIGESTIVE TRACT 审中-公开
标题翻译：用于治疗消化性溃疡的炎性疾病的方法
公开(公告)号：WO2008031013A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/077855
申请日：2007-09-07
申请人： GENE LOGIC INC. , TARTAGLIA, Louis, Anthony , BARNES, Thomas, Michael , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward , WHITE, David, William , PICARELLA, Dominic
发明人： TARTAGLIA, Louis, Anthony , BARNES, Thomas, Michael , COOPERSMITH, Robert, Mark , MALSTROM, Scott, Edward , WHITE, David, William , PICARELLA, Dominic
IPC分类号： A61K31/00 , A61K31/40 , A61P1/00 , A61P1/04
CPC分类号： A61K31/40 , A61K45/06 , A61K2300/00
摘要： A method for treating an inflammatory disease of the digestive tract, for example inflammatory bowel disease, in a subject comprises administering to the subject a therapeutically effective amount of a compound selected from the group consisting of (S,S)-2- [ 1 -carboxy-2- [3 -(3,5 -dichlorobenzyl)-3 H-imidazol-4-yl] -ethylamino] -4-methylpentanoic acid, pharmaceutically acceptable salts thereof and prodrugs thereof.
摘要翻译：用于治疗受试者的消化道炎性疾病（例如炎症性肠病）的方法包括向受试者施用治疗有效量的选自（S，S）-2- [1- 羧基-2- [3-（3,5-二氯苄基）-3H-咪唑-4-基] - 乙基氨基] -4-甲基戊酸，其药学上可接受的盐和其前药。

9. 发明申请

WO2009137543A3 METHODS FOR BREAST CANCER SCREENING AND TREATMENT 审中-公开
公开(公告)号：WO2009137543A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/042929
申请日：2009-05-06
申请人： ORE PHARMACEUTICALS INC. , WHITE, David , JIN, Shengfang , COOPERSMITH, Robert, Mark , FERNANDES, Denzyl , LIN, Xuena
发明人： WHITE, David , JIN, Shengfang , COOPERSMITH, Robert, Mark , FERNANDES, Denzyl , LIN, Xuena
IPC分类号： G01N33/574
摘要： A method for selecting a breast cancer patient for therapy with an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor, comprises (a) determining whether the cancer comprises a tumor that is estrogen receptor positive (ER+) and (b) selecting the patient for such therapy only if the cancer is determined to comprise an ER+ tumor. A method for treating breast cancer in a patient further comprises (c) administering to the patient, if so selected, an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor. A method for treating a breast tumor in a patient having SERM-resistant ER+ breast cancer comprises administering to the patient an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor. A therapeutic combination useful in treatment of a breast tumor comprises an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor, and a second agent that comprises (a) an aromatase inhibitor or (b) an estrogen receptor modulator or antagonist.

10. 发明申请

WO2009137543A2 METHODS FOR BREAST CANCER SCREENING AND TREATMENT 审中-公开
标题翻译：乳腺癌筛查和治疗方法
公开(公告)号：WO2009137543A2
公开(公告)日：2009-11-12
申请号：PCT/US2009042929
申请日：2009-05-06
申请人： ORE PHARMACEUTICALS INC , WHITE DAVID , JIN SHENGFANG , COOPERSMITH ROBERT MARK , FERNANDES DENZYL , LIN XUENA
发明人： WHITE DAVID , JIN SHENGFANG , COOPERSMITH ROBERT MARK , FERNANDES DENZYL , LIN XUENA
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N2333/515 , G01N2333/723 , G01N2800/52
摘要： A method for selecting a breast cancer patient for therapy with an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor, comprises (a) determining whether the cancer comprises a tumor that is estrogen receptor positive (ER+) and (b) selecting the patient for such therapy only if the cancer is determined to comprise an ER+ tumor. A method for treating breast cancer in a patient further comprises (c) administering to the patient, if so selected, an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor. A method for treating a breast tumor in a patient having SERM-resistant ER+ breast cancer comprises administering to the patient an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor. A therapeutic combination useful in treatment of a breast tumor comprises an agent that reduces production of angiotensin II, for example an ACE inhibitor or renin inhibitor, and a second agent that comprises (a) an aromatase inhibitor or (b) an estrogen receptor modulator or antagonist.
摘要翻译：选择乳腺癌患者用减少血管紧张素II产生的药剂进行治疗的方法，例如ACE抑制剂或肾素抑制剂，包括（a）确定癌症是否包含雌激素受体阳性（ER +）和（ b）只有当确定癌症包含ER +肿瘤时，才选择患者进行这种治疗。治疗患者乳腺癌的方法进一步包括（c）如果如此选择，给患者施用减少血管紧张素II产生的药剂，例如ACE抑制剂或肾素抑制剂。治疗患有SERM抗性ER +乳腺癌的患者中的乳腺肿瘤的方法包括给患者施用减少血管紧张素II产生的药剂，例如ACE抑制剂或肾素抑制剂。可用于治疗乳房肿瘤的治疗组合包含减少血管紧张素II（例如ACE抑制剂或肾素抑制剂）产生的试剂和包含（a）芳香酶抑制剂或（b）雌激素受体调节剂或拮抗剂。

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