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1. 发明申请

WO2006007461A3 OPTICALLY CONTROLLED MICROFLUIDIC CHIP 审中-公开
标题翻译：光学控制微流控芯片
公开(公告)号：WO2006007461A3
公开(公告)日：2006-11-02
申请号：PCT/US2005021784
申请日：2005-06-20
申请人： UNIV LELAND STANFORD JUNIOR , PALANKER DANIEL V , FISHMAN HARVEY A
发明人： PALANKER DANIEL V , FISHMAN HARVEY A
IPC分类号： A61K9/22
CPC分类号： A61N1/0543 , A61M5/14276 , A61M2205/0244 , A61M2205/3306 , A61M2210/0612 , A61N1/36046
摘要： An optically controlled microfluidic chip is provided for administering a fluid to a neuronal site. The chip is made of at least one unit or pixel., each of which constitutively emits fluid in the dark, and reduces emission of fluid in response to light. The individual pixels are capable of being individually controlled, thereby translating a spatial pattern of incident light into a spatial pattern of neuronal stimulation. Each pixel contains a housing, an aperture in the housing, and a reservoir containing fluid that is connected to the aperture. The aperture is designed to allow continuous emission of fluid from the reservoir through the aperture when the pixel is in the dark. Each pixel also includes an optical control, which reduces the emission of fluid from the reservoir through the aperture in response to light.
摘要翻译：提供光学控制的微流体芯片用于将流体施用至神经元部位。芯片由至少一个单元或像素构成，每个单元或像素在黑暗中组成性地发射流体，并且响应于光减少流体的发射。各个像素能够被单独控制，从而将入射光的空间图案转化为神经元刺激的空间图案。每个像素包含壳体，壳体中的孔以及容纳连接到孔的流体的储存器。该孔设计成当像素处于黑暗中时允许从贮存器通过孔连续地发射流体。每个像素还包括一个光学控制器，该光学控制器响应于光而减少从储存器通过孔径的流体发射。

2. 发明申请

WO02098357A3 MICROFABRICATED TISSUE AS A SUBSTRATE FOR PIGMENT EPITHELIUM TRANSPLANTATION 审中-公开
标题翻译：微晶组织作为上皮细胞移植的基质
公开(公告)号：WO02098357A3
公开(公告)日：2003-05-08
申请号：PCT/US0217363
申请日：2002-05-31
申请人： UNIV LELAND STANFORD JUNIOR , FISHMAN HARVEY A , BLUMENKRANZ MARK , BENT STACY FRANCINE , LEE CHRISTINE , HUIE PHILIP JR , PALANKER DANIEL V , BILBAO KALAYAAN V
发明人： FISHMAN HARVEY A , BLUMENKRANZ MARK , BENT STACY FRANCINE , LEE CHRISTINE , HUIE PHILIP JR , PALANKER DANIEL V , BILBAO KALAYAAN V
IPC分类号： C12M3/00 , A61F2/14 , A61L27/00 , A61L27/38 , C12N5/06 , A61F2/16
CPC分类号： A61F2/14 , A61L27/3604 , A61L27/3813 , A61L27/3839
摘要： Methods and apparatus for modifying membranous tissue 12 growing cells 14 on modified membranous tissue 12, and for transplantation of modified tissues 12 and modified tissues 12 with attached cells 14 are provided. In particular methods and apparatus for modifying membranous tissue 12 such as lens capsule tissue and inner limiting membrane tissue, for growing cells such as iris pigment epithelial IPE cells 14, retinal pigment epithelial RPE cells, stem cells, or other cells on modified membranous tissue 12, and for modifying membranous tissue 12 and growing cells 14 on biodegradable polymer substrates 16. A membranous surface 18 may be modified by contact with a stamp or by coating with a stencil having passages allowing access to portions of the membranous surface 18. A method of modifying membranous tissues 12 comprises depositing micropatterns of biomolecules onto membranous tissue 12 with a contacting surface such as a stamp.
摘要翻译：提供了用于修饰膜组织的方法和装置12，在修饰的膜组织12上生长细胞14，以及用于用附着细胞14移植修饰的组织12和修饰的组织12。特别是用于修饰膜组织12（例如晶状体囊组织和内限制膜组织）的方法和装置，用于在修饰的膜组织12上生长细胞如虹膜色素上皮细胞，视网膜色素上皮RPE细胞，视网膜色素上皮RPE细胞，干细胞或其他细胞，并且用于修饰可生物降解的聚合物基底16上的膜组织12和生长细胞14.膜表面18可以通过与印模接触或通过用具有允许进入膜表面18的部分的通道的模版涂布来改性。修饰膜组织12包括用诸如印模的接触表面将生物分子的微图案沉积到膜组织12上。

