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1. 发明申请

WO2002100295A2 FACIALLY AMPHIPHILIC POLYMERS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：作为抗感染剂的全氟化聚合物
公开(公告)号：WO2002100295A2
公开(公告)日：2002-12-19
申请号：PCT/US2002/022043
申请日：2002-03-07
申请人： THE UNIVERSITY OF PENNSYLVANIA , DeGRADO, William, F. , TEW, Gregory, N. , KLEIN, Michael, L. , LIU, Dahui , YUAN, Jing
发明人： DeGRADO, William, F. , TEW, Gregory, N. , KLEIN, Michael, L. , LIU, Dahui , YUAN, Jing
IPC分类号： A61F
CPC分类号： A61L15/44 , A01N25/10 , A01N37/18 , A01N37/22 , A01N37/24 , A01N37/28 , A01N37/30 , A01N37/42 , A01N47/22 , A01N47/30 , A01N47/44 , A61K31/74 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/20 , A61L2300/216 , A61L2300/404 , C08G18/2865 , C08G18/3225 , C08G61/02 , C08G61/10 , C08G61/122 , C08G69/26 , C08G73/028 , C08G73/22 , C08G2261/312 , Y10T428/193 , Y10T428/24207 , Y10T428/24446 , Y10T428/24455 , Y10T428/29 , Y10T428/31 , Y10T428/31504 , Y10T428/31678 , Y10T428/31725 , Y10T428/8305
摘要： Facially amphiphilic polymers and articles made therefrom having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a method to identify and optimize the facial amphiphilicity of polyamide, polyester, polyurea, polyurethane, polycarbonate and polyphenylene polymers. Utility as a contact disinfectant is disclosed.
摘要翻译：公开了两性聚合物和由其制成的制品具有杀生物面。聚合物可以抑制与表面或邻近所述杀生物表面的区域接触的微生物的生长。还公开了一种鉴定和优化聚酰胺，聚酯，聚脲，聚氨酯，聚碳酸酯和聚亚苯基聚合物的面部两亲性的方法。公开了作为接触消毒剂的效用。

2. 发明申请

WO2004082634A2 FACIALLY AMPHIPHILIC POLYMERS AND OLIGOMERS AND USES THEREOF 审中-公开
标题翻译：全氟聚合物和低聚物及其用途
公开(公告)号：WO2004082634A2
公开(公告)日：2004-09-30
申请号：PCT/US2004/008155
申请日：2004-03-17
申请人： DEGRADO, William, F. , LIU, Dahui , TEW, Gregory, N. , KLEIN, Michael, L. , YUAN, Jing , CHOI, Sungwook
发明人： DEGRADO, William, F. , LIU, Dahui , TEW, Gregory, N. , KLEIN, Michael, L. , YUAN, Jing , CHOI, Sungwook
IPC分类号： A61K
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译：本发明公开了使用表面两亲性聚合物和低聚物的方法，包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物，包括药物组合物。本发明还公开了表面两亲聚合物和低聚物的设计和合成。

3. 发明申请

WO2019242001A1 METHOD, COMPUTING DEVICE AND SYSTEM FOR GENERATING CONTENT 审中-公开
公开(公告)号：WO2019242001A1
公开(公告)日：2019-12-26
申请号：PCT/CN2018/092398
申请日：2018-06-22
申请人： MICROSOFT TECHNOLOGY LICENSING, LLC , SONG, Ruihua , XU, Yuanchun , YUAN, Jing , FU, Jianlong , ZHOU, Guang , CHENG, Wenfeng
发明人： SONG, Ruihua , XU, Yuanchun , YUAN, Jing , FU, Jianlong , ZHOU, Guang , CHENG, Wenfeng
IPC分类号： G06F17/27 , G06N3/02 , G06N5/02
摘要： Embodiments of the present disclosure provide a method for generating content, a computing and a system. The method may receive original material; obtain a first word set including at least a word describing affective feature of the original material; and generate the content by predicting each segment from a respective word in the first word set through a Recurrent Neural Network (RNN), wherein the RNN has been pre-trained by using at least one literary genre including modern poem. The content generated by the method according to the present disclosure may bring more impression and touching, have more space and better consistence.

