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1. 发明申请

WO2019060689A1 DISCRETE VOLUME DISPENSING SYSTEM FLOW RATE AND ANALYTE SENSOR 审中-公开
公开(公告)号：WO2019060689A1
公开(公告)日：2019-03-28
申请号：PCT/US2018/052176
申请日：2018-09-21
申请人： UNIVERSITY OF CINCINNATI , ECCRINE SYSTEMS, INC.
发明人： GOMEZ, Eliot , STAMPER, Isaac , HEIKENFELD, Jason , FRANCIS, Jessica , LARSEN, Mikel , HOFFMAN, Michelle
IPC分类号： B01L3/00 , A61B5/00
CPC分类号： B01L3/502715 , A61B5/14517 , A61B5/14521 , A61B5/14532 , A61B5/1486 , A61B5/4266 , B01L2200/027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/0825 , B01L2300/161 , B01L2300/163 , B01L2400/022 , B01L2400/0406 , G06N3/061
摘要： A device (10) for determining the amount or concentration of an analyte (1700) in a fluid sample (1500) and a flow rate (1000) of the fluid sample (1500) in a channel (14) is provided. The device (10) includes a chamber (20) including a channel (14) and an opening (12a), the channel (14) in fluid communication with the opening (12a). The device further includes a wicking component (16) positioned adjacent to the opening (12a) configured to receive an amount of fluid (1500) from the channel (14). The device may further include an analyte sensor (18) positioned on the wicking component (16), the analyte sensor (18) configured to detect an analyte (1700) in fluid ((1500) in contact with the analyte sensor (18), wherein the wicking component (16) is configured to contact the amount of fluid (1500) with the analyte sensor (18). Alternatively the device (10) may include at least one pair of electrodes (130, 132) configured to determine a flow rate (1000) of the fluid (1500) in the channel (14).

2. 发明申请

WO2017070640A1 DEVICES CAPABLE OF SAMPLE CONCENTRATION FOR EXTENDED SENSING OF SWEAT ANALYTES 审中-公开
标题翻译：可用于样品浓度的设备用于扩展SWEAT分析的检测
公开(公告)号：WO2017070640A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058356
申请日：2016-10-23
申请人： ECCRINE SYSTEMS, INC. , UNIVERSITY OF CINCINNATI
发明人： HEIKENFELD, Jason , BERTRAND, Jacob, A. , BROTHERS, Michael , JAJACK, Andrew
IPC分类号： A61B5/00 , A61B5/05 , A61B5/053 , A61B10/00 , G01N33/48 , G01N33/50
CPC分类号： A61B5/4266 , A61B5/0002 , A61B5/14517 , A61B5/14521 , A61B5/14546 , A61B5/1468 , A61B5/6833 , A61B10/0012 , A61B10/0064 , A61B2010/0016 , G01N33/50
摘要： The disclosed invention provides a sweat sensing device and method capable of collecting a sweat sample, concentrating the sample with respect to a target analyte, and measuring the target analyte in the concentrated sample. The invention is also capable of determining the change in molarity of the sweat sample with respect to the target analyte, as the sample is concentrated by the device.
摘要翻译：所公开的发明提供了能够收集汗液样品，相对于目标分析物浓缩样品并测量浓缩样品中的目标分析物的汗液感测装置和方法。当样品被装置浓缩时，本发明还能够测定汗样品相对于目标分析物的摩尔浓度的变化。

