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1. 发明申请

WO2005070495A3 NEURAL STIMULATION ARRAY PROVIDING PROXIMITY OF ELECTRODES TO CELLS VIA CELLULAR MIGRATION 审中-公开
标题翻译：神经刺激阵列通过细胞迁移提供电极对细胞的接近
公开(公告)号：WO2005070495A3
公开(公告)日：2006-11-23
申请号：PCT/US2005002212
申请日：2005-01-18
申请人： UNIV LELAND STANFORD JUNIOR
发明人： PALANKER DANIEL , HUIE PHILIP JR , VANKOV ALEXANDER , FISHMAN HARVEY A
IPC分类号： A61N1/36 , A61N1/00 , A61N1/04 , A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046
摘要： An interface for selective excitation or sensing of neural cells in a biological neural network is provided. The interface includes a membrane with a number of channels passing through the membrane. Each channel has at least one electrode within it. Neural cells in the biological neural network grow or migrate into the channels, thereby coming into close proximity to the electrodes. Once one or more neural cells have grown or migrated into a channel, a voltage applied to the electrode within the channel selectively excites the neural cell(s) in that channel. The excitation of these neural cell(s) will then transmit throughout the neural network (i.e. cells and axons) that is associated with the neural cell(s) stimulated in the channel. An alternative interface provides cell excitation via an array of electrically conductive pillars on a substrate. The pillars have electrically insulated sides and exposed top surfaces, to provide selective cell excitation.
摘要翻译：提供了一种生物神经网络中选择性激发或感应神经细胞的界面。界面包括具有穿过膜的多个通道的膜。每个通道内至少有一个电极。生物神经网络中的神经细胞生长或迁移到通道中，从而紧密接近电极。一旦一个或多个神经细胞已经生长或迁移到通道中，施加到通道内的电极的电压选择性地激发该通道中的神经细胞。然后，这些神经细胞的激发将通过与通道中刺激的神经细胞相关联的神经网络（即细胞和轴突）传递。另一种界面通过衬底上的导电柱阵列提供电池激发。支柱具有电绝缘的侧面和暴露的顶表面，以提供选择性的电池激发。

2. 发明申请

WO2004018622A2 SELECTIVE AND ALIGNMENT-FREE MOLECULAR PATTERNING OF SURFACES 审中-公开
标题翻译：选择性和对准的表面分子图谱
公开(公告)号：WO2004018622A2
公开(公告)日：2004-03-04
申请号：PCT/US0325634
申请日：2003-08-13
申请人： UNIV LELAND STANFORD JUNIOR
发明人： MEHENTI NEVILLE Z , FISHMAN HARVEY A , BENT STACEY F
IPC分类号： B05D1/18 , B05D1/28 , B41M3/00 , C12N11/06 , C12N11/08 , G03F7/00 , C12N
CPC分类号： G03F7/0002 , B05D1/185 , B05D1/283 , B41M3/006 , B81B2201/0214 , B81C1/00206 , B81C2201/036 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C12N11/06 , C12N11/08
摘要： The present invention is directed towards a method and means for molecularly patterning a surface to promote the patterned attachment of a target adherent. In some preferred embodiments the target adherent is a biological cell, but it can more generally be a biological or chemical species for which attachment at specific sites is desired. The method generally involves using a stamp to microcontact print a first type of molecule on the surface. With the stamp remaining in situ, the process then involves fluidic patterning of a second type of molecule through selected openings defined by selected recesses in the stamp and the surface itself. The second type of molecule should have an adhesion property relative to the target adherent that is complementary to that of the first type of molecule. The stamp is removed only after both the first and second types of molecules have been transferred to the surface.
摘要翻译：本发明涉及用于分子图案化表面以促进目标粘附剂的图案化附着的方法和装置。在一些优选的实施方案中，靶粘附物是生物细胞，但它通常可以是需要在特定部位附着的生物或化学物质。该方法通常涉及使用印模来微分印刷表面上的第一类型的分子。当邮票保留在原位时，该方法然后涉及通过由印模和表面本身中的选定凹部限定的选定开口的第二类型分子的流体图案化。第二类分子应该具有相对于与第一类型分子互补的靶粘附物的粘附性质。只有在第一种和第二种类型的分子已经转移到表面之后，才能去除印模。

