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1. 发明申请

WO1993000366A1 METHOD FOR TREATING IMMUNOLOGICAL DISORDERS AND DISEASES 审中-公开
标题翻译：治疗免疫缺陷病和疾病的方法
公开(公告)号：WO1993000366A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005360
申请日：1992-06-24
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , ROSSINI, Aldo, A. , MORDES, John, P. , HANDLER, Eugene, S. , GREINER, Dale, L.
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
IPC分类号： C07K15/06
CPC分类号： C07K14/705 , A61K38/00 , A61K39/0008 , A61K2039/5158
摘要： This invention pertains to a method and apparatus for therapeutically treating insulin-dependent diabetes mellitus and other immunological disorders and disease states which are characterized by the presence of immunologically abnormal leukocytes in the body of the afflicted subject. The method involves the therapeutic administration of postthymic T lymphocytes capable of secreting soluble factors that can ameliorate disease state associated with diabetes or other autoimmune disease. Methods of screening and/or detecting insulin-dependent diabetes are also described.
摘要翻译：本发明涉及治疗性治疗胰岛素依赖性糖尿病和其他免疫学疾病和疾病状态的方法和装置，其特征在于受影响的受试者身体中存在免疫学异常的白细胞。该方法涉及能够分泌能够改善与糖尿病或其他自身免疫疾病相关的疾病状态的可溶性因子的胸腺后T淋巴细胞的治疗性给药。还描述了筛选和/或检测胰岛素依赖性糖尿病的方法。

2. 发明申请

WO1995028957A2 METHODS FOR INDUCING T CELL TOLERANCE TO A TISSUE OR ORGAN GRAFT 审中-公开
标题翻译：用于诱导T细胞对组织或组织细胞耐受性的方法
公开(公告)号：WO1995028957A2
公开(公告)日：1995-11-02
申请号：PCT/US1995004832
申请日：1995-04-25
申请人： TRUSTEES OF DARTMOUTH COLLEGE , UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , NOELLE, Randolph, J. , DURIE, Fiona, H. , PARKER, David, C. , APPEL, Michael, C. , PHILIPS, Nancy, E. , MORDES, John, P. , GRENIER, Dale, L. , ROSSINI, Aldo, A.
发明人： TRUSTEES OF DARTMOUTH COLLEGE , UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
IPC分类号： A61K39/00
CPC分类号： A61K39/001 , A61K35/17 , A61K35/39 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/2875 , C07K2317/73 , Y10S514/885 , A61K2300/00
摘要： Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.
摘要翻译：公开了在移植受体中诱导T细胞对组织或器官移植物的耐受性的方法。所述方法包括对受试者施用：1）同种异体或异种细胞，其表达供体抗原，并且其在细胞表面上具有与介导接触依赖性辅助效应子功能的受体T细胞表面上的受体相互作用的配体; 和2）抑制配体与受体相互作用的受体拮抗剂。在一个优选的实施方案中，同种异体或异种细胞是B细胞，优选静止的B细胞，并且介导接触依赖性辅助效应子功能的T细胞表面上的分子是gp39。优选的gp39拮抗剂是抗gp39抗体。同种异体或异种细胞和gp39拮抗剂通常在移植组织或器官之前给予移植受体。本发明的方法可用于诱导移植物如肝，肾，心脏，肺，皮肤，肌肉，神经元组织，胃和肠的T细胞耐受性。还公开了一种用于治疗糖尿病的方法，其包括向受试者施用表达供体抗原的同种异体或异种细胞，gp39拮抗剂和胰岛。

