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1. 发明申请

WO1994025489A1 DOWNREGULATION OF ALLERGEN-SPECIFIC IMMUNE RESPONSE 审中-公开
标题翻译：对特异性免疫应答的调节
公开(公告)号：WO1994025489A1
公开(公告)日：1994-11-10
申请号：PCT/CA1994000228
申请日：1994-04-26
申请人： UNIVERSITY OF MANITOBA , MOHAPATRA, Shyam, S. , SEHON, Alec, H.
发明人： UNIVERSITY OF MANITOBA
IPC分类号： C07K15/06
CPC分类号： C07K14/7051 , A61K39/00
摘要： Synthetic peptides are provided for effecting immunotherapy. The peptides have an amino acid sequence comprising at least a portion of the CDR3 region of a T-cell receptor and capable of eliciting a T-cell response, particularly an amino acid sequence encoded by a nucleotide sequence comprising the J-gene of the alpha -chain and/or beta -chain of the TCR. The peptides are particularly useful in suppressing an immune response to an antigen, particularly an allergenic antigen.
摘要翻译：提供合成肽用于进行免疫治疗。肽具有包含T细胞受体的CDR3区域的至少一部分并且能够引发T细胞应答的氨基酸序列，特别是由包含α的J基因的核苷酸序列编码的氨基酸序列链和/或β链。所述肽特别可用于抑制对抗原，特别是变应原性抗原的免疫应答。

2. 发明申请

WO1994021686A1 PAPP-A, ITS IMMUNODETECTION AND USES 审中-公开
标题翻译： PAPP-A，其免疫保护和用途
公开(公告)号：WO1994021686A1
公开(公告)日：1994-09-29
申请号：PCT/AU1994000139
申请日：1994-03-21
申请人： NORTHERN SYDNEY AREA HEALTH SERVICE , SINOSICH, Michael, Joseph
发明人： NORTHERN SYDNEY AREA HEALTH SERVICE
IPC分类号： C07K15/06
CPC分类号： C07K14/4715 , Y10S435/806 , Y10S435/81
摘要： This invention concerns PAPP-A, its immunodetection and the clinical benefits of such immunodetection. Specifically, the invention includes monoclonal antibodies against PAPP-A and the use of these antibodies to detect PAPP-A at a very early stage of pregnancy. The invention also covers the use of the monoclonal antibodies for the detection of specific types of cancer and Down's Syndrome pregnancies.
摘要翻译：本发明涉及PAPP-A，其免疫检测和这种免疫检测的临床益处。具体地，本发明包括针对PAPP-A的单克隆抗体以及这些抗体在怀孕的早期阶段检测PAPP-A的用途。本发明还涉及单克隆抗体用于检测特定类型的癌症和唐氏综合征怀孕的用途。

3. 发明申请

WO1994004571A1 A SUBSTRATE FOR THE EPIDERMAL GROWTH FACTOR RECEPTOR KINASE 审中-公开
标题翻译：用于生殖因子受体激动剂的基质
公开(公告)号：WO1994004571A1
公开(公告)日：1994-03-03
申请号：PCT/US1993007996
申请日：1993-08-25
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ...
发明人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ... , DI FIORE, Pier, P. , FAZIOLI, Francesca
IPC分类号： C07K15/06
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C12Q1/48 , G01N33/57488 , G01N2333/485
摘要： A new substrate of epidermal growth factor receptor and other tyrosine kinase receptors denominated (eps)8, polynucleotide encoding (eps)8, antisense (eps)8 polynucleotide, antibodies to (eps)8, and assays for determining (eps)8.
摘要翻译：表达生长因子受体和其他酪氨酸激酶受体（eps）8，编码（eps）8，反义（eps）8多核苷酸的多核苷酸，（eps）8的抗体和确定（eps）8的测定法的新底物。

4. 发明申请

WO9400572A3 GENE FOR ATAXIA-TELANGIECTASIA COMPLEMENTATION GROUP D (ATDC) 审中-公开
标题翻译： ATAXIA-TELANGIECTASIA补充组D（ATDC）
公开(公告)号：WO9400572A3
公开(公告)日：1994-02-17
申请号：PCT/US9305794
申请日：1993-06-18
申请人： UNIV CALIFORNIA
发明人： MURNANE JOHN P , PAINTER ROBERT B , KAPP LEON N , YU LOH-CHUNG
IPC分类号： C12N15/09 , C07K14/47 , C12N15/12 , C12Q1/68 , C07K15/06
CPC分类号： C07K14/47
摘要： Disclosed herein is an AT gene for complementation group D, the ATDC gene and fragments thereof. Nucleic acid probes for said gene are provided as well as proteins encoded by said gene, cDNA therefrom, preferably a 3 kilobase (kb) cDNA, and recombinant nucleic acid molecules for expression of said proteins. Further disclosed are methods to detect mutations in said gene, preferably methods employing the polymerase chain reaction (PCR).

