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1. 发明申请

WO2006000066A2 NUCLEOTIDE PYROPHOSPHATASE INHIBITOR AND COENZYME REGENERATING SYSTEMS 审中-公开
标题翻译：核苷酸磷酸酯酶抑制剂和重组体系统
公开(公告)号：WO2006000066A2
公开(公告)日：2006-01-05
申请号：PCT/BE2005/000104
申请日：2005-06-29
申请人： PURATOS Naamloze Vennootschap , PARMENTIER, Sofie , VANDAMME, Eric , BEAUPREZ, Joeri , ARNAUT, Filip
发明人： PARMENTIER, Sofie , VANDAMME, Eric , BEAUPREZ, Joeri , ARNAUT, Filip
IPC分类号： A21D2/02 , A21D8/04
CPC分类号： A21D2/02 , A21D8/042 , C12N9/14
摘要： The present invention is related to a method for inhibiting nicotinamide coenzyme degradation in a cereal flour or wheat based product, comprising the addition of an effective amount of nucleotide pyrophosphatase inhibitor to said cereal flour based product, product such as a wheat based product. A further aspect of the present invention is a nucleotide pyrophosphatase having an amino acid N-terminal sequence being (G)IDDRHEVDLPPRP. In another aspect of the present invention, a dough comprising a nucleotide pyrophosphatase inhibitor such as pyrophosphate, and optionally a coenzyme regeneration system comprising at least one NAD(P) or NAD(P)H dependent hydrogenase or dehydrogenase is disclosed. Preferably the coenzyme regeneration system comprises (consists of) mannitol dehydrogenase and D-fructose.
摘要翻译：本发明涉及一种抑制谷类粉或小麦基产品中烟酰胺辅酶降解的方法，包括向所述谷类粉基产品，例如小麦基产品等产品中加入有效量的核苷酸焦磷酸酶抑制剂。本发明的另一方面是具有氨基酸N-末端序列为（G）IDDRHEVDLPPRP的核苷酸焦磷酸酶。在本发明的另一方面，公开了一种包含核苷酸焦磷酸酶抑制剂如焦磷酸盐的面团，以及任选地包含至少一种NAD（P）或NAD（P）H依赖性氢化酶或脱氢酶的辅酶再生系统。优选地，辅酶再生系统包含（由甘露糖醇脱氢酶和D-果糖组成）。

2. 发明申请

WO2018122225A1 IN VIVO SYNTHESIS OF SIALYLATED COMPOUNDS 审中-公开
公开(公告)号：WO2018122225A1
公开(公告)日：2018-07-05
申请号：PCT/EP2017/084593
申请日：2017-12-26
申请人： INBIOSE N.V. , BEAUPREZ, Joeri , COUSSEMENT, Pieter , VAN HERPE, Dries , PETERS, Gert , VERCAUTEREN, Annelies
发明人： BEAUPREZ, Joeri , COUSSEMENT, Pieter , VAN HERPE, Dries , PETERS, Gert , VERCAUTEREN, Annelies
IPC分类号： C12P19/26 , C12P19/18 , C12N15/52 , C12N9/16 , C12N9/90 , C12N9/10 , C12N9/80 , C12N9/12 , C12N9/88 , C12N1/21 , C12N1/19
摘要： The present invention is in the technical field of synthetic biology and metabolic engineering. More particularly, the present invention is in the technical field of fermentation of metabolically engineered microorganisms. The present invention describes engineered microorganisms able to synthesize sialylated compounds via an intracellular biosynthesis route. These microorganisms can dephosphorylate N-acetylglucosamine-6-phosphate to N- acetylglucosamine and convert the N-acetylglucosamine to N- acetylmannosamine. These microorganisms also have the ability to convert N-acetylmannosamine to N-acetyl-neuraminate. Furthermore, the present invention provides a method for the large scale in vivo synthesis of sialylated compounds, by culturing a microorganism in a culture medium, optionally comprising an exogenous precursor such as, but not limited to lactose, lactoNbiose, N-acetyllactosamine and/or an aglycon, wherein said microorganism intracellularly dephosphorylates N-acetylglucosamine-6-phosphate to N-acetylglucosamine, converts N-acetylglucosamine to N- acetylmannosamine and convert the latter further to N-acetyl- neuraminate.