3. 发明申请

WO2005082049A3 ARTIFICIAL BIOCOMPATIBLE MATERIAL AS A SUPPORT FOR CELLS IN A RETINAL IMPLANT 审中-公开
标题翻译：人工生物化学材料作为后植入物中的细胞的支持
公开(公告)号：WO2005082049A3
公开(公告)日：2007-02-01
申请号：PCT/US2005006107
申请日：2005-02-18
申请人： UNIV LELAND STANFORD JUNIOR
发明人： LENG THEODORE , YELLACHICH DIMITRI , HUIE PHILIP JR , NOOLANDI JAAN , FISHMAN HARVEY A
IPC分类号： A61F2/00 , A61F2/14 , A61K31/716
CPC分类号： A61F2/14 , A61F9/00 , A61F9/007 , C12N5/062 , C12N2533/30
摘要： A retinal implant is provided that uses an artificial biocompatible material as a support material on which retinal pigment epithelial cells, iris pigment epithelial cells, and/or stem cells can be deposited either in situ or in vivo. The support material has a surface topology that is rough to promote cell adhesion, has surface pits to allow pigment cells to grow into, and has pores to allow for proper diffusion of materials. The support material serves as a substrate for cell growth and as a patch for damaged basement membrane (Bruch's membrane). This cell-coated membrane or pigment cell-enriched membrane is surgically positioned in the sub-retinal space to rescue or restore photoreceptor cell function that may be damaged or threatened by degenerative diseases of the eye, such as age-related macular degeneration.
摘要翻译：提供视网膜植入物，其使用人造生物相容性材料作为支架材料，视网膜色素上皮细胞，虹膜色素上皮细胞和/或干细胞可原位或体内沉积。支撑材料具有粗糙的表面拓扑以促进细胞粘附，具有表面凹坑以允许颜料细胞生长并具有允许材料适当扩散的孔。支撑材料用作细胞生长的底物和用作损伤的基底膜（布鲁赫氏膜）的贴剂。这种细胞包被的膜或色素细胞富集的膜通过外科手术放置在视网膜下部空间中以挽救或恢复可能由于退行性疾病（如年龄相关性黄斑变性）而损伤或受到威胁的感光细胞功能。

4. 发明申请

WO2006007461A3 OPTICALLY CONTROLLED MICROFLUIDIC CHIP 审中-公开
标题翻译：光学控制微流控芯片
公开(公告)号：WO2006007461A3
公开(公告)日：2006-11-02
申请号：PCT/US2005021784
申请日：2005-06-20
申请人： UNIV LELAND STANFORD JUNIOR , PALANKER DANIEL V , FISHMAN HARVEY A
发明人： PALANKER DANIEL V , FISHMAN HARVEY A
IPC分类号： A61K9/22
CPC分类号： A61N1/0543 , A61M5/14276 , A61M2205/0244 , A61M2205/3306 , A61M2210/0612 , A61N1/36046
摘要： An optically controlled microfluidic chip is provided for administering a fluid to a neuronal site. The chip is made of at least one unit or pixel., each of which constitutively emits fluid in the dark, and reduces emission of fluid in response to light. The individual pixels are capable of being individually controlled, thereby translating a spatial pattern of incident light into a spatial pattern of neuronal stimulation. Each pixel contains a housing, an aperture in the housing, and a reservoir containing fluid that is connected to the aperture. The aperture is designed to allow continuous emission of fluid from the reservoir through the aperture when the pixel is in the dark. Each pixel also includes an optical control, which reduces the emission of fluid from the reservoir through the aperture in response to light.
摘要翻译：提供光学控制的微流体芯片用于将流体施用至神经元部位。芯片由至少一个单元或像素构成，每个单元或像素在黑暗中组成性地发射流体，并且响应于光减少流体的发射。各个像素能够被单独控制，从而将入射光的空间图案转化为神经元刺激的空间图案。每个像素包含壳体，壳体中的孔以及容纳连接到孔的流体的储存器。该孔设计成当像素处于黑暗中时允许从贮存器通过孔连续地发射流体。每个像素还包括一个光学控制器，该光学控制器响应于光而减少从储存器通过孔径的流体发射。