3. 发明申请

WO2019213508A1 INTEGRATED DEVICES TO CONTINUOUSLY MEASURE BOUND AND UNBOUND ANALYTE FRACTIONS IN BIOFLUIDS 审中-公开
公开(公告)号：WO2019213508A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030582
申请日：2019-05-03
申请人： ECCRINE SYSTEMS, INC. , UNIVERSITY OF CINCINNATI
发明人： HEIKENFELD, Jason
IPC分类号： G01N15/05 , G01N15/14 , G01N21/25 , G01N27/26 , G01N27/327 , G01N33/62 , G01N33/66 , G01N33/70 , G01N33/84 , G01N33/569 , G01N35/02
摘要： Embodiments of the disclosed invention provide devices for measuring concentrations of bound and unbound fractions of a target analyte in a biofluid sample. Analytes present in biofluid may be found in a free state, or bound to a binding solute, presenting difficulties for wearable analyte sensors to measure physiologically significant concentrations of the analyte in biofluid. The disclosed devices feature sensors configured to measure both the bound and unbound fractions of the analyte, as well as analyte releasers that cause a portion of the bound fraction of analytes to be released to facilitate measurement. Some embodiments include a collector and or a sample conduit. Other embodiments include a plurality of fluid pathways.

4. 发明申请

WO2018017619A1 SWEAT CONDUCTIVITY, VOLUMETRIC SWEAT RATE AND GALVANIC SKIN RESPONSE DEVICES AND APPLICATIONS 审中-公开
标题翻译：卫星电导率，体积速率和皮肤电声响应装置及应用
公开(公告)号：WO2018017619A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/042677
申请日：2017-07-18
申请人： ECCRINE SYSTEMS, INC.
发明人： BEGTRUP, Gavi , BERTRAND, Jacob, A. , HEIKENFELD, Jason , MORGAN, Austin , WEINLE, Nathan
IPC分类号： A61B5/00 , A61B5/05 , A61B5/145
摘要： The disclosed invention includes sweat sensing devices configured to periodically measure sweat conductivity and galvanic skin response, devices to measure volumetric sweat flow rate, and devices that combine the three functions. The disclosure further includes methods for using a device configured to perform periodic sweat conductivity measurements, galvanic skin response measurements, and volumetric sweat rate measurements so that each sensor modality informs composite estimates of sweat onset, sweat cessation, sweat ion concentration, and sweat rate. The method uses those measurements to inform other sweat sensing device functions, such as determining the existence of a physiological condition, or performing measurements of concentrations, ratios, and trends of sweat analytes.
摘要翻译：所公开的发明包括配置为周期性地测量汗液传导性和皮肤电流响应的汗液感测设备，测量体积汗液流速的设备以及组合这三种功能的设备。本公开还包括用于使用被配置为执行周期性汗液电导率测量，电流皮肤响应测量和体积汗液率测量的装置的方法，以便每个传感器形式通知汗水开始，汗液中止，汗液浓度和出汗率的综合估计。该方法使用这些测量值来通知其他汗液感测设备功能，例如确定生理状况的存在，或者执行汗液分析物的浓度，比率和趋势的测量。

5. 发明申请

WO2020023954A1 DEVICES AND METHODS FOR MEDICATION MONITORING 审中-公开
公开(公告)号：WO2020023954A1
公开(公告)日：2020-01-30
申请号：PCT/US2019/043858
申请日：2019-07-29
申请人： ECCRINE SYSTEMS, INC.
发明人： HEIKENFELD, Jason , BEECH, Robert , SCHWEN, Richard , BEGTRUP, Gavi
IPC分类号： G06F19/00 , A61B5/00
摘要： A method for measuring analyte concentrations in a biofluid sample to determine patient compliance with a drug regimen. These analytes include a tracer having a half-life that is longer than the drug dosage interval, the drug, or a second tracer with a half-life similar to that of the drug. Further, a method for measuring biofluid concentrations of an analyte and correlating those measurements to plasma concentrations of a drug. The biofluid concentrations are then used to compare drug plasma concentrations to toxic or minimum effective drug levels. Furthermore, a method for selecting tracer compounds for medication monitoring by biofluid sensing devices. Such tracer selection includes the following factors: percentage and molarity of dosed tracer that emerges in biofluid; timing and mechanism of the tracer emerging in biofluid; suitability of the tracer or its characteristics for drug monitoring requirements; and amenability of the tracer to interact with a randomized aptamer sequence.

