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1. 发明申请

WO2010124277A3 MATERIALS AND METHODS FOR ASSESSING AND MAPPING MICROBES AND MICROBIAL BIOFILMS ON WOUNDS 审中-公开
标题翻译：用于评估和绘制微生物和微生物生物膜的材料和方法
公开(公告)号：WO2010124277A3
公开(公告)日：2011-03-10
申请号：PCT/US2010032378
申请日：2010-04-26
申请人： UNIV FLORIDA , SCHULTZ GREGORY S , PHILLIPS PRISCILLA LORRAINE , SAMPSON EDITH MARION
发明人： SCHULTZ GREGORY S , PHILLIPS PRISCILLA LORRAINE , SAMPSON EDITH MARION
IPC分类号： C12Q1/04 , G01N33/569
CPC分类号： G01N33/569 , C12Q1/04 , G01N2400/24 , G01N2469/10
摘要： The subject invention provides point-of-care assays for assessing the topographical distribution of microbial biofilm and/or specific microorganisms in wounds.
摘要翻译：本发明提供了用于评估伤口中微生物生物膜和/或特定微生物的形貌分布的点护理测定。

2. 发明申请

WO2009082445A3 NOVEL DEVICES FOR THE DETECTION OF THE PRESENCE AND/OR ACTIVITY OF PROTEASES IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：检测生物样品中蛋白质存在和/或活性的新设备
公开(公告)号：WO2009082445A3
公开(公告)日：2009-10-01
申请号：PCT/US2008013743
申请日：2008-12-15
申请人： UNIV FLORIDA , SCHULTZ GREGORY S , AZEKE JOHN I , GIBSON DANIEL J , MOLOYE OLAJOMPO B , PHILLIPS PRISCILLA LORRAINE , TAN WEIHONG , BATICH CHRISTOPHER D
发明人： SCHULTZ GREGORY S , AZEKE JOHN I , GIBSON DANIEL J , MOLOYE OLAJOMPO B , PHILLIPS PRISCILLA LORRAINE , TAN WEIHONG , BATICH CHRISTOPHER D
IPC分类号： C12Q1/37 , G01N33/52 , G01N33/573
CPC分类号： C12Q1/37 , G01N33/542 , G01N2333/96494
摘要： The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples.
摘要翻译：本发明提供了用于检测生物样品中蛋白酶的存在和/或活性的新颖的装置和方法。

3. 发明申请

WO2010141719A3 MATERIALS AND METHODS FOR MEASURING NITRIC OXIDE LEVELS IN A BIOLOGICAL FLUID 审中-公开
标题翻译：用于测量生物流体中的氧化氮水平的材料和方法
公开(公告)号：WO2010141719A3
公开(公告)日：2011-04-28
申请号：PCT/US2010037257
申请日：2010-06-03
申请人： UNIV FLORIDA , SCHULTZ GREGORY S , GIBSON DANIEL J
发明人： SCHULTZ GREGORY S , GIBSON DANIEL J
IPC分类号： G01N33/84 , G01N33/52
CPC分类号： G01N33/582 , G01N33/84 , G01N2800/20 , Y10T436/177692
摘要： The subject invention presides novel devices and methods for the measurement of nitric oxide in biological samples, including wound fluid samples. These advantageous devices and methods can be used for clinicians to monitor the wound's nitric oxide metabolism and/or response to treatment.
摘要翻译：本发明主张用于测量生物样品中一氧化氮的新颖装置和方法，包括伤口液样品。这些有利的装置和方法可用于临床医生监测伤口的一氧化氮代谢和/或对治疗的反应。

4. 发明申请

WO2004087869A3 HERPESVIRUS RIBOZYMES AND VECTORS 审中-公开
标题翻译： HERPESVIRUS RIBOZYMES和VECTORS
公开(公告)号：WO2004087869A3
公开(公告)日：2007-11-15
申请号：PCT/US2004008926
申请日：2004-03-24
申请人： UNIV FLORIDA , LEWIN ALFRED S , BLOOM DAVID C , SCHULTZ GREGORY S , TULI SONAL S , LIU JIA
发明人： LEWIN ALFRED S , BLOOM DAVID C , SCHULTZ GREGORY S , TULI SONAL S , LIU JIA
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C07K14/005 , C12N15/1133 , C12N2310/111 , C12N2310/121 , C12N2510/02 , C12N2710/16622
摘要： Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to nontransfected cells.
摘要翻译：合成针对HSV复制（ICP4，UL20，UL30和UL54）关键组分的锤头核酶，并显示出在体外测定中有效切割编码这些成分的一部分的靶RNA。建立了稳定表达这些核酶的几种克隆细胞系。与未转染的细胞相比，用抗HSV核酶稳定转染的细胞中HSV介导的斑块形成显着降低。

