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1. 发明申请

WO2007024668A2 TARGETING OF HERPES SIMPLEX VIRUS TO SPECIFIC RECEPTORS 审中-公开
标题翻译：将单纯疱疹病毒靶向特异性受体
公开(公告)号：WO2007024668A2
公开(公告)日：2007-03-01
申请号：PCT/US2006032291
申请日：2006-08-18
申请人： UNIV CHICAGO , KAMIYAMA HIRONAGA , ZHOU GUOYING , ROIZMAN BERNARD
发明人： KAMIYAMA HIRONAGA , ZHOU GUOYING , ROIZMAN BERNARD
IPC分类号： C07K14/035 , C12N15/869
CPC分类号： C12N15/86 , A61K35/763 , C12N2710/16632 , C12N2710/16643 , C12N2810/80 , C12N2810/855 , C12N2810/859
摘要： The invention relates to engineered Herpes simplex virus (HSV) particles exhibiting a binding pair member that specifically binds to, or targets, one or more specific binding partners, such as receptors, including binding partners lacking at least one of a cytoplasmic domain or a transmembrane domain. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected, receptor, which itself may be a product of genetic engineering. The ability to selectively target cells renders the HSV particles particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.
摘要翻译：本发明涉及工程化的单纯疱疹病毒（HSV）颗粒，其显示结合对成员，其特异性结合或靶向一种或多种特异性结合配偶体，如受体，包括缺乏胞质结构域或跨膜结构中的至少一种的结合配偶体域。而且，提供了用于生产这种HSV颗粒的重组载体。通过降低HSV对其天然受体的亲和力并增加对所选受体的亲和力，本发明的HSV颗粒可用于靶向表达选择的受体的细胞，所述受体本身可以是基因工程的产物。选择性靶向细胞的能力使得HSV颗粒特别适用于选择性诊断，治疗和成像携带选择的结合对成员的细胞，例如受体。本发明还提供了对携带选择的结合对成员如受体的细胞进行基于多核苷酸的疗法。

2. 发明申请

WO2008103762A1 TARGETING OF HERPES SIMPLEX VIRUS TO SPECIFIC RECEPTORS 审中-公开
标题翻译：将特定病毒的简单病毒定向到特定受体
公开(公告)号：WO2008103762A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/054469
申请日：2008-02-20
申请人： THE UNIVERSITY OF CHICAGO , ROIZMAN, Bernard , ZHOU, Guoying
发明人： ROIZMAN, Bernard , ZHOU, Guoying
IPC分类号： C07K14/035 , C07K14/705 , A61K35/76 , C12N15/869
CPC分类号： A61K48/0008 , C07K14/005 , C07K14/5437 , C07K2319/01 , C12N7/00 , C12N9/6462 , C12N15/86 , C12N2710/16622 , C12N2710/16643 , C12N2810/852 , C12N2810/857 , C12Y304/21073
摘要： The invention relates to engineered herpes virus particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such herpes virus particles are provided. By reducing the affinity of herpes virus for its natural receptor(s) and increasing the affinity for a selected receptor, the herpes virus particles of the disclosure are useful for targeting cells that express the selected receptor, which itself may be a product of genetic engineering. The ability to selectively target cells renders the herpes virus particles particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.
摘要翻译：本发明涉及靶向一种或多种特异性结合对成员（例如受体）的工程化疱疹病毒颗粒。此外，提供了用于产生这种疱疹病毒颗粒的重组载体。通过降低疱疹病毒对其天然受体的亲和力并增加对所选受体的亲和力，本公开的疱疹病毒颗粒可用于靶向表达所选受体的细胞，其本身可以是遗传工程的产物。选择性靶向细胞的能力使得疱疹病毒颗粒特别可用于选择性地诊断，治疗和成像携带所选结合对成员（例如受体）的细胞。本发明还提供了携带选定结合对成员例如受体的细胞的基于多核苷酸的治疗。

3. 发明申请

WO2007027774A1 TARGETING OF HERPES SIMPLEX VIRUS TO SPECIFIC RECEPTORS 审中-公开
标题翻译：将特定病毒的简单病毒定向到特定受体
公开(公告)号：WO2007027774A1
公开(公告)日：2007-03-08
申请号：PCT/US2006/033865
申请日：2006-08-30
申请人： THE UNIVERSITY OF CHICAGO , ZHOU, Guoying , ROIZMAN, Bernard
发明人： ZHOU, Guoying , ROIZMAN, Bernard
IPC分类号： A61K48/00 , C12N15/869 , C12N15/62 , C07K14/19 , C07K14/035
CPC分类号： C12N15/86 , A61K47/642 , A61K47/6901 , A61K48/00 , C07K2319/74 , C12N2710/16643 , C12N2710/16645 , C12N2810/852
摘要： The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected receptor, which itself may be a product of genetic engineering. The ability to selectively target cells renders the HSV particles . particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.
摘要翻译：本发明涉及靶向一种或多种特异性结合对成员（例如受体）的工程化单纯疱疹病毒（HSV）颗粒。此外，提供了用于生产这种HSV颗粒的重组载体。通过降低HSV对其天然受体的亲合力并增加对所选受体的亲和力，本发明的HSV颗粒可用于靶向表达所选受体的细胞，其本身可能是遗传工程的产物。选择性靶向细胞的能力使得HSV颗粒。特别可用于选择性地诊断，治疗和成像携带所选择的结合对成员例如受体的细胞。本发明还提供了携带选定结合对成员例如受体的细胞的基于多核苷酸的治疗。

4. 发明申请

WO2007024668A3 TARGETING OF HERPES SIMPLEX VIRUS TO SPECIFIC RECEPTORS 审中-公开
公开(公告)号：WO2007024668A3
公开(公告)日：2007-03-01
申请号：PCT/US2006/032291
申请日：2006-08-18
申请人： THE UNIVERSITY OF CHICAGO , KAMIYAMA, Hironaga , ZHOU, Guoying , ROIZMAN, Bernard
发明人： KAMIYAMA, Hironaga , ZHOU, Guoying , ROIZMAN, Bernard
IPC分类号： C07K14/035 , C12N15/869
摘要： The invention relates to engineered Herpes simplex virus (HSV) particles exhibiting a binding pair member that specifically binds to, or targets, one or more specific binding partners, such as receptors, including binding partners lacking at least one of a cytoplasmic domain or a transmembrane domain. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected, receptor, which itself may be a product of genetic engineering. The ability to selectively target cells renders the HSV particles particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.

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