3. 发明申请

WO2007022403A3 OCULAR GENE THERAPY USING AVALANCHE-MEDIATED TRANSFECTION 审中-公开
标题翻译：使用AVALANCHE-MEDIATED TRANSFECTION的OCULAR GENE THERAPY
公开(公告)号：WO2007022403A3
公开(公告)日：2010-04-22
申请号：PCT/US2006032249
申请日：2006-08-15
申请人： UNIV LELAND STANFORD JUNIOR , CHALBERG THOMAS W JR , BLUMENKRANZ MARK , PALANKER DANIEL V , VANKOV ALEXANDER , HUIE PHILIP JR , MARMOR MICHAEL F , CALOS MICHELE P
发明人： CHALBERG THOMAS W JR , BLUMENKRANZ MARK , PALANKER DANIEL V , VANKOV ALEXANDER , HUIE PHILIP JR , MARMOR MICHAEL F , CALOS MICHELE P
IPC分类号： C12N15/87
CPC分类号： C12N15/87 , C07K14/811
摘要： The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron avalanche transfection. With this technique, a high electric field induces a vapor bubble and plasma discharge between an electrode and the surrounding medium. The formation of a vapor bubble generates mechanical stress. Plasma discharge through the ionized vapor in the bubble enables connectivity between the electrode and the surrounding medium, so that mechanical stress and electric field are applied simultaneously, which results in permeabilization of the cells or tissue. This permeabilization in turn allows the nucleic acid to enter the cell or tissue. Cells or tissue containing the nucleic acid are then transplanted into an ocular region of the subject.
摘要翻译：本发明提供了治疗受试者眼部疾病的方法。在第一步骤中，将核酸引入细胞或组织。通过电子雪崩转染引入核酸。利用这种技术，高电场在电极和周围介质之间引起蒸汽气泡和等离子体放电。气泡的形成产生机械应力。通过气泡中的电离蒸汽的等离子体放电使得电极和周围介质之间能够连接，使得同时施加机械应力和电场，这导致细胞或组织的透化。这种渗透反过来又允许核酸进入细胞或组织。然后将含有核酸的细胞或组织移植到受试者的眼部区域。

4. 发明申请

WO2007106136A3 METHOD AND APPARATUS FOR AVALANCHE-MEDIATED TRANSFER OF AGENTS INTO CELLS 审中-公开
标题翻译：用于将细胞转移到细胞中的方法和装置
公开(公告)号：WO2007106136A3
公开(公告)日：2009-04-23
申请号：PCT/US2006037010
申请日：2006-09-22
申请人： UNIV LELAND STANFORD JUNIOR , VANKOV ALEXANDER , CHALBERG THOMAS W JR , HUIE PHILIP JR , PALANKER DANIEL V
发明人： VANKOV ALEXANDER , CHALBERG THOMAS W JR , HUIE PHILIP JR , PALANKER DANIEL V
IPC分类号： C12M1/42 , C12N15/64 , C12N15/87
CPC分类号： C12N13/00 , A61K48/00 , C12N15/87
摘要： The present invention provides a method and apparatus for transferring an agent into a cell. The method includes the steps of providing an agent outside of a cell and generating a vapor bubble and a plasma discharge between an avalanche electrode and a conductive fluid surrounding the cell. The vapor bubble and plasma discharge generate a mechanical stress wave and an electric field, respectively. The combination of this mechanical stress wave and electric field results in permeabilization of the cell, which in turn results in transfer of the agent into the cell.
摘要翻译：本发明提供了一种将药剂转移到细胞中的方法和装置。该方法包括以下步骤：在电池外部提供一种试剂，并在雪崩电极和围绕电池的导电流体之间产生蒸气泡和等离子体放电。蒸气泡和等离子体放电分别产生机械应力波和电场。这种机械应力波和电场的组合导致电池的透化，这进而导致试剂转移到电池中。