6. 发明申请

WO2018035525A1 BIOFLUID SENSING DEVICES WITH TEMPERATURE REGULATION 审中-公开
标题翻译：具有温度调节的生物流体传感装置
公开(公告)号：WO2018035525A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047808
申请日：2017-08-21
申请人： ECCRINE SYSTEMS, INC.
发明人： HEIKENFELD, Jason , LARSON, Mikel , WEINLE, Nathan
IPC分类号： A61B5/00 , A61B5/01 , A61B5/02 , A61B5/04 , A61B5/053 , A61B5/11 , A61B5/145
摘要： The disclosed invention includes a biofluid sensing device capable of passively or actively regulating an operating temperature of one or more sensors. The device includes at least one biofluid sensor in a thermally isolated environment and at least one temperature sensor to measure sensor environment temperature. Some embodiments include at least one thermal component to regulate the sensor temperature by actively adjusting the sensor environment temperature in response to a signal from the temperature sensor. The invention also includes a method of regulating temperature for a biofluid sensing device having a sensor for measuring an analyte in the biofluid. The method includes measuring a biofluid sensor temperature, regulating the sensor temperature to within a selected range of the measured sensor temperature, and maintaining sensor temperature within the selected range of the measured temperature throughout device operation. In some embodiments, the measured temperature is a calibration temperature.
摘要翻译：所公开的发明包括能够无源地或主动地调节一个或多个传感器的操作温度的生物流体感测设备。该装置包括至少一个位于热隔离环境中的生物流体传感器和至少一个用于测量传感器环境温度的温度传感器。一些实施例包括至少一个热部件以通过响应于来自温度传感器的信号主动调节传感器环境温度来调节传感器温度。本发明还包括一种调节具有用于测量生物流体中的分析物的传感器的生物流体感测装置的温度的方法。该方法包括测量生物流体传感器温度，将传感器温度调节到所测量的传感器温度的选定范围内，并且在整个设备操作中将传感器温度保持在测量温度的选定范围内。在一些实施例中，测量温度是校准温度。

7. 发明申请

WO2018148261A1 EAB SENSING DEVICES WITH BIOFLUID SAMPLE CONCENTRATION 审中-公开
公开(公告)号：WO2018148261A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/017199
申请日：2018-02-07
申请人： ECCRINE SYSTEMS, INC.
发明人： BEECH, Robert , BEGTRUP, Gavi , HEIKENFELD, Jason , BERTRAND, Jacob, A.
IPC分类号： A61B5/00 , A61B5/01 , A61B5/05 , A61B5/053 , A61B5/145 , G01N27/12
摘要： The present invention provides a biofluid sensing device capable of concentrating a biofluid sample with respect to a target analyte, so that the analyte can be accurately detected or measured by EAB sensors. Methods for using such a device provide qualitative information about the presence of the analyte, and/or quantitative information about relative concentrations of the analyte in the biofluid. The disclosed device includes a concentration channel for concentrating the biofluid sample, as well as a selectively permeable membrane, one or more EAB sensors, and one or more secondary sensors carried on a water-impermeable substrate. A method for using the disclosed device to collect a biofluid sample, concentrate the sample relative to a target analyte, and measure the target analyte is also disclosed.

8. 发明申请

WO2017070641A1 SWEAT SENSING DEVICES WITH CONCENTRATION REGULATION 审中-公开
标题翻译：具有浓度调节的甜味感应装置
公开(公告)号：WO2017070641A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058357
申请日：2016-10-23
申请人： ECCRINE SYSTEMS, INC.
发明人： HEIKENFELD, Jason , PLAXCO, Kevin , WONG, Hector , BERTRAND, Jacob, A.
IPC分类号： A61B5/00 , A61B5/05 , A61B5/053 , A61B10/00 , G01N33/48 , G01N33/50
CPC分类号： G01N33/50 , A61B5/053 , A61B5/14521 , A61B5/14539 , A61B5/14546 , A61B5/1468 , A61B5/4266 , A61B5/6802 , A61B10/0064 , A61B2562/04 , A61B2562/16
摘要： Embodiments of the disclosed invention provide devices and methods for buffering sweat samples to enable accurate concentration measurements of sweat analytes by salinity - sensitive or pH- sensitive sensors. The buffering capabilities of the device include the ability to control the salinity and pH of a sweat sample, specifically, through the management of solutes in sweat such as salts, H+, other ions, and other sweat contents. The purpose of such control is to enhance particular sweat sensing device applications by improving detectability of the targeted analyte, or improving performance of analyte sensors. Some embodiments also include components to enable sample concentration to enhance the measurement of low- concentration sweat solutes.
摘要翻译：所公开的发明的实施例提供了用于缓冲汗样品的装置和方法，以使得能够通过盐敏感性或pH敏感性传感器对汗分析物进行精确的浓度测量。该设备的缓冲能力包括控制汗液样本的盐度和pH值的能力，特别是通过管理汗液中的溶质，如盐，H +，其他离子和其他汗液成分。这种控制的目的是通过改善目标分析物的可检测性或改善分析物传感器的性能来增强特定的汗液感测装置应用。一些实施方案还包括使得样品浓缩能够增强低浓度汗溶质的测量的组分。

