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1. 发明申请

WO2015076756A8 AN APPARATUS AND METHOD FOR TRACKING A DEVICE 审中-公开
标题翻译：用于跟踪装置的设备和方法
公开(公告)号：WO2015076756A8
公开(公告)日：2015-07-09
申请号：PCT/SG2014000552
申请日：2014-11-21
申请人： UNIV SINGAPORE TECHNOLOGY & DESIGN , UNIV SINGAPORE
发明人： FOONG SHAOHUI , SUN ZHENGLONG , TAN U-XUAN , TEO TEE HUI , SHABBIR ASIM
IPC分类号： A61B5/06 , A61M25/00
CPC分类号： A61B34/20 , A61B5/061 , A61B2034/2051 , A61B2090/3954 , A61M25/0127
摘要： The present invention relates to an apparatus for tracking a device comprising a magnet as the device is inserted through a subject. The apparatus is wearable by the subject and comprises a unit configured to conform to the subject. The apparatus further comprises magnetic sensors arranged with the unit. In use, the magnetic sensors detect magnetic fields of the magnet and the detected magnetic fields are processed to determine a position of the magnet. This allows tracking of the device as the device is inserted through the subject.
摘要翻译：本发明涉及一种用于跟踪包含磁体的装置的装置，该装置通过对象插入。该装置可由受试者佩戴，并且包括被配置为符合受试者的单元。该设备还包括与该单元一起布置的磁性传感器。在使用中，磁性传感器检测磁体的磁场，并且处理检测到的磁场以确定磁体的位置。这允许在装置通过主体插入时跟踪装置。

2. 发明申请

WO2016005589A2 NOVEL GENE PANEL FOR THE DIAGNOSIS OF DILATED CARDIOMYOPATHY 审中-公开
标题翻译：用于诊断血液透析病变的新型基因组
公开(公告)号：WO2016005589A2
公开(公告)日：2016-01-14
申请号：PCT/EP2015065890
申请日：2015-07-10
申请人： MAX DELBRÜCK CT FÜR MOLEKULARE MEDIZIN , UNIV SINGAPORE
发明人： SCHÄFER SEBASTIAN , HUEBNER NORBERT , COOK STUART A
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156
摘要： The application relates to a method for diagnosing dilated cardiomyopathy (DCM) in a subject or for assessing the risk of a subject to acquire DCM or the risk of heart failure comprising: (i) determining in a sample of a subject to be diagnosed the sequence of one or more polymorphisms in a (first) panel of genes, wherein the panel of genes comprises the genes of the group consisting of PIEZO1, PLEC, HELZ2, NACAD, PKD1, IGSF10, TNRC18, UNC13B, VWF, and XIRP2; (ii) comparing the determined sequence to the sequence of said polymorphism in a control derived from a control subject (control sequence), the control subject not suffering from dilated cardiomyopathy; and (iii) attributing the presence of dilated cardiomyopathy or the risk of acquiring DCM or the risk of heart failure to said subject to be diagnosed if one or more determined sequences differ from the respective sequence in said control sequence. Furthermore, the application relates to a kit or array for diagnosing dilated cardiomyopathy (DCM) in a subject or for assessing the risk of a subject to acquire DCM comprising means for determining the sequence of one or more polymorphisms in a (first) panel of genes comprising probes for detecting a one or more SNP within each gene of the first panel of genes.
摘要翻译：本申请涉及用于诊断受试者中扩张型心肌病（DCM）或用于评估受试者获得DCM或心力衰竭风险的风险的方法，包括：（i）在要诊断的受试者的样品中确定序列（第一）基因中的一个或多个多态性，其中所述基因组包含由PIEZO1，PLEC，HELZ2，NACAD，PKD1，IGSF10，TNRC18，UNC13B，VWF和XIRP2组成的组的基因; （ii）将来自对照受试者（对照序列）的对照中所确定的序列与所述多态性的序列进行比较，所述对照受试者不患有扩张型心肌病; 以及（iii）如果一个或多个确定的序列与所述控制序列中的相应序列不同，则将扩张型心肌病的存在或获得DCM的风险或心脏衰竭的风险归因于待诊断的所述受试者。此外，本申请涉及用于诊断受试者中扩张型心肌病（DCM）或用于评估受试者获得DCM的风险的试剂盒或阵列，其包括用于确定（第一）基因组中一个或多个多态性序列的方法包括用于检测第一组基因的每个基因内的一个或多个SNP的探针。