5. 发明申请

WO0071038A8 MICROFLUIDIC DEVICES AND METHODS FOR PRODUCING PULSED MICROFLUIDIC JETS IN A LIQUID ENVIRONMENT 审中-公开
标题翻译：用于在液体环境中生产脉冲微流体喷射的微流体装置和方法
公开(公告)号：WO0071038A8
公开(公告)日：2001-03-15
申请号：PCT/US0013762
申请日：2000-05-19
申请人： UNIV LELAND STANFORD JUNIOR , FLETCHER DANIEL A , PALANKER DANIEL V
发明人： FLETCHER DANIEL A , PALANKER DANIEL V
IPC分类号： A61B17/22 , A61B17/32 , A61F9/007 , A61F9/011 , A61B18/08 , A61B18/12
CPC分类号： A61B17/3203 , A61B2017/22008 , A61B2017/32032 , A61B2018/263 , A61F9/00736 , A61F9/00825
摘要： Micro-fluid devices (10), and methods for their use in producing pulsed micro-fluid jets in a fluid environment are provided. The subject micro-fluid devices are characterized by the presence of a micro-fluid chamber (14) at their distal ends. The micro-fluid chamber (14) is bounded by an opening (16) at one end, a vapor producing means (18) opposite the opening (16), and sidewalls between the opening, and the vapor producing means (18). The micro-fluid chambers (14) are further characterized in that the only way fluid can exit the micro-fluid chambers is through the opening (16). In using the subject devices to produce a fluid jet in a fluid environment, the chamber is first contacted with the fluid environment. The vapor producing means (18) is then actuated in a manner sufficient to produce a vapor bubble (11) in the chamber (14) which, in turn, produces a micro-fluid jet in the fluid environment. The subject devices (10), and methods find use in a variety of different applications, e.g., cutting tissue, introducing fluid into a cell, and the like.
摘要翻译：提供微流体装置（10）及其在流体环境中生产脉冲微流体射流中的方法。目标微流体装置的特征在于在其远端处存在微流体室（14）。微流体室（14）由一端的开口（16），与开口（16）相对的蒸气产生装置（18）以及开口和蒸气产生装置（18）之间的侧壁限定。微流体室（14）的特征还在于流体可以离开微流体室的唯一方式是通过开口（16）。在使用主体装置在流体环境中产生流体射流时，腔室首先与流体环境接触。然后，蒸汽产生装置（18）以足以在室（14）中产生蒸汽气泡（11）的方式被致动，这又在流体环境中产生微流体射流。主题装置（10）和方法可用于各种不同的应用，例如切割组织，将流体引入细胞等。

6. 发明申请

WO2008130525A3 ELECTROSURGICAL SYSTEM WITH UNIFORMLY ENHANCED ELECTRIC FIELD AND MINIMAL COLLATERAL DAMAGE 审中-公开
标题翻译：具有均匀增强电场和最小束缚损伤的电磁系统
公开(公告)号：WO2008130525A3
公开(公告)日：2009-01-22
申请号：PCT/US2008004806
申请日：2008-04-11
申请人： UNIV LELAND STANFORD JUNIOR , PALANKER DANIEL V , VANKOV ALEXANDER B
发明人： PALANKER DANIEL V , VANKOV ALEXANDER B
IPC分类号： A61B18/14
CPC分类号： A61B18/1402 , A61B2018/00083 , A61B2018/1407
摘要： The present invention is directed towards an electrosurgical cutting system. The system comprises an electrically conductive blade, having an uninsulated cutting edge that is surrounded by an insulator. A source of pulsed electrical energy may be coupled to the electrically conductive blade to provide a substantially uniform and highly enhanced electric field along a cutting portion of the blade edge. The blade may have a uniform rate of erosion during use, so that both the conductive metal edge and the surrounding insulation layer erode at approximately the same rate. Also described are methods of fabricating insulated cutting electrodes, particularly blade electrodes.
摘要翻译：本发明涉及电外科切割系统。该系统包括导电叶片，其具有被绝缘体包围的非绝缘切割边缘。脉冲电能源可以耦合到导电叶片，以沿叶片边缘的切割部分提供基本均匀且高度增强的电场。刀片在使用期间可能具有均匀的侵蚀速率，使得导电金属边缘和周围绝缘层两者以大致相同的速率腐蚀。还描述了制造绝缘切割电极，特别是刀片电极的方法。