3. 发明申请

WO1997006823A1 MONOCLONAL ANTIBODIES FOR DETECTING NORWALK VIRUS 审中-公开
标题翻译：用于检测NORWALK病毒的单克隆抗体
公开(公告)号：WO1997006823A1
公开(公告)日：1997-02-27
申请号：PCT/US1996013215
申请日：1996-08-15
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , HERRMANN, John, E. , BLACKLOW, Neil, R.
IPC分类号： A61K39/395
CPC分类号： C07K16/081 , A61K39/00 , G01N33/536 , G01N33/56983 , G01N33/686 , G01N2333/08
摘要： Monoclonal antibodies and their use in assays to determine the presence of Norwalk virus, Norwalk virus particles, or Norwalk virus-specific IgM, in a biological sample. One assay includes the steps of contacting the sample with a monoclonal antibody that specifically binds to Norwalk virus particles in human stool; reacting the sample and the antibody for a time and under conditions that allow the formation of an immunocomplex between the antibody and any Norwalk virus in the sample; and detecting the immunocomplex, the presence of the immunocomplex indicating the presence of human Norwalk virus in the sample. Another assay is an IgM capture antibody immunoassay.
摘要翻译：单克隆抗体及其在测定中用于确定诺瓦克病毒，诺瓦克病毒颗粒或诺瓦克病毒特异性IgM存在于生物样品中的用途。一个测定包括使样品与特异性结合人粪便中的诺沃克病毒颗粒的单克隆抗体接触的步骤; 使样品和抗体反应一段时间，并在允许在样品中抗体和任何诺瓦克病毒之间形成免疫复合物的条件下进行; 并检测免疫复合物，表明在样品中存在人诺沃克病毒的免疫复合物的存在。另一种测定法是IgM捕获抗体免疫测定法。

4. 发明申请

WO1997003090A2 NUCLEAR LOCALIZED TRANSCRIPTION FACTOR KINASE AND DIAGNOSTIC ASSAYS RELATED THERETO 审中-公开
标题翻译：核心定位转录因子激酶和诊断相关性测定
公开(公告)号：WO1997003090A2
公开(公告)日：1997-01-30
申请号：PCT/US1996011495
申请日：1996-07-10
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , DENIS, Gerald, V. , GREEN, Michael, R.
IPC分类号： C07K00/00
CPC分类号： G01N33/57426 , C12N9/12 , C12Q1/48
摘要： New nuclear kinases that are regulated by signal transduction and that participate in phosphorylation cascades which regulate transcription and related methods for regulating transcription. The novel nuclear kinases play a vital role in gene expression, particularly with regard to leukemia in humans. The kinase is (i) substantially exclusively intranuclearly localized; (ii) capable of autophosphorylation; (iii) selectively bindable with antibodies raised against the RING3 portion of GST-RING3; (iv) of a molecular weight of from about 82.5 to about 92.7 kilodaltons; and (v) includes peptide sequences Asp-Ser-Asn Pro-Asp-Glu-Ile-Asp-Phe-Glu-Thr-Leu-Lys-Pro-Thr-Thr-Leu and Ala-Val-His-Glu-Gln-Leu-Ala-Ala-Leu-Ser-Gln-Ala-Pro. The invention features a method of detecting leukemic cells in a biological sample, the method includes measuring the activity of a RING3-related kinase in the sample, an increase in the activity relative to a control being indicative of the presence of leukemic cells.
摘要翻译：通过信号转导调节并参与调节转录的磷酸化级联和调节转录的相关方法的新的核激酶。新型核激酶在基因表达中起重要作用，特别是人类白血病。激酶是（i）基本上仅在核内定位的; （ii）能够自磷酸化; （iii）与针对GST-RING3的RING3部分产生的抗体选择性结合; （iv）分子量为约82.5至约92.7千道尔顿; 和（v）包括肽序列Asp-Ser-Asn Pro-Asp-Glu-Ile-Asp-Phe-Glu-Thr-Leu-Lys-Pro-Thr-Thr-Leu和Ala-Val-His-Glu-Gln- 亮氨酸，丙氨酸 - 丙氨酸，亮氨酸，丝氨酸 - 谷氨酰胺丙氨酸 - 脯氨酸。本发明的特征在于一种检测生物样品中白血病细胞的方法，该方法包括测量样品中RING3相关激酶的活性，相对于控制指示白血病细胞存在的活性的增加。

