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1. 发明申请

WO1994004926A1 MONITORING METHOD 审中-公开
标题翻译：监测方法
公开(公告)号：WO1994004926A1
公开(公告)日：1994-03-03
申请号：PCT/EP1993002148
申请日：1993-08-10
申请人： UNILEVER PLC , UNILEVER NV , UNIPATH LIMITED , CATT, Michael , COLEY, John , DAVIS, Paul, James
发明人： UNILEVER PLC , UNILEVER NV , UNIPATH LIMITED
IPC分类号： G01N33/74
CPC分类号： G01N33/689 , A61B10/0012 , G01N33/743 , G01N33/76 , G01N2800/36
摘要： A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving testing of the body fluid concentration of an analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least part of the pre-ovulation phase of the current ovulation cycle of the individual subject, and identification from the results of such testing of an analyte concentration change indicative of imminent ovulation, relative to an analyte concentration reference value that has been adapted to the individual human subject on the basis of analyte concentration test data obtained from the individual human subject during one or more previous ovulation cycles. Preferably testing for said analyte concentration during the current ovulation cycle is commenced a plurality of days (preferably at least 5) following the onset of menses but at least 2 numerical days in advance of the earliest numerical day on which actual ovulation has occurred in one or more previous ovulation cycles in the same individual subject.
摘要翻译：一种监测个体人类女性受试者当前排卵周期状态的方法，包括在至少部分时间内测量相对于排卵周期状态（例如尿E3G）的有意义的分析物的体液浓度个体受试者的当前排卵周期的排卵前阶段，以及相对于已经适应于个体人受试者的分析物浓度参考值的来自对这种测试的分析物浓度变化的指示即将来临的排卵的结果的鉴定在一个或多个以前的排卵周期中从个体人受试者获得的分析物浓度测试数据的基础。优选地，在当前排卵周期期间对所述分析物浓度的测试在月经开始之后开始多天（优选至少5天），但是在实际排卵发生在一个或多个之前的最早数字日之前的至少2个数天在同一个体科目中更多的排卵周期。

2. 发明申请

WO1994004925A1 MONITORING METHOD 审中-公开
标题翻译：监测方法
公开(公告)号：WO1994004925A1
公开(公告)日：1994-03-03
申请号：PCT/EP1993002147
申请日：1993-08-10
申请人： UNIPATH LIMITED , UNILEVER PLC , UNILEVER NV , CATT, Michael , COLEY, John , DAVIS, Paul, James
发明人： UNIPATH LIMITED , UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/74
CPC分类号： A61B10/0012 , G01N33/743 , G01N33/76
摘要： A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving testing of the body fluid concentration of an analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least part of the pre-ovulation phase of the current ovulation cycle of the individual subject, and identification from the results of such testing of an analyte concentration change indicative of imminent ovulation, relative to an analyte concentration reference value that has been adapted to the individual human subject on the basis of analyte concentration test data obtained from the individual human subject during one or more previous ovulation cycles.
摘要翻译：一种监测个体人类女性受试者当前排卵周期状态的方法，包括在至少部分时间内测量相对于排卵周期状态（例如尿E3G）的有意义的分析物的体液浓度个体受试者的当前排卵周期的排卵前阶段，以及相对于已经适应于个体人受试者的分析物浓度参考值的来自对这种测试的分析物浓度变化的指示即将来临的排卵的结果的鉴定在一个或多个以前的排卵周期中从个体人受试者获得的分析物浓度测试数据的基础。

3. 发明申请

WO1994004924A1 MONITORING METHOD 审中-公开
标题翻译：监测方法
公开(公告)号：WO1994004924A1
公开(公告)日：1994-03-03
申请号：PCT/EP1993002146
申请日：1993-08-10
申请人： UNIPATH LIMITED , UNILEVER PLC , UNILEVER NV , CATT, Michael , COLEY, John , DAVIS, Paul, James
发明人： UNIPATH LIMITED , UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/74
CPC分类号： G01N33/689 , A61B10/0012 , G01N33/743 , G01N33/76 , G01N2800/36
摘要： A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving repeated testing of the body fluid concentration of at least one analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least the pre-ovulation phase of the current ovulation cycle of the individual subject, wherein testing for said analyte concentration during the current ovulation cycle is commenced a plurality of days (preferably at least 5) following the onset of menses but at least 2 numerical days in advance of the earlierst numerical day on which actual ovulation has occurred in one or more previous ovulation cycles in the same individual subject.
摘要翻译：监测个体人类女性受试者的当前排卵周期状况的方法，其涉及相对于排卵周期状态（例如尿E3G）期间至少一种有意义的分析物的体液浓度的重复测试至少是个体受试者当前排卵周期的排卵前阶段，其中在当前排卵周期内对所述分析物浓度的测试在月经开始后开始多天（优选至少5），但是至少2个数字天在相同个体受试者的一个或多个先前排卵周期中发生实际排卵的最早的数字日之前。

