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1. 发明申请

WO2007024668A2 TARGETING OF HERPES SIMPLEX VIRUS TO SPECIFIC RECEPTORS 审中-公开
标题翻译：将单纯疱疹病毒靶向特异性受体
公开(公告)号：WO2007024668A2
公开(公告)日：2007-03-01
申请号：PCT/US2006032291
申请日：2006-08-18
申请人： UNIV CHICAGO , KAMIYAMA HIRONAGA , ZHOU GUOYING , ROIZMAN BERNARD
发明人： KAMIYAMA HIRONAGA , ZHOU GUOYING , ROIZMAN BERNARD
IPC分类号： C07K14/035 , C12N15/869
CPC分类号： C12N15/86 , A61K35/763 , C12N2710/16632 , C12N2710/16643 , C12N2810/80 , C12N2810/855 , C12N2810/859
摘要： The invention relates to engineered Herpes simplex virus (HSV) particles exhibiting a binding pair member that specifically binds to, or targets, one or more specific binding partners, such as receptors, including binding partners lacking at least one of a cytoplasmic domain or a transmembrane domain. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected, receptor, which itself may be a product of genetic engineering. The ability to selectively target cells renders the HSV particles particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.
摘要翻译：本发明涉及工程化的单纯疱疹病毒（HSV）颗粒，其显示结合对成员，其特异性结合或靶向一种或多种特异性结合配偶体，如受体，包括缺乏胞质结构域或跨膜结构中的至少一种的结合配偶体域。而且，提供了用于生产这种HSV颗粒的重组载体。通过降低HSV对其天然受体的亲和力并增加对所选受体的亲和力，本发明的HSV颗粒可用于靶向表达选择的受体的细胞，所述受体本身可以是基因工程的产物。选择性靶向细胞的能力使得HSV颗粒特别适用于选择性诊断，治疗和成像携带选择的结合对成员的细胞，例如受体。本发明还提供了对携带选择的结合对成员如受体的细胞进行基于多核苷酸的疗法。

2. 发明申请

WO2007084992A3 PROGNOSIS AND THERAPY PREDICTIVE MARKERS AND METHODS OF USE 审中-公开
标题翻译：预防和治疗预后标记及其使用方法
公开(公告)号：WO2007084992A3
公开(公告)日：2008-01-17
申请号：PCT/US2007060783
申请日：2007-01-19
申请人： UNIV CHICAGO , WEICHSELBAUM RALPH , ROIZMAN BERNARD , MINN ANDY , KHODAREV NIKOLAI , LABAY EDWARDINE
发明人： WEICHSELBAUM RALPH , ROIZMAN BERNARD , MINN ANDY , KHODAREV NIKOLAI , LABAY EDWARDINE
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , G01N33/57407 , G01N33/57484 , G01N2800/52
摘要： Disclosed is a set of genes differentially expressed in chemotherapy and radiation resistant tumors useful in predicting response to therapy and assessing risk of local-regional failure, survival and metastasis in cancer patients. Also disclosed are methods for characterizing tumors according to gene expression and kits for use in the methods of the invention.
摘要翻译：公开了一组在化学疗法和耐辐射肿瘤中差异表达的基因，可用于预测治疗反应和评估癌症患者局部局部衰竭，存活和转移的风险。还公开了根据基因表达表征肿瘤的方法和用于本发明方法的试剂盒。

3. 发明申请

WO03030719A9 METHODS AND KITS FOR USE IN SELECTING APPROACHES TO TREATING CANCER 审中-公开
标题翻译：方法和试剂盒用于选择治疗癌症的方法
公开(公告)号：WO03030719A9
公开(公告)日：2004-07-01
申请号：PCT/US0232146
申请日：2002-10-09
申请人： UNIV CHICAGO , WEICHSELBAUM RALPH R , ROIZMAN BERNARD , KHODAREV NIKOLAI N , GUPTA NALIN
发明人： WEICHSELBAUM RALPH R , ROIZMAN BERNARD , KHODAREV NIKOLAI N , GUPTA NALIN
IPC分类号： A61B20060101 , A61K48/00 , C12N5/00 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： This invention provides methods and kits for use in selecting approaches to treating cancer, as well as methods for identifying genes that can be used in such methods and kits.
摘要翻译：本发明提供了用于选择治疗癌症的方法的方法和试剂盒，以及鉴定可用于这些方法和试剂盒中的基因的方法。