5. 发明申请

WO2010129552A3 A METHOD AND DEVICE FOR ELECTROMOTIVE DELIVERY OF MACROMOLECULES INTO TISSUE 审中-公开
标题翻译：一种用于电纺输送组织的方法和装置
公开(公告)号：WO2010129552A3
公开(公告)日：2011-03-24
申请号：PCT/US2010033551
申请日：2010-05-04
申请人： UNIV FLORIDA , GIBSON DANIEL J , SCHULTZ GREGORY S , TULI SONAL S
发明人： GIBSON DANIEL J , SCHULTZ GREGORY S , TULI SONAL S
IPC分类号： A61N1/30 , A61N1/05
CPC分类号： A61N1/303 , A61N1/0424 , A61N1/044 , A61N1/0448
摘要： Electromotive delivery of macromolecules can be provided using a delivery device including a first chamber for contacting a macromolecule delivery medium to a surface of a tissue or other anatomy of a patient; and a second chamber for contacting a receiving medium to the patient. A first electrode can be disposed in the first chamber so as to not directly contact the macromolecule delivery medium. A second medium having a buffering agent can be used to keep the first electrode from coming into direct contact with the macromolecule delivery medium. A second electrode can be disposed within the receiving medium in the second chamber such that the second electrode does not directly contact the patient. An electric field can be generated using the first and second electrodes in order to cause the macromolecule delivery medium to move into the tissue of interest from the first chamber of the delivery device.
摘要翻译：可以使用包括用于使大分子递送介质与组织的表面或患者的其他解剖结构接触的第一室的输送装置来提供大分子的电动势输送; 以及用于使接收介质接触患者的第二腔室。第一电极可以设置在第一室中，以便不直接接触大分子输送介质。可以使用具有缓冲剂的第二介质来保持第一电极不与大分子输送介质直接接触。第二电极可以设置在第二室中的接收介质内，使得第二电极不直接接触患者。可以使用第一和第二电极产生电场，以便使大分子递送介质从输送装置的第一室移动到感兴趣的组织中。

6. 发明申请

WO2007024972A3 NON-LEACHING ABSORBENT WOUND DRESSING 审中-公开
标题翻译：非浸出式吸收式接头
公开(公告)号：WO2007024972A3
公开(公告)日：2007-06-21
申请号：PCT/US2006032953
申请日：2006-08-22
申请人： QUICK MED TECHNOLOGIES INC , UNIV FLORIDA , LIESENFELD BERND , TOREKI WILLIAM , MOORE DAVID , SCHULTZ GREGORY S
发明人： LIESENFELD BERND , TOREKI WILLIAM , MOORE DAVID , SCHULTZ GREGORY S
IPC分类号： A61L15/16 , A61F13/02
CPC分类号： A61L15/44 , A61L15/46
摘要： An antimicrobial wound dressing (10) having a non-leaching antimicrobial activity (20), releasable antimicrobial and antiprotease agents (40), and a controlled-release bioactive agent (50), such as doxycycline. The wound dressing material is absorbent and acts as a substrate for antimicrobial and antiprotease agents, as well as bioactive agents. Releasable antimicrobial agents and releasable anti-protease agents are ionically stabilized within the device so as to be released from the device in a controlled manner and releasable bioactive agents are also attached to the substrate to assist in wound healing.
摘要翻译：具有非浸出抗菌活性（20）的抗微生物伤口敷料（10），可释放的抗微生物剂和抗蛋白酶试剂（40）和控释释放生物活性剂（50），如多西环素。伤口敷料材料是吸收剂，并且用作抗微生物剂和抗蛋白酶剂以及生物活性剂的底物。可释放的抗微生物剂和可释放的抗蛋白酶试剂在装置内离子稳定，以便以受控的方式从装置释放，并且可释放的生物活性剂也附着到基底上以辅助伤口愈合。

7. 发明申请

WO2010151878A3 RAPID BED-SIDE MEASUREMENT OF NEUTROPHIL ELASTASE ACTIVITY IN BIOLOGICAL FLUIDS 审中-公开
标题翻译：生物流体中中性粒细胞活化的快速双面测量
公开(公告)号：WO2010151878A3
公开(公告)日：2011-05-12
申请号：PCT/US2010040215
申请日：2010-06-28
申请人： UNIV FLORIDA , SCHULTZ GREGORY S , GIBSON DANIEL J
发明人： SCHULTZ GREGORY S , GIBSON DANIEL J
IPC分类号： C12Q1/37 , C12N9/66 , G01N33/52
CPC分类号： C12Q1/37 , G01N33/542 , G01N2333/966
摘要： The subject invention provides novel devices and methods for the detection and quantification of neutrophil elastase activity in biological samples.
摘要翻译：本发明提供了用于检测和定量生物样品中的嗜中性粒细胞弹性蛋白酶活性的新颖的装置和方法。