4. 发明申请

WO1994004928A1 ADVISORY METHOD 审中-公开
标题翻译：咨询方法
公开(公告)号：WO1994004928A1
公开(公告)日：1994-03-03
申请号：PCT/EP1993002144
申请日：1993-08-10
申请人： UNIPATH LIMITED , UNILEVER PLC , UNILEVER NV , COLEY, John , DAVIS, Paul, James , SENIOR, Stephanie, Jane
发明人： UNIPATH LIMITED , UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/76
CPC分类号： G01N33/76 , A61B10/0012
摘要： A method and test kit for providing contraceptive advice during the human ovulation cycle, involving simply the measurement of urinary lutenising hormone (LH) concentration on a daily basis during the early phase of the cycle until the LH surge indicative of ovulation is detected, together with calender means to advise the user to abstain from unprotected intercourse during a time interval commencing not later than a predetermined first day of LH testing and ending at least 2 days following the day of LH surge detection.
摘要翻译：一种在人类排卵周期中提供避孕建议的方法和检测试剂盒，仅涉及在循环早期阶段每天检测尿液中的尿素浓度（LH）浓度，直到检测到表示排卵的LH波动，连同压延机意味着在不迟于LH测试的预定的第一天并且在LH浪涌检测之后的至少2天结束的时间间隔内建议用户避免不受保护的性交。

5. 发明申请

WO1990009148A1 MONITORING METHOD 审中-公开
标题翻译：监测方法
公开(公告)号：WO1990009148A1
公开(公告)日：1990-08-23
申请号：PCT/GB1990000255
申请日：1990-02-16
申请人： UNILEVER PLC , UNILEVER NV , COLEY, John , DAVIS, Paul, James , PORTER, Philip
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： A61B10/00
CPC分类号： A61B10/0012 , A61B2010/0019
摘要： A method of monitoring the ovulation cycle of a female mammal, involving regular measurement of basal body temperature throughout the cycle and occasional measurement of the level of at least one urinary component of significance in the cycle, the measurement of the metabolite being conducted at predetermined stages in the cycle to check that the level is consistent with a predicted level and thus confirm that the cycle as a whole is consistent with a prediction.

6. 发明申请

WO1986001899A1 PROCESSES AND MATERIALS FOR CARRYING OUT SPECIFIC BINDING ASSAYS 审中-公开
标题翻译：执行特定绑定测试的过程和材料
公开(公告)号：WO1986001899A1
公开(公告)日：1986-03-27
申请号：PCT/GB1985000428
申请日：1985-09-16
申请人： UNILEVER PLC , UNILEVER NV , DAVIS, Paul, James , BOSLEY, John, Anthony
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/53
CPC分类号： G01N33/581 , G01N33/53 , G01N33/54306 , G01N33/582 , G01N33/583
摘要： A process for carrying out a label-linked specific binding assay, e.g. an immunoassay, comprising the steps of: providing in an aqueous reaction zone a member of a specific binding pair to participate in the assay, linked to a label which either is a first coreagent which is reactive with a second coreagent in a reaction to produce a detectable assay result, or is a generator of said coreagent; providing a dispersed quantity of said second coreagent in said reaction, or of a generator of said coreagent, within a discretely bounded zone adjacent to said aqueous reaction zone and formed by a zone-forming carrier material, which also carries in immobilised form a member of said specific binding pair; providing in said aqueous reaction zone a consumer of one of said coreagents in said reaction, thereby to ensure the substantial absence of said coreagent in said aqueous reaction zone; wherein said discretely bounded zone comprises a barrier sufficient to prevent entry of the consumer reagent from said aqueous reaction zone into the bounded zone, thereby to separate the consumer reagent from the dispersed quantity of second coreagent or generator thereof in the bounded zone; and allowing the specific binding reactions to take place whereby the assay reaction results in the binding of a variable quantity, dependent on the quantity of labelled member of said specific binding pair directly or indirectly to said immobilised specific binding material, so that said detectable assay result is produced by reaction of bound label or said coreagent generated by said bound label with said coreagent in said bounded zone.

