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1. 发明申请

WO2012007481A2 METABOLICALLY ENGINEERED ORGANISMS FOR THE PRODUCTION OF ADDED VALUE BIO-PRODUCTS 审中-公开
标题翻译：用于生产增值的生物制品的代谢工程有机体
公开(公告)号：WO2012007481A2
公开(公告)日：2012-01-19
申请号：PCT/EP2011/061891
申请日：2011-07-12
申请人： UNIVERSITEIT GENT , MAERTENS, Jo , BEAUPREZ, Joeri , DE MEY, Marjan
发明人： MAERTENS, Jo , BEAUPREZ, Joeri , DE MEY, Marjan
IPC分类号： C12N15/52
CPC分类号： C12P19/14 , C12N9/1051 , C12N9/2431 , C12N9/90 , C12N15/52 , C12N15/70 , C12N15/81 , C12P19/18 , C12P19/305 , C12Y204/01007 , C12Y204/01008 , C12Y204/01022 , C12Y204/01069 , C12Y302/01026 , C12Y504/02002
摘要： The present invention relates to genetically engineered organisms, especially microorganisms such as bacteria and yeasts, for the production of added value bio-products such as specialty saccharide, activated saccharide, nucleoside, glycoside, glycolipid or glycoprotein. More specifically, the present invention relates to host cells that are metabolically engineered so that they can produce said valuable specialty products in large quantities and at a high rate by bypassing classical technical problems that occur in biocatalytical or fermentative production processes.
摘要翻译：本发明涉及基因工程生物，特别是微生物如细菌和酵母，用于生产附加价值的生物产品如特种糖，活化糖，核苷，糖苷，糖脂或糖蛋白。更具体地说，本发明涉及代谢工程改造的宿主细胞，以便它们可以通过绕过在生物催化或发酵生产过程中发生的经典技术问题而大量且高速地生产所述有价值的特种产品。

2. 发明申请

WO2011083059A1 BACTERIAL MUTANTS AND USES THEREOF IN PROTEIN PRODUCTION 审中-公开
标题翻译：细菌菌株及其在蛋白质生产中的应用
公开(公告)号：WO2011083059A1
公开(公告)日：2011-07-14
申请号：PCT/EP2010/070683
申请日：2010-12-23
申请人： UNIVERSITEIT GENT , BEAUPREZ, Joeri
发明人： BEAUPREZ, Joeri
IPC分类号： C07K14/245 , C12N15/70 , C12P21/02
CPC分类号： C12N15/70 , C12P21/02
摘要： The present invention relates to a method for obtaining increased product yields and/or for eliminating by-product formation in micro-organisms, and to mutants and/or transformants for use in said methods. More particularly, it relates to bacterial mutants and/or transformants that are affected in the primary metabolism for enhanced product formation, for enhanced product yield and/or for eliminating production of by-products, especially mutants and/or transformants that are affected in the repression of the glyoxylate bypass and in the chromosomal gene expression in response to deprivation of oxygen or in response to absence/presence of carbon compounds such as glycerol, fatty acids, glyoxylate, acetate and the like.
摘要翻译：本发明涉及一种用于获得增加的产物产率和/或消除微生物中副产物形成的方法，以及用于所述方法的突变体和/或转化体。更具体地说，它涉及在初级代谢中受影响以增强产物形成，提高产物产量和/或用于消除副产物，特别是受影响的突变体和/或转化体的产生的细菌突变体和/或转化体。乙醛酸酯旁路的抑制和染色体基因表达响应于剥夺氧或响应于碳化合物如甘油，脂肪酸，乙醛酸盐，乙酸盐等的存在/存在。

3. 发明申请

WO2018122225A1 IN VIVO SYNTHESIS OF SIALYLATED COMPOUNDS 审中-公开
公开(公告)号：WO2018122225A1
公开(公告)日：2018-07-05
申请号：PCT/EP2017/084593
申请日：2017-12-26
申请人： INBIOSE N.V. , BEAUPREZ, Joeri , COUSSEMENT, Pieter , VAN HERPE, Dries , PETERS, Gert , VERCAUTEREN, Annelies
发明人： BEAUPREZ, Joeri , COUSSEMENT, Pieter , VAN HERPE, Dries , PETERS, Gert , VERCAUTEREN, Annelies
IPC分类号： C12P19/26 , C12P19/18 , C12N15/52 , C12N9/16 , C12N9/90 , C12N9/10 , C12N9/80 , C12N9/12 , C12N9/88 , C12N1/21 , C12N1/19
摘要： The present invention is in the technical field of synthetic biology and metabolic engineering. More particularly, the present invention is in the technical field of fermentation of metabolically engineered microorganisms. The present invention describes engineered microorganisms able to synthesize sialylated compounds via an intracellular biosynthesis route. These microorganisms can dephosphorylate N-acetylglucosamine-6-phosphate to N- acetylglucosamine and convert the N-acetylglucosamine to N- acetylmannosamine. These microorganisms also have the ability to convert N-acetylmannosamine to N-acetyl-neuraminate. Furthermore, the present invention provides a method for the large scale in vivo synthesis of sialylated compounds, by culturing a microorganism in a culture medium, optionally comprising an exogenous precursor such as, but not limited to lactose, lactoNbiose, N-acetyllactosamine and/or an aglycon, wherein said microorganism intracellularly dephosphorylates N-acetylglucosamine-6-phosphate to N-acetylglucosamine, converts N-acetylglucosamine to N- acetylmannosamine and convert the latter further to N-acetyl- neuraminate.

