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1. 发明申请

WO2005096342A3 METHOD AND APPARATUS FOR ION FRAGMENTATION BY ELECTRON CAPTURE 审中-公开
公开(公告)号：WO2005096342A3
公开(公告)日：2005-10-13
申请号：PCT/GB2005/001198
申请日：2005-03-29
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , DENISOV, Eduard V. , JUNG, Gerhard
发明人： MAKAROV, Alexander, Alekseevich , DENISOV, Eduard V. , JUNG, Gerhard
IPC分类号： H01J49/04
摘要： The present invention relates to a method and apparatus for ion fragmentation by electron capture. The present invention provides a method of generating fragment ions by electron capture, comprising; directing ions to be fragmented into a fragmentation chamber of a mass spectrometer into a fragmentation chamber of a mass spectrometer arrangement; trapping at least some of the ions to be fragmented in at least one direction of the fragmentation chamber by using a magnetic field, the ions being trapped within a volume V; generating an electron beam using an electron source located away from the volume V; irradiating the trapped ions in the volume V with the electrons generated by the electron source in the presence of the said magnetic field, so as to cause dissociation; and ejecting the resultant fragment ions from the fragmentation chamber for subsequent analysis at a different location away from the fragmentation chamber.

2. 发明申请

WO2005124821A2 RF POWER SUPPLY FOR A MASS SPECTROMETER 审中-公开
标题翻译：射频电源用于质谱仪
公开(公告)号：WO2005124821A2
公开(公告)日：2005-12-29
申请号：PCT/GB2005/002444
申请日：2005-06-21
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , DENISOV, Eduard, V. , KHOLOMEEV, Alexander
发明人： MAKAROV, Alexander, Alekseevich , DENISOV, Eduard, V. , KHOLOMEEV, Alexander
IPC分类号： H01J49/42
CPC分类号： H01J49/0031 , H01J49/022 , H01J49/36 , H01J49/423 , H01J49/427
摘要： The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. Such ion storage devices are often used to store ions prior to ejection to a subsequent mass analyser. The RF field is usually collapsed prior to ion ejection. The present invention provides a RF power supply comprising: a RF signal supply, a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device, and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
摘要翻译：本发明提供质谱仪中的射频（RF）电源。电源向存储设备的电极提供RF信号以产生捕获场。这种离子存储装置通常用于在离开之前存储离子到随后的质量分析器。射频场通常在离子喷射之前倒塌。本发明提供一种RF电源，包括：RF信号电源，被布置成接收由RF信号电源提供的信号的线圈，并提供用于供应到离子存储装置的电极的输出RF信号，以及包括开关，其操作以在第一打开位置和第二关闭位置之间切换，其中所述分流器包括可操作地在第一打开位置和第二关闭位置之间切换的开关，在所述第一打开位置和所述第二关闭位置中，所述分流器使所述线圈输出短路。

3. 发明申请

WO2006103445A2 IMPROVEMENTS RELATING TO ION TRAPPING 审中-公开
标题翻译：关于离子捕获的改进
公开(公告)号：WO2006103445A2
公开(公告)日：2006-10-05
申请号：PCT/GB2006/001170
申请日：2006-03-29
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , MALEK, Robert , LANGE, Oliver
发明人： MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , MALEK, Robert , LANGE, Oliver
IPC分类号： H01J49/42
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积排列使得离子可以从一个体积向下一个体积移动，所述体积包括目标离子阱，由此离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

4. 发明申请

WO2006103412A2 IMPROVEMENTS RELATING TO MASS SPECTROMETRY 审中-公开
标题翻译：与质谱相关的改进
公开(公告)号：WO2006103412A2
公开(公告)日：2006-10-05
申请号：PCT/GB2006/001125
申请日：2006-03-29
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , KHOLOMEEV, Alexander , LANGE, Oliver
发明人： MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , KHOLOMEEV, Alexander , LANGE, Oliver
IPC分类号： H01J49/04
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。特别地，尽管并非排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供使用具有纵轴的质谱仪的质谱法，其包括引导离子沿着前进方向沿着质谱仪的纵向轴线行进，以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便将经处理的离子沿着纵轴排出回来，再次进入中间离子储存器，并将处理的离子的一个或多个脉冲沿离轴方向排出到质量分析器。