4. 发明申请

WO2007087580A3 Y134.5 DEFICIENT HSV COMPRISING A CODING REGION OF A MEMBER OF THE MAPK PATHWAY FOR THE TREATMENT OF A CELL PROLIFERATION DISORDER 审中-公开
标题翻译： Y134.5包含用于治疗细胞增殖性疾病的MAPK途径成员的编码区的缺血性HSV
公开(公告)号：WO2007087580A3
公开(公告)日：2007-10-18
申请号：PCT/US2007061002
申请日：2007-01-24
申请人： UNIV CHICAGO , SMITH KERRINGTON D , MEZHIR JAMES J , WEICHSELBAUM RALPH R , ROIZMAN BERNARD
发明人： SMITH KERRINGTON D , MEZHIR JAMES J , WEICHSELBAUM RALPH R , ROIZMAN BERNARD
IPC分类号： C12N7/04 , A61K35/76 , A61K48/00 , A61P35/00 , C12N15/869
CPC分类号： C12N9/1205 , A61K35/763 , A61K38/00 , C07K2319/43 , C12N15/86 , C12N2710/16632 , C12N2710/16643 , A61K2300/00
摘要： The invention provides materials and methods for the identification of cells exhibiting a cell proliferative disorder that are amenable to treatment with a herpes simplex virus that does not express an approximately wild-type level of ICP34.5. Also provided are methods of treating cell proliferative diseases, disorders or conditions, such as cancers, rheumatoid arthritis and macular degeneration, using these HSVs. Further provided are methods for preventing such cell proliferative disorders by administering the HSVs as well as methods for ameliorating a symptom associated with a cell proliferative disorder by administering such HSVs.
摘要翻译：本发明提供用于鉴定表现出细胞增殖性病症的细胞的材料和方法，其适于用不表达近似野生型水平的ICP34.5的单纯疱疹病毒治疗。还提供了使用这些HSVs治疗细胞增殖性疾病，病症或病症如癌症，类风湿性关节炎和黄斑变性的方法。还提供了通过施用HSV来预防这种细胞增殖性疾病的方法以及通过施用这种HSV来改善与细胞增殖性病症相关的症状的方法。

5. 发明申请

WO2004033639A3 TARGETING OF HERPES SIMPLEX VIRUS TO SPECIFIC RECEPTORS 审中-公开
标题翻译：将单纯疱疹病毒靶向特异性受体
公开(公告)号：WO2004033639A3
公开(公告)日：2004-08-12
申请号：PCT/US0331598
申请日：2003-10-06
申请人： UNIV CHICAGO , ROIZMAN BERNARD , ZHOU GOUYING , YE GUO JIE
发明人： ROIZMAN BERNARD , ZHOU GOUYING , YE GUO JIE
IPC分类号： C07K14/035 , C12N15/869 , A61K39/245 , A61K39/12
CPC分类号： C12N15/86 , A61K47/642 , A61K47/6901 , C07K14/005 , C07K2319/20 , C12N2710/16622 , C12N2710/16643 , C12N2810/50 , C12N2810/852 , C12N2810/859
摘要： The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific receptors. Also, recombinant vectors for producing such HSV particles. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention may be used for targeting cells that express the selected receptor. The ability to selectively target cells renders the HSV particles particularly useful in selectively killing the selected receptor-bearing cells (such as tumor cells), imaging cells bearing the selected receptor, and providing gene replacement therapy to cells bearing the selected receptor.
摘要翻译：本发明涉及靶向一种或多种特异性受体的工程化单纯疱疹病毒（HSV）颗粒。此外，用于生产这种HSV颗粒的重组载体。通过降低HSV对其天然受体的亲和力并增加对所选受体的亲和力，本发明的HSV颗粒可用于靶向表达所选受体的细胞。选择性靶向细胞的能力使得HSV颗粒在选择性杀死选择的受体携带细胞（例如肿瘤细胞），对携带所选受体的成像细胞进行成像以及向携带所选受体的细胞提供基因置换疗法方面特别有用。