7. 发明申请

WO03032854A3 SURGICAL PROBE FOR USE IN LIQUID MEDIA 审中-公开
标题翻译：液体介质中使用的手术探针
公开(公告)号：WO03032854A3
公开(公告)日：2003-06-12
申请号：PCT/US0229063
申请日：2002-09-12
申请人： UNIV LELAND STANFORD JUNIOR , PALANKER DANIEL V , VANKOV ALEXANDER
发明人： PALANKER DANIEL V , VANKOV ALEXANDER
IPC分类号： A61B18/14 , A61B18/22 , A61B18/00
CPC分类号： A61B18/1477 , A61B18/22
摘要： The present invention provides a surgical probe having a tip for use in liquid media, wherein the tip has a concave body portion and a distal portion. The concave body portion of the tip is positioned after the distal portion such that the liquid jet resulting from the collapse of the cavitation bubble can be substantially reduced. Also disclosed is a surgical probe having a tip and an obstacle for use in liquid media, wherein the tip has a body portion and a distal portion. The obstacle is mounted on the outside of the probe such that the liquid jet resulting from the collapse of the cavitation bubble can be substantially reduced. The obstacle can also be a pick positioned on one side of the probe and in front of the probe.
摘要翻译：本发明提供了一种具有用于液体介质的尖端的手术探针，其中尖端具有凹形主体部分和远端部分。尖端的凹形本体部分位于远端部分之后，使得由空化气泡破裂产生的液体射流可以显着减少。还公开了一种具有用于液体介质的尖端和障碍物的手术探针，其中尖端具有主体部分和远端部分。障碍物安装在探针的外侧，使得由空化泡破裂产生的液体射流可以显着减少。障碍物也可以是位于探针一侧和探针前面的镐。

8. 发明申请

WO2005026786A2 OPTICAL PROJECTION AND TRACKING SYSTEM FOR RETINAL PROSTHESIS 审中-公开
标题翻译：光学投影与跟踪系统
公开(公告)号：WO2005026786A2
公开(公告)日：2005-03-24
申请号：PCT/US2004029966
申请日：2004-09-10
申请人： UNIV LELAND STANFORD JUNIOR
发明人： PALANKER DANIEL V , VANKOV ALEXANDER
IPC分类号： A61F9/00 , G02B20060101 , G02B
CPC分类号： A61N1/36046
摘要： A system having a retinal prosthesis inside a mammalian eye and an external imaging unit outside the eye is provided. The external imaging unit includes an imager which receives an input optical image and a display which provides a processed optical image derived from the input optical image as an input to the eye. The external imaging unit also includes a tracking subsystem, to determine the position of the retinal prosthesis relative to the display. The external imaging unit includes an image processor, which performs spatial processing dependent on the position of the retinal prosthesis relative to the display. Thus the processed image provided to the eye is spatially processed according to the position of the retinal prosthesis. The image processor can perform other kinds of image processing as well (e.g., temporal image processing). An external imaging unit. for use in such a system is also provided.
摘要翻译：提供了一种在哺乳动物眼睛内部具有视网膜假体并且在眼睛外部具有外部成像单元的系统。外部成像单元包括接收输入光学图像的成像器和从输入光学图像导出的经处理的光学图像作为眼睛的输入的显示器。外部成像单元还包括跟踪子系统，用于确定视网膜假体相对于显示器的位置。外部成像单元包括图像处理器，其根据视网膜假体相对于显示器的位置进行空间处理。因此，根据视网膜假体的位置对提供给眼睛的经处理图像进行空间处理。图像处理器也可以执行其他类型的图像处理（例如，时间图像处理）。外部成像单元。也用于这种系统。