5. 发明申请

WO1994001466A1 PLASMA FRACTION PURIFICATION 审中-公开
标题翻译：等离子体分离纯化
公开(公告)号：WO1994001466A1
公开(公告)日：1994-01-20
申请号：PCT/US1993006609
申请日：1993-07-13
申请人： ALPHA THERAPEUTIC CORPORATION
发明人： ALPHA THERAPEUTIC CORPORATION , HERRING, Steven, W. , UEMURA, Hahiro , NODA, Munehiro , SHITANISHI, Kenneth, T.
IPC分类号： C07K15/06
CPC分类号： C12N9/6429 , C07K14/745 , C12N9/6432 , C12Y304/21005 , C12Y304/21006
摘要： The present invention describes a process for activating Factor II to Factor IIa by incubating Factor II in the pressence of Factor V, Factor Xa, phospholipids, and calcium ions. Each of the factors is prepared from a single impure protein fraction which includes Factors II, V and X. The Factor II, V and X purification procedure comprises the steps of DEAE ligand chromatography and precipitation by the addition of barium chloride. Factor V is recovered from the barium chloride supernatant, and Factors II and X are contained in the barium chloride precipitate. The barium chloride precipitate is dissolved in an aqueous solution and is applied to a chromatographic resin coupled with a ligand which binds Factor X and Factor II weakly or not at all. Factor II is recovered from the fraction, which remains unbound or weakly bound to the Factor X binding ligand. Factor Xa is prepared by recovering Factor X from the ligand during the Factor II preparation procedure and activating the Factor X to Factor Xa by specific proteolytic cleavage.
摘要翻译：本发明描述了通过在因子V，因子Xa，磷脂和钙离子的压迫下孵育因子II来激活因子II至因子IIa的方法。每个因素由包含因子II，V和X的单个不纯蛋白质级分制备。因子II，V和X纯化程序包括DEAE配体层析和通过加入氯化钡沉淀的步骤。因子V从氯化钡上清液中回收，因子II和X包含在氯化钡沉淀中。将氯化钡沉淀物溶解在水溶液中，并施加到与限制因子X和因子II的配体偶联的色谱树脂上或完全不结合。因子II从部分回收，其保持未结合或弱结合于因子X结合配体。因子Xa通过在因子II制备过程中从配体中回收因子X并通过特异性蛋白水解切割活化因子X至因子Xa来制备。

6. 发明申请

WO1993017045A1 A NOVEL SERUM GROWTH FACTOR 审中-公开
标题翻译：一个新的血清生长因子
公开(公告)号：WO1993017045A1
公开(公告)日：1993-09-02
申请号：PCT/US1993001739
申请日：1993-03-01
申请人： ALLIANCE PHARMACEUTICAL CORP. , DEHAZYA, Philip
发明人： ALLIANCE PHARMACEUTICAL CORP.
IPC分类号： C07K15/06
CPC分类号： C07K16/18 , A61K38/00 , A61K51/1093 , C07K14/76
摘要： A novel glycosylated form of albumin, designated EGA, is further characterized by its cell growth promoting activity. A process of isolation of human or bovine glycosylated albumin is described. The EGA fractions have been identified by serological histochemical and biological assays as well as lectin reactivity. The growth-promoting effect of EGA is directed to various transformed cell lines and primary cells of mammalian origin. Also described is a neutralizing antibody to the EGA of the present invention produced from a parental cell line. Novel compositions of EGA containing media are provided for cell, tissue or organ culture and diagnostic and therapeutic procedures are provided. Further, hybridoma cell lines producing inhibiting or neutralizing antibodies or antibodies or antibodies against EGA are described.