4. 发明申请

WO2009096996A1 RENIN INHIBITORS 审中-公开
标题翻译：雷宁抑制剂
公开(公告)号：WO2009096996A1
公开(公告)日：2009-08-06
申请号：PCT/US2008/067650
申请日：2008-06-20
申请人： SMITHKLINE BEECHAM CORPORATION , VITAE PHARMACEUTICALS, INC. , BALDWIN, John J. , CACATIAN, Salvacion , CLAREMON, David , DILLARD, Lawrence, W. , FLAHERTY, Patrick, T. , GHAVIMI-ALAGHA, Bahman , ISHCHENKO, Alexey, V. , GHIRLANDA, Damiano , KALLANDER, Lara, S. , LAWHORN, Brian , LU, Qing , MCGEEHAN, Gerard , KNAPP-REED, Beth, A. , SEMUS, Simon , SIMPSON, Robert, D. , SINGH, Suresh, B. , TERRELL, Lamont, R. , TICE, Colin , TRAN, Tritin , Xu, Zhenrong , YUAN, Jing , ZHAO, Wei , ZHAO, Yongdong Y.
发明人： BALDWIN, John J. , CACATIAN, Salvacion , CLAREMON, David , DILLARD, Lawrence, W. , FLAHERTY, Patrick, T. , GHAVIMI-ALAGHA, Bahman , ISHCHENKO, Alexey, V. , GHIRLANDA, Damiano , KALLANDER, Lara, S. , LAWHORN, Brian , LU, Qing , MCGEEHAN, Gerard , KNAPP-REED, Beth, A. , SEMUS, Simon , SIMPSON, Robert, D. , SINGH, Suresh, B. , TERRELL, Lamont, R. , TICE, Colin , TRAN, Tritin , Xu, Zhenrong , YUAN, Jing , ZHAO, Wei , ZHAO, Yongdong Y.
IPC分类号： C09K11/06
CPC分类号： C07D211/22 , C07D265/30
摘要： Disclosed are compounds having the formula (I): wherein the R 1 , R 2 , R 3 , X, Y, A, L, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
摘要翻译：公开了具有式（I）的化合物：其中R1，R2，R3，X，Y，A，L和G如本文所定义。这些化合物与天冬氨酸蛋白酶结合以抑制其活性，并且可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。还公开了使用式I化合物在有需要的受试者中改善或治疗天冬氨酸蛋白酶相关病症的方法。

5. 发明申请

WO2007117559A3 RENIN INHIBITORS 审中-公开
公开(公告)号：WO2007117559A3
公开(公告)日：2007-10-18
申请号：PCT/US2007/008520
申请日：2007-04-05
申请人： VITAE PHARMACEUTICALS, INC. , BALDWIN, John, J. , CLAREMON, David, A. , TICE, Colin, M. , CACATIAN, Salvacion , DILLARD, Lawrence, W. , ISHCHENKO, Alexey, V. , YUAN, Jing , XU, Zhenrong , MCGEEHAN, Gerard , ZHAO, Wei , SIMPSON, Robert, D. , SINGH, Suresh, B.
发明人： BALDWIN, John, J. , CLAREMON, David, A. , TICE, Colin, M. , CACATIAN, Salvacion , DILLARD, Lawrence, W. , ISHCHENKO, Alexey, V. , YUAN, Jing , XU, Zhenrong , MCGEEHAN, Gerard , ZHAO, Wei , SIMPSON, Robert, D. , SINGH, Suresh, B.
IPC分类号： C07D211/22 , C07D265/30 , C07D401/06 , A61K31/44 , A61K31/5375 , A61P9/12
摘要： Described are compounds of the formula ( I ) which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof.

6. 发明申请

WO2006042150A1 DIAMINOALKANE ASPARTIC PROTEASE INHIBITORS 审中-公开
公开(公告)号：WO2006042150A1
公开(公告)日：2006-04-20
申请号：PCT/US2005/036230
申请日：2005-10-07
申请人： VITAE PHARMACEUTICAL, INC , BALDWIN, John, J. , CLAREMON, David, A. , TICE, Colin , CACATIAN, Salvation , DILLARD, Lawrence, W. , ISHCHENKO, Alexey, V. , YUAN, Jing , XU, Zhenrong , MCGEEHAN, Gerard , ZHAO, Wei , SIMPSON, Robert, D , SINGH, Suresh, B. , FLAHERTY, Patrick, T , WERY, Jean-Pierre
发明人： BALDWIN, John, J. , CLAREMON, David, A. , TICE, Colin , CACATIAN, Salvation , DILLARD, Lawrence, W. , ISHCHENKO, Alexey, V. , YUAN, Jing , XU, Zhenrong , MCGEEHAN, Gerard , ZHAO, Wei , SIMPSON, Robert, D , SINGH, Suresh, B. , FLAHERTY, Patrick, T , WERY, Jean-Pierre
IPC分类号： A61K31/445 , C07D211/22 , A61P9/12 , C07C235/42 , A61K31/166 , C07D265/30 , A61K31/5375 , C07D417/04 , C07D405/06 , C07D401/06 , C07D409/06 , C07D211/56 , C07D405/12
CPC分类号： C07D417/06 , C07C233/40 , C07C235/40 , C07C235/42 , C07C271/20 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D211/22 , C07D211/56 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/06 , C07F7/0812 , C07F7/0818
摘要： Diaminoalkanes of Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The invention also relates to a method for the use of the compounds of Formula I in ameliorating or treating aspartic protease related disorders in a subject in need thereof comprising administering to said subject an effective amount of a compound of Formula I.
摘要翻译：现已发现式I的二氨基烷烃是口服活性的并结合天冬氨酸蛋白酶以抑制其活性。它们可用于治疗或改善与升高的天冬氨酸蛋白酶活性水平相关的疾病。本发明还涉及在有需要的受试者中使用式I化合物来改善或治疗天冬氨酸蛋白酶相关病症的方法，包括向所述受试者施用有效量的式I化合物。

