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1. 发明申请

WO2008060927A2 HEPATITIS C VIRUS INHIBITORS 审中-公开
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：WO2008060927A2
公开(公告)日：2008-05-22
申请号：PCT/US2007084012
申请日：2007-11-08
申请人： SQUIBB BRISTOL MYERS CO , SIN NY , VENABLES BRIAN LEE , SUN LI-QIANG , SIT SING-YUEN , CHEN YAN , SCOLA PAUL MICHAEL
发明人： SIN NY , VENABLES BRIAN LEE , SUN LI-QIANG , SIT SING-YUEN , CHEN YAN , SCOLA PAUL MICHAEL
IPC分类号： C07D401/12 , A61K31/4709 , A61P31/14 , C07D401/14 , C07D417/14 , C07K5/00
CPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07K5/0812 , C07K5/0827
摘要： Hepatitis C virus inhibitors having the general formula, (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译：公开了具有通式（I）的丙型肝炎病毒抑制剂。还公开了包含所述化合物的组合物和使用所述化合物抑制HCV的方法。

2. 发明申请

WO2012125733A2 ANTIBODY SCREENING METHODS 审中-公开
标题翻译：抗体筛选方法
公开(公告)号：WO2012125733A2
公开(公告)日：2012-09-20
申请号：PCT/US2012029086
申请日：2012-03-14
申请人： X BODY INC , CHEN YAN , WOOLF TOD M , WAGNER RICHARD W
发明人： CHEN YAN , WOOLF TOD M , WAGNER RICHARD W
IPC分类号： C07K16/28 , C40B40/10 , G01N33/53
CPC分类号： G01N33/54306 , C07K16/005 , C07K16/2863 , C07K2317/21 , C07K2317/56 , C07K2317/622 , C40B30/04 , G01N33/6854
摘要： Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.
摘要翻译：提供用于产生特异性结合靶抗原的新型抗体的方法和组合物。这些方法和组合物特别可用于产生具有参考抗体的抗原结合特异性但具有相对于参照抗体具有改善的性质（例如，结合亲和力，免疫原性和热力学稳定性）的抗体。

3. 发明申请

WO2005101528A3 HETEROJUNCTION BIPOLAR TRANSISTOR HAVING NON-UNIFORMLY DOPED COLLECTOR FOR IMPROVED SAFE-OPERATING AREA 审中-公开
标题翻译：具有非均质聚光器的异相双极晶体管用于改进的安全操作区域
公开(公告)号：WO2005101528A3
公开(公告)日：2005-12-22
申请号：PCT/US2005011641
申请日：2005-04-06
申请人： WJ COMMUNICATIONS INC , LEE CHIEN PING , CHAU FRANK HIN FAI , WANG NANLEI LARRY , DUNNROWICZ CLARENCE JOHN , CHEN YAN , LIN BARRY JIA-FU
发明人： LEE CHIEN PING , CHAU FRANK HIN FAI , WANG NANLEI LARRY , DUNNROWICZ CLARENCE JOHN , CHEN YAN , LIN BARRY JIA-FU
IPC分类号： H01L29/08 , H01L29/737 , H01L31/0328
CPC分类号： H01L29/0821 , H01L29/7371
摘要： The safe-operating area (SOA) in a heterojunction bipolar transistor (HBT) is improved by providing a collector region in the transistor having a graded (continuous or stepped) doping between the base region and the underlying subcollector region with the collector doping being lowest near the base and highest near the subcollector and with the collector doping being less than the doping of the subcollector. The non-uniformly doped collector reduces Kirk effect induced breakdown when collector current increases.
摘要翻译：在异质结双极晶体管（HBT）中的安全工作区域（SOA）通过在晶体管中提供集电极区域来改善，晶体管在基极区域和下面的子集电极区域之间具有渐变（连续或阶梯）掺杂，集电极掺杂最低靠近基极并且在子集电极附近最高，并且集电极掺杂小于子集电极的掺杂。当集电极电流增加时，非均匀掺杂的集电极会降低Kirk效应引起的击穿。

