专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO02068592A3 NON-RACEMIC HEXAFLUORELEUCINE, AND METHODS OF MAKING AND USING IT 审中-公开
标题翻译：非特异性十六烷基醚，以及制备和使用它的方法
公开(公告)号：WO02068592A3
公开(公告)日：2003-02-27
申请号：PCT/US0205386
申请日：2002-02-25
申请人： TUFTS COLLEGE , FICHERA ALFIO , BILGICER ZIHNI B , KUMAR KRISHNA , XING XUECHAO
发明人： FICHERA ALFIO , BILGICER ZIHNI B , KUMAR KRISHNA , XING XUECHAO
IPC分类号： C07C211/00 , C07C237/20 , C07C271/22 , C07C327/30 , C07K5/06 , C07C53/15 , C07C53/124 , C07C53/126 , C07C53/16 , C07C69/003 , C07C69/02 , C07C69/22 , C07C69/63 , C07C229/02 , C07C229/04 , C07C229/06
CPC分类号： C07C229/20 , C07C211/00 , C07C233/47 , C07C271/16 , C07C271/22 , C07K5/06191
摘要： One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluorleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbonfluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.
摘要翻译：本发明的一个方面涉及六氟亮氨酸及其同源物，以及制备该化合物的方法。该方案的另一方面涉及包含六氟亮氨酸及其同源物的蛋白质核心的合成。使用比较生物物理学研究表征了包含六氟亮氨酸及其同系物的某些肽。通常，氟化肽显示更高的热稳定性和增强的抗化学变性。此外，混合的碳氢化合物碳芯自行分类成均匀的束，表明设计和操纵蛋白质 - 蛋白质界面的新途径。

2. 发明申请

WO2007084527A3 PROTEINS CONTAINING A FLUORINATED AMINO ACID, AND METHODS OF USING SAME 审中-公开
标题翻译：含有氟化氨基酸的蛋白质及其使用方法
公开(公告)号：WO2007084527A3
公开(公告)日：2007-11-29
申请号：PCT/US2007001184
申请日：2007-01-17
申请人： TUFTS COLLEGE , KUMAR KRISHNA , MENG HE
发明人： KUMAR KRISHNA , MENG HE
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00
CPC分类号： C12P21/02
摘要： One aspect of the invention relates to a polypeptide comprising at least one fluorinated amino acid. Another aspect of the invention relates to a method for modifying a first polypeptide, comprising replacing at least one amino acid in said first polypeptide with a fluorinated amino acid, thereby producing a second polypeptide with increased stability relative to said first polypeptide.
摘要翻译：本发明的一个方面涉及包含至少一种氟化氨基酸的多肽。本发明的另一方面涉及用于修饰第一多肽的方法，包括用氟化氨基酸替换所述第一多肽中的至少一个氨基酸，由此产生相对于所述第一多肽具有增加的稳定性的第二多肽。

3. 发明申请

WO2007084527A8 PROTEINS CONTAINING A FLUORINATED AMINO ACID, AND METHODS OF USING SAME 审中-公开
标题翻译：含有氟化氨基酸的蛋白质及其使用方法
公开(公告)号：WO2007084527A8
公开(公告)日：2011-11-24
申请号：PCT/US2007001184
申请日：2007-01-17
申请人： TUFTS COLLEGE , KUMAR KRISHNA , MENG HE
发明人： KUMAR KRISHNA , MENG HE
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00
CPC分类号： C12P21/02
摘要： One aspect of the invention relates to a polypeptide comprising at least one fluorinated amino acid. Another aspect of the invention relates to a method for modifying a first polypeptide, comprising replacing at least one amino acid in said first polypeptide with a fluorinated amino acid, thereby producing a second polypeptide with increased stability relative to said first polypeptide.
摘要翻译：本发明的一个方面涉及包含至少一种氟化氨基酸的多肽。本发明的另一方面涉及一种修饰第一多肽的方法，包括用氟化氨基酸替代所述第一多肽中的至少一个氨基酸，从而产生相对于所述第一多肽具有增加的稳定性的第二多肽。