7. 发明申请

WO2015131306A1 DYNAMICS OF TIE STRENGTH FROM SOCIAL INTERACTION 审中-公开
标题翻译：社会互动强度的动态
公开(公告)号：WO2015131306A1
公开(公告)日：2015-09-11
申请号：PCT/CN2014/072785
申请日：2014-03-03
申请人： MICROSOFT TECHNOLOGY LICENSING, LLC , YUAN, Jing , XIE, Xing , RUI, Yong
发明人： YUAN, Jing , XIE, Xing , RUI, Yong
IPC分类号： G06F17/30
CPC分类号： G06Q50/01 , G06Q10/10
摘要： Systems and methods for observing friendships and social interactions between users of online communication platforms and ranking the users of the platforms to indicate likelihood of a user responding to a communication are described herein. At least one embodiment includes calculating a degree of intimacy using a degree of reciprocity, affinity calculation, sentiment value, self-disclosure value, and/or responsiveness value derived from communications initiated by a first user of a platform and directed communications from a second user of the platform in response to communications initiated by the first user. Degree of intimacy may be leveraged to rank two or more users of the platform and the ranking may be leveraged to predict which of the two or more users is more likely to respond to a communication from the first user. Various graphical user interfaces capable of producing visualizations of user intimacy and views of communication platforms are also described.
摘要翻译：本文描述了用于观察在线通信平台的用户之间的友谊和社交交互的系统和方法，并对平台的用户进行排名以指示用户响应通信的可能性。至少一个实施例包括使用由平台的第一用户发起的通信和来自第二用户的定向通信导出的互惠程度，亲和度计算，情感值，自我披露值和/或响应度值来计算亲密度的响应于由第一用户发起的通信。可以利用亲密程度对平台的两个或多个用户进行排名，并且可以利用排名来预测两个或更多个用户中的哪一个更可能响应来自第一用户的通信。还描述了能够产生用户亲密可视化和通信平台视图的各种图形用户界面。

8. 发明申请

WO2010085775A2 SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING WIDE-FIELD SUPERRESOLUTION MICROSCOPY 审中-公开
标题翻译：用于提供宽场超分辨显微镜的系统，方法和计算机可访问介质
公开(公告)号：WO2010085775A2
公开(公告)日：2010-07-29
申请号：PCT/US2010/022034
申请日：2010-01-26
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YUAN, Jing
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YUAN, Jing
IPC分类号： G01N23/04 , G01N33/483 , G01N21/62
CPC分类号： G01N21/6458 , G02B21/0032 , G02B21/0072 , G02B21/0076 , G02B21/16 , G02B27/48
摘要： Exemplary embodiments of apparatus, system, method and computer-accessible medium using which at least one first pulsed electro-magnetic radiation is generated. Such radiation depletes at least one excited state of at least one molecule. Further, it is possible to generate at least one second electro-magnetic radiation based on the first pulsed electro-magnetic radiation(s). For example, the second electro-magnetic radiation(s) can have a pattern with a plurality of spots.
摘要翻译：使用其生成至少一个第一脉冲电磁辐射的设备，系统，方法和计算机可访问介质的示例性实施例。这种辐射消耗至少一种分子的至少一种激发态。此外，可以基于第一脉冲电磁辐射产生至少一个第二电磁辐射。例如，第二电磁辐射可以具有带有多个点的图案。

