专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008063721A3 LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES 审中-公开
公开(公告)号：WO2008063721A3
公开(公告)日：2008-11-06
申请号：PCT/US2007076047
申请日：2007-08-15
申请人： UNIV CALIFORNIA , RAYMOND KENNETH N , CORNEILLIE TODD M , XU JIDE
发明人： RAYMOND KENNETH N , CORNEILLIE TODD M , XU JIDE
IPC分类号： C07D245/04
CPC分类号： G01N33/582 , G01N2458/40
摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.
摘要翻译：本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。优选的化合物在其大环结构内掺入羟基间苯二酰胺部分，其特征在于与各种多肽例如抗体和蛋白质以及高动力学稳定性令人惊奇的低非特异性结合。这些特征将它们与已知的开放结构的配体区分开来。

2. 发明申请

WO2006001835A3 AROMATIC TRIAMIDE-LANTHANIDE COMPLEXES 审中-公开
标题翻译：芳香三酰胺 - 兰蒽配合物
公开(公告)号：WO2006001835A3
公开(公告)日：2006-04-06
申请号：PCT/US2004043968
申请日：2004-12-29
申请人： UNIV CALIFORNIA , RAYMOND KENNETH N , PETOUD STEPHANE , XU JIDE
发明人： RAYMOND KENNETH N , PETOUD STEPHANE , XU JIDE
IPC分类号： C08K5/17 , G01N33/00
CPC分类号： C07C235/60 , C07B2200/11 , C07C271/20 , C07D277/16 , C12Q1/37 , G01N33/533 , G01N33/542 , G01N33/582
摘要： The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
摘要翻译：本发明提供了包含镧系金属离子和包含至少一个邻苯二甲酰胺基部分的络合剂的发光镧系元素金属螯合物。还提供掺入本发明的邻苯二甲酰基配体的探针和利用本发明配体和包含本发明配体的探针的方法。

3. 发明申请

WO2013187971A2 MACROCYCLES 审中-公开
标题翻译：大环化合物
公开(公告)号：WO2013187971A2
公开(公告)日：2013-12-19
申请号：PCT/US2013031648
申请日：2013-03-14
申请人： UNIV CALIFORNIA , RAYMOND KENNETH N , XU JIDE , PHAM TIFFANY A
发明人： RAYMOND KENNETH N , XU JIDE , PHAM TIFFANY A
CPC分类号： A61K51/0482 , C07B59/004 , C07D259/00 , C07D401/14
摘要： The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
摘要翻译：本发明提供可用于螯合金属离子，特别是放射性核素以提供金属离子络合物的大环化合物。本发明还提供了使用本发明的化合物和复合物的方法，例如在治疗和诊断应用中。

4. 发明申请

WO2008008797A2 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES 审中-公开
标题翻译：镧系元素的发光1-羟基-2-吡啶酮螯合物
公开(公告)号：WO2008008797A2
公开(公告)日：2008-01-17
申请号：PCT/US2007073185
申请日：2007-07-10
申请人： UNIV CALIFORNIA , RAYMOND KENNETH N , XU JIDE , MOORE EVAN G , WERNER ERIC J
发明人： RAYMOND KENNETH N , XU JIDE , MOORE EVAN G , WERNER ERIC J
IPC分类号： C07F5/00
CPC分类号： C07D213/89 , C07D217/26 , C09K11/06 , C09K2211/1022 , C09K2211/1029 , C09K2211/1044 , C09K2211/1088 , C09K2211/185 , H05B33/14
摘要： The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.
摘要翻译：本发明提供了镧系元素离子和含有1,2-羟基吡啶酮单元的有机配体之间的发光络合物。本发明的复合物在水溶液中稳定并且可用作分子探针，例如在医学诊断和生物分析测定系统中。本发明还提供了使用本发明配合物的方法。

5. 发明申请

WO03016923A2 HYDROXYPYRIDONATE AND HYDROXYPYRIMIDINONE CHELATING AGENTS 审中-公开
标题翻译：羟基吡啶酮和羟基吡啶酮螯合剂
公开(公告)号：WO03016923A2
公开(公告)日：2003-02-27
申请号：PCT/US0226026
申请日：2002-08-13
申请人： UNIV CALIFORNIA , RAYMOND KENNETH N , DOBLE DANIEL M J , SUNDERLAND CHRISTOPHER J , THOMPSON MARLON
发明人： RAYMOND KENNETH N , DOBLE DANIEL M J , SUNDERLAND CHRISTOPHER J , THOMPSON MARLON
IPC分类号： A61K49/00 , A61K49/08 , C07C235/60 , C07F5/00 , G01R
CPC分类号： A61K49/10 , A61K49/085 , A61K49/101 , A61K49/103 , A61K49/126
摘要： The present invention provides hydroxypyridinone and hydroxypyrimidone chelating agents. Also provided are Gd(III) complexes of these agents, which are useful as contrast enhancing agents for magnetic resonance imaging. The invention also provides methods of preparing the compounds of the invention, as well as methods of using the compounds in magnetic resonance imaging applications.
摘要翻译：本发明提供羟基吡啶酮和羟基嘧啶酮螯合剂。还提供这些试剂的Gd（III）络合物，其可用作磁共振成像的对比增强剂。本发明还提供了制备本发明化合物的方法，以及在磁共振成像应用中使用该化合物的方法。