4. 发明申请

WO2004041806A3 SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：取代的4-氨基-1-（吡咯烷基）哌嗪作为药物受体拮抗剂
公开(公告)号：WO2004041806A3
公开(公告)日：2004-08-05
申请号：PCT/US0334444
申请日：2003-10-29
申请人： THERAVANCE INC , MAMMEN MATHAI , WILSON RICHARD , CHEN YAN , DUNHAM SARAH , HUGHES ADAM , HUSFELD CRAIG , JI YU-HUA , LI LI , MISCHKI TREVOR , STERGIADES IOANNA
发明人： MAMMEN MATHAI , WILSON RICHARD , CHEN YAN , DUNHAM SARAH , HUGHES ADAM , HUSFELD CRAIG , JI YU-HUA , LI LI , MISCHKI TREVOR , STERGIADES IOANNA
IPC分类号： A61P13/10 , C07D401/00 , C07D401/14 , A61K31/4545
CPC分类号： C07D401/14
摘要： This invention provides 4-amino-1-(pyridylmethyl) piperidine of formula (I) and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.
摘要翻译：本发明提供式（I）的4-氨基-1-（吡啶基甲基）哌啶及其可用作毒蕈碱受体拮抗剂的相关化合物及其药学上可接受的盐。本发明还提供含有这些化合物的药物组合物; 用于制备这些化合物的方法和中间体; 以及使用这些化合物治疗由毒蕈碱受体介导的疾病状况的方法，例如膀胱过度活动，肠易激综合征和慢性阻塞性肺疾病。

5. 发明申请

WO2011116720A3 METHOD, DEVICE AND BASE STATION FOR ALLOCATING POWER 审中-公开
标题翻译：方法，设备和基站分配功率
公开(公告)号：WO2011116720A3
公开(公告)日：2012-04-05
申请号：PCT/CN2011073531
申请日：2011-04-29
申请人： HUAWEI TECH CO LTD , XU XIUQIANG , XU ZHIKUN , ZHANG SHUNQING , CHEN YAN
发明人： XU XIUQIANG , XU ZHIKUN , ZHANG SHUNQING , CHEN YAN
IPC分类号： H04W52/18
CPC分类号： H04W52/04
摘要： A method, a device and a base station for allocating power, which can provide optimal energy efficiency for a system, are disclosed in the embodiments of the present invention, wherein the method includes: when total transmitting power is a fixed value, computing a proportion a of reference signal power to the fixed value and a proportion of user data power of a user to the fixed value, wherein the user is any user in connection state in the system; according to the proportion a and proportion , judging whether the energy efficiency of the system is maximum when the total transmitting power is the fixed value; if yes, obtaining the proportion a and proportion , otherwise, updating the total transmitting power ; computing the proportion a and proportion after the total transmitting power is updated, and judging whether the energy efficiency of the system is maximum after the total transmitting power is updated; if yes, obtaining the computed proportion a and proportion after the total transmitting power is updated. The method provided in the present invention can further reduce system power consumption based on optimizing total power, reduce total energy consumption of the air interface of the system greatly, and realize efficient power saving.
摘要翻译：在本发明的实施例中公开了一种用于分配功率的方法，装置和基站，其可以为系统提供最佳的能量效率，其中所述方法包括：当总发射功率是固定值时，计算比例将固定值的参考信号功率和用户的用户数据功率的比例设定为固定值，其中用户是系统中处于连接状态的任何用户; 根据比例a和比例，判断总发射功率为固定值时系统的能效是否最大; 如果是，获得比例a和比例，否则更新总发射功率; 计算总发射功率后的比例a和比例，并更新总发射功率后，判断系统的能效是否最大; 如果是，则获得计算的比例a并且在总发射功率之后的比例被更新。本发明提供的方法可以通过优化总功率，大大降低系统空中接口的总能量消耗，进一步降低系统功耗，实现高效省电。

6. 发明申请

WO2011135438A3 PATTERNED DENTAL POSITIONING APPLIANCE 审中-公开
标题翻译：图案牙定位器具
公开(公告)号：WO2011135438A3
公开(公告)日：2012-01-19
申请号：PCT/IB2011000904
申请日：2011-04-21
申请人： ALIGN TECHNOLOGY INC , LI CHUNHUA , CHEN YAN
发明人： LI CHUNHUA , CHEN YAN
IPC分类号： A61C7/08
CPC分类号： A61C7/08 , Y10T29/49568
摘要： Embodiments are provided for a patterned dental positioning appliance. One method embodiment includes receiving a dental mold of a patient's dentition, applying a pattern to a portion of the dental mold, and applying a material to the dental mold to form the removable dental positioning appliance that includes either the pattern on the portion of the dental mold or an inverse thereof.
摘要翻译：为图案化牙科定位器具提供实施例。一种方法实施方案包括接收患者牙列的牙科模具，将模型施加到牙科模具的一部分，以及将材料施加到牙科模具以形成可移除的牙科定位器具，其包括牙齿部分上的图案模具或其倒数。