9. 发明申请

WO2016197116A1 SWEAT INDICATION OF PHYSIOLOGICAL STATES 审中-公开
标题翻译：生理状态的表现
公开(公告)号：WO2016197116A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/036038
申请日：2016-06-06
申请人： ECCRINE SYSTEMS, INC.
发明人： HEIKENFELD, Jason , BEECH, Robert , PENDARVIS, Damon , BEGTRUP, Gavi
IPC分类号： A61B5/145 , G01N33/487 , G01N27/327
CPC分类号： A61B5/14517 , A61B5/01 , A61B5/024 , A61B5/1118 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1495 , A61B5/4266 , A61B5/4845 , A61B5/4875 , A61B5/6833 , A61B5/7246 , A61B10/0012 , A61B10/0064 , A61B2560/0223 , A61B2560/0252 , A61B2562/0271 , A61B2562/028 , A61B2562/029 , G01N33/48792
摘要： The disclosed invention includes: a device and method of performing physiological sweat sensing device calibration; a device and method of indicating an individual's dehydration state; a device and method of indicating an individual's stage in their ovulation cycle; a device and method of indicating that an individual is hypokalemic or hyperkalemic; a device and method of indicating that an individual is entering a hypoglycemic state; a device and method of indicating an individual's glucose trend value; and a device and method of indicating that an individual has experienced toxic substance exposure.
摘要翻译：所公开的发明包括：执行生理性汗液感测装置校准的装置和方法; 指示个人脱水状态的装置和方法; 在排卵周期中指示个体阶段的装置和方法; 指示个体是低钾血症或高钾血症的装置和方法; 指示个体进入低血糖状态的装置和方法; 指示个体血糖趋势值的装置和方法; 以及指示个体经历了有毒物质暴露的装置和方法。

10. 发明申请

WO2019183529A1 HUMIDITY-BASED SWEAT RATE SENSING DEVICES 审中-公开
公开(公告)号：WO2019183529A1
公开(公告)日：2019-09-26
申请号：PCT/US2019/023665
申请日：2019-03-22
申请人： ECCRINE SYSTEMS, INC.
发明人： HOFFMAN, Michelle , HEIKENFELD, Jason , BERTRAND, Jacob, A. , BAILEY, Nicholas
IPC分类号： A61B5/00 , A61B5/145 , A61B10/00
摘要： Embodiments of the disclosed invention provide wearable devices that use a humidity sensor to measure sweat rate generated from an area of skin. A sensing chamber is continuously filled with a sweat sample, which forms a droplet and alters the humidity measured within the chamber. Once the sweat sample droplet expands to the edge of the chamber, the droplet contacts a wick and is drawn away, so the chamber can fill with a subsequent droplet. The device uses a droplet volume and the time required to reach a maximum humidity to calculate a sweat rate. A pump is used to draw old sweat sample out of the wick to allow extended device operation. Some embodiments also include capacitive sensors to perform back up measurements. Another set of embodiments includes alternatively shaped sensing chambers configured to reduce sample volumes or improve function. A method for determining sweat rate based on humidity sensor measurements is also included.

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