3. 发明申请

WO2015057162A9 THERAPY DEVICE FOR TRAINING FINE MOTOR SKILLS 审中-公开
标题翻译：治疗精细机动技能的装置
公开(公告)号：WO2015057162A9
公开(公告)日：2015-11-12
申请号：PCT/SG2014000475
申请日：2014-10-10
申请人： UNIV SINGAPORE
发明人： TEO CHEE LEONG , TONG LIUZHU , KLEIN JULIUS , BURDET ETIENNE
IPC分类号： A61H1/02
CPC分类号： A61H1/0288 , A61B34/30 , A61B34/74 , A61B34/76 , A61H1/0285 , A61H2201/1215 , A61H2201/1638 , A61H2201/5061 , A61H2230/10 , A61H2230/25 , A61H2230/50 , A61H2230/60 , A63B1/00 , A63B21/00178 , A63B21/00181 , A63B21/0058 , A63B21/4019 , A63B21/4021 , A63B21/4049 , A63B23/16 , A63B2220/51 , A63B2230/10 , A63B2230/30 , A63B2230/50 , A63B2230/60
摘要： A therapy device (20) comprises a first handle (28) for attaching a thumb of a hand, the first handle (28) being configured to guide the thumb for moving around a first centre (127), a second handle (30) for attached at least one of the remaining fingers of the hand, the second handle (28) being configured to guide at least one of the remaining fingers for moving around a second centre (131). One or more of the first handle (28) and the second handle (30) is connected to an actuation unit (24) for guiding opening or closing of the two handles (28, 30) around the two centres (127, 131) respectively.
摘要翻译：治疗装置（20）包括用于附接手的拇指的第一手柄（28），所述第一手柄（28）被构造成引导拇指围绕第一中心（127）移动，第二手柄（30）附接至少一个手的其余手指，所述第二手柄（28）被配置为引导剩余手指中的至少一个以围绕第二中心（131）移动。第一手柄（28）和第二手柄（30）中的一个或多个连接到用于引导两个手柄（28,30）围绕两个中心（127,131）分别打开或关闭的致动单元（24）。

4. 发明申请

WO2014074072A1 CLOTHING MATCHING SYSTEM AND METHOD 审中-公开
标题翻译：服装搭配系统和方法
公开(公告)号：WO2014074072A1
公开(公告)日：2014-05-15
申请号：PCT/SG2013000482
申请日：2013-11-12
申请人： UNIV SINGAPORE TECHNOLOGY & DESIGN , UNIV HONG KONG SCIENCE & TECHN , UNIV CALIFORNIA LOS ANGELES
发明人： YEUNG SAI-KIT , CHAN TONY , ZU LAP-FAI , TERZOPOULOS DEMETRI
IPC分类号： G06F17/30 , G06Q50/00
CPC分类号： G06N7/005 , G06N99/005 , G06Q30/0269 , G06Q30/0631
摘要： The invention provides a clothing matching system and a method for generating at least an outfit suggestion comprising the steps of determining a colour classification of a user, providing a plurality of articles of clothing, selecting a dress code based on the user preference and generating at least one outfit suggestion based on the colour classification of the user, the plurality of clothing items and the selected dress code.
摘要翻译：本发明提供一种用于至少生成服装建议的服装匹配系统和方法，包括以下步骤：确定用户的颜色分类;提供多件服装;基于用户偏好选择着装代码;以及至少生成基于用户的颜色分类，多个服装项目和选择的着装代码的一个装备建议。

