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1. 发明申请

WO2014130960A1 METHODS AND APPARATUSES FOR NETWORKING NEUROMODULATION OF A GROUP OF INDIVIDUALS 审中-公开
标题翻译：一组个人网络神经网络的方法和装置
公开(公告)号：WO2014130960A1
公开(公告)日：2014-08-28
申请号：PCT/US2014/018061
申请日：2014-02-24
申请人： THYNC, INC.
发明人： WETMORE, Daniel, Z. , GOLDWASSER, Isy , CHARLESWORTH, Jonathan , PAL, Sumon, K. , TYLER, William, J. , SATO, Tomokazu
IPC分类号： H04L29/12 , A61N1/00
CPC分类号： A61N1/36014 , A61B5/0006 , A61B5/4058 , A61N1/36025 , A61N7/00 , A61N2007/0026 , A61N2007/0078 , H04L61/2015 , H04L61/6022
摘要： Networkable transcranial neuromodulation apparatuses adapted for safely and effectively applying neuromodulation, including apparatuses adapted for coordination with a group of other individuals, as well as methods for securely and effectively applying neuromodulation, including coordinated neuromodulation.
摘要翻译：适用于安全有效地应用神经调节的可网络经颅神经调节装置，包括适于与一组其他个体协调的装置，以及安全有效地应用神经调节的方法，包括协调的神经调节。

2. 发明申请

WO2014082064A1 WEARABLE TRANSDERMAL ELECTRICAL STIMULATION DEVICES AND METHODS OF USING THEM 审中-公开
标题翻译：可穿透式电刺激装置及其使用方法
公开(公告)号：WO2014082064A1
公开(公告)日：2014-05-30
申请号：PCT/US2013/071916
申请日：2013-11-26
申请人： THYNC, INC.
发明人： GOLDWASSER, Isy , TYLER, William, J. , OPITZ, Alexander , SATO, Tomokazu , CHARLESWORTH, Jonathan , PAL, Sumon, K. , LAMB, Philip , VOSS, Christopher , COOK, Steven , DEMERS, Remi , GRADWOHL, Raymond, L. , WETMORE, Daniel, Z.
IPC分类号： A61N1/36 , A61N1/04
CPC分类号： A61N1/36082 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/36014 , A61N1/36025
摘要： Described herein are devices, systems, and methods for transdermal electrical stimulation. Devices described herein can include self-contained, lightweight, and wearable components. The devices include a primary unit including a first transdermal electrode and a secondary unit including a second transdermal electrode. The device can be capable of wireless communication. The primary unit and secondary unit are placed at two locations on the skin of a user, for example on the head or neck of a user. The first and second transdermal electrodes are electrically connected. Electrical stimulation is driven between the two electrodes. The electrical stimulation induces a cognitive effect in a user of the device.
摘要翻译：本文描述了用于透皮电刺激的装置，系统和方法。本文描述的装置可以包括独立的，轻质的和可穿戴的部件。所述装置包括主要单元，其包括第一透皮电极和包括第二透皮电极的次级单元。该设备能够进行无线通信。主要单元和次要单元被放置在用户的皮肤上的两个位置，例如在用户的头部或颈部上。第一和第二透皮电极电连接。在两个电极之间驱动电刺激。电刺激在设备的用户中引起认知效果。

3. 发明申请

WO2015183620A2 WEARABLE TRANSDERMAL NEUROSTIMULATORS 审中-公开
标题翻译：耐磨的超声神经细胞
公开(公告)号：WO2015183620A2
公开(公告)日：2015-12-03
申请号：PCT/US2015/031424
申请日：2015-05-18
申请人： THYNC, INC.
发明人： GOLDWASSER, Isy , DEMERS, Remi , HAMLIN, Jay , LAW, Wing , PAL, Sumon, K. , CHARLESWORTH, Jonathan , WETMORE, Daniel, Z. , TYLER, William, J. , JEFFERY, Douglas
IPC分类号： A61N1/36
CPC分类号： A61N1/0456 , A61N1/0492 , A61N1/36025
摘要： Lightweight and wearable neurostimulators for applying transdermal electrical stimulation and methods of using them for inducing a cognitive effect. These apparatuses are lightweight and wearable and configured to be worn on a subject's temple and securely and comfortably fit a variety of head sizes in conjunction with an electrode assembly. These neurostimulator apparatuses may include hardware, software and/or firmware components that are configured to safely and effectively apply high current intensity (e.g., using a high voltage source). These apparatuses may also be configured to uniquely identify which electrodes (if any) are coupled to the neurostimulator, and to deliver complex (e.g., ensemble) waveforms that may include a capacitive discharge component to enhance user comfort.
摘要翻译：用于施用透皮电刺激的轻量和耐磨神经刺激剂以及使用它们诱导认知作用的方法。这些装置是重量轻且可穿戴的，并被配置为佩戴在被摄体的神庙上，并与电极组件一起牢固且舒适地适应各种头部大小。这些神经刺激器装置可以包括被配置为安全且有效地施加高电流强度（例如，使用高电压源）的硬件，软件和/或固件组件。这些装置还可以被配置为唯一地识别哪些电极（如果有的话）耦合到神经刺激器，并且传送可以包括电容放电部件的复杂（例如，整体）波形以增强用户舒适度。