5. 发明申请

WO1997001648A1 A NOVEL HUMAN PROTEIN CRITICAL FOR HIV REPLICATION 审中-公开
标题翻译：一个新的人类蛋白质关键的HIV复制
公开(公告)号：WO1997001648A1
公开(公告)日：1997-01-16
申请号：PCT/US1996011078
申请日：1996-06-27
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , FRITZ, Christian, C. , GREEN, Michael, R.
IPC分类号： C12Q01/70
CPC分类号： C12N9/16 , C07K14/47 , C07K14/4722 , C07K16/18
摘要： The present invention provides a human cellular polypeptide, termed hRIP, that is necessary for HIV replication. The polypeptide has a molecular mass of about 59 kDa, having the sequence set forth in the figure (SEQ ID NO:1). hRIP is the cellular cofactor required to mediate the Rev response. hRIP binds HIV Rev protein and is essential for Rev activity. The invention also includes nucleic acid sequences encoding hRIP, as well as DNA vectors and transformed cells suitable for recombinant expression of this polypeptide.
摘要翻译：本发明提供了HIV复制所必需的人细胞多肽，称为hRIP。该多肽具有约59kDa的分子量，其具有图中所示的序列（SEQ ID NO：1）。 hRIP是调节Rev反应所需的细胞辅因子。 hRIP结合HIV Rev蛋白，对于Rev活性至关重要。本发明还包括编码hRIP的核酸序列，以及适合于重组表达该多肽的DNA载体和转化细胞。

6. 发明申请

WO1996038552A1 POST-TRANSCRIPTIONAL GENE REGULATION BY SELENIUM 审中-公开
标题翻译：由SELENIUM进行转录后基因调控
公开(公告)号：WO1996038552A1
公开(公告)日：1996-12-05
申请号：PCT/US1996007496
申请日：1996-05-23
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , LEONARD, Jack, L. , NEWBURGER, Peter, E.
IPC分类号： C12N15/09
CPC分类号： A01K67/0275 , A01K2217/05 , C12N15/63 , C12N15/67 , C12N15/79
摘要： Methods of controlling the in vivo and in vitro expression of a heterologous protein by transfecting a cell with a first nucleic acid encoding the heterologous polypeptide, wherein at least one codon of mRNA transcribed from the first nucleic acid is replaced by the codon UGA, and a second nucleic acid operably linked to the first nucleic acid, the second nucleic acid directing the translation of the UGA codon as selenocysteine only when the cell can obtain selenium from the medium in which it is grown; and growing the cell under conditions in which the production of the polypeptide is controlled by the level of selenium available to the cell.
摘要翻译：通过用编码异源多肽的第一核酸转染细胞来控制异源蛋白的体内和体外表达的方法，其中至少一个从第一个核酸转录的mRNA的密码子被UGA的密码子替代，可操作地连接到第一核酸的第二核酸，仅当细胞可从其生长的培养基中获得硒时，引导UGA密码子翻译为硒代半胱氨酸的第二核酸; 并且在多肽的产生受到可用于细胞的硒水平控制的条件下生长细胞。

7. 发明申请

WO1996011265A1 CIS-ACTING SEQUENCES FOR INTRACELLULAR LOCALIZATION OF RNA 审中-公开
标题翻译：用于RNA的细胞内定位的CIS-动作序列
公开(公告)号：WO1996011265A1
公开(公告)日：1996-04-18
申请号：PCT/US1995013142
申请日：1995-10-04
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , SINGER, Robert, H. , KISLAUSKIS, Edward, H.
IPC分类号： C12N15/00
CPC分类号： C07K14/4716 , C12N15/85
摘要： Disclosed are the particular 3' noncoding nucleotide sequences (zipcode and zipcode elements) that cause beta -actin mRNA (and beta -actin protein synthesis) to be localized in specific regions of the cytoplasm. Also disclosed is the discovery that zipcode function can be fully inhibited by antisense oligonucleotides.
摘要翻译：公开了引起β-actin mRNA（和β-肌动蛋白蛋白合成）定位于细胞质特定区域的特定3'非编码核苷酸序列（zipcode和zipcode元件）。还公开了这样的发现：反义寡核苷酸可以完全抑制zipcode功能。

8. 发明申请

WO1994027428A1 POST-TRANSCRIPTIONAL GENE REGULATION BY TRACE MINERALS 审中-公开
标题翻译： TRAC矿物转基因基因调控
公开(公告)号：WO1994027428A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005388
申请日：1994-05-16
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , LEONARD, Jack, L. , NEWBURGER, Peter, E.
IPC分类号： A01K67/00
CPC分类号： A01K67/0275 , A01K2217/05 , C12N15/63 , C12N15/67 , C12N15/79
摘要： Methods of controlling the in vivo and in vitro expression of a heterologous protein which involve providing a cell containing a first nucleic acid encoding the heterologous polypeptide wherein at least one codon of the mRNA transcribed from the first nucleic acid has been replaced by the codon UGA operably linked to a second nucleic acid capable of directing the translation of the UGA codon as selenocysteine are described.
摘要翻译：控制异源蛋白的体内和体外表达的方法，其涉及提供含有编码异源多肽的第一核酸的细胞，其中从第一核酸转录的mRNA的至少一个密码子已被可操作地被密码子UGA替代描述了与能够引导UGA密码子翻译为硒代半胱氨酸的第二核酸连接。