7. 发明申请

WO1992017501A1 ISOLATED OSTEOGENIC FACTOR 审中-公开
标题翻译：分离的生物因子
公开(公告)号：WO1992017501A1
公开(公告)日：1992-10-15
申请号：PCT/CA1992000130
申请日：1992-03-25
申请人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC.
发明人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC. , LAGARDE, Alain, E. , ABDULWAJID, Abdulwahid , BUESCHKENS, Donna , BYRNE, Deanna
IPC分类号： C07K15/06
CPC分类号： C07K14/51 , A61K38/00 , Y10S530/84
摘要： Described is a purified osteogenic factor that when delivered to bone in association with a physiologically acceptable delivery vehicle is capable of inducing new bone growth at the bone surface. The osteogenic factor is water soluble, and is characterized physically by a molecular weight of about 2.5 kD when measured by gel filtration under dissociating conditions and an isoelectric point in the pH range from about 4.6 to 7.2. Use of the purified factor in treating bone defects is described. Also described is a method for obtaining the purified factor from mammalian bone.

8. 发明申请

WO1992002557A1 arg A HUMAN GENE RELATED TO BUT DISTINCT FROM abl PROTO-ONCOGENE 审中-公开
标题翻译： arg一个与abl PROTO-ONCOGENE相关但与DISTINCT相关的人类基因
公开(公告)号：WO1992002557A1
公开(公告)日：1992-02-20
申请号：PCT/US1991005288
申请日：1991-07-29
申请人： THE UNITED STATES OF AMERICA, represented by THE ...
发明人： THE UNITED STATES OF AMERICA, represented by THE ... , KRUH, Gary, D. , AARONSON, Stuart, A.
IPC分类号： C07K15/06
CPC分类号： C12N9/1205 , C07K14/47 , C07K14/82 , C07K16/32 , C07K16/40 , C07K2319/02
摘要： A new gene, arg, related to the abl proto-oncogene is isolated and sequenced. The gene is transcribed to two mRNA's, which in turn form two proteins. Antibodies, oligonucleotide probes and assays for detecting the arg gene, its mRNA and its protein products, are also included.
摘要翻译：与abl原癌基因相关的新基因arg被分离并测序。该基因被转录成两个mRNA，其又形成两个蛋白质。还包括用于检测arg基因，其mRNA及其蛋白质产物的抗体，寡核苷酸探针和测定法。

9. 发明申请

WO1992000329A1 SURFACE COMPLEXED LYMPHOTOXIN 审中-公开
标题翻译：表面复合LYMPHOTOXIN
公开(公告)号：WO1992000329A1
公开(公告)日：1992-01-09
申请号：PCT/US1991004588
申请日：1991-06-27
申请人： BIOGEN, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BROWNING, Jeffrey , WARE, Carl, F.
发明人： BIOGEN, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C07K15/06
CPC分类号： C07K14/5255 , A61K38/00 , C07K14/525
摘要： This invention relates to a membrane associated protein, p33, and the complex it forms with a soluble lymphotoxin. These proteins are found on the surface of a number of cells, including phorbol ester (PMA) stimulated T cell hybridoma II-23.D7 cells. These proteins and complexes are useful as anti-inflammatory agents, enhancers of tumor infiltrating lymphocytes, tumor growth inhibiting agents, T cell inhibiting agents and T cell activating agents.
摘要翻译：本发明涉及膜相关蛋白p33，以及与可溶性淋巴毒素形成的复合物。这些蛋白质在许多细胞的表面上发现，包括佛波酯（PMA）刺激的T细胞杂交瘤II-23.D7细胞。这些蛋白质和复合物可用作抗炎剂，肿瘤浸润淋巴细胞的增强剂，肿瘤生长抑制剂，T细胞抑制剂和T细胞活化剂。

10. 发明申请

WO1991011463A1 ENDOGENOUS BRAIN FACTOR, METHOD FOR OBTAINING IT AND THERAPEUTIC AND DIAGNOSTIC USES THEREOF 审中-公开
标题翻译：内源性脑因子，其获取方法及其治疗及诊断用途
公开(公告)号：WO1991011463A1
公开(公告)日：1991-08-08
申请号：PCT/FR1991000085
申请日：1991-02-05
申请人： INSTITUT PASTEUR , FILLION, Gilles, Marie, Bernard , ROUSELLE, Jean-Claude
发明人： INSTITUT PASTEUR
IPC分类号： C07K15/06
CPC分类号： C07K14/46 , A61K38/00
摘要： An endogenous brain factor or a fragment thereof, acting on the serotoninergic functions and having an essentially peptide nature, a molecular weight of approximately 3500 daltons, and a pK of about 5. It is heat stable and soluble in acetone up to 75 %, in primary alcohols up to 90 %, in water and in an acidic medium up to 1M, is 70 % inactive in acetonitrile, reacts negatively with anisaldehyde, and can be obtained by extraction from the cerebral cortex and by chromatographic purification.

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