6. 发明申请

WO2010129962A3 COMBINATION TREATMENT OF HYDROXYPYRIDONATE ACTINIDE/LANTHANIDE DECORPORATION AGENTS 审中-公开
标题翻译：羟基磷酸酯/盐酸盐装饰剂的组合处理
公开(公告)号：WO2010129962A3
公开(公告)日：2011-01-06
申请号：PCT/US2010034266
申请日：2010-05-10
申请人： UNIV CALIFORNIA , DURBIN-HEAVEY PATRICIA W , RAYMOND KENNETH N , ABERGEL REBECCA J , SHUH DAVID K
发明人： DURBIN-HEAVEY PATRICIA W , RAYMOND KENNETH N , ABERGEL REBECCA J , SHUH DAVID K
IPC分类号： A61B5/055
CPC分类号： A61K31/444
摘要： The invention provides for a method for treating a subject in need of such treatment comprising administering a therapeutically effective amount of one or more pharmaceutical compositions comprising a 1,2-HOPO chelating agent and a 3,2-HOPO chelating agent to a subject in need of such treatment. The use of both 1,2-HOPO and a 3,2-HOPO chelating agents in combination is more effective than using only one chelating agent alone. The invention is especially useful when practiced on a subject that has been exposed to, have been in contact with, or contaminated by one or more known or unknown actinides and/or lanthanides, or a mixture thereof.
摘要翻译：本发明提供了治疗需要这种治疗的受试者的方法，包括给予需要的受试者治疗有效量的包含1,2-HOPO螯合剂和3,2-HOPO螯合剂的一种或多种药物组合物的这种治疗。组合使用1,2-HOPO和3,2-HOPO螯合剂比仅使用一种螯合剂更有效。当已经暴露于已经被一种或多种已知或未知的锕系元素和/或镧系元素或其混合物暴露于，已经接触或污染的对象上时，本发明是特别有用的。

7. 发明申请

WO2007121453A2 2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS 审中-公开
标题翻译： 2-羟基-1-氧代1,2二氢异喹啉螯合剂
公开(公告)号：WO2007121453A2
公开(公告)日：2007-10-25
申请号：PCT/US2007066814
申请日：2007-04-17
申请人： UNIV CALIFORNIA , RAYMOND KENNETH N , SEITZ MICHAEL
发明人： RAYMOND KENNETH N , SEITZ MICHAEL
IPC分类号： A61K31/472 , A61K49/10
CPC分类号： C07D217/24 , A61K49/0002 , A61K49/085 , A61K49/126 , A61K51/0478 , A61K51/065 , C07D217/26
摘要： The invention provides a new class of strongly chelating multidentate ligands based on a 2-hydroxy-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid scaffold (hereafter 1,2-HOIQO) in combination with polyamine backbones. The extremely stable bidentate 1,2- HOIQO moiety can be synthesized by standard synthetic methodology on a large scale. An advantageous feature is the possibility to introduce a wide range of substituents on the benzene ring by standard transformations (like electrophilic aromatic substitutions). This allows, for example, for the tuning of chemical, photophysical, and solubility properties, as well as the attachment of functional moieties, relevant for sensing and imaging applications (e.g. DNA, proteins, antibodies, fluorophores, etc.). The combination of the 1,2-HOIQO chelators with polyamine backbones provides very strongly binding ligands for a variety of metals including first-row transition metals, lanthanides, actinides, etc. Metal complexes of this kind are expected to be useful in a number of applications (e.g. luminescence, MRI, actinide sequestering, metal chelation therapy, metal radioisotope labeling, etc.).
摘要翻译：本发明提供了一类基于2-羟基-1-氧代-1,2-二氢异喹啉-3-羧酸支架（以下称为1,2-HOIQO）与多胺骨架组合的强螯合多齿配体。非常稳定的二齿1,2- HOIQO部分可以通过大规模的标准合成方法合成。有利的特征是可以通过标准转化（如亲电芳族取代）在苯环上引入宽范围的取代基。这允许例如调节与传感和成像应用（例如DNA，蛋白质，抗体，荧光团等）相关的化学，光物理和溶解性质以及功能部分的附着。 1,2-HOIQO螯合剂与多胺骨架的组合为各种金属（包括一列过渡金属，镧系元素，锕系元素等）提供了非常强的结合性配体。预计这种金属络合物可用于多种应用（例如发光，MRI，锕系隔离，金属螯合治疗，金属放射性同位素标记等）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式