5. 发明申请

WO03095359A2 NANOTUBE MAT WITH AN ARRAY OF CONDUITS 审中-公开
标题翻译：具有阵列阵列的纳米带
公开(公告)号：WO03095359A2
公开(公告)日：2003-11-20
申请号：PCT/US0314255
申请日：2003-05-06
申请人： UNIV LELAND STANFORD JUNIOR
发明人： HUIE PHILIP JR , FISHMAN HARVEY A
IPC分类号： C12M3/04 , C12M3/06 , C12N5/00 , C01B
CPC分类号： C12N5/0068 , A61L27/50 , A61L2400/12 , A61L2400/18 , B82Y5/00 , C12M23/12 , C12M23/20 , C12N2533/10 , C40B40/02
摘要： A nanotube mat is provided with an array of conduits to support, direct growth, select or interface one or more biological cells or cell processes. The carbon nanotube mat provides mechanical stability, is biocompatible, will support cell growth, can desirably be derivatized with growth factors, molecules, nutrients, inhibitory factors, ligands, transduction molecules or morphogenic factors, and would allow the formation of conduits to guide cells and cell extensions to be hosted or grown. The conduits could take any size or shape to support, direct growth, select or interface one or more cells or processes. In general the conduits could be channels, discontinuous channels, tapered channels or walls. The nanotube mat could be used to interface biological cells with other cells, tissue or structures that have electrical, mechanical, magnetic means, or optical means. The nanotube mat could also incorporate chemicals, analytes, drugs, lips, carbohydrates, secretory products or the like.
摘要翻译：纳米管垫被提供有一系列管道以支持，直接生长，选择或接合一个或多个生物细胞或细胞过程。碳纳米管垫提供机械稳定性，是生物相容的，将支持细胞生长，可以期望地被生长因子，分子，营养物，抑制因子，配体，转导分子或形态发生因子衍生，并且将允许形成导管以引导细胞和单元格扩展名被托管或增长。导管可以采取任何尺寸或形状来支持，直接生长，选择或接合一个或多个细胞或过程。通常，导管可以是通道，不连续通道，锥形通道或壁。纳米管垫可以用于将生物细胞与具有电，机械，磁性装置或光学装置的其它细胞，组织或结构相接触。纳米管垫也可以掺入化学品，分析物，药物，嘴唇，碳水化合物，分泌产物等。