4. 发明申请

WO2007106886A3 FLUORINATED CARBOHYDRATES AND THEIR USE IN TUMOR VISUALIZATION, TISSUE ENGINEERING, AND CANCER CHEMOTHERAPY 审中-公开
标题翻译：氟化碳水化合物及其在肿瘤可视化，组织工程和癌症化疗中的应用
公开(公告)号：WO2007106886A3
公开(公告)日：2008-02-21
申请号：PCT/US2007064060
申请日：2007-03-15
申请人： TUFTS COLLEGE , KUMAR KRISHNA , D ALARCAO MARC , DAFIK LAILA
发明人： KUMAR KRISHNA , D ALARCAO MARC , DAFIK LAILA
IPC分类号： A61K31/7008
CPC分类号： C07H7/00 , C07H13/04 , C07H13/06
摘要： The present invention relates to fluorine-containing monosaccharides that are useful for forming extracellular fluorinated glycoconjugates. Methods of forming extracellular fluorinated glycoconjugates comprise the steps of contacting a cell with a fiuorine- containing monosaccharide, and incubating the cell under conditions whereby the cell internalizes the fluorine-containing monosaccharide, or a derivative thereof, on the surface of the cell. The present invention also relates to the use of a fluorine-containing monosaccharide in cellular imaging using fluorine NMR. The invention additionally relates to the use of fluorine containing monosaccharides in the treatment of cancer and inflammatory disease.
摘要翻译：本发明涉及可用于形成细胞外氟化糖缀合物的含氟单糖。形成细胞外氟化糖缀合物的方法包括以下步骤：使细胞与含有富含氟的单糖接触，并在细胞内将细胞内含有含氟单糖或其衍生物的细胞孵育。本发明还涉及含氟单糖在使用氟NMR的细胞成像中的用途。本发明还涉及含氟单糖在治疗癌症和炎性疾病中的用途。

5. 发明申请

WO2005118527A3 FLUOROUS CAPPING REAGENTS, AND METHODS FOR PEPTIDE PURIFICATION 审中-公开
标题翻译：荧光吸附试剂，以及用于肽纯化的方法
公开(公告)号：WO2005118527A3
公开(公告)日：2007-01-25
申请号：PCT/US2005017507
申请日：2005-05-18
申请人： TUFTS COLLEGE , KUMAR KRISHNA , MONTANARI VITTORIO
发明人： KUMAR KRISHNA , MONTANARI VITTORIO
IPC分类号： A61K38/00 , C07C17/00 , C07C229/36 , C07C309/03 , C07C311/48 , C07C331/00 , C07D211/92 , C07D275/02 , C07K1/04 , C07K1/10 , C07K5/072 , C07K5/107 , C07K7/06 , C07K7/08 , C07K16/00
CPC分类号： C07K7/06 , C07C229/36 , C07C311/48 , C07K1/04 , C07K1/10 , C07K5/06113 , C07K5/1016 , C07K7/08
摘要： Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a trivalent iodonium fluorocarbon. The trivalent iodonium fluorocarbon compound of the invention is useful for attaching a fluorocarbon group to a compound that has a nucleophilic functional group. Another aspect of the present invention relates to a method of preparing a trivalent iodonium fluorocarbon. Another aspect of the present invention relates to a method of preparing a fluorocarbon by treating a compound bearing a nucleophilic functional group with a trivalent iodonium fluorocarbon compound. Another aspect of the present invention relates to a method of purifying a mixture comprising a first and a second compound by treating the mixture with a trivalent iodonium fluorocarbon to attach a fluorocarbon group to the second compound leaving the first compound unchanged, and purifying the mixture by fluorous-phase purification.
摘要翻译：本发明的方面涉及制备碳氟化合物的化合物，制备碳氟化合物的方法，以及化合物的混合物的纯化方法。本发明的一个方面涉及三价碘代氟碳化合物。本发明的三价碘氟碳化合物可用于将氟碳基团连接到具有亲核官能团的化合物上。本发明的另一方面涉及制备三价碘代氟碳化合物的方法。本发明的另一方面涉及通过用三价碘氟碳化合物处理带有亲核官能团的化合物来制备碳氟化合物的方法。本发明的另一方面涉及一种通过用三价碘代氟碳处理混合物来纯化含有第一和第二化合物的混合物的方法，以将碳氟化合物基团连接到第二化合物上，使第一化合物保持不变，并通过氟相纯化。