5. 发明申请

WO2014027965A1 WOUND DRESSING NANOMESH IMPREGNATED WITH HUMAN UMBILICAL CORD WHARTON'S JELLY STEM CELLS 审中-公开
标题翻译：用人体脐带蛇皮干细胞引发的伤口纳米线
公开(公告)号：WO2014027965A1
公开(公告)日：2014-02-20
申请号：PCT/SG2013000348
申请日：2013-08-15
申请人： UNIV SINGAPORE
发明人： FONG CHUI YEE , CHOOLANI MAHESH , BISWAS ARIJIT , BONGSO TUAN ARIFFEEN , RAMAKRISHNA SEERAM
IPC分类号： A61K35/44 , A61K9/70 , A61K36/886 , A61P17/02 , C12N5/0797
CPC分类号： A61K35/51 , A61K36/886 , A61L15/26 , A61L15/40 , A61L15/425 , A61L15/44 , A61L27/18 , A61L27/3637 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/104 , A61L2300/30 , A61L2300/406 , A61L2300/418 , A61L2300/64 , A61L2400/12 , C12N5/0605 , C08L67/04
摘要： The invention is directed to a method of treating a wound (e.g., to suppress scar formation) in an individual in need thereof comprising contacting the wound with an effective amount of a composition comprising (i) Wharton's jelly stem cells (WJSCs), (ii) a cell culture medium that has been conditioned with WJSCs, (iii) a lysate of WJSCs, (iv) a cell culture medium that has been conditioned with WJSCs exposed to apoptotic skin cells and keloid cells, or (v) a combination thereof. The invention is directed to a medical dressing (e.g., pharmaceutical compositions) comprising Wharton's jelly stem cells (WJSCs), a cell culture medium that has been conditioned with WJSCs, a lysate of WJSCs, a cell culture medium that has been conditioned with WJSCs exposed to apoptotic skin cells and keloid cells, or a combination thereof.
摘要翻译：本发明涉及一种在有需要的个体中治疗伤口（例如，抑制瘢痕形成）的方法，包括使伤口与有效量的组合物接触，所述组合物包含（i）沃顿的果冻干细胞（WJSC），（ii 或已经用WJSC调理的细胞培养基，（iii）WJSCs的裂解物，（iv）用暴露于凋亡性皮肤细胞和瘢痕疙瘩细胞的WJSC调理的细胞培养基，或（v）其组合。本发明涉及包含沃顿的果冻干细胞（WJSC）的药物敷料（例如药物组合物），已经用WJSC调理的细胞培养基，WJSCs的裂解物，用暴露于WJSC的WJSC调理的细胞培养基凋亡皮肤细胞和瘢痕疙瘩细胞，或其组合。

6. 发明申请

WO2013043126A8 METHOD(S) FOR OBTAINING A FOETAL RED BLOOD CELL 审中-公开
标题翻译：用于获得阴性红血球细胞的方法（S）
公开(公告)号：WO2013043126A8
公开(公告)日：2013-05-30
申请号：PCT/SG2012000345
申请日：2012-09-20
申请人： UNIV SINGAPORE , MASSACHUSETTS INST TECHNOLOGY , CHOI JAE HYEOK , LOVE JOHN CHRISTOPHER , HO SHERRY SZE YEE , CHOOLANI MAHESH
发明人： CHOI JAE HYEOK , LOVE JOHN CHRISTOPHER , HO SHERRY SZE YEE , CHOOLANI MAHESH
IPC分类号： G01N33/49 , C12M1/34 , C12N5/073 , G01N15/14 , G01N21/63
CPC分类号： G01N15/1463 , G01N21/6428 , G01N21/65
摘要： In one aspect, the invention is directed to a method of separating at least one foetal nucleated red blood cell (FNRBC) from a sample comprising: a) placing the sample on at least one support surface b) contacting the sample with at least one antibody or antigen binding fragment thereof that specifically binds to at least one white blood cell, thereby producing at least one labelled cell; and c) providing a means capable of detection and isolation of at least one cell in the sample on the support surface, the cell comprising the features of: (i) being an unlabelled cell; (ii) comprising nucleic acid; and (iii) being 5 to 25pm in size, wherein the detection of the features (i), (ii) and (iii) is done simultaneously and the cell comprising the features (i), (ii) and (iii) is the FNRBC.
摘要翻译：一方面，本发明涉及从样品中分离至少一种胎儿有核红细胞（FNRBC）的方法，其包括：a）将样品置于至少一个支持物表面上b）使样品与至少一种抗体接触或其抗原结合片段，其特异性结合至少一个白细胞，由此产生至少一个标记细胞; 和c）提供能够检测和分离载体表面上样品中的至少一个细胞的装置，所述细胞包括以下特征：（i）是未标记的细胞; （ii）包含核酸; 和（iii）尺寸为5至25pm，其中特征（i），（ii）和（iii）的检测同时进行，并且包括特征（i），（ii）和（iii）的细胞是 FNRBC。