3. 发明申请

WO2012007481A2 METABOLICALLY ENGINEERED ORGANISMS FOR THE PRODUCTION OF ADDED VALUE BIO-PRODUCTS 审中-公开
标题翻译：用于生产增值的生物制品的代谢工程有机体
公开(公告)号：WO2012007481A2
公开(公告)日：2012-01-19
申请号：PCT/EP2011/061891
申请日：2011-07-12
申请人： UNIVERSITEIT GENT , MAERTENS, Jo , BEAUPREZ, Joeri , DE MEY, Marjan
发明人： MAERTENS, Jo , BEAUPREZ, Joeri , DE MEY, Marjan
IPC分类号： C12N15/52
CPC分类号： C12P19/14 , C12N9/1051 , C12N9/2431 , C12N9/90 , C12N15/52 , C12N15/70 , C12N15/81 , C12P19/18 , C12P19/305 , C12Y204/01007 , C12Y204/01008 , C12Y204/01022 , C12Y204/01069 , C12Y302/01026 , C12Y504/02002
摘要： The present invention relates to genetically engineered organisms, especially microorganisms such as bacteria and yeasts, for the production of added value bio-products such as specialty saccharide, activated saccharide, nucleoside, glycoside, glycolipid or glycoprotein. More specifically, the present invention relates to host cells that are metabolically engineered so that they can produce said valuable specialty products in large quantities and at a high rate by bypassing classical technical problems that occur in biocatalytical or fermentative production processes.
摘要翻译：本发明涉及基因工程生物，特别是微生物如细菌和酵母，用于生产附加价值的生物产品如特种糖，活化糖，核苷，糖苷，糖脂或糖蛋白。更具体地说，本发明涉及代谢工程改造的宿主细胞，以便它们可以通过绕过在生物催化或发酵生产过程中发生的经典技术问题而大量且高速地生产所述有价值的特种产品。

4. 发明申请

WO2011083059A1 BACTERIAL MUTANTS AND USES THEREOF IN PROTEIN PRODUCTION 审中-公开
标题翻译：细菌菌株及其在蛋白质生产中的应用
公开(公告)号：WO2011083059A1
公开(公告)日：2011-07-14
申请号：PCT/EP2010/070683
申请日：2010-12-23
申请人： UNIVERSITEIT GENT , BEAUPREZ, Joeri
发明人： BEAUPREZ, Joeri
IPC分类号： C07K14/245 , C12N15/70 , C12P21/02
CPC分类号： C12N15/70 , C12P21/02
摘要： The present invention relates to a method for obtaining increased product yields and/or for eliminating by-product formation in micro-organisms, and to mutants and/or transformants for use in said methods. More particularly, it relates to bacterial mutants and/or transformants that are affected in the primary metabolism for enhanced product formation, for enhanced product yield and/or for eliminating production of by-products, especially mutants and/or transformants that are affected in the repression of the glyoxylate bypass and in the chromosomal gene expression in response to deprivation of oxygen or in response to absence/presence of carbon compounds such as glycerol, fatty acids, glyoxylate, acetate and the like.
摘要翻译：本发明涉及一种用于获得增加的产物产率和/或消除微生物中副产物形成的方法，以及用于所述方法的突变体和/或转化体。更具体地说，它涉及在初级代谢中受影响以增强产物形成，提高产物产量和/或用于消除副产物，特别是受影响的突变体和/或转化体的产生的细菌突变体和/或转化体。乙醛酸酯旁路的抑制和染色体基因表达响应于剥夺氧或响应于碳化合物如甘油，脂肪酸，乙醛酸盐，乙酸盐等的存在/存在。

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