6. 发明申请

WO2014168721A2 METHODS AND SYSTEMS FOR DESIGNING AND/OR CHARACTERIZING SOLUBLE LIPIDATED LIGAND AGENTS 审中-公开
标题翻译：用于设计和/或表征可溶性脂肪配体剂的方法和系统
公开(公告)号：WO2014168721A2
公开(公告)日：2014-10-16
申请号：PCT/US2014026662
申请日：2014-03-13
申请人： TUFTS MEDICAL CT , TUFTS COLLEGE
发明人： COHEN CHARLES , KUMAR KRISHNA , DOYLE JAMIE RAUDENSKY , KOPIN ALAN S
IPC分类号： C12Q1/34
CPC分类号： C07K14/4703 , A61K38/00 , A61K47/543 , C07K7/06 , C07K7/08 , G01N33/5023 , G01N33/92 , G01N2405/00 , G01N2440/10
摘要： Among other things, the present invention provides modular systems for designing, characterizing, and/or manufacturing soluble lipidated ligand agents. In general, such soluble lipidated active agents include a ligand entity, a lipid entity, and, in some embodiments, an optional linker component. In some aspects, the present invention defines relevant structural and/or functional parameters of each of these components and/or of their linkage to one another, thereby enabling appropriate selection of components to assemble active agents for any given target of interest. In some embodiments, the invention defines and/or provides sets of such components that include appropriate reactive moieties for linking components to one another, for example using simple and/or robust chemistries, so that selected components are readily linked to one another in the production of agents as described.
摘要翻译：除其他之外，本发明提供了用于设计，表征和/或制造可溶性脂化配体试剂的模块化系统。通常，这种可溶性脂质化活性剂包括配体实体，脂质实体，在一些实施方案中，包括任选的接头组分。在一些方面，本发明定义了这些组分中的每一种的相关结构和/或功能参数和/或它们彼此连接的相关结构和/或功能参数，从而能够适当选择组分以组合用于任何给定感兴趣靶标的活性剂。在一些实施方案中，本发明定义和/或提供这样的组分的集合，其包括用于将组分彼此连接的合适的反应性部分，例如使用简单和/或稳定的化学物质，使得所选择的组分在生产中容易地彼此连接的药剂。

7. 发明申请

WO0135820A9 TISSUE INTERFACE DEVICE 审中-公开
标题翻译：组装界面装置
公开(公告)号：WO0135820A9
公开(公告)日：2002-05-16
申请号：PCT/US0031765
申请日：2000-11-17
申请人： SPECTRX INC , ALTEA TECH INC , FAUPEL MARK L , KUMAR KRISHNA , FARQUHAR DAVID , VREEKE MARK , SMITH ALAN , HATCH MICHAEL , WOODS TERESA
发明人： FAUPEL MARK L , KUMAR KRISHNA , FARQUHAR DAVID , VREEKE MARK , SMITH ALAN , HATCH MICHAEL , WOODS TERESA
IPC分类号： G01N33/487 , A61B5/00 , G01N33/48
CPC分类号： A61B5/1486
摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.
摘要翻译：适于定位在生物体的生物膜中的一个或多个人造开口上或周围的组织界面装置（10），并用于耦合到监测和控制单元和真空源。组织接口装置（10）包括壳体（100），传感器通道（130）和传感器（150）。壳体（100）限定孔口（120），孔口（120）在壳体（100）的底端（102）上具有开放的入口端口（122）和远端（124），该远端端部与传感器通道（130）连接。孔口（120）与从生物膜中形成的人造开口流动的流体流体连通。传感器通道（130）用于耦合到真空源并与之流体连通。传感器（150）在流体的流动路径中位于传感器通道（130）中，用于感测流体从人造开口流出时的特性。传感器产生代表其的传感器信号。

