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1. 发明申请

WO2006106513A3 NEW CORE AND CORE-SHELL NANOPARTICLES CONTAINING IODINE FOR X-RAY IMAGING 审中-公开
标题翻译：含有X射线成像的新核心和核壳纳米颗粒
公开(公告)号：WO2006106513A3
公开(公告)日：2007-02-15
申请号：PCT/IL2006000429
申请日：2006-04-04
申请人： UNIV BAR ILAN , MARGEL SHLOMO , GALPERIN ANNA
发明人： MARGEL SHLOMO , GALPERIN ANNA
IPC分类号： B32B15/082 , C08F20/22
CPC分类号： A61K49/0442 , A61K47/6933 , A61K49/049 , A61K49/1854 , B82Y5/00 , Y10S977/773 , Y10S977/928
摘要： Nanoparticles having an average particle size of less than 2000nm, wherein said nanoparticles comprise a polymer having pendant cleavable iodine substituted groups are provided. Processes for preparing the nanoparticles and their use as a contrast agent for X-ray imaging are also described.
摘要翻译：平均粒度小于2000nm的纳米颗粒，其中所述纳米颗粒包含具有可分离的碘取代基侧链的聚合物。还描述了制备纳米颗粒的方法及其作为X射线成像造影剂的用途。

2. 发明申请

WO2004045494A9 BIOLOGICAL GLUE BASED ON THROMBIN-CONJUGATED NANOPARTICLES 审中-公开
公开(公告)号：WO2004045494A9
公开(公告)日：2004-08-05
申请号：PCT/IL0300977
申请日：2003-11-18
申请人： UNIV BAR ILAN , MARGEL SHLOMO , SHEIHET LARISA , TENNENBAUM TAMAR
发明人： MARGEL SHLOMO , SHEIHET LARISA , TENNENBAUM TAMAR
IPC分类号： A61K9/14 , A61K47/48 , A61L24/10 , A61K
CPC分类号： A61L24/106 , A61K31/00 , A61K33/06 , A61K38/45 , A61K38/4833 , A61K45/06 , A61K47/643 , A61K47/6923 , A61K47/6929 , A61L2400/12 , B82Y5/00 , C07B2200/11 , C40B40/04 , A61K2300/00
摘要： Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated nanoparticles are suitable for use in the preparation of fibrin-based biological sealant.

3. 发明申请

WO2004045494A3 BIOLOGICAL GLUE BASED ON THROMBIN-CONJUGATED NANOPARTICLES 审中-公开
标题翻译：基于凝血因子共轭纳米粒子的生物胶体
公开(公告)号：WO2004045494A3
公开(公告)日：2004-09-16
申请号：PCT/IL0300977
申请日：2003-11-18
申请人： UNIV BAR ILAN , MARGEL SHLOMO , SHEIHET LARISA , TENNENBAUM TAMAR
发明人： MARGEL SHLOMO , SHEIHET LARISA , TENNENBAUM TAMAR
IPC分类号： A61K9/14 , A61K47/48 , A61L24/10 , A61K9/00
CPC分类号： A61L24/106 , A61K31/00 , A61K33/06 , A61K38/45 , A61K38/4833 , A61K45/06 , A61K47/643 , A61K47/6923 , A61K47/6929 , A61L2400/12 , B82Y5/00 , C07B2200/11 , C40B40/04 , A61K2300/00
摘要： Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated nanoparticles are suitable for use in the preparation of fibrin-based biological sealant.
摘要翻译：提供凝血酶 - 缀合的纳米颗粒，其中所述纳米颗粒包含一种或多种有机和/或无机化合物及其制备方法。凝血酶偶联的纳米颗粒适用于制备基于纤维蛋白的生物密封剂。

4. 发明申请

WO9802189A3 METHOD FOR PREPARING BIOACTIVE POLYMERS 审中-公开
标题翻译：制备生物聚合物的方法
公开(公告)号：WO9802189A3
公开(公告)日：1998-05-07
申请号：PCT/IL9700239
申请日：1997-07-14
申请人： UNIV BAR ILAN , MARGEL SHLOMO , BURDYGIN IRENE
发明人： MARGEL SHLOMO , BURDYGIN IRENE
IPC分类号： A61K47/48
CPC分类号： A61K47/61
摘要： A method to prepare a bioactive polymer by covalently binding at least one amino group containing ligand to at least one polymer containing a plurality of free hydroxyl groups, said method comprising the following steps: (i) reacting the at least one polymer with an appropriate activating agent; (ii) reacting the resultant activated polymer in aqueous solution with desired amino group containing ligands; (iii) blocking by reaction or removing by hydrolysis residual polymer bound-ligand unreacted, activating groups; and wherein the said activating agent and/or leaving by-products formed by step (i) and/or by step (ii) and/or by step (iii), are swelling agents of the support polymer.
摘要翻译：通过将至少一个含氨基的配体共价结合至至少一种含有多个游离羟基的聚合物来制备生物活性聚合物的方法，所述方法包括以下步骤：（i）使至少一种聚合物与合适的活化剂剂; （ii）使所得活化聚合物在水溶液中与所需含氨基的配体反应; （iii）通过反应或通过水解残余聚合物结合的配体未反应的活化基团进行封闭; 并且其中所述活化剂和/或离开由步骤（i）和/或通过步骤（ii）和/或通过步骤（iii）形成的副产物是载体聚合物的溶胀剂。