9. 发明申请

WO2004073547A3 SELF-SUFFICIENT RETINAL PROSTHESIS POWERED BY INTRAOCULAR PHOTOVOLTAIC CELLS 审中-公开
标题翻译：自发性紫外线照射引发的自发性后遗症
公开(公告)号：WO2004073547A3
公开(公告)日：2005-07-28
申请号：PCT/US2004001892
申请日：2004-01-23
申请人： UNIV LELAND STANFORD JUNIOR
发明人： PALANKER DANIEL V , VANKOV ALEXANDER , BLUMENKRANZ MARK
IPC分类号： A61F20060101 , A61F2/14 , A61N1/08 , A61N1/36 , A61N1/372
CPC分类号： A61N1/0543 , A61F2/02 , A61F2/14 , A61N1/36046 , A61N1/3787
摘要： A self-sufficient retinal prosthesis powered by intra-ocular photovoltaic cells illuminated only by ambient light is provided. Photovoltaic cells can be disposed at the periphery of the retina or in the anterior chamber of the eye. An adaptive retinal prosthesis is also provided, such that the number of pixels energized in the prosthesis is selected according to the variable available power from ambient light.
摘要翻译：提供由仅由环境光照亮的眼内光伏电池供电的自足视网膜假体。光伏电池可以设置在视网膜的周边或眼睛的前房中。还提供了自适应视网膜假体，使得根据来自环境光的可变功率来选择在假体中通电的像素的数量。

10. 发明申请

WO2004073752A3 ELECTROSURGICAL SYSTEM WITH UNIFORMLY ENHANCED ELECTRIC FIELD AND MINIMAL COLLATERAL DAMAGE 审中-公开
标题翻译：具有均匀增强电场和最小束缚损伤的电磁系统
公开(公告)号：WO2004073752A3
公开(公告)日：2005-03-24
申请号：PCT/US2004004290
申请日：2004-02-13
申请人： UNIV LELAND STANFORD JUNIOR
发明人： PALANKER DANIEL V , VANKOV ALEXANDER
IPC分类号： A61B18/14 , A61B18/18 , A61L20060101
CPC分类号： A61B18/1402 , A61B2018/00083 , A61B2018/1407 , A61B2018/1412 , A61B2018/144 , H05H1/48 , H05H2245/122
摘要： The present invention is derected towards an electrosurgical cutting system. The system comprises an electrically conductive blade (100), having first (110) and second (120) blade surfaces. First (210) and second (220) insulators are affixed to the first and second blade surfaces, respectively. A blade edge, a region between the first an second blade surfaces, has an edge radius of curvature, which preferably is small. A source (300) of pulsed electrical energy coupled to the electrically conductive blade provides a substantially uniform and highly enhanced electric field along a cutting portion of the blade edge. The system can also be comprised of a wire electrode. Despite the fact that its field is strongly enhanced around the apex, a uniform vapor cavity is formed and then ionized using an appropriately designed burst of pulses, preferably of alternating polarity.
摘要翻译：本发明朝向电外科切割系统。该系统包括具有第一（110）和第二（120）个叶片表面的导电叶片（100）。第一（210）和第二（220）绝缘体分别固定到第一和第二叶片表面。叶片边缘，第一和第二叶片表面之间的区域具有边缘曲率半径，其优选地较小。耦合到导电叶片的脉冲电能源（300）沿叶片边缘的切割部分提供基本均匀且高度增强的电场。该系统还可以由线电极组成。尽管它的场强在周围的顶点强烈增强，形成均匀的气腔，然后使用适当设计的脉冲脉冲进行电离，优选具有交替的极性。

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