7. 发明申请

WO1985000752A1 IMMUNOGENIC COMPOSITION COMPRISING LIVE ENCYSTED PROTOZOA 审中-公开
标题翻译：包含活体重编织物的免疫组合物
公开(公告)号：WO1985000752A1
公开(公告)日：1985-02-28
申请号：PCT/GB1984000268
申请日：1984-08-03
申请人： UNILEVER PLC , UNILEVER NV , DAVIS, Paul, James , HARRIS, Peter
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： A61K47/00
CPC分类号： A61K39/012 , A61K9/1652
摘要： An oral vaccine against parasitic protozoa, such as coccidia, comprises live encysted protozoa embedded in a firm gel matrix from which the protozoa are released following ingestion by a host. The gel matrix helps to maintain the essential viability of the protozoa without seriously hindering the natural mechanism by which they infect their host. Preferably the gel matrix is based on alginate. Alginate beadlets containing viable sporulated coccidia oocysts, for administration to poultry, are a preferred feature.

8. 发明申请

WO1991008482A1 ANTIBODY VARIABLE DOMAIN CONJUGATES 审中-公开
标题翻译：抗体可变域结合
公开(公告)号：WO1991008482A1
公开(公告)日：1991-06-13
申请号：PCT/GB1990001839
申请日：1990-11-27
申请人： UNILEVER PLC , UNILEVER NV , DAVIS, Paul, James , VERHOEYEN, Martine, Elisa , DE WINTER, Ronald, Franks, Jacabus
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/53
CPC分类号： C12N9/0065 , C07K16/00 , C07K16/40 , C07K16/44 , C07K2319/00 , C12N9/16 , C12N15/62 , G01N33/532 , G01N33/54353 , G01N33/6857
摘要： Small specific binding molecules, such as single variable domain antibodies (Dabs) and Fv fragments, can be coupled to solid plastics surfaces or to tracers such as enzymes by means of linkers comprising polypeptides containing from 5 to 20 amino acids and which are hydrophobic and/or contain at least one lysine residue. The coupling can be achieved without significant loss of specific binding activity. The combined Dab/linker or Fv/linker can be prepared by expression in genetically-modified organisms.
摘要翻译：小的特异性结合分子，例如单可变结构域抗体（Dabs）和Fv片段可以通过包含5至20个氨基酸的多肽的接头偶联到固体塑料表面或示踪剂如酶，并且它们是疏水和/ 或含有至少一个赖氨酸残基。可以实现偶联，而不会明显损失特异性结合活性。组合的Dab /接头或Fv /接头可以通过在遗传修饰的生物中表达来制备。

9. 发明申请

WO1990009592A1 SOLID-PHASE ANALYTICAL DEVICE 审中-公开
标题翻译：固相分析装置
公开(公告)号：WO1990009592A1
公开(公告)日：1990-08-23
申请号：PCT/GB1990000254
申请日：1990-02-16
申请人： UNILEVER PLC , UNILEVER NV , DAVIS, Paul, James , PRIOR, Michael, Evans , MAY, Keith
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N33/76
摘要： An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is freely mobile in the porous carrier when in the moist state, and an unlabelled specific binding reagent which is permanently immobilised in a detection zone on the carrier material, the labelled and unlabelled specific binding reagents being capable of participating in either a sandwich reaction or a competition reaction in the presente of the analyte, in which prior to the application to the device of a liquid sample suspected of containing the analyte, the labelled specific binding reagent is retained in the dry state in a macroporous body, e.g. of plastics material having a pore size of 10 microns or greater, through which the applied liquid sample must pass en route to the porous carrier material, the labelled specific binding reagent being freely soluble or dispersible in any liquid sample which enters the macroporous body.

10. 发明申请

WO1988001744A1 ASSAYS 审中-公开
公开(公告)号：WO1988001744A1
公开(公告)日：1988-03-10
申请号：PCT/GB1987000603
申请日：1987-08-27
申请人： UNILEVER PLC , UNILEVER NV , DAVIS, Paul, James , DRAKE, Rosemary, Ann, Lucy , HORNBY, William, Edward
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , G01N33/54366
摘要： An immunoassay for determining qualitatively or quantitatively the presence of an analyte in a sample by means of specific binding, wherein the sample is contacted with a moveable solid phase carrier material, e.g. particles (21) on which is immobilised a first binding reagent having specificity for the analyte and with a labelled reagent which can participate in either a ''sandwich'' or a ''competition'' reaction with the first reagent in the presence of the analyte and, following an incubation period sufficient to allow the reaction to take place, the carrier material is moved within the assay medium (20) to a location adjacent a signal sensing means (19), in the immediate vicinity of which a signal influencing agent, e.g. a substrate, is released into the assay medium and cooperates with the label in the generation of a signal, such as chemiluminescent light, the magnitude of the signal generated in the vicinity of the sensing means being used as a measure of the extent to which the binding reaction has occurred. Preferably the assay medium incorporates a masking or quenching agent which suppresses any signal generated in regions of the assay medium remote from the signal sensing means.

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