5. 发明申请

WO9611054A3 PROCESS FOR THE PREPARATION OF MICROSPHERES AND MIPROCESS FOR THE PREPARATION OF MICROSPHERES AND MICROSPHERES MADE THEREBY CROSPHERES MADE THEREBY 审中-公开
标题翻译：制备微球和制备微球和微球的方法及其制备方法
公开(公告)号：WO9611054A3
公开(公告)日：1996-05-23
申请号：PCT/US9512988
申请日：1995-10-05
申请人： UNIV BAR ILAN , LICHTENSTEIN JOSEPH , MARGEL SHLOMO , BAMNOLKER HANNA
发明人： MARGEL SHLOMO , BAMNOLKER HANNA
IPC分类号： A61K47/48 , B01J13/14 , G01N33/543 , G01N33/552 , B01J13/04 , A61K9/50 , A61K49/00
CPC分类号： G01N33/54346 , A61K47/6923 , A61K47/6929 , B01J13/14 , G01N33/5434 , G01N33/552 , G01N2446/10 , G01N2446/80 , G01N2446/86 , G01N2446/90
摘要： A process for the preparation of a microsphere comprising a coating composed of one or more silica nanoparticles layers, comprises the steps of: a) providing a microsphere of polymeric material, the said microsphere having adsorbed on its surface one or more surfactants; and b) causing a layer of silica nanoparticles to coat the surface of the said microsphere by means of seeded polymerization of alkyl silicates onto the surface of said microsphere.

6. 发明申请

WO2009040811A2 POLYMER NANOPARTICLES COATED BY MAGNETIC METAL OXIDE AND USES THEREOF 审中-公开
标题翻译：由金属氧化物涂覆的聚合物纳米粒子及其用途
公开(公告)号：WO2009040811A2
公开(公告)日：2009-04-02
申请号：PCT/IL2008001286
申请日：2008-09-24
申请人： UNIV BAR ILAN , FORD HENRY HOSPITAL , MARGEL SHLOMO , PERLSTEIN BENNY , BRODIE CHAYA
发明人： MARGEL SHLOMO , PERLSTEIN BENNY , BRODIE CHAYA
IPC分类号： A61K47/48 , A61K41/00 , A61K49/18
CPC分类号： A61K49/1878 , A61K41/0052 , A61K47/62 , A61K47/6921 , A61K47/6923 , A61K47/6935 , A61K49/1866 , B82Y5/00
摘要： The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer surface of the magnetic metal oxide. Pharmaceutical compositions comprising these nanoparticles may be used, inter alia, for detection and treatment of tumors and inflammations.
摘要翻译：本发明提供由聚合物组成的纳米颗粒，该聚合物是涂覆有磁性金属氧化物的金属螯合剂，其中至少一种活性剂与聚合物共价结合，所述纳米颗粒可任选地进一步包含至少一种活性剂，其物理上或共价结合磁性金属氧化物的外表面。包含这些纳米颗粒的药物组合物尤其可用于肿瘤和炎症的检测和治疗。

7. 发明申请

WO2011003902A3 MULTIMODAL VISIBLE POLYMER EMBOLIZATION MATERIAL 审中-公开
标题翻译：多模可见聚合物嵌段材料
公开(公告)号：WO2011003902A3
公开(公告)日：2011-03-03
申请号：PCT/EP2010059631
申请日：2010-07-06
申请人： BARTLING SOENKE , MARGEL SHLOMO , AVIV HAGIT
发明人： BARTLING SOENKE , MARGEL SHLOMO , AVIV HAGIT
IPC分类号： A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/12
CPC分类号： A61K49/0002 , A61B5/0035 , A61B5/0515 , A61B5/416 , A61B6/5235 , A61B6/5247 , A61B8/4281 , A61B8/4416 , A61K49/0419 , A61K49/0438 , A61K49/0442 , A61K49/048 , A61K49/1821 , A61K49/225 , A61K51/1244 , B82Y5/00
摘要： The present invention relates to embolization material for therapeutic use, wherein said material is visible via more than one imaging technique.
摘要翻译：本发明涉及用于治疗用途的栓塞材料，其中所述材料通过多于一种成像技术是可见的。

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