4. 发明申请

WO2014176483A1 FOCUSED TRANSCRANIAL ULTRASOUND SYSTEMS AND METHODS FOR USING THEM 审中-公开
标题翻译：聚焦超声超声系统及其使用方法
公开(公告)号：WO2014176483A1
公开(公告)日：2014-10-30
申请号：PCT/US2014/035413
申请日：2014-04-25
申请人： THYNC, INC.
发明人： TYLER, William, J. , SATO, Tomokazu , OPITZ, Alexander
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61N7/02 , A61N2007/0021 , A61N2007/0026 , A61N2007/003 , A61N2007/006 , A61N2007/0065
摘要： Apparatus and methods for focusing transcranial ultrasound. The systems described herein are advantageous for noninvasive neuromodulation and other transcranial ultrasound applications such as high intensity focused ultrasound (HIFU). In particular, described herein are compound acoustic lens apparatus having a short focal length for use with a transcranial ultrasound system, systems including methods of using them. These compound lens assemblies allow transcranial stimulation of even superficial cortical regions of the brain for ultrasound neuromodulation with a compact, single transducer element system at low (e.g., 0.2 to 1 MHz) frequencies with relatively large diameter (e.g., >15 mm) transducers applying 1 to 10 watts/cm2 of acoustic energy (spatial-peak, temporal-average intensity at the target brain region), and short focal length (e.g., between 15 and 35 mm).
摘要翻译：用于聚焦经颅超声的装置和方法。本文描述的系统对于非侵入性神经调节和其它经颅超声应用如高强度聚焦超声（HIFU）是有利的。特别地，这里描述了具有与经颅超声系统一起使用的短焦距的复合声透镜装置，包括使用它们的方法的系统。这些复合透镜组件允许通过紧凑的单个换能器元件系统在低（例如，0.2至1MHz）的频率下使用相对大的直径（例如> 15mm）的换能器来进行超声神经调节的甚至脑表皮质区域的经颅刺激用于超声神经调节 1至10瓦特/平方厘米的声能（空间峰值，目标脑区域的时间平均强度）和短焦距（例如，15至35毫米）。

5. 发明申请

WO2014210595A1 TRANSDERMAL ELECTRICAL STIMULATION DEVICES AND METHODS FOR MODIFYING OR INDUCING COGNITIVE STATE 审中-公开
标题翻译：超声电刺激装置及其修改或诱导认知状态的方法
公开(公告)号：WO2014210595A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/044870
申请日：2014-06-30
申请人： THYNC, INC.
发明人： PAL, Sumon, K. , CHARLESWORTH, Jonathan , DEMERS, Remi , WETMORE, Daniel, Z. , GOLDWASSER, Isy , TYLER, William, J. , GRADWOHL, Raymond, L. , LAMB, Philip , VOSS, Christopher
IPC分类号： A61N1/36
CPC分类号： A61N1/36025 , A61N1/0456 , A61N1/0476 , A61N1/0484 , A61N1/0492 , A61N1/36014
摘要： Portable transdermal electrical stimulation (TES) applicators for modifying a subject's cognitive state. In general, the portable applicators described are specifically configured and adapted to be lightweight and may be wearable, and to deliver a high-intensity TES able to evoke or enhance a predetermined cognitive effect. These TES applicators may include a pair of electrodes and a TES control module comprising a processor, a timer and a waveform generator. TES control module is adapted to deliver a biphasic electrical stimulation signal of 10 seconds or longer between the first and second electrodes having a frequency of 400 Hz or greater, a duty cycle of greater than 10 percent, an intensity of 3 mA or greater, with a DC offset.
摘要翻译：用于修改受试者认知状态的便携式透皮电刺激（TES）施用器。通常，所描述的便携式施用器被特别地配置并适于轻量化并且可以是可穿戴的，并且提供能够引起或增强预定认知效果的高强度TES。这些TES施加器可以包括一对电极和包括处理器，定时器和波形发生器的TES控制模块。 TES控制模块适用于在具有400Hz或更大频率的第一和第二电极之间传递10秒或更长的双相电刺激信号，占空比大于10％，强度为3mA或更大，与 DC偏移。