7. 发明申请

WO2012044992A3 METHODS AND REAGENTS FOR DETECTION AND TREATMENT OF ESOPHAGEAL METAPLASIA 审中-公开
公开(公告)号：WO2012044992A3
公开(公告)日：2012-06-14
申请号：PCT/US2011054323
申请日：2011-09-30
申请人： AGENCY SCIENCE TECH & RES , MULTICLONAL THERAPEUTICS INC , BRIGHAM & WOMENS HOSPITAL , UNIV SINGAPORE , UNIV HARVARD , XIAN WA , MCKEON FRANK , VINCENT MATTHEW , CRUM CHRISTOPHER , HO KHEK YU
发明人： XIAN WA , MCKEON FRANK , VINCENT MATTHEW , CRUM CHRISTOPHER , HO KHEK YU
IPC分类号： G01N33/50 , C12N5/09 , G01N33/574
CPC分类号： C12N5/0695 , C12N5/068 , C12Q1/6886 , G01N33/5011 , G01N33/5073 , G01N33/57407 , G01N33/57446
摘要： The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of Barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of Barrett's esophagus.

8. 发明申请

WO2012044992A2 METHODS AND REAGENTS FOR DETECTION AND TREATMENT OF ESOPHAGEAL METAPLASIA 审中-公开
标题翻译：用于检测和治疗食管鳞状细胞癌的方法和试剂
公开(公告)号：WO2012044992A2
公开(公告)日：2012-04-05
申请号：PCT/US2011054323
申请日：2011-09-30
申请人： AGENCY SCIENCE TECH & RES , MULTICLONAL THERAPEUTICS INC , BRIGHAM & WOMENS HOSPITAL , UNIV SINGAPORE , UNIV HARVARD , XIAN WA , MCKEON FRANK , VINCENT MATTHEW , CRUM CHRISTOPHER , HO KHEK YU
发明人： XIAN WA , MCKEON FRANK , VINCENT MATTHEW , CRUM CHRISTOPHER , HO KHEK YU
IPC分类号： G01N33/50 , C12N5/09 , G01N33/574
CPC分类号： C12N5/0695 , C12N5/068 , C12Q1/6886 , G01N33/5011 , G01N33/5073 , G01N33/57407 , G01N33/57446
摘要： The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of Barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of Barrett's esophagus.
摘要翻译：本文描述的发明涉及各种癌症的治疗，检测和诊断，包括食管癌或胃腺癌和相关的化生。本发明还包括巴雷特食管祖细胞的克隆群体及其用于治疗，检测和诊断巴雷特食管的方法。

