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    • 2. 发明申请
    • METHODS FOR DETERMINING RESISTANCE OR SUSCEPTIBILITY TO HIV ENTRY INHIBITORS
    • 确定对HIV入侵抑制剂的抗性或易感性的方法
    • WO2006133266A3
    • 2007-05-18
    • PCT/US2006022071
    • 2006-06-06
    • MONOGRAM BIOSCIENCES INCHUANG WEI
    • HUANG WEI
    • C12Q1/68C12Q1/70
    • C12Q1/703C12Q2600/156C12Q2600/158
    • The invention provides a method for determining whether a human immunodeficiency virus is likely to be more resistant to a viral entry inhibitor than a reference HIV. In certain aspects, the methods comprise comparing the length of one or more variable regions of an envelope protein of the HIV or a number of glycosylation sites on the envelope protein of the HIV to a length of one or more corresponding variable regions of an envelope protein of the reference HIV or a number of glycosylation sites on the envelope protein of the reference HIV, wherein the HIV is likely to be more resistant to the CD4 binding site entry inhibitor than the reference HIV when the HIV has longer variable regions than the reference HIV or the HIV has more glycosylation sites than the reference HIV.
    • 本发明提供了确定人类免疫缺陷病毒是否可能比参考HIV对病毒进入抑制剂更具抗性的方法。 在某些方面,所述方法包括比较HIV的包膜蛋白的一个或多个可变区的长度或HIV的包膜蛋白上的多个糖基化位点的长度与包膜蛋白的一个或多个相应可变区的长度 的参考HIV或参考HIV的包膜蛋白上的多个糖基化位点,其中当HIV具有比参考HIV更长的可变区时,HIV可能比参考HIV更耐受CD4结合位点进入抑制剂 或者HIV比参考HIV具有更多的糖基化位点。
    • 4. 发明申请
    • METHODS FOR DETERMINING RESISTANCE OR SUSCEPTIBILITY TO HIV ENTRY INHIBITORS
    • 用于确定艾滋病毒入侵抑制剂耐药性或易感性的方法
    • WO2006133266A9
    • 2007-04-12
    • PCT/US2006022071
    • 2006-06-06
    • MONOGRAM BIOSCIENCES INCHUANG WEI
    • HUANG WEI
    • C12Q1/68C12Q1/70
    • C12Q1/703C12Q2600/156C12Q2600/158
    • The invention provides a method for determining whether a human immunodeficiency virus is likely to be more resistant to a viral entry inhibitor than a reference HIV. In certain aspects, the methods comprise comparing the length of one or more variable regions of an envelope protein of the HIV or a number of glycosylation sites on the envelope protein of the HIV to a length of one or more corresponding variable regions of an envelope protein of the reference HIV or a number of glycosylation sites on the envelope protein of the reference HIV, wherein the HIV is likely to be more resistant to the CD4 binding site entry inhibitor than the reference HIV when the HIV has longer variable regions than the reference HIV or the HIV has more glycosylation sites than the reference HIV.
    • 本发明提供了一种用于确定人类免疫缺陷病毒是否比参照HIV更可能对病毒进入抑制剂更具抗性的方法。 在某些方面,所述方法包括将HIV的包膜蛋白的一个或多个可变区的长度或HIV的包膜蛋白上的多个糖基化位点的长度与包膜蛋白的一个或多个相应可变区的长度进行比较 参考HIV或参考HIV的包膜蛋白上的多个糖基化位点,其中当艾滋病毒具有比参考HIV更长的可变区时,HIV比参照HIV更可耐CD4结合位点进入抑制剂 或者HIV比参考HIV具有更多的糖基化位点。
    • 9. 发明申请
    • METHOD AND APPARATUS FOR CWDM OPTICAL TRANSMITTER WITH EXTENDED OPERATING TEMPERATURE RANGE
    • 具有延长工作温度范围的CWDM光学发射器的方法和装置
    • WO2006099128A2
    • 2006-09-21
    • PCT/US2006008583
    • 2006-03-10
    • HARMONIC INCBONEN ADINGUYEN HOACHEN LIPINGHUANG WEI
    • BONEN ADINGUYEN HOACHEN LIPINGHUANG WEI
    • H01S5/02453H01S5/02415
    • An optical transmitter for coarse wavelength division multiplexed (CWDM) optical communication systems uses a conventional laser (e.g. laser diode) and in addition a heater element is provided thermally coupled to the laser. A thermal sensor and associated control circuit drive the heater so as to control the power consumed by the heater to assure that the laser's temperature is not lower than a predetermined minimum working temperature. When the sensed laser temperature is above this predetermined minimum temperature, the control circuit turns off the heater. The total operating range of the transmitter in terms of ambient temperature is thus extended beyond its inherent operating range by the maximum laser temperature rise created by the heater. This allows a CWDM optical transmitter with the heater and control circuitry to be used in outdoor applications where a wide ambient temperature range is required.
    • 用于粗波分复用(CWDM)光通信系统的光发射机使用常规激光器(例如激光二极管),此外,加热元件被热耦合到激光器。 热传感器和相关控制电路驱动加热器,以便控制加热器消耗的功率,以确保激光器的温度不低于预定的最低工作温度。 当感测的激光温度高于该预定的最低温度时,控制电路关闭加热器。 因此,通过由加热器产生的最大激光温度上升,传感器在环境温度方面的总工作范围因此延伸到其固有的工作范围之外。 这允许具有加热器和控制电路的CWDM光发射机用于需要宽环境温度范围的户外应用中。