7. 发明申请

WO2007103302A3 WEIGHTING FUNCTION OF ENHANCE MEASURED DIFFRACTION SIGNALS IN OPTICAL METROLOGY 审中-公开
标题翻译：光学计量学中加权偏差信号的加权函数
公开(公告)号：WO2007103302A3
公开(公告)日：2008-08-28
申请号：PCT/US2007005573
申请日：2007-03-05
申请人： TOKYO ELECTRON LTD , VUONG VI , BAO JUNWEI , LI SHIFANG , CHEN YAN
发明人： VUONG VI , BAO JUNWEI , LI SHIFANG , CHEN YAN
IPC分类号： G06F15/00 , G01B11/14
CPC分类号： G01B11/24
摘要： A weighting function is obtained to enhance measured diffraction signals used in optical metrology. To obtain the weighting function, a measured diffraction signal is obtained. The measured diffraction signal was measured from a site on a wafer using a photometric device. A first weighting function is defined based on noise that exists in the measured diffraction signal. A second weighting function is defined based on accuracy of the measured diffraction signal. A third weighting function is defined based on sensitivity of the measured diffraction signal. A fourth weighting function is defined based on one or more of the first, second, and third weighting functions.
摘要翻译：获得加权函数以增强光学计量学中使用的测量衍射信号。为了获得加权函数，获得测量的衍射信号。使用光度测量装置从晶片上的位置测量测量的衍射信号。基于存在于测量的衍射信号中的噪声来定义第一加权函数。基于测量的衍射信号的精度来定义第二加权函数。基于测量的衍射信号的灵敏度来定义第三加权函数。基于第一，第二和第三加权函数中的一个或多个来定义第四加权函数。

8. 发明申请

WO2005056764A3 INHIBITORS OF TYPE 2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS 审中-公开
标题翻译： 2型血管内皮生长因子受体的抑制剂
公开(公告)号：WO2005056764A3
公开(公告)日：2006-05-11
申请号：PCT/US2004040885
申请日：2004-12-06
申请人： COMPOUND THERAPEUTICS INC , CHEN YAN , GETMANOVA ELENA , WRIGHT MARTIN C , HARRIS AL , LIM AI CHING , GOKEMEIJER JOCHIM
发明人： CHEN YAN , GETMANOVA ELENA , WRIGHT MARTIN C , HARRIS AL , LIM AI CHING , GOKEMEIJER JOCHIM
IPC分类号： A61K38/00 , A61K39/395 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/78 , C07K17/00 , C12N20060101 , G01N33/53
CPC分类号： C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
摘要： The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
摘要翻译：本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。本公开还提供了与单结构域结合多肽相关的各种改进。