9. 发明申请

WO1997007153A1 METHODS OF CONTROLLING MICROBIAL POLYESTER STRUCTURE 审中-公开
标题翻译：控制微波聚合物结构的方法
公开(公告)号：WO1997007153A1
公开(公告)日：1997-02-27
申请号：PCT/US1995010396
申请日：1995-08-14
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , GROSS, Richard, A. , SHI, Fengying , ASHBY, Richard, D.
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
IPC分类号： C08G63/00
CPC分类号： C08G63/664 , C12P7/625
摘要： The addition of PEG to culture media of Alcaligenes eutrophus and A. latus resulted in the following: (1) the controlled decrease in polyhydroxyalkanoate (PHA) molecular weight, which decreases the melt viscosity and bioresorption time; (2) the modulation of the repeat unit composition of the PHA products containing 3-hydroxybutyrate, 3-hydroxyvalerate, and 4-hydroxybutyrate, which provides polymers with varied physical properties; (3) the alteration of PHA repeat unit sequence distribution so that complex polymeric mixtures are obtained in place of random copolymers; and (4) the formation of PHA-PEG diblock copolymers where the carboxylate terminus of PHA chains are covalently linked by an ester bond to PEG chain segments. This is an example of the cellular production of a naturally synthesized diblock copolymer. The invention features new diblock copolymers, copolyester blends, and methods of preparation.
摘要翻译：向富含产碱杆菌和肠杆菌的培养基中添加PEG导致以下结果：（1）聚羟基链烷酸酯（PHA）分子量的受控降低，降低了熔体粘度和生物吸收时间; （2）含有3-羟基丁酸酯，3-羟基戊酸酯和4-羟基丁酸酯的PHA产物的重复单元组成的调节，其提供具有不同物理性质的聚合物; （3）PHA重复单元序列分布的改变使得获得复合聚合物混合物代替无规共聚物; 和（4）PHA-PEG二嵌段共聚物的形成，其中PHA链的羧酸酯末端通过酯键与PEG链段共价连接。这是天然合成的二嵌段共聚物的细胞生产的实例。本发明的特征在于新的二嵌段共聚物，共聚酯共混物和制备方法。

10. 发明申请

WO1996041212A1 FIBER OPTIC PLATES FOR GENERATING SEAMLESS IMAGES 审中-公开
标题翻译：用于生成无缝图像的光纤板
公开(公告)号：WO1996041212A1
公开(公告)日：1996-12-19
申请号：PCT/US1996002243
申请日：1996-02-20
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , KARELLAS, Andrew
IPC分类号： G01T01/20
CPC分类号： G01T1/202 , G01T1/2018 , G01T1/2928 , G21K4/00 , H04N5/32
摘要： The invention features an optical imaging system for generating a seamless image during, for example X-ray imaging procedures. The imaging system features at least two optical detectors (64a, 64b), each including an optically active region (68a, 68b) for generating separate light-induced images, and a fiber optic plate separated by a groove into first and second fiber-containing section (62a, 62b). Each of the first and second sections are connected to a separate optical detector so that, duriing operation, fibers (63) contained in these sections function to deliver light exclusively to the optically active regions of the connected detectors (64a, 64b), thereby allowing generation of separate light-induced images. These images can then be combined to form a seamless image.
摘要翻译：本发明的特征在于用于在例如X射线成像过程期间产生无缝图像的光学成像系统。成像系统具有至少两个光学检测器（64a，64b），每个光学检测器包括用于产生分离的光诱导图像的光学有效区域（68a，68b）和由凹槽分隔成第一和第二纤维含有（62a，62b）。第一部分和第二部分中的每一个连接到单独的光学检测器，使得在操作期间，包含在这些部分中的光纤（63）用于仅将光传送到连接的检测器（64a，64b）的光学活性区域，从而允许产生单独的光诱导图像。然后可以将这些图像组合以形成无缝图像。

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