6. 发明申请

WO2014127091A1 TRANSCRANIAL ULTRASOUND SYSTEMS 审中-公开
标题翻译：超声超声系统
公开(公告)号：WO2014127091A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/016178
申请日：2014-02-13
申请人： THYNC, INC.
发明人： TYLER, William, J. , SATO, Tomokazu , WETMORE, Daniel, Z. , GOLDWASSER, Isy , CHARLESWORTH, Jonathan , PAL, Sumon, K. , COOK, Steven
IPC分类号： A61B8/06
CPC分类号： A61N7/02 , A61B8/4236 , A61B8/4254 , A61B8/429 , A61B8/4416 , A61B8/4427 , A61B8/4455 , A61B8/4472 , A61B2017/00044 , A61B2017/00734 , A61B2090/065 , A61N2007/003 , A61N2007/0078
摘要： Apparatuses for transcranial ultrasound neuromodulation. Described herein are apparatuses for transcranial ultrasound neuromodulation that are self-contained, self-powered, self-adhering, and self-coupling and referred to as transcranial ultrasound neuromodulation pucks, which may be disposable and semi-disposable. These apparatuses may include one or more controls to confirm their position on the subject's head, e.g., using acoustic impedance. These transcranial ultrasound neuromodulation devices may be wireless controlled, and may be configured specifically to conform to the subject's head. The transcranial ultrasound neuromodulation systems described herein are advantageous for achieving neuromodulation to affect learning and memory, attention, creativity, decision-making, and other cognitive states.
摘要翻译：经颅超声神经调节装置。本文描述的是经颅超声神经调节的装置，其是独立的，自动的，自粘的和自联结的，并且被称为经颅超声神经调节球，其可以是一次性的和半一次性的。这些装置可以包括一个或多个控制以确认其在被检者的头上的位置，例如使用声阻抗。这些经颅超声神经调节装置可以是无线控制的，并且可以被特别地配置成符合受检者的头部。本文描述的经颅超声神经调节系统有利于实现神经调节以影响学习和记忆，注意力，创造力，决策和其他认知状态。

7. 发明申请

WO2016111974A1 SYSTEMS AND METHODS FOR TRANSDERMAL ELECTRICAL STIMULATION TO IMPROVE SLEEP 审中-公开
标题翻译：用于超声电刺激以改善睡眠的系统和方法
公开(公告)号：WO2016111974A1
公开(公告)日：2016-07-14
申请号：PCT/US2016/012128
申请日：2016-01-05
申请人： THYNC, INC.
发明人： TYLER, William, J. , BOASSO, Alyssa, M. , MORTIMORE, Hailey, M. , SILVA, Rhonda, S. , PAL, Sumon, K. , CHARLESWORTH, Jonathan
IPC分类号： A61M21/02
CPC分类号： A61M21/02 , A61M16/0688 , A61M2021/0072 , A61M2230/06 , A61M2230/10 , A61M2230/42 , A61M2230/60 , A61M2230/65 , A61N1/0456 , A61N1/0492 , A61N1/36025 , A61M2230/005
摘要： Methods and apparatuses for improving sleep by transdermal electrical stimulation (TES). In general, described herein are methods for applying TES to a subject, and particularly the subject's head (e.g., temple/forehead region) and/or neck with an TES waveform adapted to improve sleep, including reducing sleep onset (falling to sleep) more quickly and/or lengthening the duration of sleep. TES waveform(s) particularly well suited to enhancing sleep are also described herein.
摘要翻译：通过透皮电刺激（TES）改善睡眠的方法和装置。一般来说，这里描述的是将TES应用于受试者，特别是受试者的头部（例如，神经/前额区域）和/或具有适于改善睡眠的TES波形的颈部的方法，包括减少睡眠开始（下降到睡眠）快速和/或延长睡眠持续时间。本文还描述了特别适合于增强睡眠的TES波形。

8. 发明申请

WO2016109851A1 METHODS AND APPARATUSES FOR TRANSDERMAL STIMULATION OF THE OUTER EAR 审中-公开
标题翻译：外耳炎的超声刺激的方法和装置
公开(公告)号：WO2016109851A1
公开(公告)日：2016-07-07
申请号：PCT/US2016/012054
申请日：2016-01-04
申请人： THYNC, INC.
发明人： TYLER, William, J. , LAW, Wing , JEFFERY, Douglas , PIERSIAK, Rafal
IPC分类号： A61M21/00 , A61M21/02
CPC分类号： A61N1/0472 , A61M21/00 , A61M21/02 , A61M2021/0072 , A61M2210/0662 , A61N1/0408 , A61N1/0476 , A61N1/32 , A61N1/36025 , A61N1/36036 , G10L15/02
摘要： Transdermal electrical stimulation (TES) applicators that are wearable and configured to attached to a subject's pinna (ear) and adapted to apply TES to modulate the subject's cognitive and/or physiological state. These apparatuses may be configured so that they can be worn against the ear (e.g., the cymba of the ear) to deliver TES. Also described herein are methods of using them to modulate a subject's cognitive state. These TES applicators may also be adapted to function as audio headphones for concurrent delivery of TES and audible signals (e.g., music).
摘要翻译：经皮电刺激（TES）施用器，其穿戴并配置成附着于受试者的针刺（耳朵）并适于应用TES以调节受试者的认知和/或生理状态。这些装置可以被配置为使得它们可以佩戴在耳朵上（例如，耳朵的环形体）以传递TES。本文还描述了使用它们来调节受试者的认知状态的方法。这些TES施加器还可以适于作为用于TES和可听信号（例如，音乐）的并发传送的音频耳机。