6. 发明申请

WO02098357A3 MICROFABRICATED TISSUE AS A SUBSTRATE FOR PIGMENT EPITHELIUM TRANSPLANTATION 审中-公开
标题翻译：微晶组织作为上皮细胞移植的基质
公开(公告)号：WO02098357A3
公开(公告)日：2003-05-08
申请号：PCT/US0217363
申请日：2002-05-31
申请人： UNIV LELAND STANFORD JUNIOR , FISHMAN HARVEY A , BLUMENKRANZ MARK , BENT STACY FRANCINE , LEE CHRISTINE , HUIE PHILIP JR , PALANKER DANIEL V , BILBAO KALAYAAN V
发明人： FISHMAN HARVEY A , BLUMENKRANZ MARK , BENT STACY FRANCINE , LEE CHRISTINE , HUIE PHILIP JR , PALANKER DANIEL V , BILBAO KALAYAAN V
IPC分类号： C12M3/00 , A61F2/14 , A61L27/00 , A61L27/38 , C12N5/06 , A61F2/16
CPC分类号： A61F2/14 , A61L27/3604 , A61L27/3813 , A61L27/3839
摘要： Methods and apparatus for modifying membranous tissue 12 growing cells 14 on modified membranous tissue 12, and for transplantation of modified tissues 12 and modified tissues 12 with attached cells 14 are provided. In particular methods and apparatus for modifying membranous tissue 12 such as lens capsule tissue and inner limiting membrane tissue, for growing cells such as iris pigment epithelial IPE cells 14, retinal pigment epithelial RPE cells, stem cells, or other cells on modified membranous tissue 12, and for modifying membranous tissue 12 and growing cells 14 on biodegradable polymer substrates 16. A membranous surface 18 may be modified by contact with a stamp or by coating with a stencil having passages allowing access to portions of the membranous surface 18. A method of modifying membranous tissues 12 comprises depositing micropatterns of biomolecules onto membranous tissue 12 with a contacting surface such as a stamp.
摘要翻译：提供了用于修饰膜组织的方法和装置12，在修饰的膜组织12上生长细胞14，以及用于用附着细胞14移植修饰的组织12和修饰的组织12。特别是用于修饰膜组织12（例如晶状体囊组织和内限制膜组织）的方法和装置，用于在修饰的膜组织12上生长细胞如虹膜色素上皮细胞，视网膜色素上皮RPE细胞，视网膜色素上皮RPE细胞，干细胞或其他细胞，并且用于修饰可生物降解的聚合物基底16上的膜组织12和生长细胞14.膜表面18可以通过与印模接触或通过用具有允许进入膜表面18的部分的通道的模版涂布来改性。修饰膜组织12包括用诸如印模的接触表面将生物分子的微图案沉积到膜组织12上。

7. 发明申请

WO2004073785A3 PERFORATED ELECTRODE ARRAY FOR NEURAL STIMULATION 审中-公开
标题翻译：用于神经刺激的执行电极阵列
公开(公告)号：WO2004073785A3
公开(公告)日：2005-04-28
申请号：PCT/US2004002038
申请日：2004-01-22
申请人： UNIV LELAND STANFORD JUNIOR
发明人： HUIE PHILLIP JR , PALANKER DANIEL V , FISHMAN HARVEY A , VANKOV ALEXANDER
IPC分类号： A61B5/04 , A61B5/0478 , A61N20060101 , A61N1/04 , A61N1/05 , A61N1/36
CPC分类号： A61B5/0478 , A61B5/04001 , A61N1/0543 , A61N1/36046
摘要： An interface (110) for selective excitation or sensing of neural cells (520) in a biological neural network (140, 150, 160, 170) is provided. The interface includes a membrane with a number of channels (120) passing through the membrane. Each channel has at least one electrode within it. Neural cells in the biological neural network grow or migrate into the channels, thereby coming into close proximity to the electrodes. Once one or more neural cells have grown or migrated into a channel, a voltage applied to the electrode within the channel selectively excites the neural cell (or cells) in that channel. The excitation of these neural cell(s) will then transmit throughout the neural network (i.e. cells and axons) that is associated with the neural cell(s) stimulated in the channel.
摘要翻译：提供了用于在生物神经网络（140,150,160,170）中选择性激发或感测神经细胞（520）的界面（110）。界面包括具有通过膜的多个通道（120）的膜。每个通道内至少有一个电极。生物神经网络中的神经细胞生长或迁移到通道中，从而接近电极。一旦一个或多个神经细胞已经生长或迁移到通道中，施加到通道内的电极的电压选择性地激发该通道中的神经细胞（或细胞）。然后，这些神经细胞的激发将通过与通道中刺激的神经细胞相关联的神经网络（即细胞和轴突）传递。

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