9. 发明申请

WO2008124582A1 RENIN INHIBITORS 审中-公开
标题翻译：雷宁抑制剂
公开(公告)号：WO2008124582A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/059399
申请日：2008-04-04
申请人： SMITHKLINE BEECHAM CORPORATION , VITAE PHARMACEUTICALS, INC. , BALDWIN, John, J. , CACATIAN, Salvacion , CLAREMON, David , DILLARD, Lawrence, W. , FLAHERTY, Patrick, T. , GHAVIMI-ALAGHA, Bahman , GHIRLANDA, Damiano , HOU, Xiaoping , ISHCHENKO, Alexey, V. , KALLANDER, Lara, S. , KNAPP-REED, Beth, A. , LAWHORN, Brian , LU, Qing , MCGEEHAN, Gerard , SEMUS, Simon , SIMPSON, Robert, D. , SINGH, Suresh, B. , TERRELL, Lamont, R. , TICE, Colin , TRAN, Tritin , XU, Zhenrong , YUAN, Jing , ZHANG, Jing , ZHAO, Wei
发明人： BALDWIN, John, J. , CACATIAN, Salvacion , CLAREMON, David , DILLARD, Lawrence, W. , FLAHERTY, Patrick, T. , GHAVIMI-ALAGHA, Bahman , GHIRLANDA, Damiano , HOU, Xiaoping , ISHCHENKO, Alexey, V. , KALLANDER, Lara, S. , KNAPP-REED, Beth, A. , LAWHORN, Brian , LU, Qing , MCGEEHAN, Gerard , SEMUS, Simon , SIMPSON, Robert, D. , SINGH, Suresh, B. , TERRELL, Lamont, R. , TICE, Colin , TRAN, Tritin , XU, Zhenrong , YUAN, Jing , ZHANG, Jing , ZHAO, Wei
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： C07D401/06 , C07D211/22 , C07D265/30
摘要： Described are compounds which bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof.
摘要翻译：描述了结合天冬氨酸蛋白酶抑制其活性的化合物。它们可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。还描述了本文所述化合物在有需要的受试者中改善或治疗天冬氨酸蛋白酶相关病症的方法。

10. 发明申请

WO2008115313A1 MOTORCYCLE WHEEL ISOLATOR 审中-公开
标题翻译：摩托车轮隔离器
公开(公告)号：WO2008115313A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/001249
申请日：2008-01-30
申请人： THE GATES CORPORATION , FAN, Xinjian , YUAN, Jing , ZHU, Lin , FENG, Yuding
发明人： FAN, Xinjian , YUAN, Jing , ZHU, Lin , FENG, Yuding
IPC分类号： B62M21/00 , F16H55/14 , F16H55/30
CPC分类号： F16H55/14 , B62M21/00 , F16H55/171
摘要： A motorcycle wheel isolator comprising a first sprocket member (600), the first sprocket member having a first projecting member (300), a second hub member (400), the second hub member having a second projecting member (401), at least one first projecting member disposed between two second projecting members (401), whereby a receiving portion (601) is defined, at least one resilient isolator (10) having a first portion and a second portion connected by a connecting member (150), the resilient isolator disposed in the receiving portion, an edge of each first portion and second portion having a chamfer (175, 176) disposed adjacent either the first projecting member or second. projecting member, each first portion and second portion having a projecting member (102, 104, 204,. 205) disposed on an outer surface of each first portion and second portion such that a compressive force applied to the first portion and second portion causes a bending mode in each first portion and second portion, and each first portion and second portion having- a relief portion (40, 50, 60) disposed on an outer surface of each first portion and second portion such that the first portion and second portion may expand under the compressive force.
摘要翻译：一种摩托车车轮隔离器，包括第一链轮构件（600），所述第一链轮构件具有第一突出构件（300），第二轮毂构件（400），所述第二轮毂构件具有第二突出构件（401），至少一个第一突出构件设置在两个第二突出构件（401）之间，由此限定接收部分（601），至少一个弹性隔离器（10），具有第一部分和由连接构件（150）连接的第二部分，弹性隔离器设置在接收部分中，每个第一部分的边缘和第二部分具有邻近第一突出部件或第二部分设置的倒角（175,176）。每个第一部分和第二部分具有设置在每个第一部分和第二部分的外表面上的突出部件（102,104,204,205），使得施加到第一部分和第二部分的压缩力导致每个第一部分和第二部分具有设置在每个第一部分和第二部分的外表面上的释放部分（40,50,60），使得第一部分和第二部分可以在压缩力下膨胀。

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