9. 发明申请

WO2011082422A3 HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) HIGHLY CONSERVED AND LOW VARIANT SEQUENCES AS TARGETS FOR VACCINE AND DIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：人免疫缺陷病毒（HIV-1）高度保守和低变异序列作为疫苗和诊断应用的目标
公开(公告)号：WO2011082422A3
公开(公告)日：2011-11-24
申请号：PCT/US2011020122
申请日：2011-01-04
申请人： UNIV JOHNS HOPKINS , UNIV SINGAPORE , AUGUST J THOMAS , SIMON GREGORY GEORGE , TAN TIN WEE , KHAN ASIF MOHAMMAD , YONGLI HU
发明人： AUGUST J THOMAS , SIMON GREGORY GEORGE , TAN TIN WEE , KHAN ASIF MOHAMMAD , YONGLI HU
IPC分类号： C07K14/16 , A61K39/21 , A61P31/18 , C12N15/49 , C12N15/63 , C12Q1/70
CPC分类号： A61K39/21 , A61K39/00 , C07K14/005 , C12N2740/16022 , C12N2740/16034
摘要： We identified regions of the HIV-1 proteome with high conservation, and low variant incidence. Such highly conserved sequences have direct relevance to the development of new-generation vaccines and diagnostic applications. The immune relevance of these sequences was assessed by their correlation to previously reported human T-cell epitopes and to recently identified human HIV- 1 T-cell epitopes (identified using HLA transgenic mice). We identified (a) sequences specific to HIV-1 with no shared identity to other viruses and organisms, and (b) sequences that are specific to primate lentivirus group, with multiclade HIV-1 conservation.
摘要翻译：我们发现HIV-1蛋白质组的区域具有高度保守性和低变异发生率。这种高度保守的序列与新一代疫苗和诊断应用的开发直接相关。这些序列的免疫相关性通过它们与先前报道的人T细胞表位和最近鉴定的人HIV-1 T细胞表位（使用HLA转基因小鼠鉴定）的相关性来评估。我们确定了（a）特定于HIV-1的序列，与其他病毒和生物体没有共有的同一性，以及（b）特异于灵长类慢病毒组的具有多重病毒核苷酸HIV-1保守性的序列。

10. 发明申请

WO2011099940A8 SYSTEM, DEVICE, AND PROCESS FOR MODIFYING ABSORPTION OF MATTER BY A GASTROINTESTINAL WALL 审中-公开
标题翻译：系统，装置和过程，用于通过气体壁修改物质的吸收
公开(公告)号：WO2011099940A8
公开(公告)日：2011-10-20
申请号：PCT/SG2011000060
申请日：2011-02-10
申请人： UNIV SINGAPORE , LIM JUI , SO BOK YAN JIMMY , HO PEI , HONG TSUI YING RACHEL , LEE HEOW PUEH , SHABBIR ASIM , CHUNG SYDENY SHEUNG CHEE
发明人： LIM JUI , SO BOK YAN JIMMY , HO PEI , HONG TSUI YING RACHEL , LEE HEOW PUEH , SHABBIR ASIM , CHUNG SYDENY SHEUNG CHEE
IPC分类号： A61F2/04 , A61B17/00 , A61M29/00
CPC分类号： A61F5/0076 , A61F5/003
摘要： A device that can be placed, retained, and/or anchored within a gastrointestinal tract. The device includes an anchor portion and a chute that is couplable to the anchor portion. The anchor portion includes at least one retention unit. The anchor portion can be shaped, dimensioned, and/or configured for retention in a trans-pyloric configuration. The chute includes a channel disposed along a wall of the chute. The channel includes a passage. Flow of fluid through the passage of the channel effectuates longitudinal extension of the chute. A process for deploying, expanding, and retaining the device within the gastrointestinal tract is also provided, as well as a process for re-inflating the chute of the device.
摘要翻译：可以放置，保留和/或锚定在胃肠道内的装置。该装置包括可锚定部分连接的锚固部分和滑槽。锚定部分包括至少一个保持单元。锚定部分可以成形，尺寸确定和/或构造成保持在幽门结构中。滑槽包括沿着滑槽的壁布置的通道。通道包括通道。通过通道通道的流体流动导致滑槽的纵向延伸。还提供了用于在胃肠道内部署，扩张和保持装置的过程，以及用于重新充气装置的滑槽的过程。

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