4. 发明申请

WO2006000066A2 NUCLEOTIDE PYROPHOSPHATASE INHIBITOR AND COENZYME REGENERATING SYSTEMS 审中-公开
标题翻译：核苷酸磷酸酯酶抑制剂和重组体系统
公开(公告)号：WO2006000066A2
公开(公告)日：2006-01-05
申请号：PCT/BE2005/000104
申请日：2005-06-29
申请人： PURATOS Naamloze Vennootschap , PARMENTIER, Sofie , VANDAMME, Eric , BEAUPREZ, Joeri , ARNAUT, Filip
发明人： PARMENTIER, Sofie , VANDAMME, Eric , BEAUPREZ, Joeri , ARNAUT, Filip
IPC分类号： A21D2/02 , A21D8/04
CPC分类号： A21D2/02 , A21D8/042 , C12N9/14
摘要： The present invention is related to a method for inhibiting nicotinamide coenzyme degradation in a cereal flour or wheat based product, comprising the addition of an effective amount of nucleotide pyrophosphatase inhibitor to said cereal flour based product, product such as a wheat based product. A further aspect of the present invention is a nucleotide pyrophosphatase having an amino acid N-terminal sequence being (G)IDDRHEVDLPPRP. In another aspect of the present invention, a dough comprising a nucleotide pyrophosphatase inhibitor such as pyrophosphate, and optionally a coenzyme regeneration system comprising at least one NAD(P) or NAD(P)H dependent hydrogenase or dehydrogenase is disclosed. Preferably the coenzyme regeneration system comprises (consists of) mannitol dehydrogenase and D-fructose.
摘要翻译：本发明涉及一种抑制谷类粉或小麦基产品中烟酰胺辅酶降解的方法，包括向所述谷类粉基产品，例如小麦基产品等产品中加入有效量的核苷酸焦磷酸酶抑制剂。本发明的另一方面是具有氨基酸N-末端序列为（G）IDDRHEVDLPPRP的核苷酸焦磷酸酶。在本发明的另一方面，公开了一种包含核苷酸焦磷酸酶抑制剂如焦磷酸盐的面团，以及任选地包含至少一种NAD（P）或NAD（P）H依赖性氢化酶或脱氢酶的辅酶再生系统。优选地，辅酶再生系统包含（由甘露糖醇脱氢酶和D-果糖组成）。

5. 发明申请

WO2016075243A1 MUTANT MICROORGANISMS RESISTANT TO LACTOSE KILLING 审中-公开
标题翻译：具有杀菌作用的突变微生物
公开(公告)号：WO2016075243A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/076449
申请日：2015-11-12
申请人： UNIVERSITEIT GENT
发明人： BEAUPREZ, Joeri , DE MAESENEIRE, Sofie , TIMMERMANS, Eric
IPC分类号： C12Q1/10 , C12N1/16 , C12N1/20 , C12N9/12
CPC分类号： C12P19/12 , C07K14/245 , C12N15/10 , C12N15/81
摘要： The present invention relates to a method to produce mutated microorganisms which resist the phenomenon of lactose killing and to the microorganisms obtainable via said method. Such engineered microorganisms can be applied for the production of specialty products, such as but not limited to specialty carbohydrates, glycolipids and galactosylated compounds.
摘要翻译：本发明涉及一种产生突变的微生物的方法，所述突变的微生物抵抗乳糖杀灭的现象以及通过所述方法获得的微生物。这样的工程微生物可以用于生产特殊产品，例如但不限于特殊碳水化合物，糖脂和半乳糖基化化合物。

6. 发明申请

WO2013087884A1 MUTANT MICROORGANISMS TO SYNTHESIZE COLANIC ACID, MANNOSYLATED AND/OR FUCOSYLATED OLIGOSACCHARIDES 审中-公开
标题翻译：合成甘草酸，芒硝酸酯和/或FUCOSYLATED OLIGOSACCHARIDES的突变微生物
公开(公告)号：WO2013087884A1
公开(公告)日：2013-06-20
申请号：PCT/EP2012/075639
申请日：2012-12-14
申请人： UNIVERSITEIT GENT
发明人： BEAUPREZ, Joeri , LEQUEUX, Gaspard , MAERTENS, Jo
IPC分类号： C12R1/19 , C07K14/245 , C12N15/70
CPC分类号： C12P19/04 , C07K14/245 , C12N15/52 , C12P7/40 , C12P19/12 , C12P19/32
摘要： The present invention relates to mutated and/or transformed microorganisms for the synthesis of various compounds. More specifically, the present invention discloses microorganisms mutated in the genes encoding for the regulators ArcA and IclR. The latter mutations result in a significant upregulation of the genes that are part of the colanic acid operon. Hence, said microorganisms are useful for the synthesis of any compound being part of the colanic acid pathway such as GDP-fucose, GDP-mannose and colanic acid, and/or, can be further used –starting form GDP-fucose as a precursor-to synthesize fucosylated oligosaccharides or -starting from GDP-mannose as a precursor –to synthesize mannosylated oligosaccharides. In addition, mutations in the genes coding for the transcriptional regulators ArcA and IclR lead to an acid resistance phenotype in the exponential growth phase allowing the synthesis of pH sensitive molecules or organic acids.
摘要翻译：本发明涉及用于合成各种化合物的突变和/或转化的微生物。更具体地，本发明公开了在编码稳定剂ArcA和IclR的基因中突变的微生物。后一种突变导致作为荚蛋酸操纵子一部分的基因的显着上调。因此，所述微生物可用于合成作为荚状酸途径的一部分的任何化合物，例如GDP-岩藻糖，GDP-甘露糖和col烷酸，和/或可进一步使用 - 以GDP-岩藻糖为起始剂，合成岩藻糖化寡糖或从GDP-甘露糖作为前体开始合成甘露糖基化寡糖。此外，编码转录调节因子ArcA和IclR的基因中的突变导致指数生长期的耐酸性表型，允许合成pH敏感的分子或有机酸。

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