6. 发明申请

WO03030719A2 METHODS AND KITS FOR USE IN SELECTING APPROACHES TO TREATING CANCER 审中-公开
标题翻译：用于选择治疗癌症的方法和工具
公开(公告)号：WO03030719A2
公开(公告)日：2003-04-17
申请号：PCT/US0232146
申请日：2002-10-09
申请人： UNIV CHICAGO , WEICHSELBAUM RALPH R , ROIZMAN BERNARD , KHODAREV NIKOLAI N , GUPTA NALIN
发明人： WEICHSELBAUM RALPH R , ROIZMAN BERNARD , KHODAREV NIKOLAI N , GUPTA NALIN
IPC分类号： A61B20060101 , A61K48/00 , C12N5/00 , C12Q1/68 , G01N33/53 , G01N33/574 , A61B
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： This invention provides methods and kits for use in selecting approaches to treating cancer, as well as methods for identifying genes that can be used in such methods and kits.
摘要翻译：本发明提供了用于选择治疗癌症的方法的方法和试剂盒，以及用于鉴定可用于这些方法和试剂盒的基因的方法。

7. 发明申请

WO9846637A3 HERPES SIMPLEX VIRUS US3 AND ICP4 AS INHIBITORS OF APOPTOSIS 审中-公开
标题翻译： HERPES SIMPLEX VIRUS US3和ICP4作为APOPTOSIS的抑制剂
公开(公告)号：WO9846637A3
公开(公告)日：1999-01-28
申请号：PCT/US9807573
申请日：1998-04-16
申请人： ARCH DEV CORP , LEOPARDI ROSARIO , ROIZMAN BERNARD
发明人： LEOPARDI ROSARIO , ROIZMAN BERNARD
IPC分类号： A61K38/00 , C07K14/035 , C12N5/02 , C07K14/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/16622
摘要： The ICP4 protein of herpes simplex virus plays an important role in the transactivation of viral genes. The present invention discloses that ICP4 also has the ability to inhibit apoptosis. This function appears to reside in functional domain distinct from the transactivating function, as indicated by studies using temperature sensitive mutants of ICP4 that have transactivating function at elevated temperatures. Also disclosed are methods for inhibition of apoptosis using ICP4 or an ICP4 encoding gene, such as an α4 gene, methods for inhibiting ICP4's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections. Further, the present invention discloses that the HSV-1 mutant lacking the α4 gene, has a secondary mutation in the gene US3 specifying a protein kinase. Thus a functional US3, a viral gene encoding a protein kinase known to phosphorylate serine/threonine within a specific arginine rich consensus sequence, is required in order to block apoptosis. Also disclosed are methods for inhibition of apoptosis using US3 or an US3 encoding gene, methods for inhibiting US3's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections.