9. 发明申请

WO2015183690A1 CANTILEVER ELECTRODES FOR TRANSDERMAL AND TRNASCRANIAL STIMULATION 审中-公开
标题翻译： CANTILEVER电极用于超声和三叉神经刺激
公开(公告)号：WO2015183690A1
公开(公告)日：2015-12-03
申请号：PCT/US2015/031966
申请日：2015-05-21
申请人： THYNC, INC.
发明人： JEFFREY, Douglas , GOLDWASSER, Isy , LAW, Wing , DEMERS, Remi , HAMLIN, Jay, Frederick , WETMORE, Daniel, Z. , PAL, Sumon, K. , CHALRESWORTH, Jonathan , TYLER, William, J.
IPC分类号： A61N1/04 , A61N1/36
CPC分类号： A61N1/0492 , A61N1/0404 , A61N1/0456 , A61N1/0476 , A61N1/0484 , A61N1/36014 , A61N1/36025
摘要： Described herein are cantilever electrode apparatuses for wearable neuromodulation devices configured to be worn on a subject's (user's) head or on the subject's head and neck. These cantilever electrodes may be configured to mate with the wearable neuromodulation devices to form a neuromodulation system. Methods for attaching a wearable neurostimulator to a user's head (or head and neck) using a cantilever electrode apparatuses for neuromodulation are also described. An electrode assembly may mate with the wearable neuromodulation devices so that the device is worn over one portion of the electrode assembly while the rest of the electrode assembly attaches to another portion of the body. The neuromodulator may be worn on a portion of the electrode assembly in a cantilevered manner (e.g., held at one end while the opposite end is free-floating), which allows the rigid neuromodulation device to conform to a variety of user head sizes and shapes.
摘要翻译：这里描述了用于穿戴神经调节装置的悬臂电极装置，其被配置为佩戴在被检者（用户）的头部或被检者的头颈部上。这些悬臂电极可以配置成与可穿戴的神经调节装置配合以形成神经调节系统。还描述了使用用于神经调节的悬臂电极装置将可穿戴神经刺激器附接到使用者头部（或头颈部）的方法。电极组件可以与可穿戴的神经调节装置配合，使得该装置佩戴在电极组件的一部分上，而电极组件的其余部分连接到身体的另一部分。神经调节器可以以悬臂方式（例如，保持在一端而相对端是自由浮动的）佩戴在电极组件的一部分上，这允许刚性神经调节装置符合各种用户头部尺寸和形状。

10. 发明申请

WO2015179281A3 METHODS AND APPARATUSES FOR THE APPLICATION OF ENSEMBLE WAVEFORMS USING TRANSDERMAL NEUROSTIMULATION 审中-公开
公开(公告)号：WO2015179281A3
公开(公告)日：2015-11-26
申请号：PCT/US2015/031350
申请日：2015-05-18
申请人： THYNC, INC.
发明人： PAL, Sumon, K. , CHARLESWORTH, Jonathan , DEMERS, Remi , HAMLIN, Jay , WETMORE, Daniel, Z. , TYLER, William, J. , GOLDWASSER, Isy
IPC分类号： A61N1/36
摘要： Methods and apparatuses for electrical stimulation (e.g., neurostimulation) of a subject using ensemble waveforms that is made up of a sequence of different component waveforms each having predetermined waveform components (e.g., current amplitude, frequency, percent duty cycle, percent charge imbalance), in which one or more of these waveform components is changed between sequential component waveforms in the sequence forming the ensemble waveform delivered by transdermal electrical stimulation (TES). The ensemble waveforms described herein may be particularly effective at evoking a desired cognitive state by TES. Also described herein are methods of modulating the ensemble waveforms (e.g., by amplitude modulation) to enhance their efficiency and effectiveness. Methods and apparatuses for controlling the application of ensemble waveforms using TES by a neurostimulator, including streamlined communication of component waveforms between the neurostimulator and a separate controller are also described.

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