5. 发明申请

WO2006129083A2 MULTIPLE ION INJECTION IN MASS SPECTROMETRY 审中-公开
标题翻译：多重离子注入大量光谱
公开(公告)号：WO2006129083A2
公开(公告)日：2006-12-07
申请号：PCT/GB2006/001976
申请日：2006-05-31
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , LANGE, Oliver , HORNING, Stevan, Roy
发明人： MAKAROV, Alexander, Alekseevich , LANGE, Oliver , HORNING, Stevan, Roy
IPC分类号： H01J49/42
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions.; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译：本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。具体地说，尽管不是排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括累积所述一种类型离子的样品和/或另一类型离子的样品，以根据先前测量相应类型离子的结果来实现目标数目的离子。

6. 发明申请

WO2004083805A2 OBTAINING TANDEM MASS SPECTROMETRY DATA FOR MULTIPLE PARENT IONS IN AN ION POPULATION 审中-公开
标题翻译：在离子人群中获得多个离子的离子质谱数据
公开(公告)号：WO2004083805A2
公开(公告)日：2004-09-30
申请号：PCT/GB2004/001174
申请日：2004-03-19
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , SYKA, John, Edward, Philip
发明人： MAKAROV, Alexander, Alekseevich , SYKA, John, Edward, Philip
IPC分类号： G01N
CPC分类号： H01J49/063 , H01J49/004 , H01J49/423
摘要： This invention relates to tandem mass spectrometry and, in particular, to tandem mass spectrometry using a linear ion trap and a time of flight detector to collect mass spectra to form a MS/MS experiment. The accepted standard is to store and mass analyze precursor ions in the ion trap before ejecting the ions axially to a collision cell for fragmentation before mass analysis of the fragments in the time of flight detector. This invention makes use of orthogonal ejection of ions with a narrow range of m/z values to produce a ribbon beam of ions that are injected into the collision cell. The shape of this beam and the high energy of the ions are accommodated by using a planar design of collision cell. Ions are retained in the ion trap during ejection so that successive narrow ranges may be stepped through consecutively to cover all precursor ions of interest.
摘要翻译：本发明涉及串联质谱法，特别涉及使用线性离子阱和飞行时间检测器的串联质谱法来收集质谱以形成MS / MS实验。所接受的标准是在离子阱中存储和质量分析前体离子，然后在飞行时间内对碎片进行质量分析之前，将离子轴向排列到碰撞池进行碎裂。本发明利用具有窄范围m / z值的离子的正交喷射来产生注入到碰撞池中的带状离子束束。通过使用碰撞池的平面设计来容纳该束的形状和离子的高能量。在喷射期间离子被保留在离子阱中，使得连续的窄范围可以连续地步进以覆盖所有感兴趣的前体离子。

7. 发明申请

WO2012024412A1 ION TRANSFER TUBE HAVING ELONGATE BORE SEGMENTS 审中-公开
标题翻译：离子转移管具有最近的部分
公开(公告)号：WO2012024412A1
公开(公告)日：2012-02-23
申请号：PCT/US2011/048102
申请日：2011-08-17
申请人： THERMO FINNIGAN LLC , WOUTERS, Eloy, R. , MAKAROV, Alexander, Alekseevich , ATHERTON, R., Paul , DUNYACH, Jean Jacques
发明人： WOUTERS, Eloy, R. , MAKAROV, Alexander, Alekseevich , ATHERTON, R., Paul , DUNYACH, Jean Jacques
IPC分类号： H01J49/26
CPC分类号： H01J49/0404
摘要： An ion transfer tube for a mass spectrometer comprises a tube member having an inlet end and an outlet end; and at least one bore extending through the tube member from the inlet end to the outlet end, the at least one bore having a non-circular cross section. A method of forming an ion transfer tube comprises the steps of providing a tube member having a length and an internal bore, the internal bore having a wall of circular cross section; and etching or eroding portions of the tube member adjacent to the wall so as to form an enlarged bore having a non-circular cross section.
摘要翻译：用于质谱仪的离子转移管包括具有入口端和出口端的管构件; 以及至少一个孔，其从所述入口端延伸到所述管构件到所述出口端，所述至少一个孔具有非圆形横截面。形成离子转移管的方法包括提供具有长度和内孔的管构件的步骤，内孔具有圆形横截面的壁; 并且蚀刻或侵蚀与壁相邻的管构件的部分，以形成具有非圆形横截面的扩大孔。