8. 发明申请

WO0033778A9 INTRINSICALLY BACTERICIDAL ABSORBENT DRESSING AND METHOD OF FABRICATION 审中-公开
标题翻译：特异性杀菌剂吸收剂和制造方法
公开(公告)号：WO0033778A9
公开(公告)日：2001-11-15
申请号：PCT/US9929091
申请日：1999-12-08
申请人： QUICK MED TECHNOLOGIES INC , UNIV FLORIDA , BATICH CHRISTOPHER D , SCHULTZ GREGORY S , MAST BRUCE A , OLDERMAN GERALD M , LERNER DAVID
发明人： BATICH CHRISTOPHER D , SCHULTZ GREGORY S , MAST BRUCE A , OLDERMAN GERALD M , LERNER DAVID
IPC分类号： A61F13/49 , A61F5/441 , A61F13/00 , A61F13/15 , A61F13/20 , A61F13/472 , A61F13/53 , A61L2/16
CPC分类号： A61F13/8405
摘要： A superabsorbent polymer dressing having antimicrobial properties for use in fabricating wound dressings, sanitary napkins, tampons and the like, includes a synthetic polymer matrix fabricated to have an enhanced surface area. Antimicrobial compounds are coupled to the surface of the polymer matrix by non-siloxane bonds.
摘要翻译：具有用于制造伤口敷料，卫生巾，卫生棉条等的抗微生物性能的超吸收性聚合物敷料包括制造成具有增强的表面积的合成聚合物基质。抗微生物化合物通过非硅氧烷键与聚合物基质的表面偶联。

9. 发明申请

WO2004052236A3 METHODS AND COMPOSITIONS FOR TREATMENT OF OTITIS MEDIA 审中-公开
标题翻译：治疗中耳炎的方法和组合物
公开(公告)号：WO2004052236A3
公开(公告)日：2004-08-26
申请号：PCT/US0339053
申请日：2003-12-08
申请人： ARRIVA PHARMACEUTICALS INC , BARR PHILIP J , PEMBERTON PHILIP A , ANTONELLI PATRICK J , SCHULTZ GREGORY S , SUNDIN DAVID J
发明人： BARR PHILIP J , PEMBERTON PHILIP A , ANTONELLI PATRICK J , SCHULTZ GREGORY S , SUNDIN DAVID J
IPC分类号： A61F20060101 , A61K31/56 , A61K38/00 , A61K38/57 , A61K39/395
CPC分类号： A61K38/57
摘要： The invention is directed to the treatment of otitis media by administration of protease inhibitors. In some embodiments, the protease inhibitors are alpha one-antitrypsin and/or ilomastat.
摘要翻译：本发明涉及通过施用蛋白酶抑制剂来治疗中耳炎。在一些实施方案中，蛋白酶抑制剂是α1-抗胰蛋白酶和/或ilomastat。

10. 发明申请

WO2004099372A3 ANTI-SCARRING RIBOZYMES AND METHODS 审中-公开
标题翻译：抗锯齿剂RIBOZYMES和方法
公开(公告)号：WO2004099372A3
公开(公告)日：2005-12-29
申请号：PCT/US2004013357
申请日：2004-04-30
申请人： UNIV FLORIDA
发明人： SCHULTZ GREGORY S , LEWIN ALFRED S , BLALOCK TIMOTHY D
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , A01N43/04 , C07H21/02 , C07H21/04 , C12N15/63 , C12N15/88 , C12P19/34
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/111 , C12N2310/12 , C12N2310/121
摘要： Methods and compositions for treating scarring conditions associated with increased expression of connective tissue growth factor (CTGF). Aspects of the invention include ribozymes that cleave mRNA targets required for CTGF expression, cells containing anti CTGF ribozymes and vectored anti-CTGF ribozymes suitable for delivery to cellular targets capable of CTGF expression.
摘要翻译：用于治疗与增加结缔组织生长因子（CTGF）表达相关的瘢痕形成病症的方法和组合物。本发明的方面包括切割CTGF表达所需的mRNA靶标的核酶，含有抗CTGF核酶的细胞和适于递送至能够进行CTGF表达的细胞靶标的向量抗CTGF核酶。

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