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1. 发明申请

WO2009155610A2 METHOD AND APPARATUS FOR IN-SITU ADJUSTABILITY OF A MIDDLE EAR PROSTHESIS 审中-公开
标题翻译：用于中前期可调性的方法和装置
公开(公告)号：WO2009155610A2
公开(公告)日：2009-12-23
申请号：PCT/US2009048177
申请日：2009-06-22
申请人： UNIV FLORIDA , WIENS GLORIA JEAN , ANTONELLI PATRICK J , RIPPERE TROY BENJAMIN , RAO KOUSTUBH JAYAPRAKASH
发明人： WIENS GLORIA JEAN , ANTONELLI PATRICK J , RIPPERE TROY BENJAMIN , RAO KOUSTUBH JAYAPRAKASH
IPC分类号： A61F2/18 , A61L27/06
CPC分类号： A61F2/18 , A61F2002/183 , A61F2250/0007 , A61L27/06 , A61L27/54 , A61L2300/404 , A61L2300/606 , A61L2430/14
摘要： Embodiments of the present invention provide a middle ear prosthesis that can be adjusted in situ. Embodiments of the invention also relate to a method for adjusting a middle ear prosthesis in situ. In specific embodiments, the middle ear prosthesis can be inserted into the middle ear of a patient during surgery and then, after the surgery, the length of, or distance between the end resting on the malleus and the end resting on the stapes, can be adjusted without the need to touch the prosthesis through a surgical intervention. A middle ear prosthesis can include a first element 1 having a first interconnecting end 3 and a malleus end 9, for resting on a malleus or tympanic membrane, and a second element 5 having a second interconnecting end 7 and a stapes end 11, for resting on a stapes (either capitulum or footplate), where the first and second interconnecting ends interconnect with each other. The first element can incorporate an outer cylinder with an approximately cylindrical head 9, at the malleus end, and the second element can include an inner cylinder with an approximately conical foot 11, acting as the stapes end. When the prosthesis is implanted in a patient, the head 9 of the outer cylinder can rest on the malleus or tympanic membrane and the foot 11 of the inner cylinder can rest on the stapes capitulum or footplate. The inner cylinder can be inserted into the outer cylinder and inhibited from sliding by a clamp 15 with a compliant portion 17. External forces can be applied to the clamp 15 to actuate release of the clamp 15 and allow for adjustment of the length of the prosthesis in situ.
摘要翻译：本发明的实施例提供可以原位调节的中耳假体。本发明的实施例还涉及一种用于原位调整中耳假体的方法。在具体实施例中，中耳假体可以在手术期间插入到患者的中耳中，然后在手术之后，搁置在踝上的末端或搁置在镫骨上的末端之间的距离或距离可以是调整而不需要通过外科手术触摸假体。中耳假体可以包括具有第一互连端3和垂直端9的第一元件1，用于搁置在马蹄形或鼓膜上，第二元件5具有第二互连端7和镫端端11，用于休息在第一和第二互连端彼此互连的镫骨（头帽或脚板）上。第一元件可以包括在圆柱形端部具有近似圆柱形头部9的外圆柱体，并且第二元件可以包括具有近似圆锥形的脚11的内圆柱体，其作为镫形端。当假体植入患者体内时，外筒的头部9可以搁置在锤骨或鼓膜上，并且内筒的脚11可以搁置在镫骨头或脚板上。内筒可以插入到外筒中并且通过具有柔性部分17的夹具15阻止滑动。外力可以施加到夹具15以致致动夹具15的释放并且允许调节假体的长度在原地。

2. 发明申请

WO2004052236A2 METHODS AND COMPOSITIONS FOR TREATMENT OF OTITIS MEDIA 审中-公开
标题翻译：用于治疗传播媒介的方法和组合物
公开(公告)号：WO2004052236A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039053
申请日：2003-12-08
申请人： ARRIVA PHARMACEUTICALS, INC. , BARR, Philip, J. , PEMBERTON, Philip, A. , ANTONELLI, Patrick, J. , SCHULTZ, Gregory, S. , SUNDIN, David, J.
发明人： BARR, Philip, J. , PEMBERTON, Philip, A. , ANTONELLI, Patrick, J. , SCHULTZ, Gregory, S. , SUNDIN, David, J.
IPC分类号： A61F
CPC分类号： A61K38/57
摘要： The invention is directed to the treatment of otitis media by administration of protease inhibitors. In some embodiments, the protease inhibitors are alpha one-antitrypsin and/or ilomastat.
摘要翻译：本发明涉及通过施用蛋白酶抑制剂治疗中耳炎。在一些实施方案中，蛋白酶抑制剂是α一抗胰蛋白酶和/或伊洛司特（ilomastat）。