9. 发明申请

WO0194664A3 COATING SYSTEM FOR HIGH TEMPERATURE STAINLESS STEEL 审中-公开
标题翻译：高温不锈钢涂层系统
公开(公告)号：WO0194664A3
公开(公告)日：2002-08-01
申请号：PCT/CA0100848
申请日：2001-06-08
申请人： SURFACE ENGINEERED PRODUCTS CO , TZATZOV KONSTANTIN K , FISHER GARY ANTHONY , PRESCOTT ROBERT , CHEN YAN , ZHENG HANG , SUBRAMANIAN CHINNIA GOUNDER , WYSIEKIERSKI ANDREW GEORGE , MENDEZ ACEVEDO JUAN MANUEL , GORODETSKY ALEXANDER S , REDMOND EDWARD JOHN
发明人： TZATZOV KONSTANTIN K , FISHER GARY ANTHONY , PRESCOTT ROBERT , CHEN YAN , ZHENG HANG , SUBRAMANIAN CHINNIA GOUNDER , WYSIEKIERSKI ANDREW GEORGE , MENDEZ ACEVEDO JUAN MANUEL , GORODETSKY ALEXANDER S , REDMOND EDWARD JOHN
IPC分类号： C23C14/14 , C22C19/05 , C22C21/02 , C23C14/34 , C23C26/00 , C23C28/00 , C23C30/00 , C10G9/16
CPC分类号： C23C28/345 , C23C26/00 , C23C28/321 , C23C28/3215
摘要： A method for protecting carbon steel and stainless steel, and particularly high temperature stainless steel, from coking and corrosion at elevated temperatures in corrosive environments, such as during ethylene production by pyrolysis of hydrocarbons or the reduction of oxide ores, by coating the steel with a coating of MCrA1X or MCrA1XT in which M is nickel, cobalt, iron or a mixture thereof, X is yttrium, hafnium, zirconium, lanthanum, scandium or combination thereof, and T is silicon, tantalum, titanium, platinum, palladium, rhenium, molybdenum, tungsten, niobium, or combination thereof. The coating and substrate preferably are heat-treated at about 1000 to 1200 DEG C for at least about 10 minutes, preferably about 20 minutes to 24 hours, effective to metallurgically bond the overlay coating to the substrate and to form a multiphased microstructure. The coating preferably is aluminized by depositing a layer of aluminum thereon and subjecting the resulting coating to oxidation at a temperature above about 1000 DEG C for a time effective to form an alumina surface layer. An intermediary aluminum-containing interlayer may be deposited directly onto the substrate prior to deposition of the overlay coating and is heat-treated with the coating to form a protective interlayer between the stainless steel substrate and coating to disperse nitride formation at the substrate/coating interface. Also, the coating may be deposited onto and metallurgically bonded to the substrate by plasma transferred arc deposition of atomized powder of MCrA1XT, obviating the need for a separate heat treatment. Alternatively, a blended powder composition to produce a desired MCrA1XT alloy may be applied to the substrate.
摘要翻译：一种用于保护碳钢和不锈钢特别是高温不锈钢的方法，在高温下在腐蚀性环境中的焦化和腐蚀，例如通过碳氢化合物的热解生产乙烯或氧化物矿石的还原，通过用钢 MCrA1X或MCrA1XT的涂层，其中M为镍，钴，铁或其混合物，X为钇，铪，锆，镧，钪或其组合，T为硅，钽，钛，铂，钯，铼，钼，钨，铌或其组合。涂层和基材优选在约1000至1200℃下热处理至少约10分钟，优选约20分钟至24小时，有效地将覆盖涂层冶金结合到基底上并形成多相微结构。涂层优选通过在其上沉积铝层而使其镀铝，并使所得涂层在高于约1000℃的温度下氧化一段时间以有效形成氧化铝表面层。中间含铝中间层可以在沉积覆盖涂层之前直接沉积到基底上，并用涂层进行热处理，以在不锈钢基底和涂层之间形成保护性中间层，以在基底/涂层界面上分散氮化物形成。此外，可以通过等离子体转移电弧沉积MCrA1XT的雾化粉末将涂层沉积在冶金上结合到基底上，从而避免了单独的热处理的需要。或者，可以将用于产生所需MCrAlXT合金的混合粉末组合物施加到基材上。

10. 发明申请

WO2014055427A2 FLAMESHEET COMBUSTOR DOME 审中-公开
标题翻译：火焰喷墨打印机
公开(公告)号：WO2014055427A2
公开(公告)日：2014-04-10
申请号：PCT/US2013062673
申请日：2013-09-30
申请人： ALSTOM TECHNOLOGY LTD , STUTTAFORD PETER JOHN , JORGENSEN STEPHEN , HUI TIMOTHY , CHEN YAN , RIZKALLA HANY , OUMEJJOUD KHALID
发明人： STUTTAFORD PETER JOHN , JORGENSEN STEPHEN , HUI TIMOTHY , CHEN YAN , RIZKALLA HANY , OUMEJJOUD KHALID
IPC分类号： F23R3/54
CPC分类号： F23R3/54 , F23C2201/20 , F23C2900/06043 , F23C2900/07001 , F23R3/14 , F23R3/16 , F23R3/26 , F23R3/286 , F23R3/34 , F23R3/343 , F23R3/60 , F23R2900/00014 , F23R2900/03343
摘要： The present invention discloses a novel apparatus and way for controlling a velocity of a fuel-air mixture entering a gas turbine combustion system. The apparatus comprises a hemispherical dome assembly which directs a fuel-air mixture along a portion of the outer wall of a combustion liner and turns the fuel-air mixture to enter the combustion liner in a manner coaxial to the combustor axis and radially outward of a pilot fuel nozzle so as to regulate the velocity of the fuel-air mixture.
摘要翻译：本发明公开了一种用于控制进入燃气轮机燃烧系统的燃料 - 空气混合物的速度的新型装置和方法。该装置包括半球形圆顶组件，其引导燃料 - 空气混合物沿着燃烧衬套的外壁的一部分并且以与燃烧器轴线同轴的方式转动燃料 - 空气混合物进入燃烧衬套并径向向外引燃燃料喷嘴，以调节燃料 - 空气混合物的速度。

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