8. 发明申请

WO02058994A9 VACUUM DEVICE FOR SUBSTANCE EXTRACTION 审中-公开
标题翻译：用于物质萃取的真空装置
公开(公告)号：WO02058994A9
公开(公告)日：2004-01-08
申请号：PCT/US0202233
申请日：2002-01-24
申请人： SPECTRX INC , LINCOLN DANNY F , KUMAR KRISHNA , SAMUELS MARKS A
发明人： LINCOLN DANNY F , KUMAR KRISHNA , SAMUELS MARKS A
IPC分类号： F04B17/00 , F04B43/00 , F04B43/04 , F04B45/047 , B65B1/04
CPC分类号： F04B45/047 , F04B17/00 , F04B43/0009 , F04B43/043
摘要： A vacuum device and method for extraction of a substance from a fluid source the vacuum device including an upper member (20) that may be selectively, and operably, connected to a lower membrane. The upper member (20) defines a bottom opening (24) and has a vacuum pump (40) in fluid communication with the bottom opening (24). The vacuum pump (40) is selectively coupled to an energy source. The lower member defines an inner cavity, a first opening, and a second opening. An elastic membrane defining an interior cavity is disposed in the inner cavity and is coupled to the first opening of the lower member.
摘要翻译：一种用于从流体源提取物质的真空装置和方法，所述真空装置包括可以选择性地且可操作地连接到下膜的上部构件（20）。上部构件（20）限定底部开口（24）并且具有与底部开口（24）流体连通的真空泵（40）。真空泵（40）选择性地耦合到能量源。下部构件限定内腔，第一开口和第二开口。限定内腔的弹性膜设置在内腔中并且联接到下构件的第一开口。

9. 发明申请

WO2009042972A9 FLUORINATED LIPIDS AND METHODS OF USE 审中-公开
标题翻译：氟化脂肪和使用方法
公开(公告)号：WO2009042972A9
公开(公告)日：2011-02-03
申请号：PCT/US2008078030
申请日：2008-09-26
申请人： UNIV TUFTS , KALSANI VENKATESHWARLU , DAFIK LAILA , KUMAR KRISHNA , KRISHNAJI SUBRAHMANIAN TARAKKAD
发明人： KALSANI VENKATESHWARLU , DAFIK LAILA , KUMAR KRISHNA , KRISHNAJI SUBRAHMANIAN TARAKKAD
IPC分类号： A01N31/14 , A61K31/02
CPC分类号： C07F9/6561 , C07F9/1411 , C07F9/65324
摘要： The invention provides methods and compounds for delivering agents to cells. The compounds can include a fluorinated lipid, a linker, and an agent for delivery to a cell.
摘要翻译：本发明提供了将药剂递送至细胞的方法和化合物。化合物可以包括氟化脂质，接头和用于递送至细胞的试剂。

10. 发明申请

WO2005079149A3 METHOD AND APPARATUS TO TERMINATE DIAL-UP CONNECTIONS ON MOBILE DEVICES 审中-公开
标题翻译：终止移动设备上的拨号连接的方法和装置
公开(公告)号：WO2005079149A3
公开(公告)日：2006-08-24
申请号：PCT/IB2005000065
申请日：2005-01-13
申请人： NOKIA CORP , NOKIA INC , JAIN KULDEEP , YANG JIANHAO MICHAEL , KUMAR KRISHNA
发明人： JAIN KULDEEP , YANG JIANHAO MICHAEL , KUMAR KRISHNA
IPC分类号： G06F15/16 , H04L12/56 , H04L29/06 , H04L29/08
CPC分类号： H04L67/34 , H04L69/16 , H04L69/168 , H04W80/04 , H04W88/04 , H04W88/06
摘要： Disclosed is a method and apparatus to provide an IP connection between a mobile station (MS 10) and a computing device (CD 12). The method includes initiating the set up of the IP connection with a command sent from the CD to the MS over a local interface (13) and, in response to receiving over the local interface an IP message at the MS from the CD, routing the received IP message to an application that is resident in the MS. 2. In a presently preferred first embodiment the command is an AT command, more specifically an AT+CRM command having a value of five. In a presently preferred second embodiment the command places the MS into an auto-answer mode, and is an ATSO=1 command.
摘要翻译：公开了一种在移动站（MS 10）和计算设备（CD 12）之间提供IP连接的方法和装置。该方法包括通过本地接口（13）从CD发送到MS的命令来启动IP连接的建立，并且响应于通过本地接口接收来自CD的MS处的IP消息，将路由收到IP消息给驻留在MS中的应用程序。在目前优选的第一实施例中，命令是AT命令，更具体地说是具有值为5的AT + CRM命令。在目前优选的第二实施例中，命令将MS置于自动应答模式，并且是ATSO = 1命令。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式