3. 发明申请

WO2004052236A3 METHODS AND COMPOSITIONS FOR TREATMENT OF OTITIS MEDIA 审中-公开
标题翻译：治疗中耳炎的方法和组合物
公开(公告)号：WO2004052236A3
公开(公告)日：2004-08-26
申请号：PCT/US0339053
申请日：2003-12-08
申请人： ARRIVA PHARMACEUTICALS INC , BARR PHILIP J , PEMBERTON PHILIP A , ANTONELLI PATRICK J , SCHULTZ GREGORY S , SUNDIN DAVID J
发明人： BARR PHILIP J , PEMBERTON PHILIP A , ANTONELLI PATRICK J , SCHULTZ GREGORY S , SUNDIN DAVID J
IPC分类号： A61F20060101 , A61K31/56 , A61K38/00 , A61K38/57 , A61K39/395
CPC分类号： A61K38/57
摘要： The invention is directed to the treatment of otitis media by administration of protease inhibitors. In some embodiments, the protease inhibitors are alpha one-antitrypsin and/or ilomastat.
摘要翻译：本发明涉及通过施用蛋白酶抑制剂来治疗中耳炎。在一些实施方案中，蛋白酶抑制剂是α1-抗胰蛋白酶和/或ilomastat。

4. 发明申请

WO2009155610A3 METHOD AND APPARATUS FOR IN-SITU ADJUSTABILITY OF A MIDDLE EAR PROSTHESIS 审中-公开
公开(公告)号：WO2009155610A3
公开(公告)日：2009-12-23
申请号：PCT/US2009/048177
申请日：2009-06-22
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , WIENS, Gloria, Jean , ANTONELLI, Patrick, J. , RIPPERE, Troy, Benjamin , RAO, Koustubh, Jayaprakash
发明人： WIENS, Gloria, Jean , ANTONELLI, Patrick, J. , RIPPERE, Troy, Benjamin , RAO, Koustubh, Jayaprakash
IPC分类号： A61F2/18 , A61L27/06
摘要： Embodiments of the present invention provide a middle ear prosthesis that can be adjusted in situ. Embodiments of the invention also relate to a method for adjusting a middle ear prosthesis in situ. In specific embodiments, the middle ear prosthesis can be inserted into the middle ear of a patient during surgery and then, after the surgery, the length of, or distance between the end resting on the malleus and the end resting on the stapes, can be adjusted without the need to touch the prosthesis through a surgical intervention. A middle ear prosthesis can include a first element 1 having a first interconnecting end 3 and a malleus end 9, for resting on a malleus or tympanic membrane, and a second element 5 having a second interconnecting end 7 and a stapes end 11, for resting on a stapes (either capitulum or footplate), where the first and second interconnecting ends interconnect with each other. The first element can incorporate an outer cylinder with an approximately cylindrical head 9, at the malleus end, and the second element can include an inner cylinder with an approximately conical foot 11, acting as the stapes end. When the prosthesis is implanted in a patient, the head 9 of the outer cylinder can rest on the malleus or tympanic membrane and the foot 11 of the inner cylinder can rest on the stapes capitulum or footplate. The inner cylinder can be inserted into the outer cylinder and inhibited from sliding by a clamp 15 with a compliant portion 17. External forces can be applied to the clamp 15 to actuate release of the clamp 15 and allow for adjustment of the length of the prosthesis in situ.

5. 发明申请

WO2007038744A1 DEVICES AND METHODS FOR TESTING TYMPANOSTOMY TUBES 审中-公开
标题翻译：用于测试管状管的装置和方法
公开(公告)号：WO2007038744A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/038054
申请日：2006-09-28
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , SHERMAN, Ethan, Glenn , TRAN-SON-TAY, Roger , ANTONELLI, Patrick, J.
发明人： SHERMAN, Ethan, Glenn , TRAN-SON-TAY, Roger , ANTONELLI, Patrick, J.
IPC分类号： A61F11/00
CPC分类号： A61F11/002
摘要： The subject invention provides devices capable of simulating the outer and middle inner ear environments. The subject invention provides a means for introducing liquid and/or air into the devices, under varying or continuous pressure, to simulate the natural conditions in the outer and middle ear environments. The device facilitates in vitro testing of tympanostomy tubes and their rates and susceptibility to occlusion.
摘要翻译：本发明提供了能够模拟外耳和中耳内环境的装置。本发明提供了一种用于在变化或连续压力下将液体和/或空气引入装置中以模拟外耳环和中耳环境中的自然条件的装置。该装置促进鼓室造口管的体外测试及其速率和对闭塞的易感性。

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