8. 发明申请

WO9804709A3 Herpes simplex virus ICP4 is an inhibitor of apoptosis 审中-公开
标题翻译：单纯疱疹病毒ICP4是凋亡抑制剂
公开(公告)号：WO9804709A3
公开(公告)日：1998-03-12
申请号：PCT/US9712904
申请日：1997-07-23
申请人： ARCH DEV CORP , LEOPARDI ROSARIO , ROIZMAN BERNARD
发明人： LEOPARDI ROSSARIO , ROIZMAN BERNARD
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K14/035 , C12N5/10 , C12N15/02 , C12N15/38 , C12P21/08
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C12N2710/16622
摘要： The ICP4 protein of herpes simplex virus plays an important role in the transactivation of viral genes. The present invention discloses that ICP4 also has the ability to inhibit apoptosis. This function appears to reside in functional domain distinct from the transactivating function, as indicated by studies using temperature sensitive mutants of ICP4 that transactivating function at elevated temperatures. Also disclosed are methods for inhibition of apoptosis using ICP4 or an ICP4 encoding gene, such as an α4 gene, methods of inhibiting ICP4's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections.

9. 发明申请

WO0245431A2 GENETICALLY ENGINEERED HERPES VIRUS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于治疗心血管疾病的遗传性工程化病毒
公开(公告)号：WO0245431A2
公开(公告)日：2002-06-06
申请号：PCT/US0144279
申请日：2001-11-28
申请人： UNIV CHICAGO
发明人： SCHWARTZ LEWIS B , WEICHSELBAUM RALPH R , ROIZMAN BERNARD
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P37/02 , A61P43/00 , C12N7/04 , C12N15/869 , H04N7/173
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0058 , C12N7/00 , C12N2710/16643 , C12N2710/16661
摘要： The present invention provides methods of expressing a nucleic acid or producing a proteinaceous composition encoded by a nucleic acid in vascular and cardiovascular cells by administration of a herpesvirus vector. The present invention provides methods of producing a therapeutic benefit in vascular and cardiovascular tissue by administration of a herpesvirus vector. In additional aspects, the invention concerns combination therapies for vascular and cardiovascular diseases comprising administration of a herpesvirus vector and treatment with at least addition pharmacological agent or surgical procedure.
摘要翻译：本发明提供了通过施用疱疹病毒载体在血管和心血管细胞中表达核酸或产生由核酸编码的蛋白质组合物的方法。本发明提供了通过施用疱疹病毒载体在血管和心血管组织中产生治疗益处的方法。在另外的方面，本发明涉及用于血管和心血管疾病的组合疗法，包括施用疱疹病毒载体和用至少添加的药理学试剂或外科手术进行治疗。

10. 发明申请

WO2014185973A3 MODULATION OF REACTIVATION OF A LATENT VIRUS 审中-公开
标题翻译：调控病毒的反应
公开(公告)号：WO2014185973A3
公开(公告)日：2015-01-22
申请号：PCT/US2014000110
申请日：2014-05-14
申请人： UNIV CHICAGO
发明人： ROIZMAN BERNARD , ZHOU GUOYING , DU TE
IPC分类号： A61K38/00 , A01N37/18 , C12N5/00 , C12N5/02
CPC分类号： A61K31/5377 , A61K31/12 , A61K31/165 , A61K31/167 , A61K31/185 , A61K31/255 , A61K31/40 , A61K31/4045 , A61K31/4192 , A61K31/436 , A61K31/4375 , A61K31/4402 , A61K31/4406 , A61K31/4745 , A61K31/517 , A61K45/06
摘要： The disclosure relates to methods of controlling the state of a virus (lytic or lysogenic) in an individual, such as a method of reactivating a latent virus in an individual, comprising administering one or more agents that modulates the activity of signal transducer and activator of transcription 3 (STAT3) or any of p300, CBP or p300/CBP. Also contemplated are methods further comprising administering an HDAC modulating agent, such as an HDAC inhibiting agent or an HDAC activating agent.
摘要翻译：本公开涉及控制个体中的病毒（溶解或溶解性）状态的方法，例如重新激活个体潜伏病毒的方法，包括施用一种或多种调节信号转导子和活化剂的活性的试剂转录3（STAT3）或p300，CBP或p300 / CBP中的任何一种。还考虑的方法还包括施用HDAC调节剂，例如HDAC抑制剂或HDAC活化剂。

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