8. 发明申请

WO2006103448A2 IMPROVEMENTS RELATING TO A MASS SPECTROMETER 审中-公开
标题翻译：关于质谱仪的改进
公开(公告)号：WO2006103448A2
公开(公告)日：2006-10-05
申请号：PCT/GB2006/001174
申请日：2006-03-29
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich
发明人： MAKAROV, Alexander, Alekseevich
IPC分类号： H01J49/04
CPC分类号： H01J49/004 , H01J49/04
摘要： This invention relates to mass spectrometers comprising a reaction cell and where mass spectra are collected both from unreacted ions and also from reaction product ions. In particular, although not exclusively, this invention finds use in tandem mass spectrometry where mass spectra are collected from precursor and fragment ions. The present invention provides an arrangement where ions may be sent to a reaction cell for fragmentation or other processing before onward transport to a mass analyser. Alternatively, ions may be passed directly to a mass analyser along a bypass path.
摘要翻译：本发明涉及包括反应池的质谱仪，其中质谱是从未反应的离子以及反应产物离子收集的。特别地，尽管不是排他地，本发明用于串联质谱法，其中从前体和碎片离子收集质谱。本发明提供了一种布置，其中离子可以在向前输送到质量分析器之前被送到反应池进行分段或其它处理。或者，离子可以沿着旁路路径直接传递到质量分析器。

9. 发明申请

WO2009091456A2 MASS SPECTROMETER WITH LOOPED ION PATH 审中-公开
标题翻译：带循环离子通道的质谱仪
公开(公告)号：WO2009091456A2
公开(公告)日：2009-07-23
申请号：PCT/US2008/085734
申请日：2008-12-05
申请人： THERMO FINNIGAN LLC , KOVTOUN, Viatcheslav, V. , MAKAROV, Alexander, Alekseevich
发明人： KOVTOUN, Viatcheslav, V. , MAKAROV, Alexander, Alekseevich
IPC分类号： B01D59/44
CPC分类号： H01J49/0081 , H01J49/062
摘要： A mass spectrometer includes at least one ion selector, at least one collision cell, and an ion path switching device arranged to define a looped ion path around which ions derived from a sample may be sent multiple times (without reversal of ion travel) in order to effect a desired number of isolation/fragmentation cycles for MSn analysis. When the desired number of isolation/fragmentation cycles have been completed, the ion path switching device directs the ions to a detector or a separate mass analyzer for acquisition of a mass spectrum.
摘要翻译：质谱仪包括至少一个离子选择器，至少一个碰撞池和离子路径切换装置，该离子路径切换装置被设置成限定循环的离子路径，围绕该离子路径从样品衍生的离子可以顺次多次发射（不反转离子行程）以实现MSn分析所需数量的分离/分段循环。当所需数量的隔离/破碎循环已经完成时，离子路径切换装置将离子引导到用于获取质谱的检测器或单独的质量分析器。

10. 发明申请

WO2007000587A2 MULTI-ELECTRODE ION TRAP 审中-公开
标题翻译：多电极离子阱
公开(公告)号：WO2007000587A2
公开(公告)日：2007-01-04
申请号：PCT/GB2006/002361
申请日：2006-06-27
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich
发明人： MAKAROV, Alexander, Alekseevich
IPC分类号： H01J49/42
CPC分类号： H01J49/282 , H01J49/0009 , H01J49/0031 , H01J49/22 , H01J49/424 , H01J49/425
摘要： This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes.
摘要翻译：本发明一般涉及多反射静电系统，更具体地涉及Orbitrap静电离子阱的改进和涉及。提出了一种操作具有可操作以模拟单个电极的电极阵列的静电离子捕获装置的方法，所述方法包括确定当施加到所述多个电极中的各个电极时产生静电捕获场的三个或更多个不同的电压其近似于将通过向单个电极施加电压而产生的场，以及将三个或更多个如此确定的电压施加到各个电极。进一步的改进在于从具有不同强度的峰与一个或多个收集的质谱测量多个特征以导出特性，并且使用测量的特性来改善施加到多个电极的电压。

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